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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Interaction between Helicobacter pylori and non-steroidal anti-inflammatory drugs in peptic ulcers bleeding显示文摘 | Wu CY Poon SK Chen GH | 1999 | Scand J Gastroenterol1999，34，： | 1 |
| 4 | The incidence ofreflux esophagitis among the Chinese显示文摘 | Chang CS Poon SK Lien HC | 1997 | Am J Gas-troenterol1997，92，： | 1 |
| 5 | Primary resistance to antibiotics and its clinical impact on the efficacy of Helicobaeter Pytori lansoprazde-based triple therapies显示文摘 | Poon SK Chang CS Su I | 2002 | Aliment Pharm acol Ther2002，16，： | 1 |
| 6 | Long-term Results of Surgical Techniques andProcedures in Men with Benign Prostatic Hyperplasia显示文摘 | Matcalfe C Poon SK | 2011 | CurrUrol Rep2011，12，4： | 1 |
| 7 | Two liters of polyethylene glycol- electrolyte lavage solution versus sodium phosphate as bowel cleansing regimen for colonoscopy: a prospective randomized controlled trial显示文摘 | Poon CM Lee DW Mak SK | 2002 | Endoscopy2002，34，7： | 1 |
| 8 | Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia 显示文摘 | WOO PC Lau SK Chu CM Chan KH Tsoi HW Huang Y Wong BH Poon RW Cai JJ Luk WK Poon LL Wong SS Guan Y Peiris JS Yuen KY | 2005 | J Virol2005，79，2： | 1 |
| 9 | Primary resistance to antibiotics and its clinical impact on the efficacy of Helicobacter pylori lansop razole based triple the rapies 显示文摘 | Poon SK Chang CS SU J | 2002 | A Liment Pharmacol Ther2002，16，2： | 1 |
| 10 | Primary resistance to antibiotics and its clinical impact on the efficacy of Helicobacter pylori lansoprazole based triple therapies显示文摘 | Poon SK Chang CS Su I | 2002 | Aliment Pharmacol Ther2002，16，： | 1 |
| 11 | MAP-1 is a mitochondrial effector of Bax显示文摘 | Tan KO Fu NY Sukumaran SK Chan SL Kang JH Poon KL | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 12 | Coping and caring: support for family caregivers of stroke survivors显示文摘 | Chow SK Wong FK Poon CY | 2007 | J Clin Nurs2007，16，7： | 1 |
| 13 | Coping and caring: support for family caregivers of stroke survivors显示文摘 | Chow SK Wong FK Poon CY | 2007 | J Clin Nurs2007，16，： | 1 |
| 14 | The incidence of reflux esophagitis among the Chinese显示文摘 | Chang CS Poon SK Lien HC | 1997 | Am J Gastroenterol1997，92，4： | 1 |
| 15 | Coexistence of dif-ferent genotypes in the same bat and serological character-ization of Rousettua bat coronavirus HKU9 belonging to anovel betacoronavirus subgroup 显示文摘 | Lau SK Poon RW Wong BH | 2010 | J Virol2010，84，11： | 1 |
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