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| 1 | Tumor-infiltrating B cells:their role and application in antitumor immunity in lung cancer显示文摘Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells,stromal fibroblasts,and immune cells.Tumor-infiltrating immune cells play a significant role in the promotion or inhibition of tumor growth.As an integral component of the tumor microenvironment,tumor-infiltrating B lymphocytes(TIBs)exist in all stages of cancer and play important roles in shaping tumor development.Here,we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development,assess their prognostic significance,and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment. | Si-si Wang Wei Liu Dalam Ly Hao Xu Limei Qu Li Zhang | 2019 | Cellular & Molecular Immunology2019，16，1： | 21 |
| 2 | Dynamic Changes in the Wetland Landscape Pattern of the Yellow River Delta from 1976 to 2016 Based on Satellite Data显示文摘The Yellow River Delta wetland is the youngest wetland ecosystem in China's warm temperate zone. To better understand how its landscape pattern has changed over time and the underlying factors responsible, this study analyzed the dynamic changes of wetlands using five Landsat series of images, namely MSS(Mulri Spectral Scanner), TM(Thematic Mapper), and OLI(Operational Land Imager) sensors in 1976, 1986, 1996, 2006, and 2016. Object-oriented classification and the combination of spatial and spectral features and both the Normalized Difference Vegetation Index(NDVI) and Normalized Difference Water Index(NDWI), as well as brightness characteristic indices, were used to classify the images in eCognition software. Landscape pattern changes in the Yellow River Delta over the past 40 years were then delineated using transition matrix and landscape index methods. Results show that: 1) from1976 to 2016, the total area of wetlands in the study area decreased from 2594.76 to 2491.79 km^2, while that of natural wetlands decreased by 954.03 km^2 whereas human-made wetlands increased by 851.06 km^2. 2) The transformation of natural wetlands was extensive: 31.34% of those covered by Suaeda heteropteras were transformed into reservoirs and ponds, and 24.71% with Phragmites australis coverage were transformed into dry farmland. Some human-made wetlands were transformed into non-wetlands types: 1.55% of reservoirs and ponds became construction land, and likewise 21.27% were transformed into dry farmland. 3) From 1976 to 2016, as the intensity of human activities increased, the number of landscape types in the study area continuously increased. Patches were scattered and more fragmented. The whole landscape became more complex. In short, over the past 40 years, the wetlands of the Yellow River Delta have been degraded, with the area of natural wetlands substantially reduced. Human activities were the dominant forces driving these changes in the Yellow River Delta. | CONG Pifu CHEN Kexin QU Limei HAN Jianbo | 2019 | Chinese Geographical Science2019，29，3： | 12 |
| 3 | The relationships among aerosol optical depth, ice, phytoplankton and dimethylsulfide and the implication for future climate in the Greenland Sea显示文摘The sea-to-air flux of dimethylsulphide(DMS) is one of the major sources of marine biogenic aerosol, and can have an important radiative impact on climate, especially in the Arctic Ocean. Satellite-derived aerosol optical depth(AOD) is used as a proxy for aerosol burden which is dominated by biogenic aerosol during summer and autumn. The spring sea ice melt period is a strong source of aerosol precursors in the Arctic. However, high aerosol levels in early spring are likely related to advection of continental pollution from the south(Arctic haze).Higher AOD was generally registered in the southern part of the study region. Sea ice concentration(SIC) and AOD were positively correlated, while cloud cover(CLD) and AOD were negative correlation. The seasonal peaks of SIC and CLD were both one month ahead of the peak in AOD. There is a strong positive correlation between AOD and SIC. Melting ice is positively correlated with chlorophyll a(CHL) almost through March to September,but negatively correlated with AOD in spring and early summer. Elevated spring and early summer AOD most likely were influenced by combination of melting ice and higher spring wind in the region. The peak of DMS flux occurred in spring due to the elevated spring wind and more melting ice. DMS concentration and AOD were positively correlated with melting ice from March to May. Elevated AOD in early autumn was likely related to the emission of biogenic aerosols associated with phytoplankton synthesis of DMS. The DMS flux would increase more than triple by 2100 in the Greenland Sea. The significant increase of biogenic aerosols could offset the warming in the Greenland Sea. | QU Bo GABRIC Albert J. ZHAO Li SUN Wenjing LI Hehe GU Peijuan JIANG Limei ZENG Meifang | 2018 | Acta Oceanologica Sinica2018，37，5： | 4 |
