|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 2 | Reliability and construct validity of the Health-Promoting Lifestyle Profile Ⅱ in an adult Turkish population显示文摘 | Pinar R Celik R Bahcecik N | 2009 | Nurs Res2009，58，3： | 1 |
| 3 | Total ankle arthroplasty in westernFrance : influence of volume on complications and clinical outcome显示文摘 | Pinar N Vemet E Bizot P ef al | 2012 | Orthop Traum Surg Res2012，98，： | 1 |
| 4 | Worst-case robust decisions for multi-period mean-variance portfolio optimization显示文摘 | Güpinar N Rustem B | 2007 | Euro-pean Journal of Operational Research2007，183，3： | 1 |
| 5 | Rapid detection of bacterial atypical pneumonia agents by multiplex PCR显示文摘 | Pinar A Bozdemir N Kocagz T | 2004 | Cent Eur J Public Health2004，12，1： | 1 |
| 6 | Reliability and construct validity of the Heahh-Promoting lifestyle profile II in an adult Turkish population显示文摘 | Pinar R Celik R Bahcecik N | 2009 | Nurs Res2009，58，3： | 1 |
| 7 | Major Vault Protein May Affect Nonhomologous End-Joining Repair and Apoptosis Through Ku70/80 and BAX Downregulation in Cervical Carcinoma Tumors显示文摘 | Marta Lloret Pedro Carlos Lara Elisa Bordón Fausto Fontes Agustin Rey Beatriz Pinar Orlando Falcón | 2009 | International Journal of Radiation Oncology Biology Physics2009，，4： | 1 |
| 8 | Bowen's disease:an uncommon presentation显示文摘 | Kilin N Pinar Z | 2004 | In?nüüniversitesi Tip Fakültesi Dergisi2004，11，2： | 1 |
| 9 | Total ankle arthroplasty- total ankle arthroplasty in Western France: influence of vol- ume on complications and clinical outcome 显示文摘 | Pinar N Vemet E Bizot P | 2012 | Orthop Traumatol Surg Res2012，98，4： | 1 |
| 10 | Severe um- bilical cord inflammation-a predictor of periventricular leu- komalaeia in very low birth weitht infants 显示文摘 | Wharton K N Pinar H Stonestree B S | 2004 | Early Hum Dev2004，77，： | 1 |
| 11 | Endoscopic endonasal transsphe- noidal surgery for pituitary adenomas显示文摘 | Pinar E Yuceer N Imre A | 2015 | J Craniofac Surg2015，26，： | 1 |
| 12 | Anticoagulant and Antiplatelet Therapy Use in 426 Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention and Stent Implantation显示文摘 | Juan M. Ruiz-Nodar Francisco Marín José Antonio Hurtado José Valencia Eduardo Pinar Javier Pineda Juan Ramón Gimeno Francisco Sogorb Mariano Valdés Gregory Y.H. Lip | 2008 | Journal of the American College of Cardiology2008，，8： | 1 |
| 13 | Reliability and construct validity of the Health - Promoting Lifestyle Profile H in an adult Turkish population显示文摘 | Pinar R Celik R Bahcecik N | 2009 | NursRes2009，58，3： | 1 |
| 14 | Experimental sinusitis in a rhinogenic model显示文摘 | Kara C O Cetin C B Demirkan N Sengül M Topuz B Pinar HS | 2004 | Laryn-goscope2004，114，： | 1 |
| 15 | Update on interventional cardiology显示文摘 | Pinar E Albarrán A Baz JA | | 0，，01： | 1 |
| 16 | PROJECTED COLOR SLIDES AS A METHOD FOR MASS SCREENING TEST FOR COLOR VISION DEFICIENCY (A PRELIMINARY STUDY)显示文摘 | N?MET üNAY GüNDOGAN NEZ?H DURMAZLAR KORAY GüMü? PINAR GEY?K ?ZDEM?R AY?E GüL ALTINTA? IRMAK DURUR G?LGE ACAROGLU | 2005 | International Journal of Neuroscience2005，，8： | 1 |
| 17 | Endoscopic endonasal transsphenoidal surgery for pituitary adenomas 显示文摘 | Pinar E Yuceer N Imre A | 2014 | J Cra- niofac Surg2014，26，1： | 1 |
| 18 | Reliability and construct validity of the Health-Promoting Lifestyle Profile Ⅱ in an adult Turkish population 显示文摘 | Pinar R Celik R Bahcecik N | 2009 | Nuts Res2009，58，3： | 1 |
| 19 | Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study显示文摘OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT score.Co-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as control.RESULTS Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex PCI.Co-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored therapy.No stent thrombosis reported in the subgroup with 1-3 months DAPT duration.As compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes. | Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado | 2022 | Journal of Geriatric Cardiology2022，19，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员