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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Influence of the properties of zeolite BEA on its performance in the nitration of toluene and nitrotoluene显示文摘 | Bernasconi S Pirngruber G D Prins R | 2004 | J Catalysis2004，，224： | 1 |
| 4 | A monoclonal antibody-based immunoperoxidase monolayer assay for detection of type 1 and type 2 bovine viral diarrhea viruses显示文摘 | Deregt D Prins S | 1998 | Can J Vet Res1998，62，： | 1 |
| 5 | Cerebral white matter lesions and the risk of dementia显示文摘 | Prins N D van Dijk E J den Heijer T | | 0，，10： | 1 |
| 6 | Genes prefereutially induced by depolarization after con-cussive brain injury: effects of age and injury sever- ity显示文摘 | GIZA C C PRINS M L HOVDA D A | 2002 | J Neurotrauma2002，19，4： | 1 |
| 7 | Silent brain infarcts and the risk of dementia and cognitive decline显示文摘 | Vermeer S E Prins N D den Heijer T | 2003 | N Engl J Med2003，348，17： | 1 |
| 8 | Efficacy and safety of the oral direct factor X a inhibitor apixaban for symptoma- tic deep vein thrombosis: the Botticelli DVT dose-ranging study 显示文摘 | Buller H Deitchman D Prins M | 2008 | J Thromb Haemost2008，6，： | 1 |
| 9 | EGFR signaling through an Akt-SREBP-1 -dependent,rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy显示文摘 | Guo D Prins RM Dang J | 2009 | Science Signaling2009，2，101： | 1 |
| 10 | Diagnosis of arterial disease of the lower extremities with duplex uhrasonography 显示文摘 | Koelemay MJ den Hartog D Prins MH | 1996 | Br J Surg1996，83，： | 1 |
| 11 | Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells 显示文摘 | Prins FA Mason DY | 1994 | Cancer Res1994，54，1： | 1 |
| 12 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 13 | Batch and continuous nitration of toluene and chlorobenzene with acetyl nitrate over zeolite beta显示文摘 | Kuba M G Prins R Pirngruber G D | 2007 | Appl Catal A: General(S0926-860X)2007，333，1： | 1 |
| 14 | In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells显示文摘 | PRINS H J BRAAT A K GAWLITTA D | 2013 | Stem Cell Res2013，12，： | 1 |
| 15 | The lung pulse : A nearly ultrasound sign of complete atelectasis显示文摘 | Lichtenstein D Lascols N Prin S el al | 2003 | Intensive Care Med2003，29，10： | 1 |
| 16 | Potential global fire monitoring from EOS-MODIS显示文摘 | Kaufman Y J Justice C O Flynn L P Kendall J D Prins E M Giglio L Ward D E Menzel W P & Setzer A W | 1998 | Journal of Geophysical Research1998，103，32： | 1 |
| 17 | The pathophysiology of traumatic brain injury at a glance显示文摘 | PRINS M GRECO T ALEXANDER D | 2013 | Dis Model Mech2013，6，6： | 1 |
| 18 | The effect of glycol on phosphate-doped CoMo/A12O3hydrotreatingcatalysts显示文摘 | Nicosia D Prins R | 2005 | JournalofCatalysis2005，229，： | 1 |
| 19 | Risk factors and outcome of transfusion-related acute lung injury in the critically ill:a nested case-control study显示文摘 | Vlaar AP Binnekade JM Prins D | 2010 | Crit Care Med2010，38，： | 1 |
| 20 | Objective and per- ceived availability of physical activity opportunities: Differences in associations with physical activity behavior among adoles- cents显示文摘 | PRINS R G OENEMA A VAN D H K | 2009 | Int J Behav Nutr Physic Activ2009，6，2： | 1 |
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