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| 1 | Chylois ascites:Treated with total parenteral nutrition and somatostatin显示文摘AIM: To determine the effects of total parenteral nutrition and somatostatin on patients with chylous ascites.METHODS: Five patients were diagnosed with chylous ascites on the basis of laboratory findings of ascites sample from Nov 1999 to May 2003. Total parenteral nutrition and somatostatin or its analogue was administered to 4 patients,while the other one only received total parenteral nutrition.All the patients had persistent peritoneal drainage, with the quantity and quality of drainage fluid observed daily.Necessary supportive treatments were given to the patients individually during the therapy.RESULTS: Two of 4 patients who received somatostatin therapy obtained complete recovery within 10 d without any recurrence while on a normal diet. In these 2 patients,the peritoneal drainage reduced to zero in one and the other's decreased from 2 000 mL to 80 mL with a clear appearance and negative qualitative analysis of chyle. Recurrent chylous ascites, though relieved effectively by the same method every time, developed in one patient with advanced pancreatic cancer. The other patient's lymphatic fistula was blocked with the fibrin glue after conservative treatment. The patient who only received total parenteral nutrition was cured 24 d after therapy.CONCLUSION: Total parenteral nutrition along with somatostatin can relieve the symptoms and close the fistula in patients with chylous ascites rapidly. It appears to be an effective therapy available for the treatment of chylous ascites caused by various disorders. | QiHuang Zhi-WeiJiang JunJiang NingLi ]ie-ShouLi | 2004 | World Journal of Gastroenterology2004，10，17： | 14 |
| 2 | Optical microcavity: from fundamental physics to functional photonics devices显示文摘Optical microcavities have attracted strong research interests,for their unique property of confining photons for a long time in small volumes,which significantly enhances light–matter interaction[1].In recent decades,various fabrication techniques of microcavities with higher quality factors(Q)and smaller mode volumes(V_m)have been developed,pushing forward studies from fundamental physics to functional photonics devices.Microcavity optomechanics provides an ideal platform for exploring the quantum nature of macroscopic objects[2]。 | Yun-Feng Xiao Qihuang Gong | 2016 | Science Bulletin2016，61，3： | 9 |
| 3 | C/EBPα regulates SIRT1 expression during adipogenesis显示文摘SIRT1 在 adipogenesis 起一个重要作用,但是 SIRT1 怎么在 adipogenesis 被调整,大部分是未知的。在这研究,我们证明 SIRT1 蛋白质和 mRNA 层次与 CCAAT/enhancer-binding 蛋白质伪一起被增加(C/EBP 伪) 在 adipocyte 区别期间。C/EBP 伪,然而并非 C/EBP 伪 p 30,在 HeLa 房间和 3T3-L1 的激活的 SIRT1 倡导者 preadipocytes。而且, C/EBP 伪 upregulated SIRT1 mRNA 和蛋白质在 Soas2 房间以一种 p53 独立的方式在 HeLa 铺平房间和增加的 SIRT1 表示。在 preadipocytes, C/EBP 伪 upregulated SIRT1 蛋白质水平的宫外的表示并且导致的 C/EBP 伪击倒 SIRT1 的减少蛋白质水平。而且由倡导者删除分析,胶化移动试金和染色质 immunoprecipitation,我们发现了那 C/EBP,伪在一个一致 C/EBP 伪绑定地点跳了到 SIRT1 倡导者。这些数据证明那 C/EBP 伪在 adipogenesis 期间调整 SIRT1 表示由对 SIRT1 倡导者直接有约束力。 | Qihuang Jin Fang Zhang Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai | 2010 | Cell Research2010，20，4： | 8 |
| 4 | Optomechanical sensing with on-chip microcavities显示文摘 | Yi-Wen Hu Yun-Feng Xiao Yong-Chun Liu Qihuang Gong | 2013 | Frontiers of physics2013，8，5： | 8 |
| 5 | Coupling-induced excitation of a forbidden surface plasmon mode of a gold nanorod显示文摘Using the finite-difference time-domain(FDTD) method,we simulate the coupling between a gold nanorod and gold nanoparticles with different plasmonic resonant frequencies/volumes as well as that between the nanorod and a dielectric nanosphere.The influences of coupling with different nanoparticles on the excitation of a forbidden longitudinal surface plasmon mode of the nanorod under normal incidence are investigated.It is found that the cause of this excitation is the broken symmetry of the local electric field experienced by the nanorod resulting from the charge pileup on the other nanoparticle.This result is valuable for understanding the near-field optical characterization of plasmonic metal nanoparticles. | YAO HaoMin LI Zhi GONG QiHuang | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 8 |
