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| 1 | Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. | Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu | 2012 | Neural Regeneration Research2012，7，12： | 20 |
| 2 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 3 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 4 | Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance显示文摘Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. | WANG Qi Qi YU Shi Cheng XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 5 | Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways显示文摘Inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy.Lupeol,a natural triterpenoid,has shown anti-inflammatory and anti-apoptotic activities as well as potential protective effects on cardiovascular diseases.In this study we investigated whether lupeol attenuated cardiac hypertrophy and fibrosis induced by pressure overload in vivo and in vitro,and explored the underlying mechanisms.Cardiac hypertrophy was induced in mice by transverse aortic constriction(TAC)surgery,and in neonatal rat cardiomyocytes(NRCMs)by stimulation with phenylephrine(PE)in vitro.We showed that administration of lupeol(50 mg·kg^(-1)·d^(-1),i.g.,for 4 weeks)prevented the morphological changes and cardiac dysfunction and remodeling in TAC mice,and treatment with lupeol(50μg/mL)significantly attenuated the hypertrophy of PE-stimulated NRCMs,and blunted the upregulated hypertrophic markers ANP,BNP,andβ-MHC.Furthermore,lupeol treatment attenuated the apoptotic and inflammatory responses in the heart tissue.We revealed that lupeol attenuated the inflammatory responses including the reduction of inflammatory cytokines and inhibition of NF-κB p65 nuclear translocation,which was mediated by the TLR4-PI3K-Akt signaling.Administration of a PI3K/Akt agonist 740 Y-P reversed the protective effects of lupeol in TAC mice as well as in PE-stimulated NRCMs.Moreover,pre-treatment with a TLR4 agonist RS 09 abolished the protective effects of lupeol and restored the inhibition of PI3K-Akt-NF-κB signaling by lupeol in PE-stimulated NRCMs.Collectively,our results demonstrate that the lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms,which results from inhibiting the TLR4-PI3K-Akt-NF-κB signaling. | Dan Li Ying-ying Guo Xian-feng Cen Hong-liang Qiu Si Chen Xiao-feng Zeng Qian Zeng Man Xu Qi-zhu Tang | 2022 | Acta Pharmacologica Sinica2022，43，8： | 3 |
| 6 | GEOLOGICAL AND GEOCHEMICAL STUDY ON THE GENESIS OF THE FANKOU Pb-Zn DEPOSIT显示文摘The super large Pb Zn deposit at Fankou is very complex in metallogenic mechanism. Syngenetic brine sedimentation, hot submarine spring eruption—accumulation, syngenetic sedimentation—vadose brine replacement had been supposed as the genetic models before. Under these models, syngenetic mineralization should be dominant in ore formation. However, a series of geological and geochemical properties investigated by authors of this paper are contrary to these models. Therefore, the authors here suggest that this deposit is a typical polygenetic compound ore deposit which share the properties of multistages of geotectonic evolution, multifactors of mineralization control, multisystem of material derivation of mineralization, multimodes of mineralization and multitypes of genesis. | ZHANG Shu gen 1, ZHAN Jian pu 1, HUANG Man xiang 1, FAN Zhong heng 1,WANG Li 1, MA Guo qiu 2, LIU Rui di 2, YANG Han zhuang 2, LIU Sheng bo 2, XU Shui ping 2 and LUO Wen sheng 2 (1. College of Mineral Resource, Environment and | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 7 | Sensors for measuring plant phenotyping:A review显示文摘Food crisis is a matter of prime importance because it becomes more severe as the global population grows.Among the solutions to this crisis,breeding is deemed one of the most effective ways.However,traditional phenotyping in breeding is time consuming and laborious,and the database is insufficient to meet the requirements of plant breeders,which hinders the development of breeding.Accordingly,innovations in phenotyping are urgent to solve this bottleneck.The morphometric and physiological parameters of plant are particularly interested to breeders.Numerous sensors have been employed and novel algorithms have been proposed to collect data on such parameters.This paper presents a brief review on the parameter measurement for phenotyping to describe its development in recent years.Some parameters that have been measured in phenotyping are introduced and discussed,including plant height,leaf parameters,in-plant space,chlorophyll,water stress,and biomass.And the measurement methods of each parameter with different sensors were classified and compared.Some comprehensive measurement platforms were also summarized,which are able to measure several parameters simultaneously.Besides,some deficiencies of phenotyping should be addressed,and novel methods should be proposed to reduce cost,improve efficiency,and promote phenotyping in the future. | Ruicheng Qiu Shuang Wei Man Zhang Han Li Hong Sun Gang Liu Minzan Li | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 2 |
