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| 1 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 2 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 3 | Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function显示文摘Background:Wnt/β-catenin signal has been reported to exert cytoprotective effects in cellular models of several diseases,including Parkinson’s disease(PD).This study aimed to investigate the neuroprotective effects of actived Wnt/β-catenin signal by Wnt3a on SH-SY5Y cells treated with 6-hydroxydopamine(6-OHDA).Methods:Wnt3a-conditioned medium(Wnt3a-CM)was used to intervene dopaminegic SH-SY5Y cells treated with 6-OHDA.Cell toxicity was determined by cell viability and lactate dehydrogenase leakage(LDH)assay.The mitochondria function was measured by the mitochondrial membrane potential,while oxidative stress was monitored with intracellular reactive oxygen species(ROS).Western blot analysis was used to detect the expression of GSK3β,β-catenin as well as Akt.Results:Our results showed that 100μM 6-OHDA treated for 24 h significantly decreased cell viability and mitochondrial transmembrane potential,reduced the level ofβ-catenin and p-Akt,increased LDH leakage,ROS production and the ratio of p-GSK3β(Tyr216)to p-GSK3β(Ser9).However,Wnt3a-conditioned medium reversing SH-SY5Y cells against 6-OHDA-induced neurotoxicity by reversing these changes.Conclusions:Activating of Wnt/β-catenin pathway by Wnt3a-CM attenuated 6-OHDA-induced neurotoxicity significantly,which related to the inhibition of oxidative stress and maintenance of normal mitochondrial function. | Lei Wei Li Ding Ming-shu Mo Ming Lei Limin Zhang Kang Chen Pingyi Xu | 2015 | Translational Neurodegeneration2015，4，1： | 2 |
| 4 | The kinematic synthesis of involute spiral bevel gears and their tooth contact analysis显示文摘 | Li Haitao Wei Wenjun Liu Pingyi | 2014 | Mechanism and Machine Theory2014，79，9： | 1 |
| 5 | Steam reforming of methane to hydrogen ovet Ni - based metal monolith catalysts显示文摘 | Pingyi Wu Xiujin Li Shengfu Ji | 2009 | Catalysis Today2009，146，12： | 1 |
| 6 | On the characteristics of queueing and scheduling at encoding nodes for network coding 显示文摘 | MA Yi LI Wei FAN Pingyi | 2009 | Wiley International Journal of Communication Systems2009，22，6： | 1 |
| 7 | The kinematic synthesis of involute spiral bevel gears and their tooth contact analysis显示文摘 | LI Haitao WEI Wenjun LIU Pingyi | 2014 | Mechanism and Machine Theory2014，79，9： | 1 |
| 8 | Outage probability of space-time network coding over rayleigh fading channels显示文摘 | XIONG Ke FAN Pingyi LI Tao | 2014 | IEEE Transactions on Vehicular Technology2014，63，4： | 1 |
| 9 | Outage probability of space- time network coding over rayleigh fading channels显示文摘 | Ke Xiong Pingyi Fan Tao Li Khaled Ben Letaief | 2014 | IEEE Transactions on Vehicular Technology2014，63，4： | 1 |
| 10 | Steam reforming of methane to hydrogen over Ni based metal monolith catalysts 显示文摘 | Wu Pingyi Li Xiuiin Ji Shengfu Lang Ban Fabien Habimana Li Chengyue | 2009 | Catalysis Today2009，146，12： | 1 |
| 11 | Catalytic oxidation of CO over Cux Ce1-xO2- x/ SBA-15/FeCrAl monolithic catalysts显示文摘 | Zhao Fuzhen Ji Shengfu Wu Pingyi Li Zhenfeng Li Chengyue | 2009 | Catalysis Today2009，147，1： | 1 |
| 12 | A study of the protein-protein interactions in the phycocyanin monomer from Synechocystis sp.PCC 6803 using a bacterial two-hybrid system显示文摘Investigations into the intramolecular interactions of the native protein in solution are important to understand its structural stability as well as its potential uses in future applications.In this study,we used a bacterial two-hybrid system to investigate the interaction between the phycocyanin��and��subunits that form the phycocyanin monomer.Key amino acid residues responsible for the interaction between the subunits were identified,providing direct experimental evidence for the intramolecular interaction. | Simi Shao Longsheng Zhao Pingyi Li Hainan Su Xiulan Chen Yuzhong Zhang | 2022 | Engineering Microbiology2022，2，2： | 0 |
| 13 | Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma显示文摘Previous studies suggest that the reduction of SMAD3(mothers against decapentaplegic homolog 3)has a great impact on tumor development,but its exact pathological function remains unclear.In this study,we found that the protein level of SMAD3 was greatly reduced in human-grade IV glioblastoma tissues,in which LAMP2A(lysosome-associated membrane protein type 2A)was significantly up-regulated.LAMP2A is a key ratelimiting protein of chaperone-mediated autophagy(CMA),a lysosome pathway of protein degradation that is activated in glioma.We carefully analyzed the amino-acid sequence of SMAD3 and found that it contained a pentapeptide motif biochemically related to KFERQ,which has been proposed to be a targeting