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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | Suicide risk in relation to air pollen counts : a study based on data from Danish registers显示文摘 | Qin P Waltoft BL Mortensen PB | 2013 | BMJ Open2013，3，00： | 1 |
| 4 | A new method for protection zone selection in microprocessor-based bus relays显示文摘 | Qin BL quzman-Casillas A Schweitzer E 0 IlI | 2000 | IEEE Trans on Power Delivery2000，15，87： | 1 |
| 5 | Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines显示文摘 | Niu N Qin Y Fridley BL | 2010 | Genome Res2010，20，11： | 1 |
| 6 | Inactivation of Escherichiacoli suspended in liquid egg using pulsed electric fields显示文摘 | Martin-Belloso O Vega-Mercado H Qin BL Chang FJ Barbosa-Ca'novas GV Swason BG | 1997 | Journal of Food Processing and Preservation1997，21，： | 1 |
| 7 | Food Pas-teurization Using High-Intensity Pulsed Elec-tric Fields显示文摘 | Qin BL Pothakamury UR VegaH | 1995 | Food Technol1995，，49： | 1 |
| 8 | Food pasteurization using high-imensity pulsed electric fields显示文摘 | QIN BL | 1995 | Food Technol1995，49，12： | 1 |
| 9 | Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells显示文摘 | QIN BL ARIYAMA H BABA E | 2006 | Cancer Chemother Pharmacol2006，58，5： | 1 |
| 10 | Autophagy regulates the processing of amino terminal huntingtin fragments显示文摘 | Qin ZH Wang Y Kegel KB Kazantsev A Apostol BL Thompson LM | 2003 | Hum Mol Genet2003，12，24： | 1 |
| 11 | Flourescent switch constructed basedon hemin-sensitive anionic conjugated polymer and its applications indna-related sensors 显示文摘 | Wang LX Li BL Qin CJ | 2009 | Anal Chem2009，81，9： | 1 |
| 12 | Modeling and Evaluation for Encapsulation Efficiency of Zircon-based Heteromorphic Encapsulation Pigments显示文摘 | Lei BL Qin W Kang GL | 2015 | Dyes and Pigmen ts2015，112，： | 1 |
| 13 | Conductance Behaviour of Tunneling Junctions with Fractal Structures显示文摘Conductance behaviours of resonant tunneling junction with elementary, second and third Sier pinskii structures are considered. Numerical calculation shows that a tunneling junction with higher order fractal structure possesses more meticulous resonant behaviour. It provides the possibility of fabricating exact energy selecting tunneling devices. The structure of tunneling junction can be determined by experimental observation. The energetic spectrum of such device is supposed to be a fractal one. The effect of electrode is alteration of the shape and maximum of conductance peaks. | Qin, RS Su, SX Guo, JD He, GH Zhou, BL | 1998 | Journal of Materials Science & Technology1998，14，5： | 0 |
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