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| 1 | A toolkit of thread-based microfluidics,sensors,and electronics for 3D tissue embedding for medical diagnostics显示文摘Threads,traditionally used in the apparel industry,have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and repair.The wicking property and flexibility of threads also make them promising candidates for the creation of three-dimensional(3D)microfluidic circuits.In this paper,we report on thread-based microfluidic networks that interface intimately with biological tissues in three dimensions.We have also developed a suite of physical and chemical sensors integrated with microfluidic networks to monitor physiochemical tissue properties,all made from thread,for direct integration with tissues toward the realization of a thread-based diagnostic device(TDD)platform.The physical and chemical sensors are fabricated from nanomaterial-infused conductive threads and are connected to electronic circuitry using thread-based flexible interconnects for readout,signal conditioning,and wireless transmission.To demonstrate the suite of integrated sensors,we utilized TDD platforms to measure strain,as well as gastric and subcutaneous pH in vitro and in vivo. | Pooria Mostafalu Mohsen Akbari Kyle A.Alberti Qiaobing Xu Ali Khademhosseini Sameer R.Sonkusale | 2016 | Microsystems & Nanoengineering2016，2，1： | 6 |
| 2 | Biocompatibility and degradation of tendon-derived scaffolds显示文摘Decellularized extracellular matrix has often been used as a biomaterial for tissue engineering applications.Its function,once implanted can be crucial to determining whether a tissue engineered construct will be successful,both in terms of how the material breaks down,and how the body reacts to the material’s presence in the first place.Collagen is one of the primary components of extracellular matrix and has been used for a number of biomedical applications.Scaffolds comprised of highly aligned collagen fibrils can be fabricated directly from decellularized tendon using a slicing,stacking,and rolling technique,to create two-and three-dimensional constructs.Here,the degradation characteristics of the material are evaluated in vitro,showing that chemical crosslinking can reduce degradation while maintaining fiber structure.In vivo,non-crosslinked and crosslinked samples are implanted,and their biological response and degradation evaluated through histological sectioning,trichrome staining,and immunohistochemical staining for macrophages.Non-crosslinked samples are rapidly degraded and lose fiber morphology while crosslinked samples retain both macroscopic structure as well as fiber orientation.The cellular response of both materials is also investigated.The in vivo response demonstrates that the decellularized tendon material is biocompatible,biodegradable and can be crosslinked to maintain surface features for extended periods of time in vivo.This study provides material characteristics for the use of decellularized tendon as biomaterial for tissue engineering. | Kyle AAlberti Qiaobing Xu | 2016 | Regenerative Biomaterials2016，3，1： | 4 |
| 3 | Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins,and drugs显示文摘Lipid nanoparticle(LNP)-based drug delivery systems have become the most clinically advanced non-viral delivery technology.LNPs can encapsulate and deliver a wide variety of bioactive agents,including the small molecule drugs,proteins and peptides,and nucleic acids.However,as the physicochemical properties of small-and macromolecular cargos can vary drastically,every LNP carrier system needs to be carefully tailored in order to deliver the cargo molecules in a safe and efficient manner.Our group applied the combinatorial library synthesis approach and in vitro and in vivo screening strategy for the development of LNP delivery systems for drug delivery.In this Review,we highlight our recent progress in the design,synthesis,characterization,evaluation,and optimization of combinatorial LNPs with novel structures and properties for the delivery of small-and macromolecular therapeutics both in vitro and in vivo.These delivery systems have enormous potentials for cancer therapy,antimicrobial applications,gene silencing,genome editing,and more.We also discuss the key challenges to the mechanistic study and clinical translation of new LNP-enabled therapeutics. | Yamin Li Zhongfeng Ye Hanyi Yang Qiaobing Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 3 |
| 4 | Roles of Mitogen-Activated Protein Kinases in the Modulation of Endothelial Cell Function Following Thermal Injury显示文摘 | Wei Wu Qiaobing Huang Fei He Mingjia Xiao Shiyu Pang Xiaohua Guo Ulf T. Brunk Kesen Zhao Ming Zhao | 2011 | Shock2011，，6： | 2 |
| 5 | 显示文摘 | Gates B D Xu Qiaobing Christopher Love J | 2004 | Annu Rev Mater Res2004，34，： | 1 |
| 6 | New approa- ches to nanofabrication: molding, printing, and other techniques 显示文摘 | Gates B D Xu Qiaobing Stewart M | 2005 | Chem Rev2005，105，： | 1 |
| 7 | A new hydrodynamic approach by infusion of drag-reducing polymers to improve left ventricular function in rats with myocardial infarction显示文摘 | Xianghui Chen Daogang Zha Jiancheng Xiu Yulin Liao Kai Cui Huanbing Lin Zhengwei Jian Feng Hu Xuliang Huang Biying Zhou Qiaobing Huang Jianping Bin Yili Liu | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 8 | Identifying Restructuring Types of Rural Settlement Using Social Network Analysis:A Case Study of Ezhou City in Hubei Province of China显示文摘Social interaction has become one of the key factors affecting the spatial reconstruction of rural settlements(SRRS).However,most studies ignored the multi-scale impact of social networks on the identification of restructuring types of rural settlements.This paper,taking Ezhou City of Hubei Province,China as the case study area,developed a potential inter-settlement network through considering settlements as nodes,and inter-settlement interactions induced by the spatial disparity of public facilities as edges,divided towns in Ezhou City into three zones based on community structure at the town level,and then identified four types of rural settlements in light of the characteristics of cluster patterns and centrality at the patch level.The results show that the inter-settlement network in Ezhou City presents apparent disparities in terms of community structure,cluster