| 6 | Reconfigurable directional coupler in lithium niobate crystal fabricated by three-dimensional femtosecond laser focal field engineering显示文摘For crystals, depressed cladding waveguides have advantages such as preservation of the spectroscopic as well as non-linear properties and the capability to guide both horizontal and vertical polarization modes, but fabrication is always quite time consuming. In addition, it is usually difficult to couple modes propagating in different depressed cladding waveguides through evanescent field overlap, so it is often required to dynamically reconfigure photonic waveguide devices using external fields for classical or quantum applications. Here, we experimentally demonstrate the single-scan femtosecond laser transverse writing of depressed cladding waveguides to form a 2 × 2 directional coupler inside lithium niobate crystal, which is integrated with two deeply embedded microelectrodes on both sides of the interaction region to reconfigure the coupling. By focal field engineering of the femtosecond laser, we specially generate a three-dimensional longitudinally oriented ring-shaped focal intensity profile composed of 16 discrete spots to simultaneously write the entire cladding region. The fabricated waveguides exhibit good single guided modes in two orthogonal polarizations at 1550 nm. By applying voltage to the deeply embedded microelectrodes fabricated with the femtosecond laser ablation followed by selective electroless plating, we successfully facilitate the light coupling from the input arm to the cross arm and thus actively tune the splitting ratio. These results open new important perspectives in the efficient fabrication of reconfigurable complex three-dimensional devices in crystals based on depressed cladding waveguides. | Qian Zhang Meng Li Jian Xu Zijie Lin Haofeng Yu Min Wang Zhiwei Fang Ya Cheng Qihuang Gong Yan Li | 2019 | Photonics Research2019，7，5： | 7 |
| 7 | Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general. | Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 8 | High performance integrated photonic circuit based on inverse design method显示文摘The basic indexes of all-optical integrated photonic circuits include high-density integration,ultrafast response and ultralow energy consumption.Traditional methods mainly adopt conventional micro/nano-structures.The overall size of the circuit is large,usually reaches hundreds of microns.Besides,it is difficult to balance the ultrafast response and ultra-low energy consumption problem,and the crosstalk between two traditional devices is difficult to overcome.Here,we propose and experimentally demonstrate an approach based on inverse design method to realize a high-density,ultrafast and ultra-low energy consumption integrated photonic circuit with two all-optical switches controlling the input states of an all-optical XOR logic gate.The feature size of the whole circuit is only 2.5μm×7μm,and that of a single device is 2μm×2μm.The distance between two adjacent devices is as small as 1.5μm,within wavelength magnitude scale.Theoretical response time of the circuit is 150 fs,and the threshold energy is within 10 fJ/bit.We have also considered the crosstalk problem.The circuit also realizes a function of identifying two-digit logic signal results.Our work provides a new idea for the design of ultrafast,ultra-low energy consumption all-optical devices and the implementation of high-density photonic integrated circuits. | Huixin Qi Zhuochen Du Xiaoyong Hu Jiayu Yang Saisai Chu Qihuang Gong | 2022 | Opto-Electronic Advances2022，5，10： | 5 |
| 9 | The plasmonic coupling of metal nanoparticles and its implication for scanning near-field optical microscope characterization显示文摘Researchers at State Key Laboratory for Mesoscopic Physics and Department of Physics,Peking University (PKU),have recently shown that an | LI Zhi GONG QiHuang | 2009 | Chinese Science Bulletin2009，54，20： | 5 |
