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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | Ulcerative colitis: From inflammation to cancer. Do estrogen receptors have a role?显示文摘Ulcerative colitis(UC) is a condition at increased risk for colorectal carcinoma(CRC) development. Nowadays, screening and follow-up programs are routinely performed worldwide to promote the early detection of CRCs in subjects with well known risk factors(extent, duration and severity of the disorder). The diffusion of these procedures is presumably the main reason for the marked reduction of cancer incidence and mortality in the course of UC. In addition, chemoprevention has been widely investigated and developed in many medical fields, and aspirin has shown a preventive effect against CRC, while mesalazine has been strongly invoked as a potential chemopreventive agent in UC. However, available studies show some limitations due to the obvious ethical implications of drug withdrawal in UC in order to design a control group. The estrogenreceptors(ER) alpha/beta balance seems to have a relevant influence on colorectal carcinogenesis and ER beta appears to parallel apoptosis, and hence an anticarcinogenic effect. Phytoestrogens are compounds acting as ER beta agonists and have shown a promising chemopreventive effect on sporadic as well as genetically inherited CRC. There is evidence suggesting a role for ERs in UC-related carcinogenesis. In this perspective, since these substances can be considered as dietary supplements and are completely free from side effects, phytoestrogens could be an interesting option for CRC prevention, even when the disease is a consequence of long-term chronic inflammation, as in the course of UC. Further studies of their effects are warranted in both the basic research and clinical fields. | Mariabeatrice Principi Michele Barone Maria Pricci Nicola De Tullio Giuseppe Losurdo Enzo Ierardi Alfredo Di Leo | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 3 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 4 | Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver显示文摘 | Carla Iacobini Stefano Menini Carlo Ricci Claudia Blasetti Fantauzzi Angela Scipioni Laura Salvi Samantha Cordone Francesca Delucchi Matteo Serino Massimo Federici Flavia Pricci Giuseppe Pugliese | 2010 | Journal of Hepatology2010，，5： | 2 |
| 5 | Increased retinal endothelial cell monolayer permeability induced by the diabetic milieu:role of advanced non-enzymatic glycation and polyol pathway activation显示文摘 | Leto G Pricci F Amadio L | 2001 | Diabetes Metab Res Rev2001，17，6： | 1 |
| 6 | Glomerular cell replication and cell loss through apoptosis in experimental diabetes mellitus显示文摘 | Pesce C Menini S Pricci F | 2002 | Nephron2002，90，4： | 1 |
| 7 | Distribution of estrogen receptor subtypes , expression of their variant forms and clinicopathological characteristics of human colorectal cancer显示文摘 | Cavallini A Messa C Pricci M | 2002 | Dig Dis Sci2002，47，12： | 1 |
| 8 | Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice显示文摘 | Pugliese G Pricci F Iacobini C | 2001 | FASEB2001，15，： | 1 |
| 9 | Mechanisms of glucose - enhanced extracellular matrix accumulation in rat glomerular mesangial cells 显示文摘 | Pugliese G Pricci F | 1994 | Diabetes1994，43，： | 1 |
| 10 | Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C显示文摘 | Pricci F Leto G Amadio L | 2003 | Free Radic Biol Med2003，35，6： | 1 |
| 11 | Upregulation of mesangial growth factor and extracellular matrix synthesis by advanced glycation end products via a receptor-mediated mechanism显示文摘 | Pugliese G Pricci F Romeo G | 1997 | Diabetes1997，46，： | 1 |
| 12 | Up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in left-sided human colon cancer 显示文摘 | Notarnicola M Messa C Pricci M | 2004 | Anticancer Res2004，24，6： | 1 |
| 13 | The diabetic milieu modulates the advanced glycation end product 2 receptor complex in the mesangium by inducing or up regulating galectin 23 expression显示文摘 | Pricci F Leto G | 2000 | Diabetes2000，49，： | 1 |
| 14 | Early, but not ad- vanced glomerulopathy is reversed by pancreatic is- let transplants in experimental diabetic rats corre- lated with glomerular extracellular matrix mRNA lev- el显示文摘 | Pagliase G Pricci F Pasce C | 1997 | Diabetes1997，40，： | 1 |
| 15 | Early, but not advanced, glomerulopathy is reversed by pancreatic islet transplants in experimental diabetic rats: correlation with glomerular extracellular matrix mRNA levels显示文摘 | Pugliese G Pricci F Pesce C Romeo G Lenti E Caltabiano V | 1997 | Diabetes1997，46，7： | 1 |
| 16 | Increased retinal endothelial cell monolayer permeability induced by the diabetic milieu:role of advanced non-enzymatic glycation and polyol pathway activation显示文摘 | Leto G Pricci F Amadio L Iacobini C Cordone S Diaz-Horta O | 2001 | Diabetes Metab Res2001，17，： | 1 |
| 17 | Role of Galectin-3 as a receptor for advanced glycosylation end products 显示文摘 | Pricci F Leto G Amadio L | 2000 | Kidney Int Suppl2000，77，： | 1 |
| 18 | Glomerular cell replication and cell loss through apoptosis in experimental diabetes mellitus显示文摘 | Menini S Pricci F | 2002 | Nephron2002，90，： | 1 |
| 19 | Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver显示文摘 | Carla Iacobini Stefano Menini Carlo Ricci Claudia Blasetti Fantauzzi Angela Scipioni Laura Salvi Samantha Cordone Francesca Delucchi Matteo Serino Massimo Federici Flavia Pricci Giuseppe Pugliese | 2010 | Journal of Hepatology2010，，5： | 1 |
| 20 | Glomercular cell replication and cell loss through apoptosis in experiment diabetes mellitus 显示文摘 | Pesce C Menini S Pricci F | 2002 | Nepbron2002，90，4： | 1 |
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