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| 1 | Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects显示文摘Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor,but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site.In this work,we report a rational integration of photonic-responsive two-dimensional(2D)ultrathin niobium carbide(Nb2C)MXene nanosheets(NSs)into the 3D-printed bone-mimetic scaffolds(NBGS)for osteosarcoma treatment.The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared(NIR-II)biowindow with high tissue-penetrating depth,making it highly efficient in killing bone cancer cells.Importantly,Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site,which can transport more oxygen,vitamins and energy around the bone defect for the reparative process,and gather more immune cells around the defect site to accelerate the degradation of NBGS.The degradation of NBGS provides sufficient space for the bone remodeling.Besides,calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue.The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXeneintegrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor. | Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen | 2021 | Nano-Micro Letters2021，13，2： | 5 |
| 2 | Hyaluronidase-triggered anticancer drug and siRNA delivery from cascaded targeting nanoparticles for drug- resistant breast cancer therapy显示文摘药抵抗在结缔组织生长的治疗使标准化疗变为无效因素(CTGF )-overexpressing 乳癌。由共同嵌入胸肿瘤渗透房间的肽( PEGA-pVEC )和玻尿的酸(哈)作为指向媒介,新奇串联指向的 nanoparticles ( HACT NP )在格格声 mesoporous 硅石上被创造(为与 anticancer 药一起的 siRNAs 的针尖交货的 rmSiO 2)支架,瞄准在 vivo 克服 CTGF-overexpressing 乳癌的药抵抗。指向的 nanoparticles 有选择地在 PEGA-pVEC 肽的指导下面在 vasculature 积累了,在另一个指向的代理人的帮助下由调停受体的 endocytosis 串联了,哈,介绍一在比单个指向指向能力的 vivo 肿瘤更大 ligand 向量。另外, HA 壳在货物运输过程期间阻止了治疗学的药的漏直到玻尿酸酵素(HAase ) 在 lysosomes 进入之上触发了降级,保证在目标房间内的一个可控制的药版本。当保护的壳瓦解时,释放 siRNA 负责了到基因与药抵抗联系了的沉默, CTGF,因此便于导致 doxorubicin 的 apoptosis。串联指向的媒介(PEGA-pVEC 并且哈) 在 vivo 推进指导精确的治疗,当进一个化疗药交货系统的 siRNAs 的封装为药抵抗癌症的治疗提供有效策略时。 | Jie Ding Tingxizi Liang Ying Zhou Zhiwei He Qianhao Min Liping Jiang Junjie Zhu | 2017 | Nano Research2017，10，2： | 2 |
| 3 | Postmortem molecular analysis of KCNQ1 , KCNH2 , KCNE1 and KCNE2 genes in sudden unexplained nocturnal death syndrome in the Chinese Han population显示文摘 | Chao Liu Qianhao Zhao Terry Su Shuangbo Tang Guoli Lv Hong Liu Li Quan Jianding Cheng | 2013 | Forensic Science International . 2013 (1-3)2013，，1： | 1 |
| 4 | Sunlight-controlled CO_(2) separation resulting from a biomass-based CO_(2) absorber显示文摘Renewable solid sorbents for CO_(2) capture and storage have shown great potentials for the sake of gaseous separation,tail gas treatment,environmental regulation and climate governance.However,current existed preparation and reusability of solid sorbents are generally subject to high energy consumption and complicated procedure.Herein,a light-controlled CO_(2) separation system with high working temperature resulting from natural sawdust combined with polyethyleneimine is fabricated,which involves low energy input and few operating sequences.This system shows a direct and ratiometric response to sunlight illumination by which CO_(2) can be reversibly adsorbed and released.This light-controlled CO_(2) separation process is prospective to become an attractive alternative to traditional alkaline CO_(2) collection method in terms of its convenience and low cost.As a practical demonstration,CO_(2) mixed with N_(2) is successfully separated through this light-controlled carbon capture and storage(CCS) system,which offers great promise for CO_(2) capture and enrichment with applicability across a wide range of scales. | Shiming Zhang Qianhao Pan Yapei Wang | 2022 | Green Energy & Environment2022，7，3： | 1 |
| 5 | The New Economic Constitution in China: A Third Way for Competition Regime? 显示文摘 | Young Jin Jung QianHao | 2003 | Northwestern Journal of International Law & Busines2003，，1： | 1 |
| 6 | Correction to:Nb2C MXene‑Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects显示文摘The original version of this article unfortunately contain some mistakes in figure.The authors found that the curves in Fig.1f,g were missing.The corrected version of Fig.1 is given below:Fig.1 Fabrication and characterization of ultrathin 2D Nb2C MXene NSs.a,b SEM images of Nb2AlC ceramics with corresponding element mapping(Nb,Al and C).c,d SEM images of multilayered Nb2C MXene and the corresponding element mapping(Nb,Al and C). | Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen | 2022 | Nano-Micro Letters2022，14，5： | 0 |
