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| 1 | Hepatitis B:Epidemiology and prevention in developing countries显示文摘Hepatitis B virus(HBV)infection is a serious global public health problem.The infection may be transmitted through sexual intercourse,parenteral contact or from an infected mother to the baby at birth and,if contracted early in life,may lead to chronic liver disease,including cirrhosis and hepatocellular carcinoma.On the basis of the HBV carrier rate,the world can be divided in 3 regions of high,medium and low endemicity.The major concern is about high endemicity countries,where the most common route of infection remains vertical transmission from mother to child.Screening of all pregnant women and passive immunization with human hepatitis B immunoglobulin are not affordable for many developing countries.The infection rate can be reduced by modifying behavior,improving individual education,testing all blood donations,assuring asepsis in clinical practice and screening all pregnant women.However,availability of a safe and efficacious vaccine and adoption of appropriate immunization strategies are the most effective means to prevent HBV infection and its consequences.The unsolved problem for poorest countries,where the number of people currently infected is high,is the cost of the vaccine.A future challenge is to overcome the social and economic hurdles of maintaining and improving a prevention policy worldwide to reduce the global burden of the disease. | Elisabetta Franco Barbara Bagnato Maria Giulia Marino Cristina Meleleo Laura Serino Laura Zaratti | 2012 | World Journal of Hepatology2012，4，3： | 39 |
| 2 | Hepatitis A:Epidemiology and prevention in developing countries显示文摘Hepatitis A is the most common form of acute viral hepatitis in the world.Major geographical differences in endemicity of hepatitis A are closely related to hygienic and sanitary conditions and other indicators of the level of socioeconomic development.The anti-hepatitis A virus(HAV)seroprevalence rate is presently decreasing in many parts of the world,but in less developed regions and in several developing countries,HAV infection is still very common in the first years of life and seroprev-alence rates approach 100%.In areas of intermediate endemicity,the delay in the exposure to the virus has generated a huge number of susceptible adolescents and adults and significantly increased the average age at infection.As the severity of disease increases with age,this has led to outbreaks of hepatitis A.Several factors contribute to the decline of the infection rate,including rising socioeconomic levels,increased access to clean water and the availability of a hepatitis A vaccine that was developed in the 1990s.For populations with a high proportion of susceptible adults,implementing vaccination programs may be considered.In this report,we review available epidemiological data and implementation of vaccination strategies,particularly focusing on developing countries. | Elisabetta Franco Cristina Meleleo Laura Serino Debora Sorbara Laura Zaratti | 2012 | World Journal of Hepatology2012，4，3： | 20 |
| 3 | The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 Protein Forms an SCF Ubiquitin Ligase and Regulates Hypocotyl Elongation显示文摘由 ubiquitin proteasome 系统(不间断电源) 的蛋白质周转的规定是在优核质的主要 posttranslational 机制。UPS,的关键部件之一 COP9 signalosome (CSN ) ,调整 cullinring E3 ubiquitin ligases。在植物, CSN 参予多样的细胞、发展的进程,从到房间周期控制的轻发信号。在这个工作,我们孤立新植物特定的交往 CSN F 盒子蛋白质,我们它给 CFK1 (COP9 交往 F 盒子 KELCH 1 ) 取名。我们证明在 Arabidopsis thaliana, CFK1 是功能的 ubiquitin ligase 建筑群的一个部件。我们也证明那 CFK1 稳定性被 CSN 并且由 proteasome 依赖的解朊作用调整,并且那盏灯在胚轴导致 CFK1 抄本的累积。CFK1 的分析击倒,异种,和 overexpressing 幼苗显示 CFK1 由增加支持胚轴延伸房间尺寸。CSN 层次的减小提高弄空 CFK1 的幼苗的短胚轴显型,当 CSN 活动的完全的损失压制 CFK1-overexpressing 幼苗的长胚轴的显型时。我们建议那 CFK1 (并且它由 CSN 的规定) 细胞的机制的一个新奇部件正在控制胚轴延伸。 | Anna Franciosini Benedetta Lombardi Silvia lafrate Valeria.Pecce Giovanni Mele Leonardo Lupacchini Gianmarco Rinaldi Youichi Kondou Giuliana Gusmaroli Shiori Aki Tomohiko Tsuge Xing-Wang Deng Minami Matsui Paola Vittorioso Paolo Costantin Giovanna Serino | 2013 | Molecular Plant2013，6，5： | 3 |
| 4 | The Ever Expanding Role of Ubiquitin and SUMO in Plant Biology显示文摘When it was discovered in the 1970s as a ubiquitous protein,ubiquitin, a 76-aminoacid peptide, had no assigned function. It was not until later that ubiquitin was found to be a necessary cofactor in a vital cellular process: the degradation of proteins.Work by Avram Hershko, Aaron Ciechanover, and Irwin | Giovanna Serino Qi Xie | 2013 | Journal of Integrative Plant Biology2013，55，1： | 3 |
