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| 1 | 用PCR-RFLP技术鉴别嗜人按蚊和中华按蚊的研究显示文摘目的 依据嗜人按蚊和中华按蚊rDNA的ITS2区段基因特征 ,建立一种新的嗜人按蚊和中华按蚊基因鉴别技术。方法 对不同地区的嗜人按蚊、可疑嗜人按蚊和中华按蚊样本通过采用特异性ITS2 引物PCR扩增 ,限制性内切酶RsaI和HinfI消化 ,以及琼脂糖凝胶电泳分析进行PCR -RFLP基因鉴别。 结果 不同地区嗜人按蚊rDNA的ITS2 基因PCR扩增产物能被限制性内切酶HinfI酶切 ,并显示一条 4 5 0bp的酶切DNA条带 ;中华按蚊的ITS2 基因PCR扩增产物则能被限制性内切酶RsaI酶切 ,并显示 4 0 0bp和 2 0 0bp两条酶切DNA条带 ;辽宁可疑嗜人按蚊的PCR -RFLP结果与嗜人按蚊相同而广东珠海可疑嗜人按蚊的PCR -RFLP结果与中华按蚊相同。结论 依据rDNA的ITS2 区段基因特征建立的PCR -RFLP技术可用于嗜人按蚊和中华按蚊的基因鉴别。采用该PCR -RFLP基因鉴别技术发现辽宁可疑嗜人按蚊的基因与中国大陆的嗜人按蚊属同种 ,而广东可疑嗜人按蚊的基因与中华按蚊属同种。 | 高琪 R D Cooper 周华云 潘波 杨文 郭传坤 黄光全 李凤华 李菊林 沈宝祥 Qin Cheng | 2002 | 中国人兽共患病杂志2002，18，6： | 15 |
| 2 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 3 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 4 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 5 | Exploring Seasonal and Circadian Rhythms in Structural Traits of Field Maize from LiDAR Time Series显示文摘Plant growth rhythm in structural traits is important for better understanding plant response to the ever-changing environment.Terrestrial laser scanning(TLS)is a well-suited tool to study structural rhythm under field conditions.Recent studies have used TLS to describe the structural rhythm of trees,but no consistent patterns have been drawn.Meanwhile,whether TLS can capture structural rhythm in crops is unclear.Here,we aim to explore the seasonal and circadian rhythms in maize structural traits at both the plant and leaf levels from time-series TLS.The seasonal rhythm was studied using TLS data collected at four key growth periods,including jointing,bell-mouthed,heading,and maturity periods.Circadian rhythms were explored by using TLS data acquired around every 2 hours in a whole day under standard and cold stress conditions.Results showed that TLS can quantify the seasonal and circadian rhythm in structural traits at both plant and leaf levels.(1)Leaf inclination angle decreased significantly between the jointing stage and bell-mouthed stage.Leaf azimuth was stable after the jointing stage.(2)Some individual-level structural rhythms(e.g.,azimuth and projected leaf area/PLA)were consistent with leaf-level structural rhythms.(3)The circadian rhythms of some traits(e.g.,PLA)were not consistent under standard and cold stress conditions.(4)Environmental factors showed better correlations with leaf traits under cold stress than standard conditions.Temperature was the most important factor that significantly correlated with all leaf traits except leaf azimuth.This study highlights the potential of time-series TLS in studying outdoor agricultural chronobiology. | Shichao Jin Yanjun Su Yongguang Zhang Shilin Song Qing Li Zhonghua Liu Qin Ma Yan Ge LingLi Liu Yanfeng Ding Frédéric Baret Qinghua Guo | 2021 | Plant Phenomics2021，3，1： | 5 |
| 6 | Characteristics of ^(137)Cs deposition in steppe area显示文摘Soil wind erosion in the semiarid steppe area was studied using the 137Cs tracing technique. Comparisons of 137Cs deposition characteristics between different soil profiles indicated that slight aeolian activities occurred on sandy grasslands and semi-fixed dunes with erosion/deposition rates of less than 0.108 cm/a, whereas they were intense on semi-shifting dunes with erosion/deposition rates of higher than 1.35 cm/a. | ZHANG Chunlai, ZOU Xueyong,DONG Guangrong, ZHANG Xinbao & QIN ZhiLaboratory of Blown Sand Physics and Engineering, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China China Center of D | 2002 | Chinese Science Bulletin2002，47，10： | 5 |