| 7 | Vehicle-following system based on deep reinforcement learning in marine scene显示文摘In order to solve the problems that the feature data type are not rich enough in the data collection process about the vehicle-following task in marine scene which results in a long model convergence time and high training difficulty,a two-stage vehicle-following system was proposed.Firstly,semantic segmentation model predicts the number of pixels of the followed target,then the number of pixels of the followed target is mapped to the position feature.Secondly,deep reinforcement learning algorithm enables the control equipment to make decision action,to ensure that two moving objects remain within the safe distance.The experimental results show that the two-stage vehicle-following system has a 40%faster convergence rate than the model without position feature,and the following stability is significantly improved by adding the position feature. | Zhang Xin Lou Haoran Jiang Li Xiao Qianhao Cai Zhuwen | 2022 | The Journal of China Universities of Posts and Telecommunications2022，29，5： | 0 |
| 8 | Achieving oxidation protection effect for strips hot rolling via Al_(2)O_(3) nanofluid lubrication显示文摘It was discovered the application of Al_(2)O_(3) nanofluid as lubricant for steel hot rolling could synchronously achieve oxidation protection of strips surface.The underlying mechanism was investigated through hot rolling tests and molecular dynamics (MD) simulations.The employment of Al_(2)O_(3) nanoparticles contributed to significant enhancement in the lubrication performance of lubricant.The rolled strip exhibited the best surface topography that the roughness reached lowest with the sparsest surface defects.Besides,the oxide scale generated on steel surface was also thinner,and the ratio of Fe_(2)O_(3) among various iron oxides became lower.It was revealed the above oxidation protection effect of Al_(2)O_(3) nanofluid was attributed to the deposition of nanoparticles on metal surface during hot rolling.A protective layer in the thickness of about 193 nm was formed to prevent the direct contact between steel matrix and atmosphere,which was mainly composed of Al_(2)O_(3) and sintered organic molecules.MD simulations confirmed the diffusion of O_(2) and H_(2)O could be blocked by the Al_(2)O_(3) layer through physical absorption and penetration barrier effect. | Jianlin Sun Boyuan Huang Jiaqi He Erchao Meng Qianhao Chang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，5： | 0 |
| 9 | Sudden Cardiac Death and Cardiac Sodium Channel Diseases显示文摘Sudden cardiac death(SCD),accounting for a substantial part of the forensic autopsy,is a leading cause of mortality worldwide.Lethal arrhythmia due to sodium channel diseases is recognized as one of the most prevalent etiologies of SCD.In these disorders,defective cardiomyocytes,including the pacemaker and the working cardiomyocytes,would manifest as abnormal electrical activity and morphology,thereby predisposing individuals to SCD.It is always a problem for forensic pathologists to adjudicate a sudden death caused by sodium channel diseases since structural changes in those cases are often inconspicuous.With the advent of the molecular autopsy,forensic pathologists can conduct targeted gene testing to identify the risk of SCD for family members of the probands.This review aims to discuss the relationship between SCD and sodium channel diseases,clarify the underlying mechanisms,and provide prophylactic suggestions for the relatives of SCD patients at risk. | Wenzhao Wei Ying Fang Nan Zhou Qiuping Wu Qianhao Zhao Jianding Cheng | 2022 | Journal of Forensic Science and Medicine2022，8，4： | 0 |
| 10 | Lensless polarimetric coded ptychography for high-resolution,high-throughput gigapixel birefringence imaging on a chip显示文摘Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample.It can infer crucial birefringence properties of specimens without using labels,thereby facilitating the diagnosis of diseases such as cancer and osteoarthritis.In this study,we present a novel polarimetric coded ptychography(pol-CP)approach that enables high-resolution,high-throughput gigapixel birefringence imaging on a chip.Our platform deviates from traditional lens-based systems by employing an integrated polarimetric coded sensor for lensless coherent diffraction imaging.Utilizing Jones calculus,we quantitatively determine the birefringence retardance and orientation information of biospecimens from the recovered images.Our portable pol-CP prototype can resolve the 435 nm linewidth on the resolution target,and the imaging field of view for a single acquisition is limited only by the detector size of 41 mm2.The prototype allows for the acquisition of gigapixel birefringence images with a 180 mm^(2) field of view in~3.5 min,a performance that rivals high-end whole slide scanner but at a small fraction of the cost.To demonstrate its biomedical applications,we perform high-throughput imaging of malaria-infected blood smears,locating parasites using birefringence contrast.We also generate birefringence maps of label-free thyroid smears to identify thyroid follicles.Notably,the recovered birefringence maps emphasize the same regions as autofluorescence images,underscoring the potential for rapid on-site evaluation of label-free biopsies.Our approach provides a turnkey and portable solution for lensless polarimetric analysis on a chip,with promising applications in disease diagnosis,crystal screening,and label-free chemical imaging,particularly in resource-constrained environments. | LIMING YANG RUIHAI WANG QIANHAO ZHAO PENGMING SONG SHAOWEI JIANG TIANBO WANG XIAOPENG SHAO CHENGFEI GUO RISHIKESH PANDEY GUOAN ZHENG | 2023 | Photonics Research2023，11，12： | 0 |
