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| 1 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 2 | 监测降钙素原指导抗生素治疗显示文摘降钙素原(PCT)是一种可用于评估细菌感染可能性的生物学标志物。用PCT指导抗生素治疗是减少其滥用的一种新的手段,这有助于降低抗生素不良反应及多重耐药菌出现的风险。然而,对PCT水平的解读必须密切结合临床实际情况和检测方法的特性。在临床实践中,我们应使用敏感度较高的PCT检测方法,并根据临床实际情况确定具体的检测界值。现将PCT水平检测对指导不同临床表现和不同潜在感染患者抗生素治疗的优点和局限性概述如下。 | Philipp Schuetz Werner Albrich Beat Mueller Miriam Christ-Crain Jean Chastre | 2013 | 中华结核和呼吸杂志2013，36，7： | 4 |
| 3 | Epidemiology of traumatic spine fractures显示文摘 | Philipp Leucht Klaus Fischer Gert Muhr Ernst J. Mueller | 2008 | Injury2008，，2： | 2 |
| 4 | Injury patterns of seniors in traffic accidents: A technical and medical analysis显示文摘AIM:To investigate the actual injury situation of seniors in traffic accidents and to evaluate the different injury patterns.METHODS:Injury data,environmental circumstances and crash circumstances of accidents were collected shortly after the accident event at the scene.With these data,a technical and medical analysis was performed,including Injury Severity Score,Abbreviated Injury Scale and Maximum Abbreviated Injury Scale.The method of data collection is named the German InDepth Accident Study and can be seen as representative.RESULTS:A total of 4430 injured seniors in traffic accidents were evaluated.The incidence of sustaining severe injuries to extremities,head and maxillofacial region was significantly higher in the group of elderly people compared to a younger age(P<0.05).The number of accident-related injuries was higher in the group of seniors compared to other groups.CONCLUSION:Seniors are more likely to be involved in traffic injuries and to sustain serious to severe injuries compared to other groups. | Stephan Brand Dietmar Otte Christian Walter Mueller Maximilian Petri Philipp Haas Timo Stuebig Christian Krettek Carl Haasper | 2012 | World Journal of Orthopedics2012，3，9： | 2 |
| 5 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 6 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 7 | Influence of the process parameters on the multi-directional forging operation of a two cylinder crankshatt显示文摘 | Mueller Sven Lau Philipp Nickel Rouven | 2008 | Materials processing and properties2008，，3： | 1 |
| 8 | Monito- ring Innovation in Electrochemical Energy Storage Technologies : A Patent-based Approach 显示文摘 | Simon C Mueller Philipp G Sandner Isabell M Welpe | 2015 | Applied Energy2015，137，2015： | 1 |
| 9 | Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory treat infections in primary care显示文摘 | Matthias B Philipp S Mueller B | | 0，，18： | 1 |
| 10 | Extracorporeal Life Sup- port -Systems, Indications, and Limitations 显示文摘 | Schmid C Philipp A Mueller T | 2009 | Thorac Cardiov Surg2009，57，8： | 1 |
| 11 | Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: results from an observational cohort study显示文摘 | Philipp Schuetz Natalie Friedli Eva Grolimund Alexander Kutz Sebastian Haubitz Mirjam Christ-Crain Robert Thomann Werner Zimmerli Claus Hoess Christoph Henzen Beat Mueller | 2014 | Diabetologia2014，，2： | 1 |
| 12 | Screw fixation of radial head fractures: Compression screw versus lag screw—A biomechanical comparison显示文摘 | Klaus J. Burkhart Tobias E. Nowak Philipp Appelmann Werner Sternstein Pol M. Rommens Lars P. Mueller | 2010 | Injury2010，，10： | 1 |
| 13 | FRG wasterwater treatment state of the art in the Federal Republic of Germany显示文摘 | Abert bursik Erich dieterlc Philipp mueller | 1988 | IWC1988，，38： | 1 |
| 14 | Procalcitonin guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care显示文摘 | Matthias B Philipp S Mueller B | 2008 | Arch Intern Med2008，168，18： | 1 |
| 15 | Sirolimus has a potential to influent viral recurrence in HCV positive liver transplant candidates显示文摘 | Doris Wagner Daniela Kniepeiss Silvia Schaffellner Estrella Jakoby Helmut Mueller Astrid Fahrleitner-Pammer Philipp Stiegler Karl-Heinz Tscheliessnigg Florian Iberer | 2010 | International Immunopharmacology2010，，8： | 1 |
| 16 | China's R&D explosion--Analyzing productivity effects across Ownership types and over time显示文摘 | Philipp Boeing Elisabeth Mueller | 2016 | Research Pllicy 452016，，： | 1 |
| 17 | Procalcitonin for diagnosis of infection and guide to antibiotic decisions:past,present and future显示文摘 | Philipp Schuetz Werner Albrich Beat Mueller | 2011 | BMC Med2011，9，： | 1 |
| 18 | Extracorporeal circulatorysystems as a bridge to lung transplantation at remote transplant centers显示文摘 | Haneya A Philipp A Mueller T | 2011 | Ann Thorac Surg2011，91，1： | 1 |
| 19 | Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care显示文摘 | MATTHIAS B PHILIPP S MUELLER B | 2008 | Arch Intern Med2008，168，18： | 1 |
| 20 | Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity显示文摘 | Philipp Jakob Carola Doerries Sylvie Briand Pavani Mocharla Nicolle Kr?nkel Christian Besler Maja Mueller Costantina Manes Christian Templin Christof Baltes Markus Rudin Heiner Adams Mathias Wolfrum Georg Noll Frank Ruschitzka Thomas F. Lüscher Ulf Landme | 2012 | Circulation2012，，25： | 1 |
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