| 5 | Emerging Role of the Ubiquitin Proteasome System in the Control of Shoot Apical Meristem Function显示文摘The shoot apical meristem (SAM) is a population of undifferentiated cells at the tip of the shoot axis that establishes early during plant embryogenesis and gives rise to all shoot organs throughout the plant's life. A plethora of different families of transcription factors (TFs) play a key role in establishing the equilibrium between cell differentiation and stem cell maintenance in the SAM. Fine tuning of these regulatory proteins is crucial for a proper and fast SAM response to environmental and hormonal cues, and for development progression. One effective way to rapidly inactivate TFs involves regulated proteolysis by the ubiquitin/26S proteasome system (UPS). However, a possible role of UPS-dependent proteindegradation in the regulation of key SAM TFs has not been thoroughly investigated. Here, we summarize recent evidence supporting a role for the UPS in SAM maintenance and function. We integrate this survey with an in silico analysis of publicly-available microarray databases which identified ubiquitin ligases that are expressed in specific areas within the SAM, suggesting that they may regulate or act downstream of meristem-specific factors. | Elisabetta Di Giacomo Giovanna Serino Giovanna Frugis | 2013 | Journal of Integrative Plant Biology2013，55，1： | 2 |
| 6 | Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver显示文摘 | Carla Iacobini Stefano Menini Carlo Ricci Claudia Blasetti Fantauzzi Angela Scipioni Laura Salvi Samantha Cordone Francesca Delucchi Matteo Serino Massimo Federici Flavia Pricci Giuseppe Pugliese | 2010 | Journal of Hepatology2010，，5： | 2 |
| 7 | Testing and modelling a semi-actively controlled steel frame structure equipped with MR dampers 显示文摘 | RENZI E SERINO G | 2004 | Structural Control and Health Monitoring2004，11，3： | 1 |
| 8 | Interactions of the cop9 signalosome with the e3 ubiquitin ligase scftiri in mediating auxin response显示文摘 | Schwechheimer C Serino G Callis J | 2001 | Science2001，292，： | 1 |
| 9 | Plastid transformation in Arabidopsis thaliana 显示文摘 | Sikdar S R Serino G Chaudhuri S Pal M | 1998 | Plant Cell Rep1998，18，1： | 1 |
| 10 | High-fat diet induces periodontitis in mice through lipopolysaccharides(LPS)receptor signaling:protective action of estrogens显示文摘 | BLASCO-BAQUE V SERINO M VERGNES J N | 2012 | PLoS One2012，7，48： | 1 |
| 11 | Excimer Laser Ablation in the Treatment of Total Chronic Obstructions in Critical Limb Ischaemia in Diabetic Patients. Sustained Efficacy of Plaque Recanalisation in Mid-term Results显示文摘 | F. Serino Y. Cao C. Renzi L. Mascellari F. Toscanella D. Raskovic P. Tempesta G. Bandiera A. Santini | 2009 | European Journal of Vascular & Endovascular Surgery2009，，2： | 1 |
| 12 | A common mutation in the gene for coagulation factor Ⅻ-A(Va134Leu) :a risk factor for primary intracerebral hemorrhage is protective against atherothrombotic diseases显示文摘 | Gemmati D Serino ML Ongaro A | 2001 | Am J Hematol2001，67，3： | 1 |
| 13 | Abnormal rniR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy显示文摘 | Serino G Sallustio F Cox SN | 2012 | J Am Soe Nephrol2012，23，5： | 1 |
| 14 | A physiological role for adrenomedullin in rats, a potent hypotensive peptide in the hypothalamo-neurohypophysial system 显示文摘 | Ueta Y Serino R Shibuya I | 2000 | Exp Physiol2000，85，： | 1 |
| 15 | Distance-driven skeletonization in voxel images 显示文摘 | ARCELLI C SANNNITI DI BAJA G SERINO L | 2011 | IEEE Trans Pat-tern Anal Mach Intell2011，33，4： | 1 |
| 16 | Metabolic adaptation to a highfat diet is associated with a change in the gut microbiota显示文摘 | Serino M Luche E Gres S | | 0，，： | 1 |
| 17 | Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa显示文摘 | Serino L Reimmann C Haas D | 1997 | Journal of Bacteriology1997，179，1： | 1 |
| 18 | Immobilization of oligodeoxyribonucleotides with multiple anchors to microchips 显示文摘 | Zhao Xiao-dong Nampalli S Serino AJ | 2001 | Nucleic Acids Research2001，29，： | 1 |
| 19 | Gene therapy in peripheral artery disease显示文摘 | Melillo G Serino F Cirielli C | 2004 | Curr Drug Targets Cardiovase Haemmatol Disord2004，4，3： | 1 |
| 20 | Extent and location of bone loss at dental implants in patients with peri-implantitis显示文摘 | Serino G Turri A | 2011 | J Biomech2011，44，2： | 1 |
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