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| 1 | C/EBPα regulates SIRT1 expression during adipogenesis显示文摘SIRT1 在 adipogenesis 起一个重要作用,但是 SIRT1 怎么在 adipogenesis 被调整,大部分是未知的。在这研究,我们证明 SIRT1 蛋白质和 mRNA 层次与 CCAAT/enhancer-binding 蛋白质伪一起被增加(C/EBP 伪) 在 adipocyte 区别期间。C/EBP 伪,然而并非 C/EBP 伪 p 30,在 HeLa 房间和 3T3-L1 的激活的 SIRT1 倡导者 preadipocytes。而且, C/EBP 伪 upregulated SIRT1 mRNA 和蛋白质在 Soas2 房间以一种 p53 独立的方式在 HeLa 铺平房间和增加的 SIRT1 表示。在 preadipocytes, C/EBP 伪 upregulated SIRT1 蛋白质水平的宫外的表示并且导致的 C/EBP 伪击倒 SIRT1 的减少蛋白质水平。而且由倡导者删除分析,胶化移动试金和染色质 immunoprecipitation,我们发现了那 C/EBP,伪在一个一致 C/EBP 伪绑定地点跳了到 SIRT1 倡导者。这些数据证明那 C/EBP 伪在 adipogenesis 期间调整 SIRT1 表示由对 SIRT1 倡导者直接有约束力。 | Qihuang Jin Fang Zhang Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai | 2010 | Cell Research2010，20，4： | 8 |
| 2 | SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi Qiwei Zhai | 2007 | Cell Metabolism2007，，4： | 3 |
| 3 | SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B显示文摘 | SUN Cheng ZHANG Fang GE Xinjian | 2007 | Cell Metab2007，6，4： | 1 |
| 4 | SIRT1 Improves Insulin Sensitivity under Insulin - Resistant Conditions by Re- pressing PTP1 B 显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi and Qiwei Zha | 2007 | Cell Metabolism2007，6，： | 1 |
| 5 | SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B显示文摘 | Cheng Sun Fang Zhang Xinjian Ge Tingting Yan Xingmiao Chen Xianglin Shi Qiwei Zhai | 2007 | Cell Metabolism2007，，4： | 1 |
| 6 | Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity显示文摘 | Tingting Yan Yan Feng Jin Zheng Xinjian Ge Yi Zhang Dongmei Wu Jian Zhao Qiwei Zhai | 2009 | Neurochemistry International2009，，1： | 1 |
| 7 | SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B显示文摘 | SUN Cheng ZHANG Fang GE Xinjian | 2007 | Cell Metab2007，6，4： | 1 |
| 8 | A highly selective and sensitive upconversion nanoprobe for monitoring hydroxyl radicals in living cells and the liver显示文摘Excessive reactive oxygen species(ROS)would attack living cells and cause a series of oxidative stress related diseases,such as liver damage.Hydroxyl radicals(·OH)are currently known as one of the most toxic and harmful free radicals to organisms.Therefore,studies involving hydroxyl radicals have become important research topics in the fields of biology,biochemistry,and biomedicine.In addition,imaging of analytes using upconversion nanoparticles(UCNPs)possesses significant advantages over that using general fluorescent dyes or nanoparticles due to its high spatial resolution,reduced photodamage,and deep tissue penetration properties.Herein,we designed a highly selective and sensitive hydroxyl radical nanoprobe based on the luminescence resonance energy transfer between upconversion nanoparticles and methylene blue(MB).The concentration of·OH could be determined by the fluorescence recovery of the UCNPs due to the oxidative damage of MB.Using this nanoprobe,the·OH in living cells or in liver tissues could be monitored with high sensitivity and selectivity. | Guangshun Yu Na Feng Dan Zhao Hao Wang Yi Jin Dandan Liu Zhenhua Li Xinjian Yang Kun Ge Jinchao Zhang | 2021 | Science China(Life Sciences)2021，64，3： | 0 |
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