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| 1 | Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed. | Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico | 2015 | World Journal of Hepatology2015，7，10： | 23 |
| 2 | Modern approach to the clinical management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease worldwide.It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver mortality.Common metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population.The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration.Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide.First-line management focuses on lifestyle modifications.Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.Several therapeutic interventions have been proposed.These include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin D3.However,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes.Metabolic conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual patients.Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients.The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. | Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo Loffredo Francesco Angelico | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 3 | Role of melatonin supplementation in neurodegenerative disorders显示文摘 | POLIMENI G ESPOSITO E BEVELACQUA V | 2014 | Front Bio Sci ( Landmark Ed)2014，19，1： | 1 |
| 4 | Drag-reducing polymers: a novel class of diuretic and natriuretic compounds 显示文摘 | Smyth DD Polimeni PI | 1990 | Cardiovasc Drugs Ther1990，4，1： | 1 |
| 5 | Non-alcoholic fatty liverdisease and cardiovascular disease: epidemiological, clinical and pathophysiologieal evidences显示文摘 | Del Ben M Baratta F Polimeni L | 2012 | Intern Emerg Med2012，7，3： | 1 |
| 6 | HIF-1 activation induces doxorubicin resistance in MCF-7 3-D spheroids via P-glycoprotein ex- pression:a potential model of the chemo-resistance of invasive micro- papillary carcinoma of the breast 显示文摘 | Doublier S Belisario DC Polimeni M | 2012 | BMC Cancer2012，12，： | 1 |
| 7 | Soluble CD40 ligand predicts ischemic stroke and myocardial infarction in patients with nonvalvular atrial fibrillation显示文摘 | Ferro D Loffredo L Polimeni L | 2007 | Arterioscler Thromb Vasc Biol2007，27，12： | 1 |
| 8 | Humor perception deficits in schizophrenia 显示文摘 | Polimeni J Reiss JP | 2006 | Psychiatry Res2006，141，2： | 1 |
| 9 | Regenerative potential and heal- ing dynamics of the periodontium: a critical-size supra-alveolar pe- riodontal defect study显示文摘 | Polimeni G Susin C Wikesjfi UM | 2009 | J Clin Periodontol2009，36，3： | 1 |
| 10 | Diminished humour perception in schizophrenia: Relationship to social and cognitive functioning 显示文摘 | Polimeni 10 Campbell DW Gill D | 2010 | J Psychiatr Res2010，44，7： | 1 |
| 11 | Soluble CD40 ligand predicts ischemic stroke and myocardial infarction in patients with nonvalvular atrial fibrillation显示文摘 | Ferro D Loffredo L Polimeni L | | 0，，： | 1 |
| 12 | Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation:radiographic observations显示文摘 | Pryor ME Yang J Polimeni G | | 0，，08： | 1 |
| 13 | Relation of Nonalcoholic Fatty Liver Disease and Framingham Risk Score to Flow-Mediated Dilation in Patients With Cardiometabolic Risk Factors显示文摘 | Daniele Pastori Lorenzo Loffredo Ludovica Perri Francesco Baratta Laura Scardella Licia Polimeni Arianna Pani Monica Brancorsini Fabiana Albanese Elisa Catasca Maria Del Ben Francesco Violi Francesco Angelico | 2015 | The American Journal of Cardiology2015，，10： | 1 |
| 14 | Non-alcoholic fatty liver disease and cardiovascular disease: epidemiological, clinical and pathophysiological evidences显示文摘 | DEL BM BARATTA F POLIMENI L | 2012 | Intern Emerg Med2012，7，3： | 1 |
| 15 | Histopathological observa- tions of a polylactic acid-based device intended for guided bone/ti- ssue regeneration显示文摘 | Polimeni G Koo KT Pringle GA | 2008 | Clin Implant Dent Relat Res2008，10，2： | 1 |
| 16 | The global financial crisis and its transmission to Asia Pacific显示文摘By virtue of the US markets closing later than Asia-Pacific(AP)markets,returns observed in the US include information not reflected in AP until the next day.Provided there is enough integration among markets,this asymmetry should then generate Granger causality from the US returns towards returns in the AP region.It is thus obvious that when testing for Granger causality among the Western and AP markets,interdependence due to non-synchronicity should be clearly identified and factored out.Our novel method is to measure contagion,usually defined as excessive market integration during crises,as excess interdependence beyond the non-synchronicity induced.We test for contagion of the 2008 Financial Crisis from the US to AP.The unmistakable emergence of a new cointegration relation that intertwines the US and AP markets only during the crisis,but not before,presents evidence of long-run contagion,that is a new channel that transmits crisis-related info.We find strong contagion from US to Korea,no contagion to Hong Kong,and Australia is a mixed case.Our explanation is that the Korean economy is the most vulnerable due to its export orientation,Hong Kong becomes disentangled due to its relation to China,which is consistent with the theory of‘decoupling’of China,and the Australian case is somewhere in the middle,probably due to its close ties to the US but also its strong reliance on natural resources and gold. | Vassilis Polimenis Ioannis Neokosmidis | 2014 | Journal of Management Analytics2014，1，4： | 1 |
| 17 | Renal sympathetic denerva- tion for treating resistant hypertension 显示文摘 | Polimeni A Curcio A Indolfi C | 2013 | Circ J2013，77，4： | 1 |
| 18 | Effects of a drag-reducing polyelectrolyte of microscopic linear dimension (Separan AP-273) on rat hemodynamics显示文摘 | Ottenbreit BT Polimeni PI | 1987 | Circ Res1987，61，6： | 1 |
| 19 | Current and future therapies of erectile dysfunction in neurological disorders 显示文摘 | Calabrb RS Polimeni'G Bramanti P | 2011 | Recent Pat CNS Drug Discov2011，6，1： | 1 |
| 20 | Hemodynamic effects of a poly(ethylene oxide) drag-reducing polymer,Polyox WSR N-60K,in the open-chest rat显示文摘 | Ottenbreit BT | 1989 | J Cardiovasc Pharmacol1989，14，3： | 1 |
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