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| 1 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 2 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 3 | Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation显示文摘在稳固的肿瘤的本地组织缺氧经常导致抵抗到放射疗法(RT ) ,在哪个氧为提高 DNA 损坏的一个必要元素被电离引起放射。此处,我们开发了 gold@manganese 二氧化物(有聚乙烯乙二醇(木钉) 的 Au@MnO 2) 核心壳 nanoparticles 是的涂层在癌症治疗期间改进 RT 功效的一个新奇 radiosensitizing 代理人。在这 Au@MnO 2 nanostructure ,当金核心是著名 RT 时,交往与的 sensitizer X光检查为在 RT 下面杀死的改进癌症生产控告的粒子, MnO 2壳可以触发内长的 H 2在肿瘤微型环境到的 O 2产生氧并且克服 hypoxiaassociated RT 抵抗。是示威了由在 vitro 并且在 vivo 实验, Au@MnO 2-PEG nanoparticles 充当了有效 radiosensitizers 显著地在 RT 期间提高癌症治疗功效。而且, Au@MnO 2-PEG 的明显的副作用都没在老鼠被观察。因此,我们的工作为 hypoxic 肿瘤的提高的 RT 治疗与潜力介绍 radiosensitizer 的一种新类型。 | Xuan Yi Lei Chen Xiaoyan Zhong Roulin Gao Yitao Qian Fan Wu Guosheng Song Zhifang Chai Zhuang Liu Kai Yang | 2016 | Nano Research2016，9，11： | 12 |
| 4 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 5 | DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling显示文摘endoplasmic 蜂窝胃(嗯) 由原子信封, perinuclear 表和一个外部管状的网络组成。外设嗯并且线粒体形式在特定的子域的紧密的接触,它协调二个细胞器的函数并且为象 Ca 2+ 转移和 apoptosis 那样的多重细胞的进程被要求。然而,它大部分是未知的怎么嗯形态学并且嗯线粒体发信号动态地在象 DNA 那样的不同生理或病理学的条件下面被调整损坏。这里,我们证明外设,管状嗯响应 DNA 经历重要扩展损坏,和那这个过程依赖于嗯塑造蛋白质 REEP1, REEP2 和 EI24 (别名 PIG8 ) 的调停 p53 的 transcriptional 激活。这通过 EI24 和 mitochondrial 支持嗯线粒体接触的形成外部膜蛋白质 VDAC2,便于 Ca 2+ 转移从嗯到线粒体并且支持 DNA 导致损坏的 apoptosis。因此,我们识别包含改变在的一条唯一的 DNA 损坏反应小径嗯形态学,发信号的嗯线粒体,和 apoptosis。 | Pengli Zheng Qingzhou Chen Xiaoyu Tian Nannan Qian Peiyuan Chai Bing Liu Junjie Hu Craig Blackstone Desheng Zhu Junlin Teng Jianguo Chen | 2018 | Cell Research2018，28，8： | 9 |
| 6 | Impact of potentially lethal ventricular arrhythmias on long-term outcome in patients with chronic heart failure显示文摘背景潜在地致命的室的心律不齐( PLVA )在尖锐心肌的梗塞以后在幸存者经常发生并且逐渐地在调查的结构的心 diseases.This 学习的另外的形式被认出流行和在有长期的心失败( CHF )的病人的 PLVA 的预示的意义有关人口分布的 .Methods 数据,心失败的病原学, NYHA 功能的班,生物化学的变量, electrocardiographic 和 echocardiographic 调查结果,和医疗是 c 23.4 在病人 45 岁, 27.8 在那些在 45-65 岁之间,并且 33.5 没有 PLVAs.Age ,在病人,有 PLVA 的 65 岁( P=0.033 ) .Patients 比那些在5年的后续期间有更大的 LV 尺寸和更低的喷射部分(两 P 0.01 )和更高的所有原因死亡( P=0.014 )(或 1.041,95 Cl 1.004-1.079 , P=0.03 )并且 LV 结束心脏舒张的尺寸(或 1.068,95 Cl 1.013-1.126 , P=0.015 )独立地预言 PLVAs.And PLVA 的出现是为所有原因死亡的一个独立因素( RR 1.702。 | Liu Ye-hong Su Jing-ying Wang Lin-jie Li Jin-ping Zhou Qing-fen Gan Qian Chai Xi-chen Dai Li-ying Zhang Feng-ru Shen Wei-feng | 2012 | Chinese Medical Journal2012，，4： | 8 |
| 7 | Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats显示文摘 | Dun-quan XU Cao GAO Wen NIU Yan LI Yan-xia WANG Chang-jun GAO Qian DING Li-nong YAO Wei CHAI Zhi-chao LI | 2013 | Acta Pharmacologica Sinica2013，34，12： | 7 |
| 8 | Persistent efficacy of live attenuated hepatitis A vaccine (H2-strain) after a mass vaccination program显示文摘Background Live attenuated hepatitis A vaccine (H2 strain) is widely applied in prevention of hepatitis A epidemic in China and other countries now. It is essential to observe and confirm the vaccine immune efficacy, population antibody level and its persistent efficacy after mass immunization.Methods A total of 220 children with negative anti-HAV antibody (aged 1-3 years) were taken for follow-up assay to observe seroconversion and geometric mean titre(GMT)level 2 months, 12 months, 6 years, and 10 years after inoculation. Another survey sampled from subjects of different age groups (3, 