| 4 | Comparison Between Early and Late 21stC Phytoplankton Biomass and Dimethylsulfide Flux in the Subantarctic Southern Ocean显示文摘Time-series of chlorophyll-a(CHL),a proxy for phytoplankton biomass,and various satellite-derived climate indicators are compared in a region of the Subantarctic Southern Ocean(40°-60°S,110°-140°E)for years 2012-2014.CHL reached a minimum in winter(June)and a maximum in late summer(early February).Zonal mean CHL decreased towards the south.Mean sea surface temperature(SST)ranged between 8℃and 15℃and peaked in late February.CHL and SST were positively correlated from March to June,negatively correlated from July to September.CHL and wind speed(WIND)were negatively correlated with peak WIND occurred in winter.Wind direction(WIRD)was mostly in the southwest to westerly direction.The Antarctic Oscillation index(AAO)and CHL were negatively correlated(R=−0.58),indicating that as synoptic wind systems move southwards,CHL increases,and conversely when wind systems move northwards,CHL decreases.A genetic algorithm is used to calibrate the biogeochemical DMS model’s key parameters.Under 4×CO2(after year 2100)Regional mean SST increases 12%-17%,WIND increases 1.2ms−1,Cloud Cover increases 4.8%and mixed layer depth(MLD)decreases 48m.The annual CHL increases 6.3%.The annual mean DMS flux increase 25.2%,increases 37%from day 1 to day 280 and decrease 3%from day 288 to day 360.The general increase of DMS flux under 4×CO2 conditions indicates the Subantarctic regional climate would be affected by changes in the DMS flux,with the potential for a cooling effect in the austral summer and autumn. | QU Bo Albert JGABRIC JIANG Limei LI Chunyue | 2020 | Journal of Ocean University of China2020，19，1： | 2 |
| 5 | Influence of annealing in N2 on the properties of In2O3: Sn thin films prepared by direct current magnetron sputtering 显示文摘 | Lin Limei Lai Fachun Qu Yan | 2007 | Mater Sci Eng B2007，138，2： | 1 |
| 6 | Influence of annealing in N2 on the properties of In2O3:Sn thin films prepared by direct current magnetron sputtering显示文摘 | Lin Limei Lai Fachun Qu Yah | | 0，，： | 1 |
| 7 | Improved SFS 3D Measurement Based on BP Neural Network显示文摘 | LiMei Song XingHua Qu ShengHua Ye | 2007 | Image and Vision Computing2007，5，25： | 1 |
| 8 | Novel SFS-NDT in the field of defect detection显示文摘 | Song Limei Qu Xinghua Xu Kexin | 2005 | International NDT&E2005，38，5： | 1 |
| 9 | Three-dimensional measurement and defect detection based on single image 显示文摘 | SONG Limei QU Xinghua XU Kexin | 2005 | Optoelectronics and Advanced Materials2005，7，2： | 1 |
| 10 | Novel SFS NDT in the Field of Defect Detection显示文摘 | Song Limei Qu Xinghua Xu Kexin el al | 2005 | NDT & E International2005，38，5： | 1 |
| 11 | Im- proved SFS 3D measurement based on BP neural network 显示文摘 | SONG LIMEI QU XINGHUA YE SHENGHUA | 2007 | Image and Vision Computing2007，25，5： | 1 |
| 12 | Novel SFS - NDT in the Field of Defect Detection 显示文摘 | Limei Song Xinghua Qu Kexin Xu | 2005 | NDT & E International2005，38，5： | 1 |
| 13 | Application of Structured Lighdng Sensor for Online Meaanrement 显示文摘 | Limei Song Xinghua Qu Yangang Yang | 2005 | Optics and Lasers in Engineering2005，43，10： | 1 |
| 14 | Novel SFS NDT in the Field of Defect Detection 显示文摘 | Song Limei Qu Xinghua Xu Kexin | 2005 | NDT & E International2005，38，5： | 1 |
| 15 | Novel SFS NDT in the field of defect detection 显示文摘 | SONG Limei QU Xinghua XU Kexin | 2005 | International NDT & E2005，38，5： | 1 |
| 16 | Rhodium-catalyzed formal[4+3]annulation reaction of N-methoxybenzamides with gem–difluorocyclopropenes:A combination of experimental and theoretical studies显示文摘A rhodium-catalyzed[4+3]cycloaddition reaction between N-methoxybenzamides and gem–difluorocyclopropenes is described.The reaction offers a mild and efficient approach towards the synthesis of fluorinated 2 H-azepin-2-ones with broad substrate scope.A consecutive HOAc-assisted C–N bond formation and fluorine elimination are involved as key steps for success as illustrated by detailed DFT studies. | Yimiao He Limei Tian Xuexue Chang Zeming Qu Yanmin Huang Chusheng Huang Qing Sun Honggen Wang | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 17 | Seroprevalence of human enterovirus A71 in Guangzhou,China,2019-2021显示文摘Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021. | Huimin Lian Huimin Jianng Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng | 2023 | Biosafety and Health2023，5，3： | 0 |
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