| 10 | Robust and high-speed rotation control in optical tweezers by using polarization synthesis based on heterodyne interference显示文摘The rotation control of particles in optical tweezers is often subject to the spin or orbit angular momentum induced optical torque,which is susceptible to the mechanical and morphological properties of individual particle.Here we report on a robust and high-speed rotation control in optical tweezers by using a novel linear polarization synthesis based on optical heterodyne interference between two circularly polarized lights with opposite handedness.The synthesized linear polarization can be rotated in a hopping-free scheme at arbitrary speed determined electronically by the heterodyne frequency between two laser fields.The experimental demonstration of a trapped vaterite particle in water shows that the precisely controlled rotation frequency of 300 Hz can be achieved.The proposed method will find promising applications in optically driven micro-gears,fluidic pumps and rotational micro-rheology. | Wei Liu Dashan Dong Hong Yang Qihuang Gong Kebin Shi | 2020 | Opto-Electronic Advances2020，3，8： | 5 |
| 11 | Mixed-cation perovskite solar cells in space显示文摘The metal halide perovskite materials demonstrate outstanding performance in photovoltaics because of their excellent optoelectronic properties (1-7)The perovskite solar cells (PSCs) exhibiting outstanding efficiency [8,9], high power-per-weight [10], and excellent radiation resistance[11-13] are considered to be promising for developing the new-generation energy technology for space application. | YongGuang Tu GuoNing Xu XiaoYu Yang YiFei Zhang ZhaoJie Li Rui Su DeYing Luo WenQiang Yang Ying Miao Rong Cai LuHua Jiang XiaoWei Du YanChu Yang QianShi Liu Yang Gao Shuai Zhao Wei Huang QiHuang Gong Rui Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 4 |
| 12 | Optically sizing single atmospheric particulates with a 10-nm resolution using a strong evanescent field显示文摘Although an accurate evaluation of the distribution of ultrafine particulate matter in air is of utmost significance to public health,the usually used PM2.5 index fails to provide size distribution information.Here we demonstrate a low-profile and cavity-free size spectrometer for probing fine and ultrafine particulate matter by using the enhanced particle-perturbed scattering in strong optical evanescent fields of a nanofiber array.The unprecedented size resolution reaches 10 nm for detecting single 100-nm-diameter nanoparticles by employing uniform nanofibers and controlling the polarizations of the probe light.This size spectrometry was tested and used to retrieve the size distribution of particulate matter in the air of Beijing,yielding mass concentrations of nanoparticles,as a secondary exercise,consistent with the officially released data.This nanofiber-array probe shows potential for the full monitoring of air pollution and for studying early-stage haze evolution and can be further extended to explore nanoparticle interactions. | Xiao-Chong Yu Yanyan Zhi Shui-Jing Tang Bei-Bei Li Qihuang Gong Cheng-Wei Qiu Yun-Feng Xiao | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 13 | Applications of cesium in the perovskite solar cells显示文摘Perovskite solar cells have experienced an unprecedented rapid development in the power conversion efficiency(PCE)during the past 7 years,and the record PCE has been already comparable to the traditional polycrystalline silicon solar cells.Presently,it is more urgent to address the challenge on device stability for the future commercial application.Recently,the inorganic cesium lead halide perovskite has been intensively studied as one of the alternative candidates to improve device stability through controlling the phase transition.The cesium(Cs)-doped perovskites show more superior stability comparing with organic methylammonium(MA)lead halide perovskite or formamidinium(FA)lead halide perovskite.Here,recent progress of the inorganic cesium application in organic-inorganic perovskite solar cells(PSCs)is highlighted from the viewpoints of the device efficiency and the device stability. | Fengjun Ye Wenqiang Yang Deying Luo Rui Zhu Qihuang Gong | 2017 | Journal of Semiconductors2017，38，1： | 4 |