| 7 | Research on Product Information Integrating and Sharing for Dynamic Colla boration显示文摘Dynamic Collaboration emerges as the new trend of n et working and collaborating work in manufacturing industry, in which product infor mation sharing among allied enterprises plays very important roles in collaborat ing product development. This thesis aims at studying the integrating, contr olling and sharing mode of product information among the heterogeneous and dispe rsed environments through Internet, and proposes the information integrating/sha ring architecture based on the Product Master Model (PMM). The following are the main contents of this thesis: 1) Research on the XML based PMM model for integration and sharing of product in formation After analyzing the requirement of the allied Enterprise for the product infor mation, the XML based product master model (XPMM) is proposed as the integrating mechanism of heterogeneous and dispersed product information. The XPMM is divid ed into some sub-models: whole-life controlling model, product defining model, conception model, design model, product structure model, machining model, q uality model, evaluating model. The character and accessing approach of XPMM is discussed in detail. 2) Research on the mapping pattern and mapping rule of STEP/XML According to feature of XML Schema and STEP EXPRESS, the memory-constructing-t ree model is put forward as STEP/XML mapping pattern, which is constructed dynam ically according to the bottom-to-top reference relationship. Based on mapping pattern, the multi-layer XML/STEP mapping rule is discussed detailed including relation mapping, entity mapping, data type mapping, reference mapping and func tion mapping. 3) Research on the Product Information Integration and Sharing (PIIS) Architectu re Based on the XPMM, the PIIS architecture is proposed. The PIIS support the local and dispersed product information to be integrated and shared on the contro l of the XPMM. The architecture is divided into three layers :Applying-Obj ect-LayerData-Integration-Layer and STEP-Data-Layer. The kernel of the PI IS Architecture is this Data-Integration-Layer, which control the whole proces s of XPMM creating, the data approaching. The function and structure of every la yer is discussed too. | HE Wen-rui, QIN Zhong-bao, Qin Ji-feng, HE Wei-ping (Education Ministry Key Laboratory of Contemporary Design and Integrate d Manufacturing Technology, Northwestern Polytechnical University, Xi’an 710072, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 4 |
| 8 | Synthesis, Crystal Structure and Calculated β Value of a Tetrahedral Zinc (II) Complex——Zn(2-NH_2py)_2Br_2显示文摘A new zinc(II) complex, Zn(2-NH2py)2Br2 (py=pyridine), has been synthesized, and its molecular structure has been confirmed by IR, elemental analysis and -ray crystal structure analysis. Its space group is P21/n with Mr=413.43 (C10H12Br2N4Zn), a=7.435(2), b=12.865(3), c=14.186(4)? b=94.08(2)? V=1353.5(5) 3, Z=4, Dc=2.029 g/cm3, F(000)=328, ?2.378mm-1, R=0.0283, wR=0.0501. The total observed reflections with I≥2?I) were 5314, of which the independent reflections were 3106. The complex structure contains a distorted tetrahedron formed by four atoms coordinated to zinc atom, namely two bromide atoms and two nitrogen atoms. The two ZnBr bond lengths within one molecule, 2.3763(6) and 2.4002(5)? respectively, are not equal; and so are the two ZnN bond lengths, which are 2.031(2) and 2.044(2)?respectively. The calculation results using PM3 method through MOPAC software package in Chem 3D show that its first molecular hyperpolarizability b value is 5.210-30esu, which is comparable with that of p-nitroaniline. No bulk SHG effect has been detected due to the centrosymmetric space group. | REN Peng a SU Nan-Bing a QIN Jin-Gui a Michael W. Day b CHEN Chuang-Tianc ( aDepartment of Chemistry, Wuhan University, Wuhan 43007, China) ( bBeckman Institute, California Institute of Technology, Pasadena, CA91125, USAQ ) ( cBeijing R & D Center | 2002 | Chinese Journal of Structural Chemistry2002，21，1： | 3 |
