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| 1 | Colorectal cancer:Metastases to a single organ显示文摘Colorectal cancer(CRC) is a common malignancy worldwide. In CRC patients, metastases are the main cause of cancer-related mortality. In a group of metastatic CRC patients, the metastases are limited to a single site(solitary organ); the liver and lungs are the most commonly involved sites. When metastatic disease is limited to the liver and/or lungs, the resectability of the metastatic lesions will dictate the management approach and the outcome. Less commonly, the site of solitary organ CRC metastasis is the peritoneum. In these patients, cytoreduction followed by hyperthermic intraperitoneal chemotherapy may improve the outcome. Rarely, CRC involves other organs, such as the brain, bone, adrenals and spleen, as the only site of metastatic disease. There are limited data to guide clinical practice in these cases. Here, we have reviewed the disease characteristics, management approaches and prognosis based on the metastatic disease site in patients with CRC with metastases to a single organ. | Sina Vatandoust Timothy J Price Christos S Karapetis | 2015 | World Journal of Gastroenterology2015，21，41： | 30 |
| 2 | How to use magnetic resonance imaging following neoadjuvant chemotherapy in locally advanced breast cancer显示文摘Magnetic resonance imaging(MRI) is highly sensitive in identifying residual breast cancer following neoadjuvant chemotherapy(NAC), and consequently is a commonly used imaging modality in locally advanced breast cancer patients. In these patients, tumor response is an important prognostic indicator. However, discrepancies between MRI findings and surgical pathology are well documented. Overestimation of residual disease by MRI may result in greater surgery than is actually required while underestimation may result in insufficient surgery. Thus, it is important to understand when MRI findings are reliable and when they are less accurate. MRI most accurately predicts pathology in triple negative, Her2 positive and hormone receptor negative tumors, especially if they are of a solid imaging phenotype. In these cases, post-NAC MRI is highly reliable for surgical planning. Hormone receptor positive cancers and those demonstrating non mass enhancement show lower concordance with surgical pathology, making surgical guidance more nebulous in these cases. Radiologists and surgeons must assess MRI response to NAC in the context of tumor subtype. Indiscriminate interpretations will prevent MRI from achieving its maximum potential in the pre-operative setting. | Elissa R Price Jasmine Wong Rita Mukhtar Nola Hylton Laura J Esserman | 2015 | World Journal of Clinical Cases2015，3，7： | 6 |
| 3 | Management of gastric cancer in Asia: resource-stratified guidelines显示文摘 | Lin Shen Yan-Shen Shan Huang-Ming Hu Timothy J Price Bhawna Sirohi Kun-Huei Yeh Yi-Hsin Yang Takeshi Sano Han-Kwang Yang Xiaotian Zhang Sook Ryun Park Masashi Fujii Yoon-Koo Kang Li-Tzong Chen | 2013 | Lancet Oncology2013，，12： | 5 |
| 4 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 5 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 6 | Effects of microstructure and of protective coatings on the attack on steel by molten zinc显示文摘 | Price G D S Charles J A | 1973 | J Iron and Steel Institute1973，211，12： | 2 |
| 7 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 8 | Estimating leaf area index from satellite data显示文摘 | PRICE J C | 1993 | IEEE Transactions on Geoscience and Remote Sensing1993，，3： | 1 |
| 9 | The Logic of Animal Conflicts显示文摘 | MAYNARD-SMITH J PRICE G R | 1973 | Nature1973，246，11： | 1 |
| 10 | The potential of remotely sensed thermal infrared data to infer surface soil moisture and evaporation 显示文摘 | Price J C | 1980 | Water Resources Research1980，16，4： | 1 |
| 11 | Simulation of Dynamic Stall for a NACA 0012 Airfoil Using a Vortex Method 显示文摘 | Akbari M H Price S J | 2003 | Journal of Fluids and Structures2003，17，85： | 1 |
| 12 | Oxygen in the Earth' s core: A first-principles study显示文摘 | Alfe D Price G D Gillan M J | 1999 | Physics of Earth and Planetary Interior1999，110，： | 1 |
| 13 | Detection of the hybrid BCR/ABL messenger RNA in single CFU-GM colonies using the polymerase chain reaction显示文摘 | Hemandez A Osterholz J Price CM | 1990 | Exp Hematol1990，18，11： | 1 |
| 14 | Blood flow and leukocyte mobilization in infection:A comparison between ischemic and wellperfused flaps显示文摘 | Feng L J Price DC Hohn D | 1983 | Plast Surg Forum1983，86，： | 1 |
| 15 | Uptake of urea C and urea N by the coastal marine diatom 显示文摘 | Price N M Harrison P J | 1988 | Limnol Oceanogr1988，33，： | 1 |
| 16 | p53 mutation does not affect prognosis in ovarian epithelial malignancies显示文摘 | Fallows S Price J Atkinson RJ | 2001 | J Pathol2001，8，： | 1 |
| 17 | α1- Adrenergic receptor subtypes in human detrusor 显示文摘 | MALLOY B J PRINCE D T PRICE P R | 1998 | J Urol1998，160，： | 1 |
| 18 | Face recognition using direct,weighted discriminant analysis and modular subspaces显示文摘 | Price J R Gee T F | 2005 | Pattern Recognition2005，38，： | 1 |
| 19 | Alzheimer's disease: a dis-order of cortical cholinergie innervation显示文摘 | Coyle JT Price D J Delong MR | 1983 | Science1983，219，： | 1 |
| 20 | Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials显示文摘 | ROTHWELL P M PRICE J F FOWKES F G et 02 | 2012 | Lancet2012，379，9826： | 1 |
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