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| 1 | Competing Risks Data Analysis with High-dimensional Covariates:An Application in Bladder Cancer显示文摘Analysis of microarray data is associated with the methodological problems of high dimension and small sample size. Various methods have been used for variable selection in highdimension and small sample size cases with a single survival endpoint. However, little effort has been directed toward addressing competing risks where there is more than one failure risks. This study compared three typical variable selection techniques including Lasso, elastic net, and likelihood-based boosting for high-dimensional time-to-event data with competing risks. The performance of these methods was evaluated via a simulation study by analyzing a real dataset related to bladder cancer patients using time-dependent receiver operator characteristic(ROC) curve and bootstrap.632+ prediction error curves. The elastic net penalization method was shown to outperform Lasso and boosting. Based on the elastic net, 33 genes out of 1381 genes related to bladder cancer were selected. By fitting to the Fine and Gray model, eight genes were highly significant(P < 0.001). Among them, expression of RTN4, SON, IGF1 R, SNRPE, PTGR1, PLEK, and ETFDH was associated with a decrease in survival time, whereas SMARCAD1 expression was associated with an increase in survival time. This study indicates that the elastic net has a higher capacity than the Lasso and boosting for the prediction of survival time in bladder cancer patients.Moreover, genes selected by all methods improved the predictive power of the model based on only clinical variables, indicating the value of information contained in the microarray features. | Leili Tapak Massoud Saidijam Majid Sadeghifar Jalal Poorolajal Hossein Mahjub | 2015 | Genomics, Proteomics & Bioinformatics2015，13，3： | 2 |
| 2 | The association between body mass index and preeclampsia: a meta-analysis 显示文摘 | Poorolajal J Jenabi E | 2016 | J Materu Fetal Neonatal Med2016，，： | 1 |
| 3 | Long term protection provided by hepatitis B vaccine and need for booster dose : a meta-analysis 显示文摘 | Poorolajal J Mahmoodi M Majdzadeh R | 2010 | Vaccine2010，28，3： | 1 |
| 4 | Evaluation of miR-141, miR-200c, miR-30b Expression and Clinicopathological Features of Bladder Cancer显示文摘 | Mahdavinezhad A Mousavi-Bahar S H Poorolajal J | 2015 | Int J Mol Cell Med2015，4，1： | 1 |
| 5 | Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis显示文摘 | Cheraghi Z Poorolajal J Hashem T | 2012 | PLoS One2012，7，51： | 1 |
| 6 | Long-termprotection provided by hepatitis B vaccine and need for booster dose:a meta-analysis显示文摘 | Poorolajal J Mahmoodi M Majdzadch R | 2010 | Vaccine2010，28，3： | 1 |
| 7 | Prevalence of osteoporosis in/ran: A meta-analysis 显示文摘 | Irani AD Poorolajal J Khalilian A | 2013 | J Res Med Sci2013，18，9： | 1 |
| 8 | The effect of body mass index on endometrial cancer: a meta-analysis 显示文摘 | Jenabi E Poorolajal J | 2015 | Public Health2015，129，7： | 1 |
| 9 | The association between body mass index and preeclampsia:a meta-analysis显示文摘 | Poorolajal J Jenabi E | 2016 | J Matern Fetal Neonatal Med2016，12，： | 1 |
| 10 | Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis显示文摘 | Cheraghi Z Poorolajal J Hashem T | 2012 | PLoS One2012，7，51： | 1 |
| 11 | Long - term protection provided by hepatitis B vaccine and need for booster dose: a meta-analysis 显示文摘 | Poorolajal J Mahmoodi M Majdzadeh R | 2010 | Vaccine2010，，28： | 1 |
| 12 | Survival rate of AIDS dis- ease and mortality in HIV - infected patients in Hamadan, Iran: a registry - based retrospective cohort study ( 1997 - 2011 ) 显示文摘 | Mirzaei M Poorolajal J Khazaei S | 2013 | Int J STD AIDS2013，24，11： | 1 |