| 9 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 10 | Analysis of solar radiation variations over Nanjing region in recent 40 years显示文摘The data utilized in this analysis consisted of extraterrestrial radiation, global radiation, d iffuse radiation, direct radiation, total cloud cover and relative suns hine. The annual variations and trend were analyzed for monthly mean daily total global, direct, and diffuse radiation on a horizontal surface and for the relations between global, direct, diffuse radiation and relative sunshine, tota l cloud cover. The climatological calculation equations of global and d irect radiation are put forward. The results show that global and dir ect radiations are characterized by decrease and diffuse radiation by increase. The main causes are due to the increase of concentration of suspended particles and atmospheric turbidities rather than cloud cover var iations. | ZHANG Yunlin,QIN Boqiang,CHEN Weimin(Nanjing Institute of Geography an d Limnology, CAS, Nanjing 210008, China) | 2003 | Journal of Geographical Sciences2003，13，1： | 3 |
| 11 | Hybrid dual-channel phototransistor based on ID t-Se and 2D ReS2 mixed-dimensional heterostructures显示文摘The com bination of mixed-dimensional semiconducti ng materials can provide additional freedom to construct integrated n anoscale electronic and optoelectronic devices with diverse functionalities. In this work, we report a high-performanee dual-channel phototransistor based on one-dimensional (1D)/two-dimensional (2D) trigonal selenium (t-Se)/ReS2 heterostructures grown by chemical vapor deposition. The injection and separati on efficie ncy of photoge nerated electro n-hole pairs can be greatly improved due to the high-quality in terfacial con tact betwee n t-Se nano belts and ReS2 films. Compared with bare ReS2 film devices, the dual-cha nnel phototra nsistor based on t-Se/ReS2 heterostructure exhibits considerable enhancement with the responsivity (R) and detectivity (D^*) up to 98 A·W^-1 and 6 x 10^10 Jones at 400 nm illumination with an in tensity of 1.7 mW·cm^-2, respectively. Besides, the respo nse time can also be reduced by three times of magnitude to less than 50 ms due to the type-11 band alignment at the in terface. This study opens up a promising ave nue for high-performa nee photodetectors by constructing mixed-dimensional heterostructures. | Jingkai Qin Hang Yan Gang Qiu Mengwei Si Peng Miao Yuqin Duan Wenzhu Shao Liang Zhen Chengyan Xu Peide D Ye | 2019 | Nano Research2019，12，3： | 2 |
| 12 | 显示文摘 | Zhang S Qin C D | 1993 | International Journal of Refractory Metals & Hard Materials1993，12，： | 1 |
| 13 | Soft lithography for micro-and nanoscale patterning显示文摘 | Qin D Xia Y N Whitesides G M | 2010 | Nature Protocols2010，5，3： | 1 |
| 14 | Feelback stabilization via designed planar centre manifold显示文摘 | DONG Y L CHENG D Z QIN H S | 2004 | International Journal of Robust and Nonlinear Control2004，14，1： | 1 |
| 15 | Functionalization of single-walled carbon nanotubes with polystyrene via grafting to and grafting from methods显示文摘 | Qin S Qin D Ford W T | 2004 | Macromolecules2004，37，： | 1 |
| 16 | Thin bismuth oxide films prepared through the sol-gel method as photocatalyst 显示文摘 | Wu X H Qin W He W D | 2007 | Journal of Molecular Catalysis A :Chemical2007，261，2： | 1 |
| 17 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 18 | Comparative Study on Wayfinding by Foreigners and Japanese at Osaka Umeda Area 显示文摘 | Qin D Funahashi K Kita M | 2002 | Papers on City Planning2002，，37： | 1 |
| 19 | CD4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease 显示文摘 | Mahajan D Wang Y Qin X | 2006 | J Am Soe Nephrol2006，17，10： | 1 |
| 20 | 查看详情显示文摘 | Wang G E Qin W P Zhang J S Zhang J S Wang Y Cao C Y Wang L L Wei G D Zhu P E Wu C E Kim Ryongjin | | 0，，： | 1 |
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