| 14 | Spontaneous T-symmetry breaking and exceptional points in cavity quantum electrodynamics systems显示文摘Spontaneous symmetry breaking has revolutionized the understanding in numerous fields of modern physics. Here, we theoretically demonstrate the spontaneous time-reversal symmetry breaking in a cavity quantum electrodynamics system in which an atomic ensemble interacts coherently with a single resonant cavity mode. The interacting system can be effectively described by two coupled oscillators with positive and negative mass, when the two-level atoms are prepared in their excited states. The occurrence of symmetry breaking is controlled by the atomic detuning and the coupling to the cavity mode,which naturally divides the parameter space into the symmetry broken and symmetry unbroken phases.The two phases are separated by a spectral singularity, a so-called exceptional point, where the eigenstates of the Hamiltonian coalesce. When encircling the singularity in the parameter space, the quasiadiabatic dynamics shows chiral mode switching which enables topological manipulation of quantum states. | Yu-Kun Lu Pai Peng Qi-Tao Cao Da Xu Jan wiersig Qihuang Gong Yun-Feng Xiao | 2018 | Science Bulletin2018，63，17： | 4 |
| 15 | All-optical computing based on convolutional neural networks显示文摘The rapid development of information technology has fueled an ever-increasing demand for ultrafast and ultralow-en-ergy-consumption computing.Existing computing instruments are pre-dominantly electronic processors,which use elec-trons as information carriers and possess von Neumann architecture featured by physical separation of storage and pro-cessing.The scaling of computing speed is limited not only by data transfer between memory and processing units,but also by RC delay associated with integrated circuits.Moreover,excessive heating due to Ohmic losses is becoming a severe bottleneck for both speed and power consumption scaling.Using photons as information carriers is a promising alternative.Owing to the weak third-order optical nonlinearity of conventional materials,building integrated photonic com-puting chips under traditional von Neumann architecture has been a challenge.Here,we report a new all-optical comput-ing framework to realize ultrafast and ultralow-energy-consumption all-optical computing based on convolutional neural networks.The device is constructed from cascaded silicon Y-shaped waveguides with side-coupled silicon waveguide segments which we termed“weight modulators”to enable complete phase and amplitude control in each waveguide branch.The generic device concept can be used for equation solving,multifunctional logic operations as well as many other mathematical operations.Multiple computing functions including transcendental equation solvers,multifarious logic gate operators,and half-adders were experimentally demonstrated to validate the all-optical computing performances.The time-of-flight of light through the network structure corresponds to an ultrafast computing time of the order of several picoseconds with an ultralow energy consumption of dozens of femtojoules per bit.Our approach can be further expan-ded to fulfill other complex computing tasks based on non-von Neumann architectures and thus paves a new way for on-chip all-optical computing. | Kun Liao Ye Chen Zhongcheng Yu Xiaoyong Hu Xingyuan Wang Cuicui Lu Hongtao Lin Qingyang Du Juejun Hu Qihuang Gong | 2021 | Opto-Electronic Advances2021，4，11： | 3 |
| 16 | Preparation, characterization and nonlinear optical properties of colloidal gallium arsenide nanocrystals显示文摘GaAs nanocrystals were prepared via a simple mechanical ball milling technique. The prepared GaAs nanocrys- tals have high purity and could form colloidal ethanol suspension without any surfactant additives. The colloidal GaAs nanocrystal suspension displayed excellent two-photon absorption property over the visible and near-infrared region from 490 nm to 1064 nm, which enables it to become a promising broadband optical limiting material. | LIU Zhengang LIU Chunling LI Quanshui CHEN Zhijian GONG Qihuang | 2006 | Rare Metals2006，25，2： | 3 |
