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| 1 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 2 | Oxidation Protective C/SiC/Si-SiC Multilayer Coating for Carbon/Carbon Composites Applying at 1873 K显示文摘A C/SiC/Si-SiC multilayer coating for protecting carbon/carbon(C/C) composites against oxidation was prepared by slurry and pack cementation.X-ray diffraction(XRD) and energy dispersive spectroscopy(EDS) analysis showed that the inner coating obtained from the slurry and pack cementation was a C/SiC gradient layer acting as bonding layer,and the exterior coating formed in the second pack cementation was a Si-SiC double phase coating.Oxidation tests at 1873 K in air showed that the coating exhibited excellent oxidation protective ability and thermal shock resistance.The coating could effectively protect C/C composites from oxidation at 1873 K in air for 170 h and undergo the thermal cycling between 1873 K and room temperature for 8 cycles.The weight loss of the coated C/C composites is due to the formation of cracks and holes in the coating and the volatilization of SiO2 glass at high temperature. | Yulei Zhang,Hejun Li,Xinfa Qiang and Kezhi Li C/C Composites Research Center,State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,Xi an 710072,China | 2010 | Journal of Materials Science & Technology2010，26，12： | 4 |
| 3 | Power-Efficient Cross-Layer De- sign for OFDMA Systems with Heteroge- neous QoS, Imperfect CS显示文摘 | ZARAKOVITIS C C QIANG Ni SKORDOULIS D E | 2012 | [EEE Transactions on Ve- hicular Technology2012，61，2： | 1 |
| 4 | From clusters to phase diagrams: Composition rules of quasicrystals and bulk metallic glasses 显示文摘 | DONG C WANG Q QIANG J B WANG Y M JIANG N HAN G LI Y H WU J XIA J H | 2007 | J Phys D: Appl Phys2007，40，： | 1 |
| 5 | Response of wild Brassica juncea populations to glyphosate显示文摘 | Huangfu C H Song X L Qiang S | 2007 | Pest Management Science2007，63，： | 1 |
| 6 | Dynamic changes of the cervical ligamental flovum in Hyperextension-Hyperflexion movement and their measurements显示文摘 | Lianshun J Qiang Q Deyu C | 1990 | Chinese Medical J1990，103，1： | 1 |
| 7 | Disinfection of swine wastewater using chlorine, ultraviolet light and ozone 显示文摘 | Macauley J J Qiang Z Adams C D | 2006 | Water research2006，40，10： | 1 |
| 8 | Composition rule of bulk metallic glasses and quasicrystals using electron concentration criterion 显示文摘 | Wang Y M Qiang J B Dong C | 2003 | J Mater Res2003，18，： | 1 |
| 9 | Magnetostratigraph ic record of the Late Miocene onset of the East Asian monsoon, and Pliocene uplift of northern Tibet显示文摘 | Qiang X K Li Z X Powell C Zheng H | 2001 | Earth and Planetary Science Letters2001，187，： | 1 |
| 10 | Size and phonon-confinement effects on low-frequency raman mode of anatase TiO2 nanocrystal显示文摘 | KE R Z MING S Z QIANG C | 2005 | Phys Lett A2005，340，： | 1 |
| 11 | A physical short-channel threshold voltage model for undoped symmetric double-gate MOSFETs显示文摘 | Qiang C Harrell E M I Meindl J D | 2003 | IEEE Transactions on Electron Devices2003，50，7： | 1 |
| 12 | Determination of ozonation rateconstants for lincomycin and spectinomycin显示文摘 | Qiang Z Adams C Surampalli R | 2004 | Ozone Sci Eng2004，26，6： | 1 |
| 13 | Chloroplastic oxidative burst induced by tenuazonic acid,a natural photosynthesis inhibitor,triggers cell necrosis in Eupatorium adenophorum Spreng显示文摘 | CHEN S G YIN C Y QIANG S | 2010 | Biochim Biophys ActaBioenergetics2010，1797，： | 1 |
| 14 | Study on grid connected inverter used in high power wind generation system 显示文摘 | QIANG Z LEWEI Q DAVID C | 2006 | IEEE Industry Applications Society Annual 2006 Conference2006，，： | 1 |
| 15 | Simultaneous Determi- nation of Sulfonamides, Tetracyclines and Tiamulin in Swine Wastewater by Solid-Phase Extraction and Liquid Chromatography- Mass Spectrometry显示文摘 | BEN W W QIANG Z M ADAMS C | 2008 | Journal of Chromatography A2008，1202，2： | 1 |
| 16 | Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs显示文摘 | QIANG W ZHAI C LEI J | 2009 | Analyst2009，134，9： | 1 |
| 17 | Potentiometric determination of acid dissocia-tion constants ( pKa) for human and veterinary antibiotics 显示文摘 | Qiang Z Adams C | 2004 | Water Research2004，38，12： | 1 |
| 18 | Study on preparation, characteriza- tion and sizing performance of modified collagen surface sizing agent显示文摘 | Wang X C Hao X L Qiang T T | 2014 | Bio Resources2014，9，1： | 1 |
| 19 | Detection of IgG bound lipoprotein(a) immune complexes in patients with coronary heart disease显示文摘 | Wang J Qiang H Zhang C | 2003 | Clin Chim Acta2003，327，12： | 1 |
| 20 | Electrochemical generation of hydrogen peroxide from dissolved oxygen in acidic solutions显示文摘 | Qiang Z Chang J H Huang C P | 2002 | Water Res2002，36，： | 1 |
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