| 8 | Gradual upregulation of OCI-5 expression during occurrence and progression of rat hepatocellular carcinoma显示文摘BACKGROUND: OCI-5, the rat homologene of human glypican 3 ( GPC3), is confirmed upregulated in hepatocellular carcinoma (HCC). The present study was undertaken to detect gene expression change of OCI-5 during occurrence and progression of rat HCC. METHODS: Male Sprague-Dawley rats were given diethyl-nitrosamine ( DENA) to induce HCC. Three DENA-induced rats and one control rat were sacrificed every week for 18 weeks during the development of HCC. Tissues specimens were snap-frozen in liquid nitrogen and total RNA was isolated. Sk-Hepl cells were treated with DENA at different concentrations. The gene expression levels of OCI-5 and GPC3 were detected with the RT-PCR method. RESULTS: OCI-5 was not expressed in normal rat liver tissues. When HCC occurred and aggravated, OCI-5 expression was gradually elevated to a very high level. GPC3 was not expressed in the DENA-treated Sk-Hepl cells. CONCLUSIONS: OCI-5 was not expressed in normal rat liver tissues but in rat HCC tissues. High-expression of OCI-5 in DENA-induced rat HCC model was the gene expression change of HCC not the DENA-induced gene expression. The expression level of OCI-5 was not only elevated in rat HCC but also gradually along the occurrence and progression of HCC, indicating that GPC3 might serve as a sensitive marker of early stage HCC. | Wei-Jun Jiang, Xiao-Bo Man, Liang Tang, Hong-Yin Song, Shen-Jing Li, Guo-Jun Cai, Xiu-Hua Qiu and He-Ping Hu Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai 200050, China Department of Gastroenterology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Department of Phannacology, Second Military Medical University, Shanghai 200433, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 2 |
| 9 | Enhanced mixing with streamwise vorticity 显示文摘 | Waitz I A Qiu Q J Manning T A | 1997 | Progress in Aerospace Sciences1997，33，56： | 1 |
| 10 | Abnormal Activity of Sympathetic Nervous System in Girls with Adolescent Idiopathic Scoliosis: A Cross-sectional Study显示文摘The objective of this study was to characterize sympathetic nervous system (SNS) activity in girls with adolescent idiopathic scoliosis (AIS) and investigate the correlation of such activity with body weight and bone mass. Fifty-eight girls with AIS and 21 healthy controls were recruited. Abnormal growth pattern (lower weight, lower body mass index (BMI), and longer arm span) and | HU Zong Shan ZHAO Zhi Hui TSENG Chang-Chun LI Jie MAN Gene Chi-Wai LAM Tsz-Ping QIU Yong CHENG Chun-Yiu Jack ZHU Ze Zhang LIU Zhen | 2018 | Biomedical and Environmental Sciences2018，31，9： | 1 |
| 11 | Microstructure of β-Dicalcium Silicate after Accelerated Carbonation显示文摘The present work presents the microstructure of β-Ca_2SiO_4(β-C_2S) after accelerated carbonation. The synthesis procedure of β-C_2S was examined first, and the crystalline and amorphous structure, the distribution and the pore structure of β-C_2S carbonation products were also determined by X-ray diffraction(XRD) quantitative analysis, simultaneous thermal analyzer(TG/DTA), Fourier transform-infrared spectroscopy(FT-IR), high resolution ^(29)Si magic angle spinning nuclear magnetic resonance(^(29)Si NMR), N_2-sorption techniques, and scanning electron microscopy(SEM), respectively. Test results indicate that carbonation products are dramatically formed in the initial 2 h. The main carbonation products are crystalline calcite and amorphous three-dimensional network silica gels, which contain nanometer-sized pores. The calcite, silica gels and un-carbonated β-C_2S are distributed hierarchically. | 刘松辉 WANG Junjie 张海波 GUAN Xuemao QIU Man DOU Zhenzhen | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 12 | Lack of association between catechol- O-methyhransferase Va1108/158Met polymnrphism and breast cancer risk :a meta-analysis of 25,627 cases and 34,222 controls 显示文摘 | Man C Wang XW Qiu LX | 2010 | Breast Cancer Res Treat2010，121，3： | 1 |
| 13 | Clinical evaluation of the anterior chest wall deformity in thoracic adolescent idiopathic seoliosis显示文摘 | Man SH Qiu Y Zhu ZZ | 2012 | Spine2012，37，9： | 1 |
| 14 | Enhanced mixing with streamwise vorlicity显示文摘 | Waitz I A Qiu Y J Manning T A etal | 1997 | Prog Aerospace Sci1997，，33： | 1 |
| 15 | Enhanced Mixing with Streamwise Vorticity显示文摘 | WAITZ I A QiU Y J MANNING T A | 1997 | Prog Aerospace Sci1997，33，： | 1 |
| 16 | Enhanced mixing with streamwise vorticity显示文摘 | Waitz I A Qiu Y J Manning T A | 1997 | Progress in Aerospace Sciences1997，33，： | 1 |
| 17 | Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma显示文摘 | Jin Hou Ye Zhou Yuanyuan Zheng Jia Fan Weiping Zhou Irene O.L. Ng Huichuan Sun Lunxiu Qin Shuangjian Qiu Joyce M.F. Lee Chung-Mau Lo Kwan Man Yuan Yang Yun Yang Yingyun Yang Qian Zhang Xuhui Zhu Nan Li Zhengxin Wang Guoshan Ding Shi-Mei Zhuang Limin Zheng | 2013 | Cancer Cell2013，，： | 1 |
| 18 | Dopant emission mechanism and the effects of host materials on the behavior of doped organic light-emitting diocles显示文摘 | QIU Cheng-feng CHEN Hai-ying Wong Man | 2002 | IEEE Trans Electron Devices2002，49，9： | 1 |
| 19 | Enhanced mixing with streamwise vorticity 显示文摘 | Waitz I A Qiu Y J Manning T A | 1997 | Progress in Aerospace Sciences1997，33，56： | 1 |
| 20 | Dopant emission mechanism and the effects of host materials on the behavior of doped organic light-emitting diodes显示文摘 | QIU Cheng-feng CHEN Hai-ying WONG Man | 2002 | IEEE Transactions on Electron Devices2002，49，： | 1 |
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