| 11 | Guide to forensic pathology practice for death cases related to coronavirus disease 2019(COVID-19)(Trial draft)显示文摘Autopsy is of great significance for elucidating the pathological changes,pathogenesis and cause of death of Coronavirus Disease 2019(COVID-19)and can provide a theoretical basis for scientific and accurate prevention and control of its outbreak.Based on related laws and regulations,such as the Law of the People's Republic of China on Prevention and Control of Infectious Diseases,clinical manifestations and epidemiological characteristics of COVID-19 and guidelines on the prevention and control of this epidemic,combined with the practical work of forensic pathology examinations,we developed the Guide to Forensic Pathology Practice for Death Cases Related to Coronavirus Disease 2019(COVID-19)(Trial Draft).This guide describes the background investigation of the death cases,autopsy room requirements,personal pre-vention and protections,external examinations,autopsy practices and auxiliary examinations,and thus offers a reference for forensic and pathological examination institutions and staff. | Danmi Mao Nan Zhou Da Zheng Jiacheng Yue Qianhao Zhao Bin Luo Dawei Guan Yiwu Zhou Bingjie Hu Jianding Cheng(Translated) | 2020 | Forensic Sciences Research2020，5，1： | 0 |
| 12 | Recent progress on rational design of catalysts for fermentative hydrogen production显示文摘The increasingly severe energy crisis has strengthened the determination to develop environmentally friendly energy.And hydrogen has emerged as a candi-date for clean energy.Among many hydrogen generation methods,biohydrogen stands out due to its environmental sustainability,simple operating environ-ment,and cost advantages.This review focuses on the rational design of catalysts for fermentative hydrogen production.The principles of microbial dark fermen-tation and photo-fermentation are elucidated exhaustively.Various strategies to increase the efficiency of fermentative hydrogen production are summa-rized,and some recent representative works from microbial dark fermentation and photo-fermentation are described.Meanwhile,perspectives and discussions on the rational design of catalysts for fermentative hydrogen production are provided. | Yifan Chai Zhaoyuan Lyu Huitong Du Pan Li Shichao Ding Yujing Jiang Hua Wang Qianhao Min Dan Du Yuehe Lin Wenlei Zhu | 2022 | SusMat2022，2，4： | 0 |
| 13 | Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation显示文摘To form fully functional four-chambered structure,mammalian heart development undergoes a transient finger-shaped trabeculae,crucial for efficient contraction and exchange for gas and nutrient.Although its developmental origin and direct relevance to congenital heart disease has been studied extensively,the time-resolved cellular mechanism underlying hypotrabeculation remains elusive.Here,we employed in toto live imaging and reconstructed the holistic cell lineages and cellular behavior landscape of control and hypotrabeculed hearts of mouse embryos from E9.5 for up to 24 h.Compared to control,hypotrabeculation in ErbB2 mutants arose mainly through dual mechanisms:both reduced proliferation of trabecular cardiomyocytes from early cell fate segregation and markedly impaired oriented cell division and migration.Further examination of mosaic mutant hearts confirmed alterations in cellular behaviors in a cell autonomous manner.Thus,our work offers a framework for continuous live imaging and digital cell lineage analysis to better understand subtle pathological alterations in congenital heart disease. | Xin Li Yanzhu Yue Youdong Zhang Yuanhui Liao Qianhao Wang Yunkun Bian Jie Na Aibin He | 2022 | Fundamental Research2022，2，1： | 0 |
| 14 | Efficient Improvement of Nutritional Content in Rice Grains by Precise Base Editing of OsROS1显示文摘Aleurone forms the outermost layer of the rice endosperm and plays a critical role in apoplastic nutrient uptake during endosperm development.Thickening the aleurone layer has been proposed to significantly increase the nutrient content of rice grains.In this study,we used a CRISPR/Cas9-mediated precise base editing method to target OsROS1,a gene associated with aleurone thickness,in the background of the japonica glutinous rice cultivar Zhennuo 19。 | XU Yang WANG Fangquan LI Wenqi WANG Jun TAO Yajun FAN Fangjun CHEN Zhihui JIANG Yanjie ZHU Jianping LI Xia ZHU Qianhao YANG Jie | 2023 | Rice science2023，30，6： | 0 |
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