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| 1 | Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury显示文摘Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography(a EEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with a EEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. a EEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, a EEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury. | Wendong You Qilin Tang Xiang Wu Junfeng Feng Qing Mao Guoyi Gao Jiyao Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 15 |
| 2 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 3 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 4 | Comprehensive Proteomic Profiling of Patients'Tears Identifies Potential Biomarkers for the Traumatic Vegetative State显示文摘The vegetative state is a complex condition with unclear mechanisms and limited diagnostic, prognostic,and therapeutic methods. In this study, we aimed to explore the proteomic profile of tears from patients in a traumatic vegetative state and identify potential diagnostic markers using tears—a body fluid that can be collected noninvasively. Using i TRAQ quantitative proteomic technology, in the discovery phase, tear samples collected from 16 patients in a traumatic vegetative state and 16 normal individuals were analyzed. Among 1080 identified tear proteins, 57 were upregulated and 15 were downregulated in the patients compared to the controls. Bioinformatics analysis revealed that the differentially-expressed proteins were mainly involved in the wound response and immune response signaling pathways. Furthermore, we verified the levels of 7 differentially-expressed proteins in tears from50 traumatic vegetative state patients and 50 normal controls(including the samples used in the discovery phase) using ELISA. The results showed that this 7-protein panel had a high discrimination ability for traumatic vegetative state(area under the curve = 0.999). In summary, the altered tear proteomic profile identified in this study provides a basis for potential tear protein markers for diagnosis and prognosis of the traumatic vegetative state and also provides novel insights into the mechanisms of traumatic vegetative state. | Qilin Tang Chao Zhang Xiang Wu Wenbin Duan Weiji Weng Junfeng Feng Qing Mao Shubin Chen Jiyao Jiang Guoyi Gao | 2018 | Neuroscience Bulletin2018，34，4： | 3 |
| 5 | Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients显示文摘Voxel-based morphometry can be used to quantitatively compare structural differences and functional changes of gray matter in subjects.In the present study,we compared gray matter images of 32 patients with Parkinson's disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores.Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls.In particular,the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced,but mean scores of non-motor symptoms significantly increased,in patients with Parkinson's disease.In addition,gray matter volume was significantly diminished in Parkinson's disease patients compared with normal controls,including bilateral temporal lobe,bilateral occipital lobe,bilateral parietal lobe,bilateral frontal lobe,bilateral insular lobe,bilateral parahippocampal gyrus,bilateral amygdale,right uncus,and right posterior lobe of the cerebellum.These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease,and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson's disease. | Jianguo Xia Juan Wang Weizhong Tian Hongbin Ding Qilin Wei Huanxin Huang Jun Wang Jinli Zhao Hongmei Gu Lemin Tang | 2013 | Neural Regeneration Research2013，8，27： | 1 |
| 6 | Introgression of perennial teosinte genome into maize and identification of genomic in situ hybridization and microsatellite markers显示文摘 | Qilin Tang Tingzhao Rong Yunchun Song | 2005 | Crop Science2005，45，： | 1 |
| 7 | Combining Ability and Parent-Offspring Correlation of Maize(Zea may L.) Grain β-Carotene Content with a Complete Diallel显示文摘Vitamin A deficiency has become a worldwide problem.Biofortified foods can potentially be an inexpensive,locally adaptable,and long-term solution to dietary-nutrient deficiency.In order to improve the β-carotene content in maize grain by breeding and minimize vitamin A deficiency,a complete diallel cross was designed with eight inbred lines of maize,and 64 combinations were obtained in this study.The experimental combinations were planted in Yunnan and Sichuan provinces,respectively,with a random complete block design.The β-carotene contents in the grains of the experimental materials were analyzed by high-performance liquid chromatography.Among the tested materials,the effect difference of general combining ability of the β-carotene content was significant;however,the effect difference of the special combining ability