6, 9, 15, 18, 25 and 35 years) to compare anti-HA antibody positive rate before and after inoculation performed 10 years previously. Epidemiological observations were taken for 10 years to evaluate the relationship between vaccine coverage and hepatitis A morbidity. Serum antibody to HAV was detected by enzyme linked immunoassay (ELISA, calibrated by WHO international reference) and ABBOTT Axsym HAVAB microparticle enzyme immunoassay. Results Seroconversion in follow-up assay 2 months and 10 years after inoculation was 98.6% and 80.2% respectively. For children, the vaccination anti-HA antibody positive rates were significantly different before and after 10 years, 7.69% cf 70.45% (aged 3 years) and 52.58% cf 71.78% (aged 18 years). When vaccine coverage rose from 57% to 74%, there were no any HA epidemics. When vaccine coverage reached 85%, there were no any HA cases. With vaccine coverage between 85% and 91%, there were no any HA cases in cohorts from the age of 1 year to 15 years during the 10 years. Conclusions Live attenuated hepatitis A vaccine has an obvious long-term effectiveness in prevention and control of HA epidemics through mass vaccination. | ZHUANG Fang-cheng QIAN Wen MAO Zi-an GONG Yue-ping JIANG Qi JIANG Li-min CHEN Nian-liang CHAI Shao-ai MAO Jiang-sen | 2005 | Chinese Medical Journal2005，，22： | 6 |
| 9 | Efficacy and safety of micafungin for invasive candida infections:a meta-analysis of randomized controlled trials显示文摘象 candidiasis 那样的背景侵略真菌的感染和模子感染在严重有病的 patients.Micafungin 引起重要病态和死亡是有 Candida 和 Aspergillus.We 的种类做了这元分析澄清 micafungin 是否为治疗感染与另外的抗真菌的代理人相比提供优异功效和安全的对大多数的有势力活动的抗真菌的代理人与联系了的 echinocandin 我们做了使随机化的控制 tri 的元分析的侵略 candidiasis.Methods 随机效果的模型,或 1.20,95 CI 1.00-1.45 , P=0.0487 ) .In 增加, micafungin 是比为经历造血的干细胞移植的 neutropenic 病人的抗真菌的预防的比较仪更有效的(或 1.47,95 CI 1.08-2.00 , P=0.01 )在那里的 .Although 不以不利的药效果的发生是比较政体之间的重要差别(或 0.94,95 CI 0.77-1.11 ),因为不利事件,与 micafungin 对待的更少病人从研究撤退了(或 0.64,95 | Chen Qian Lin Mao-hu Chen Meng-li Liu Zhe-yuan Chai Dong Wang Rui | 2012 | Chinese Medical Journal2012，，2： | 4 |
| 10 | Clinical significance of pain in patients with chronic heart failure显示文摘 | GAN Qian ZHANG Feng-ru ZHOU Qing-fen DAI Li-ying LIUYe-hong CHAI Xi-chen WU Fang SHEN Wei-feng | 2012 | Chinese Medical Journal2012，，18： | 4 |
| 11 | Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma显示文摘瞄准: 在调整树枝状的房间成熟并且在尖锐气喘的病理决定胸回归 protein-39 (BRP-39 ) 的角色。 | Qian XU Shou-jie CHAI Ying-ying QIAN Min ZHANG Kai WANG | 2012 | Acta Pharmacologica Sinica2012，33，12： | 3 |
| 12 | Tracing Method of Natural Sediments by Neutron Activation and Its Application显示文摘A new method of Neutron Activation Analysis (NAA) for sediment movement study is presented in this paper. Through analyzing the natural sediment, the information about natural tracing agents has been obtained, which can show the direction of sediment movement and relative discharge of sediment transportation. Test results in some areas, such as Shantou Harbour and Hangzhou Bay, are in good agreement with those from normal hydrologic measurements and some results are not obtainable with the latter. The NAA is economical, practical and reliable, and should be widely used in engineering practice. | Mao, Zhixiang Yan, Peilan Huang, Jianwei Dai, Xiankai Han, Naibing Chai, Zhifang Qian, Qinfang Ma, Shulan Ma, Jianguo | 1991 | China Ocean Engineering1991，6，3： | 3 |