| 13 | Mesh fixation compared with nonfixation in transabdominal preperitoneallaparoscopic inguinal hernia repalr显示文摘 | Amirzargar MA Mohseni M Poorolajal J | 2013 | Surg Technol Int2013，23，9： | 1 |
| 14 | Long-term protection provided by hepatitis B vaccine and need for booster dose: A meta-analysis显示文摘 | Jalal Poorolajal Mahmood Mahmoodi Reza Majdzadeh Siavosh Nasseri-Moghaddam AliAkbar Haghdoost Akbar Fotouhi | 2009 | Vaccine2009，，3： | 1 |
| 15 | Long-term protection provided by hepatitis B vaccine and need for booster dose : a meta-a- nalysis 显示文摘 | Poorolajal J Mahmoodi M Majdzadeh R | 2010 | Vaccine2010，28，3： | 1 |
| 16 | Long-term protection provided by hepatitis B vaccine and need for booster dose:a meta- analysis显示文摘 | Poorolajal J Mahmoodi M Majdzadeh R | 2010 | Vaccine2010，28，3： | 1 |
| 17 | Survival rate and the determinants of progression from HIV to AIDS and from AIDS to the death in Iran: 1987 to 2016显示文摘Objective: To examine the prognostic factors of progression from HIV to AIDS and AIDS to the death in people living with HIV/AIDS in Iran.Methods: In this registry-based retrospective cohort study, we recruited 28 873 HIV-infected people from 158 Behavioral Diseases Counseling Centers of Iran.Two outcomes of interest included survival rates from HIV diagnosis to AIDS and from AIDS to the death.We used Kaplan-Meier and Cox regression model to investigate survival rate and factors affecting on survival controlling effect of confounding factors.Results: The one, three, five, and ten-year survival rate from HIV to AIDS were 85%, 73%, 61% and 32%, and for AIDS to death were 90%, 81%, 74% and 55%, respectively.Multivariate Cox regression analysis indicated that the risk of progression from AIDS phase toward death in individuals with CD4 less than 200/mm^3, infected with tuberculosis(TB) and not treated by antiretroviral therapy(ART) was 2.17(95% CI: 1.62-2.90), 1.49(95% CI: 1.01-2.20) and 4.88(95% CI: 3.42-6.96) times higher respectively.The risk of progression to AIDS in patients with baseline CD4 less than 200/mm^3 was 2.32(95% CI: 2.14, 2.51) times higher than patients with CD4 > 200/mm^3(P=0.001).On the other hand, tuberculosis increases the risk of death by 49.0%(P=0.04).The hazard ratio of death in patients who did not receive ART was 4.88(95% CI: 3.42, 6.96) times higher than patients who received ART(P<0.001).Conclusion: The early detection of HIV, the screening and treatment of TB and receiving the ART improve the survival of HIV/AIDS patients significantly, and prevent the transmission of HIV to other people. | Mohammad Mirzaei Maryam Farhadian Jalal Poorolajal Parvin Afsar Kazerooni Katayoun Tayeri Younes Mohammadi | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，2： | 0 |
| 18 | Association between socioeconomic inequality and the global prevalence of anxiety and depressive disorders:an ecological study显示文摘Introduction Anxiety and depressive disorders pose significant public health issues across the world.Depression and other depressive disorders are mental illnesses characterised by a profound and persistent feeling of sadness or despair and a loss of interest in formerly pleasurable activities.Disturbances in sleep,appetite and cognitive processes are common symptoms.Globally,5%of adults are estimated to suffer from the disorder.1 Anxiety disorder is a chronic condition characterised by excessive and persistent apprehension,with physical symptoms such as sweating,palpitations,feelings of stress and increased blood pressure. | Fatemeh Shahbazi Marjan Shahbazi Jalal Poorolajal | 2022 | General Psychiatry2022，35，3： | 0 |
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