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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Multiplexing of Y chromosome specific STRs and performance for mixed samplex显示文摘 | Prinz M Boll K Baum H | | Forensic Sci Int0，85，： | 1 |
| 3 | Monte Carlo simulation of particulate matter segregation显示文摘 | ROSATE A PRINZ F STANDBURG K J | 1986 | Powder Technology1986，49，1： | 1 |
| 4 | IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses显示文摘 | Schellack C Prinz K Egyed A | 2006 | Vaccine2006，24，26： | 1 |
| 5 | Burnout, depression and depersonalization psychological factors and coping strategies in dent- al and medical students显示文摘 | Prinz P Hertrich K Hirsehfelder U | 2012 | GMS Zeitschrifi fiir Medizinische Aus- bildung2012，29，： | 1 |
| 6 | Free- standing and overgrown InGaAs/GaAs nanotubes, nanohelices and their arrays显示文摘 | PRINZ V Y SELEZNEV V A GUTAKOVSKY A K | 2000 | Physica2000，6，14： | 1 |
| 7 | Migratory orientation of pied flycatchers:interaction of stellar and magnetic information during ontogeny显示文摘 | Prinz K Wiltschko W | | 0，，： | 1 |
| 8 | The CR (Renazzo-type) carbonaceous chondrite group and its implications显示文摘 | Weisberg M K Prinz M Clayton R N Mayeda T K | 1993 | Geochim Cosmochim Acta1993，57，7： | 1 |
| 9 | Multiplexing of Y chromosome abnormalities DNA testing using amelogenin and sex chromosome shortandem repeats 显示文摘 | Prinz M Boll K Baum H | 2001 | Forensic Sci2001，46，2： | 1 |
| 10 | Believe it or not= how much can we rely on published data on potential drug targets? 显示文摘 | Prinz F Schlange T Asadullah K | 2011 | Nature Reviews Drug Discovery2011，10，9： | 1 |
| 11 | TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis 显示文摘 | Takahashi K Prinz M Stagi M | 2007 | PLoS Med2007，4，4： | 1 |
| 12 | Free-standing and overgrown InGaAs/GaAs nanotubes,nanohelices and their arrays显示文摘 | Prinz V Ya Seleznev V A Gutakovsky A K | 2000 | Physica E2000，6，： | 1 |
| 13 | An algorithm for seam tracking applications显示文摘 | Neuman C P Prinz F B | 1985 | The International Journal of Robotics Research1985，4，1： | 1 |
| 14 | Why the Brazil nuts are on top:size segregation of particulate matter by shaking显示文摘 | Rosato A D Strandburg K J Prinz F Swendsen R H | 1987 | Physical Review Letters1987，58，： | 1 |
| 15 | Sleep complaints cosegregate with illness in older adults: clinical research by and informing epidemiolojical studies of sleep 显示文摘 | Vitiello M V Moe K E Prinz P N | 2002 | J Psy- chosem Res2002，53，1： | 1 |
| 16 | Structural effects in the analysis of supported lipid bilayers by time-of-flight secondary ion mass spectrometry显示文摘 | PRINZ C HK F MALM J | 2007 | Langmuir2007，23，15： | 1 |
| 17 | Burnout, depression and depersonalisation-psyehologieal factors and coping strategies in dental and medical students 显示文摘 | Prinz P Hertrieh K Hirsehfelder Lr | 2012 | GMS Z bled Ausbild2012，29，1： | 1 |
| 18 | An algorithm for seam tracking applications显示文摘 | Neuman C P Prinz F B | 1985 | International Journal of Robotics Research1985，4，： | 1 |
| 19 | Mayeda: CV3 chondrites: three subgroups, not two (absti'act) 显示文摘 | Weisberg M K Prinz M Clayton R N | 1997 | Meteoritics Planet Sci1997，32，： | 1 |
| 20 | The K (Kakangari) chon- drlte grouplet 显示文摘 | Weisberg M K Prinz M Clayton R N Mayeda T K Grady M M Franchi I Pillinger C T Kallemenn G W | 1996 | Geochim Cosmochim Acta1996，60，： | 1 |
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