| 13 | Smart Travel Based on Space-Time Behavior Study显示文摘In view of the significant demands and development trends of urbanization during the 12 th Five-Year Plan period, 'smart city' has attracted wide attention as an advanced city development concept in China. Under the circumstance of rapid urbanization, traffic congestion and accessibility defi ciency become major challenges to many Chinese cities, as transportation and travel are closely related to the effi ciency of a city's operation and the quality of people's life. As essential part of smart city planning and management, smart travel offers an effective behavior planning countermeasure to reduce the amount of urban traffi c and optimize the space-time distribution of travels and provides an effective technology to enrich the theories and methodologies of urban and transportation planning. Orienting at the practical demand of citizens and focusing on their travel behavior, this paper carries out a discussion on the smart travel framework based on space-time behavior study and analyzes smart travel planning and its policy route from multiple perspectives, including a prediction on travel demand, transportation planning, public policy-making, and urban planning. What's more, the paper suggests travel services for citizens based on space-time behavior analysis, such as providing personalized information, smart decision-making support, and individual behavior planning. | Chai Yanwei Shen Yue Ta Na Qian Fang | 2015 | China City Planning Review2015，24，1： | 3 |
| 14 | Discovery of novel PTP1B inhibitors with antihyperglycemic activity显示文摘 | Zhang LIU Qian CHAI Yuan-yuan LI Qiang SHEN Lan-ping MA Li-na ZHANG Xin WANG Li SHENG Jing-ya LI Jia LI Jing-kang SHEN | 2010 | Acta Pharmacologica Sinica2010，31，8： | 3 |
| 15 | NFAT2 is implicated in corticosterone-induced rat Leydig cell apoptosis显示文摘瞄准:为了调查激活的 T 的原子因素的激活,房间(NFAT ) 和它在皮质脂酮(CORT ) 的功能导致了老鼠 Leydig 房间的 apoptosis。方法:在老鼠 Leydig 房间的 NFAT 被组织化学的染色的西方的弄污和免疫检测。Cyclosporin A (CsA ) 被用来在 Leydig 房间的导致 CORT 的 apoptosis 评估 NFAT 的潜在的参与。细胞内部的 Ca^(2+) 用 Fluo-3/AM 在对待 CORT 的 Leydig 房间被监视。在 Leydig 房间为 12 h 加 CsA 与 CORT 或 CORT 被孵化以后,在原子核并且在细胞质的 NFAT2 的层次被半量的西方的弄污测量。在导致 CORT 的 Leydig 房间 apoptosis 的 NFAT2 的角色被在 FasL 表示和 apoptosis 上由 CsA 在表示和 NFAT2 激活的抑制上观察 NFAT2 的效果进一步评估。结果:我们发现 NFAT2 是在 Leydig 房间的占优势的 isoform。CsA 堵住了 Leydig 房间的导致 CORT 的 apoptosis。在 Leydig 房间的细胞内部的 Ca^(2+) 水平显著地在 CORT 处理以后被增加。CORT 在原子核增加了 NFAT2 的水平并且减少它在细胞质的水平。CsA 在 Leydig 房间堵住了 NFAT2 的导致 CORT 的原子 translocation。在老鼠 Leydig 房间的导致 CORT 的 apoptosis 和 FasL 表示被提高由过去 NFAT2 的表示并且由 CsA 反对了。结论:NFAT2 在导致 CORT 的 Leydig 房间 apoptosis 被激活。在表示和 NFAT2 激活的抑制上的 NFAT2 的效果建议 NFAT2 可以潜在地通过 FasL 的起来规定在导致 CORT 的 Leydig 房间 apoptosis 起一个 pro-apoptotic 作用。 | Wei-Ran Chai Qian Wang Hui-Bao Gao | 2007 | Asian Journal of Andrology2007，9，5： | 2 |
| 16 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 17 | Effect of current emission abatement strategies on air quality improvement in China:A case study of Baotou,a typical industrial city in Inner Mongolia显示文摘The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_(2.5) levels over China.To explore more effective emission abatement strategies in industrial cities,a case study was conducted in Baotou to evaluate the current national control measures.The total emissions of SO_2,NO_X,PM_(2.5) and NMVOC(non-methane volatile organic compounds) in