| 17 | Solving surface plasmon resonances and near field in metallic nanostructures:Green’s matrix method and its applications显示文摘With the development of nanotechnology,many new optical phenomena in nanoscale have been demonstrated.Through the coupling of optical waves and collective oscillations of free electrons in metallic nanostructures,surface plasmon polaritons can be excited accompanying a strong near field enhancement that decays in a subwavelength scale,which have potential applications in the surface-enhanced Raman scattering,biosensor,optical communication,solar cells,and nonlinear optical frequency mixing.In the present article,we review the Green's matrix method for solving the surface plasmon resonances and near field in arbitrarily shaped nanostructures and in binary metallic nanostructures.Using this method,we design the plasmonic nanostructures whose resonances are tunable from the visible to near-infrared,study the interplay of plasmon resonances,and propose a new way to control plasmonic resonances in binary metallic nanostructures. | GU Ying LI Jia MARTIN Olivier J F GONG QiHuang | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 18 | Progress in femtochemistry and femtobiology显示文摘Femtoscience offers a unique way to understand the dynamics in physics, chemistry and biology. This subject focuses on the process happening at femto-to pico-second time scale by femtosecond optical methods. Widely used in chemistry it reveals chemical reactions, including bond breaking, forming, and stretching, which happens at an ultrafast time scale. Femtoscience is also important in the biological system, for example, light harvesting system and vision system. Femtoscience in physics is also widely used, but it is not studied in this paper. Instead, we report new advances in femtochemistry and femtobiology, including structural dynamics, coherent control, enzyme function dynamics and hydration in the protein system. We also introduce attosecond science, focusing on electron dynamics at an extreme short time scale. | WANG ShuFeng GONG QiHuang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 3 |
| 19 | Spatial evolution of the near-field distribution on planar gold nanoparticles with the excitation wavelength across dipole and quadrupole modes显示文摘We investigate the superposition properties of the dipole and quadrupole plasmon modes in the near field both experimentally, by using photoemission electron microscopy(PEEM), and theoretically. In particular, the asymmetric near-field distributions on gold(Au) nanodisks and nanoblocks under oblique incidence with different polarizations are investigated in detail. The results of PEEM measurements show that the evolutions of the asymmetric near-field distributions are different between the excitation with s-polarized and p-polarized light.The experimental results can be reproduced very well by numerical simulations and interpreted as the superposition of the dipole and quadrupole modes with the help of analytic calculations. Moreover, we hypothesize that the electrons collected by PEEM are mainly from the plasmonic hot spots located at the plane in the interface between the Au particles and the substrate in the PEEM experiments. | JINGHUAN YANG QUAN SUN HAN YU KOSEI UENO HIROAKI MISAWA QIHUANG GONG | 2017 | Photonics Research2017，5，3： | 3 |
| 20 | An actively ultrafast tunable giant slow-light effect in ultrathin nonlinear metasurfaces显示文摘A slow-light effect based on metamaterial-induced transparency(MIT)possesses great practical applications for integrated photonic devices.However,to date,only very weak slow-light effects have been obtained in metamaterials because of the intrinsic loss of metal.Moreover,no active control of slow-light has been achieved in metamaterials.Here,we report the realization of a giant slow-light effect on an ultrathin metasurface that consists of periodic arrays of gold nanoprism dimers with a thickness of 40 nm sandwiched between a multilayer-graphene micro-sheet/zinc oxide nanoparticle layer and a monolayer graphene/polycrystalline indium tin oxide layer.The strong field confinement of the plasmonic modes associated with the MIT ensures a tremendous reduction in the group velocity around the transparency window.A group index of more than 4×10^(3) is achieved,which is one order of magnitude greater than that of previous reports.A large tunable wavelength range of 120 nm is achieved around the center of the transparency window when the pump light intensity is only 1.5 kW cm^(-2).The response time is as fast as 42.3 ps.These results demonstrate the potential for the realization of various functional integrated photonic devices based on metasurfaces,such as all-optical buffers and all-optical switches. | Cuicui Lu Xiaoyong Hu Kebin Shi Qin Hu Rui Zhu Hong Yang Qihuang Gong | 2015 | Light(Science & Applications)2015，4，1： | 3 |
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