patterns and centrality.In community analysis,high inter-community and intra-community interactions are concentrated in well-developed areas in the north and east,while weak interactions between communities occur in the southern areas dominated by traditional agricultural production.Accordingly,three zones are divided such as the urban-leading zone,urban-rural integration zone and rural-leading zone.For the network centrality and cluster patterns,high-level rural settlements are mainly distributed in the urban-leading zone,followed by the urban-rural integration zone and the rural-leading zone.Moreover,the lump cluster pattern is observed in each zone,but the chain pattern and dispersed pattern largely occur in the rural-leading zone.At same time,four types of rural settlements are identified,namely urbanized settlements,central settlements,grassroots settlements and relocated settlements.The corresponding plans are discussed in different zones regarding urbanization,integration and characteristics to provide meaningful insights for policymakers to guide SRRS.This study would contribute to our understanding of the impact of social network involved in daily life on rural settlement reconstruction,and expect to provide theoretical and methodological support for rural sustainable development in practice. | YUE Qiaobing HE Jianhua LIU Dianfeng | 2021 | Chinese Geographical Science2021，31，6： | 1 |
| 9 | Synthetic and nature-derived lipid nanoparticles for neural regeneration显示文摘Challenges and opportunities in nerve regeneration:The central nervous system(CNS)has a limited ability to regenerate.Subsequent to spinal injury,glial scar formation,created by fibroblasts,neuroglia,monocytes,and endothelial cells,inhibits regeneration of the injured nerve.The peripheral nervous system(PNS)has a greater regeneration potential than the CNS;however,the current gold standard of treatment for a large nerve defect is still autologous nerve grafts, | Yuji S.Takeda Qiaobing Xu | 2015 | Neural Regeneration Research2015，10，5： | 1 |
| 10 | Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model显示文摘Lipid nanoparticles are promising carriers for oral drug delivery.For bioactive cargos with intracellular targets,e.g.gene-editing proteins,it is essential for the cargo and carrier to remain complexed after crossing the epithelial layer of intestine in order for the delivery system to transport the cargos inside targeted cells.However,limited studies have been conducted to verify the integrity of cargo/carrier nanocomplexes and their capability in facilitating cargo delivery intracellularly after the nanocomplex crossing the epithelial barrier.Herein,we used a traditional 2D transwell system and a recently developed 3D tissue engineered intestine model and demonstrated the synthetic lipid nanoparticle(carrier)and protein(cargo)nanocomplexes are able to cross the epithelial layer and deliver the protein cargo inside the underneath cells.We found that the EC16-63 LNP efficiently encapsulated the GFP-Cre recombinase,penetrated the intestinal monolayer cells in both the 2D cell culture and 3D tissue models through temporarily interrupting the tight junctions between epithelial layer.After transporting across the intestinal epithelia,the EC16-63 and GFP-Cre recombinase nanocomplexes can enter the underneath cells to induce gene recombination.These results suggest that the in vitro 3D intestinal tissue model is useful for identifying effective lipid nanoparticles for potential oral drug delivery. | Tao Yang Haobo Han Ying Chen Liu Yang Rachael Parker Yamin Li David L.Kaplan Qiaobing Xu | 2021 | Bioactive Materials2021，6，11： | 0 |
| 11 | Marine oil spill contingency planning显示文摘According to the practice researching and formulating “The Oil Spill Contingency Plan of South Chinese Sea”, this paper analyses and discusses the structure, functions and main contents of marine oil spill contingency planning, programs the organizing and commanding system and emergency response system, and advances the planning and researching method to coordinate comprehensively and to design practically the detailed emergency response steps until to formulate the ease operating programs for the plan implementation(PPI) and the PPI to apply high techniques supporting emergency administrations and response. | QiaoB ChuJC | 2002 | Journal of Environmental Sciences2002，14，1： | 0 |
| 12 | In Vivo Activation of Pro-Protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction显示文摘Selective and temporal control over protein activity is of great importance for the advancement of the protein of interest into precise molecular medicine.Simply installing synthetic ligands to proteins for activity regulation,however,is often obscured by either nonspecificity or insufficient efficiency.This study reports a chemical approach in which enzymatic cascade reactions were designed for selective activation of pro-protein both in vitro and in vivo.Specifically,the system consisted of aromatic boronic-acid-modified nanoparticles,reactive oxygen species(ROS)-responsive pro-protein(RNase A-NBC),a small molecule drug,β-Lapachone(β-Lap),and strategically screened synthetic lipids,required for the assembly of the nanocomplexes.Once target-delivered into tumor cells,the reduction ofβ-Lap produces massive H2O2 in response to NAD(P)H quinone oxidoreductase 1(NQO1),a tumor-specific enzyme,which triggers further induction by selective chemical modification of ROS-responsive cytosolic protein ribonuclease A(RNase A)-NBC,thus,switching from“inert”pro-protein to active therapeutics,that ultimately prohibit tumor cell growth.Moreover,the designed enzymatic cascade activation of the pro-protein was effective in vivo,displaying superior therapeutic efficacy to either the pro-protein alone or theβ-Lap via tumor-targeted delivery and the consequent suppression of the tumor growth.As both RNase A andβ-Lap have been evaluated clinically as antitumor therapeutics,our chemical multi-step cascade methodology is,therefore,a promising strategy for selective modulation of pro-protein chemistry in the living system for fundamental investigations,favorable toward potential anticancer applications. | Xiaoti Yang Jin Chang Ying Jiang Qiaobing Xu Ming Wang Lanqun Mao | 2021 | CCS Chemistry2021，3，2： | 0 |
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