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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions显示文摘AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) execution.METHODS:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was made.The following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for comparison.RESULTS:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both explorations.Three anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both groups.CONCLUSION:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session. | Juan J Vila Marcos Kutz Silvia Goi Miriam Ostiz Edurne Amorena Carlos Prieto Cristina Rodriguez Ignacio Fernández-Urien Francisco J Jiménez | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 3 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 4 | Reversible and athermal photo-vitrification of As50 ·Se50 thin films deposited onto silicon wafer and glass substrates 显示文摘 | PRIETO - ALCON R MARQUEZ E GONZALEZ- LEAL J M | 1999 | Appl Phys A1999，68，： | 2 |
| 5 | Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes 显示文摘 | Guillen J de Ahneida RF Prieto M | 2009 | Mol Membr Biol2009，26，4： | 1 |
| 6 | Biochemical traits and antimicrobial susceptibility of Streptococcus suis isolated from slaughtered pigs显示文摘 | Prieto C Garcia F J Suarez P | 1994 | J Vet Med1994，41，9： | 1 |
| 7 | Isolation,purification,and characterization of a cold-active lipase from Aspergillus nidulans显示文摘 | Mayordomo I Randez-Gil F Prieto J A | 2000 | J Agric Food Chem2000，48，1： | 1 |
| 8 | Potential use of near infrared reflectance spectroscopy (NIRS) for the estimation of chemical composition of oxen meat samples显示文摘 | Prieto N Andr6s S Gir/:ldez F J | 2006 | Meat Science2006，74，3： | 1 |
| 9 | A new minimal approach in cochlear implant surgery:the Colombian experience显示文摘 | Almario J Lora J Prieto J | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 10 | Environmental efficiency and regulatory standards:the case of CO2 emissions from OECD industries显示文摘 | ZOFIO J L PRIETO A M | 2001 | Resource and Energy Economics2001，23，1： | 1 |
| 11 | Isolation, purification and characterization of a cold-active lipase from Aspergillus nidulans 显示文摘 | Mayordomo I Randez-Gil F Prieto J A | 2000 | J Agric Food Chem2000，48，： | 1 |
| 12 | The phytotoxic activity of some metabolites of Botrytis cinerea 显示文摘 | Rebordinos L Cantoral J M Prieto M V | 1996 | Phytochemistry1996，42，： | 1 |
| 13 | Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocation显示文摘 | Prieto J Lensmar C Roquet A | 2000 | Respir Med2000，94，： | 1 |
| 14 | Effects of intense pulsed light on sun-damaged human skin:routine,and ultrastructural analysis显示文摘 | Prieto VG Sadick NS Lloreta J | 2002 | Lasers Surg Med2002，30，： | 1 |
| 15 | Abnormal gamma- IFN and alpha-TNF secretion in purified CD2^+ cells from autoimmune thrombocytopenic purpua (ATP) patient : their implication in the clinical course of the disease显示文摘 | GARCIA-SUAREZ J PRIETO A REYES E | 1995 | Am H Hematol1995，49，4： | 1 |
| 16 | Determination of fipronil by solid-phase microextraction and gas chromatography-mass spectrometry 显示文摘 | Vilchez J L Prieto A Araujo L | 2001 | Journal of Chromatography A2001，919，1： | 1 |
| 17 | Single phase power factor correction: a survey显示文摘 | Garcia O Cobos J A Prieto R | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
| 18 | Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxzcin显示文摘 | ARAUJO L PRIETO A | 2001 | J Phar and Biome Anal2001，26，1： | 1 |
| 19 | Loss of Mda-7 expression with progression of melanoma显示文摘 | Ellerhorst J A Prieto V G Ekmekcioglu S | 2002 | J Clin Oncol2002，20，4： | 1 |
| 20 | Statistical evaluation of mathematical models for microbial growth Intematonal显示文摘 | S Lopez M prieto J Dijkstra | 2004 | Jourmal of Food Microbiology2004，96，： | 1 |
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