sequence for CMA.In vitro,we confirmed that SMAD3 was degraded in either serum-free or KFERQ motif deleted condition,which was regulated by LAMP2A and interacted with HSC70(heat shock cognate 71 kDa protein).Using isolated lysosomes,amino-acid residues 75 and 128 of SMAD3 were found to be of importance for this process,which affected the CMA pathway in which SMAD3 was involved.Similarly,down-regulating SMAD3 or up-regulating LAMP2A in cultured glioma cells enhanced their proliferation and invasion.Taken together,these results suggest that excessive activation of CMA regulates glioma cell growth by promoting the degradation of SMAD3.Therefore,targeting the SMAD3-LAMP2Amediated CMA-lysosome pathway may be a promising approach in anti-cancer therapy. | Hanqun Liu Yuxuan Yong Xingjian Li Panghai Ye Kai Tao Guoyou Peng Mingshu Mo Wenyuan Guo Xiang Chen Yangfu Luo Yuwan Lin Jiewen Qiu Ziling Zhang Liuyan Ding Miaomiao Zhou Xinling Yang Lin Lu Qian Yang Pingyi Xu | 2022 | Neuroscience Bulletin2022，38，6： | 0 |
| 14 | High Stable and Accurate Vehicle Selection Scheme Based on Federated Edge Learning in Vehicular Networks显示文摘Federated edge learning(FEEL)technology for vehicular networks is considered as a promising technology to reduce the computation workload while keeping the privacy of users.In the FEEL system,vehicles upload data to the edge servers,which train the vehicles’data to update local models and then return the result to vehicles to avoid sharing the original data.However,the cache queue in the edge is limited and the channel between edge server and each vehicle is time-varying.Thus,it is challenging to select a suitable number of vehicles to ensure that the uploaded data can keep a stable cache queue in edge server while maximizing the learning accuracy.Moreover,selecting vehicles with different resource statuses to update data will affect the total amount of data involved in training,which further affects the model accuracy.In this paper,we propose a vehicle selection scheme,which maximizes the learning accuracy while ensuring the stability of the cache queue,where the statuses of all the vehicles in the coverage of edge server are taken into account.The performance of this scheme is evaluated through simulation experiments,which indicates that our proposed scheme can perform better than the known benchmark scheme. | Qiong Wu Xiaobo Wang Qiang Fan Pingyi Fan Cui Zhang Zhengquan Li | 2023 | China Communications2023，20，3： | 0 |
| 15 | Temporal Characteristics of the Queueing Process ot 3uffer-aided Wireless Communications显示文摘 | DONG Yunquan FAN Pingyi LI Enyu SONG Chuanwang LI Yansheng | 2014 | China Communications2014，11，A01： | 0 |
| 16 | Features on N/P ratio of plants with different functional groups between two types of steppe in semi-arid area显示文摘The differences in nitrogen/phosphorus(N/P)ratios of different functional groups in ecology are more helpful in explaining species competition and community dynamics.Based on the functional groups of plant growth type,carbon metabolism pathway,root type and phylogenetic type,we analyzed characteristics of leaf N/P ratios of 77 species in Sanggendalai(typical grassland zone)of Zhenglan Banner,Inner Mongolia,China and 91 species in the Habahu National Nature Reserve(desertified grassland zone)in Yanchi County of Ningxia,China.The results show that the N/P ratio(16.91)of C3 plants in the desertified steppe was significantly larger than that(12.72)in the typical steppe,but there was no significant difference between the N/P ratios of C4 plants in the two zones.There was no significant difference in N/P ratios between C3 plants and C4 plants in the same zone.Similarly,the N/P ratio(16.60)of dicotyledons in desertified steppe were significantly higher than that(12.98)in typical steppe,while differences in N/P ratios between monocotyledonous plants of the two zones was not significant,and there existed no significant difference in N/P ratios between dicotyledonous and monocotyledonous plants in the same zone.The N/P ratio had significant difference between gramineous and non-gramineous plants in the typical steppe but not in the desertified steppe,but there existed no significant difference in N/P ratios among different root types of perennial herbaceous plants in the same type of steppe or between two types of steppe.Thus,different features on the N/P ratios of C3 plants and dicotyledonous plants between typical steppe and desertified steppe may lead to different growth status of plants,and the N/P ratio stoichiometric of the same plant functional group may be a foundation of the changes of a plant community. | YueDan Zhao XingDong He Lei Chen XinFeng Ding MengQi Li PingYi Xu YuBao Gao | 2019 | Research in Cold and Arid Regions2019，11，5： | 0 |
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