Baotou were 211.2 Gg,156.1 Gg,28.8 Gg,and 48.5 Gg,respectively in 2013,and they would experience a reduction of 30.4%,26.6%,15.1%,and 8.7%,respectively in 2017 and 39.0%,32.0%,24.4%,and 12.9%,respectively in2020.The SO_2,NO_Xand PM_(2.5) emissions from the industrial sector would experience a greater decrease,with reductions of 37%,32.7 and 24.3%,respectively.From 2013 to 2020,the concentrations of SO_2,NO_2,and PM_(2.5) are expected to decline by approximately 30%,10% and 14.5%,respectively.The reduction rate of SNA(sulfate,nitrate and ammonium)concentrations was significantly higher than that of PM_(2.5) in 2017,implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.Although air pollution control measures implemented in the industrial sector could greatly reduce total emissions,constraining the emissions from lower sources such as residential coal combustion would be more effective in decreasing the concentration of PM_(2.5) from 2017 to 2020.These results suggest that even for a typical industrial city,the reduction of PM_(2.5) concentrations not only requires decreases in emissions from the industrial sector,but also from the low emission sources.The seasonal variation in sulfate concentration also showed that emission from coal-burning is the key factor to control during the heating season. | Xionghui Qiu Lei Duan Siyi Cai Qian Yu Shuxiao Wang Fahe Chai Jian Gao Yanping Li Zhaoming Xu | 2017 | Journal of Environmental Sciences2017，29，7： | 2 |
| 18 | Possible functions of the microtrichia on the cuticle of Ulomoides dermestoides(Chevrolat)(Coleoptera:Tenebrionidae)显示文摘Ulomoides dermestoides(Chevrolat)(Coleoptera: Tenebrionidae) is one of the most notorious pests in northeastern China. We examined microtrichia on the thorax, elytra and abdomen of U. dermestoides using scanning electron microscopy and recorded their conformations(size, shape and insertion method) and distributions(length, width and location). Possible functions of the microtrichia were(1) stridulation: microtrichia on the inner surface of the elytra interacted with microtrichia on the dorsoventral axis of the thorax or on the costal vein of the hind wing;(2) to increase friction: at the major surface on the middle of the abdominal tergum, hind-wings, inner surface of the medial edge of the elytra and the posterior end of the elytra;(3) protection: the microtrichia covering the posterior face of the abdomen conserved water in the body and protected the body from damage; and(4) sensing organ: the special shape of the microtrichia on the nervation near the vannal fold of the hind wing, the anteriometapleuron on the metathorax, and the posterior field of the abdomen could perceive the environment. In conclusion, the size and shape of the microtrichia are tightly related to their functions, which may have evolved with the beetles' lifestyle. | Jingjing Qian Defu Chi Rusong Chai | 2016 | Journal of Forestry Research2016，27，6： | 1 |
| 19 | The study of iodine in Chinese totaldiets显示文摘 | HOU X L CHAI C F QIAN Q F | 1997 | The Science of the Total Environment1997，193，： | 1 |
| 20 | Synthesis, characterisation and liquid crystal properties of 2,5 - bis bromobenzenes 显示文摘 | Chun - peng Chai Qian Yang Xing - he Fan Xiao - fang Chen Zhi -hao Shen Qi -feng Zhou | 2008 | Liquid Crystals2008，35，2： | 1 |
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