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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism显示文摘 | An H Xu H Zhang M Zhou J Feng T Qian C Qi R Cao X | 2006 | 第二军医大学学报2006，27，1： | 6 |
| 3 | N_2O emissions from agricultural soils in the North China Plain: the effect of chemical nitrogen fertilizer and organic manure显示文摘An enclosed chamber technique was used to measure N 2O emissions from intensively agricultural soils of the North China Plain during the periods of 1995—1996 and 1997—1998, to reflect distinct components of winter wheat and summer maize growing seasons. The results showed that the continuous application of fertilizer in agricultural soils increased N\-2O emissions by a factor of 24.1—28.1, the calculated annual chemical N fertilizer\|transformed N\-2O\|N emissions was 0.67%. Our results indicated that the application of organic manure also had a significant influence on soil N 2O emissions, which combined with the use of chemical N increased about 20% in a year. It was calculated that there were about 0.11% N of organic manure transformed as N 2O N. Annual mean N 2O emission from our study area of fertilized soils was estimated to be 57.1 μgN 2O/(m 2·h). A weak correlation was also found between N 2O emissions and soil available nitrogen content NH + 4. | DONG Yun\|she 1,2,3 , Dieter Scharffe 2, Manfred Domroes 3, QI Yu chun 1, ZHANG Shen 1 (1. Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China E\|mail: dongys@dls.iog.ac.cn 2. M | 2000 | Journal of Environmental Sciences2000，12，4： | 6 |
| 4 | AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function显示文摘LSD1 (在新名称下面的 KDM1 ) 是属于黄素依赖者胺 oxidase 家庭的首先识别的离氨酸特定的 histone demethylase。这里,我们报导那 AOF1 (在新名称下面的 KDM1B ) ,与 LSD1 有关的哺乳动物的蛋白质,也为 H3K4me1 和 H3K4me2 与特性拥有 histone demethylase 活动。象 LSD1 一样,高度保存的 SWIRM 领域为它的酶的活动被要求。然而, AOF1 在几个方面不同于 LSD1。首先, AOF1 不看起来形成包含 histone deacetylases 的稳定的蛋白质建筑群。第二, AOF1 被发现在房间周期的有丝分裂的阶段期间本地化到染色体,而 LSD1 不做。第三, AOF1 镇压抄写什么时候拴住到 DNA 和这项压抑活动,独立于它的 demethylase 活动。结构、功能的分析为 demethylase 作为必要识别了它的唯一的 N 终端 Zf-CW 领域活动无关的压抑功能。一起,我们的学习在黄素依赖者胺 oxidases 的家庭作为第二 histone demethylase 识别 AOF1 并且揭示 AOF1 的 demethylase 独立的压抑功能。 | Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong | 2010 | Cell Research2010，20，3： | 6 |
| 5 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 6 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 7 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 8 | 从菠萝薄细胞层切片直接诱导体细胞胚显示文摘以菠萝(Ananas comosus L. Merrill)杂交种MD1无菌苗为材料,通过培养薄细胞层切片(Thin cell layer,TCL)的方法,研究直接再生胚的固体培养体系。结果证明,预培养的设计2(在预培养基PT上黑暗预培养无菌苗1周后,从预培养苗茎顶端切取TCL,在MS+2,4-D2mg·L-1或1mg·L-1胚诱导培养基EI2上黑暗培养1周,然后转到光照条件下继续诱导胚1周,再在成熟胚培养基EM上培养2周,最后转入幼苗培养基PL上培养)是直接诱导获得体胚的最佳途径;诱导的体胚最初均来自于薄细胞层上微管束附近的细胞;picloram有利于芽的诱导,2,4-D有利于直接再生胚,但如果球形胚形成后一直培养在较高浓度的2,4-D培养基中,将阻碍球形胚和心形胚进一步发育为成熟胚,反而促进芽的生成。 | 梁雪莲 陈晓玲 Kheng Cheah Diane M Sether Qi Li John Hu | 2009 | 园艺学报2009，36，11： | 3 |
| 9 | Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。 | Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen | 2014 | Cell Research2014，24，5： | 3 |
| 10 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 11 | Reductive soil disinfestation (RSD) alters gross N transformation rates and reduces NO and N 2 O emissions in degraded vegetable soils显示文摘 | Tongbin Zhu Qi Dang Jinbo Zhang Christoph Müller Zucong Cai | 2014 | 2014 (1-2)2014，，1： | 2 |
| 12 | Spatial and temporal dynamics of vegetation in the San Pedro River Basin area显示文摘 | Qi J R C Marsett M S Moran | 2000 | Agricultural and Forest Meteorology2000，105，13： | 2 |
| 13 | Leukemia inhibitory factor ameliorates experimental anti-GBM Ab glomerulonephritis 显示文摘 | Tang WW Qi M Van GY | 1996 | Kidney Int1996，50，6： | 1 |
| 14 | Soil -surface CO2 eftlux and its spatial and temporal variation in a young ponderosa pine plantation in northern Califomia 显示文摘 | u M & Qi Y | 2001 | Global Change Biology2001，7，6： | 1 |
| 15 | A simple method of preparing plant samples for PCR显示文摘 | WANG H QI M CUTLER A J | 1993 | Nucleic Acids Research1993，21，： | 1 |
| 16 | Capillary zone electrophoretic chiral discrimination using 6-O-(2-hy- droxy-3-trimethylammoniopropyl)--eyclodextrin as achiral selector显示文摘 | LIN X L ZHAO M G QI X Y | 2006 | Electrophoresis2006，27，4： | 1 |
| 17 | Uplift behaviour of tapered piles established from model tests显示文摘 | Hesham M El Naggar Jin Qi Wei | 2000 | Canadian Geotechnical Journal2000，37，1： | 1 |
| 18 | Size and shape dependent lattice parameters of metallic nanoparticles显示文摘 | Qi W H Wang M P | 2005 | Journal of Nanoparticle Research2005，7，1： | 1 |
| 19 | 显示文摘 | Qi W H Wang M P | 2002 | J Mater Sci Lett2002，21，： | 1 |
| 20 | Expression of midkine in the early stage of carcinogenesis in human colorectal cancer显示文摘 | Ye C Qi M Fan QW | 1999 | Br J Cancer1999，79，1： | 1 |
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