and the reciprocal effect were not significant.The β-carotene content of maize grain was not influenced significantly by the cross and the reciprocal cross.There was a significant correlation about the β-carotene content in the maize grains between the F 1 and their parents.The combinations with high β-carotene content were obviously influenced by the environment,and the mean value of β-carotene content for the experimental materials planted in Ya'an of Sichuan was higher than that planted in Yuanjiang of Yunnan,with the results being significant at the 0.01 level. | LI Run XIAO Lan-hai WANG Jing LUYan-li RONG Ting-zhao PAN Guang-tang WU Yuan-qi TANG Qilin LAN Hai CAO Mo-ju | 2013 | Journal of Integrative Agriculture2013，12，1： | 1 |
| 8 | Mechanisms of white matter changes induced by meditation显示文摘 | Yi-Yuan Tang Qilin Lu Ming Fan Yihong Yang Michael I. Posner | | Proceedings of the National Academy of Sciences0，，： | 1 |
| 9 | Near-infrared responsive shape memory hydrogels with programmable and complex shape-morphing显示文摘In this work,semi-crystalline nanocomposite hydrogels(i.e.,PAAmA_(11)A/GO gels)were synthesized by micellar copolymerization of acrylamide and N-acryloyl-11-aminoundecanoic acid(A_(11)A)in the presence of a large amount of sodium dodecyl sulfonate(SDS)micelles and GO nanosheets.The resulting hydrogels(SMHs)not only demonstrated high strength and high toughness,but also exhibited good shape memory property.Because of near-infrared(NIR)light absorbability of GO nanosheets,shape recovery and shape of PAAmA_(11)A/GO gels could be tuned by NIR irradiation.Moreover,bilayer hydrogels and trilayer hydrogels were also fabricated by the integration of shape-memorized PAAmA_(11)A/GO gel and elastic hydrophobic associated hydrogel(E-gel).Based on the NIR-responsive shape memory property and layered structure,shape deformation of bilayer hydrogels and trilayer hydrogels was rather different from the single PAAmA_(11)A/GO gel.Each kind of gel structure exhibited diverse and complex shapes via programmable NIR irradiation.More importantly,the shape morphing of NIR-SMHs-based hydrogels could mimic the hand and flower and be used as actuators. | WANG QiLin ZHU Lin WEI DanDan SUN Huan TANG Chen LIU Zhao LI Ke YANG Jia QIN Gang SUN GengZhi CHEN Qiang | 2021 | Science China(Technological Sciences)2021，64，8： | 0 |
| 10 | Genome-wide identification and characterization of basic helix-loop-helix transcription factors in Spodoptera litura upon pathogen infection显示文摘Basic helix-loop-helix(bHLH)transcription factors play an important role in a wide range of metabolic and developmental processes in eukaryotes,and bHLH proteins also participate in immune responses,especially in plants.However,their roles in insects upon entomopathogen infection are unknown.In this study,54 bHLH genes in 41 families were identified in a polyphagous pest,Spodoptera litura,including a new bHLH gene in group B,which is specifically present in Lepidoptera and was thus named Lep.The conserved amino acids in the bHLH domain,structural architecture,and chromosomal distribution of bHLH genes in S.litura were analyzed.The bHLH genes in Plutella xylostella and Apis mellifera were also updated,and genome-wide comparison and phylogenetic analysis of bHLH members in 5 holometabolous insects were performed.The expression profiles of S.litura bHLH(SlbHLH)genes in 3 tissues at different developmental stages and their responses to S.litura nucleopolyhedrovirus(SpltNPV),Nomuraea rileyi(Nr),and Bacillus thuringiensis(Bt)infection were investigated.More SlbHLHs in group B were expressed and differentially expressed during pathogen infections,and SlbHLHs tended to be downregulated in the midgut of S.litura larvae after B.thuringiensis treatment.Our study provides an overview of bHLH family members in S.litura and their responses to different pathogens used for pest biocontrol.These findings on bHLH members may contribute to uncovering the mechanism of host-pathogen interaction. | Jie Zhang Mengyao Zhu Qilin Li Ting Tang Liang Wen Jielai Zhong Ruonan Zhang Xiao-Qiang Yu Yuzhen Lu | 2022 | Insect Science2022，29，4： | 0 |
| 11 | Repetitive sequence analysis and karyotyping reveal different genome evolution and speciation of diploid and tetraploid Tripsacum dactyloides显示文摘In the subtribe Maydeae, Tripsacum and Zea are closely related genera. Tripsacum is a horticultural crop widely used as pasture forage. Previous studies suggested that Tripsacum might play an important role in maize origin and evolution. However, our understanding of the genomics and the evolution of Tripsacum remains limited. In this study, two diploids,T. dactyloides var. meridionale(2n = 36, MR) and T. dactyloides(2n = 36, DD), and one tetraploid,T. dactyloides(2n = 72, DL) were sequenced by low-coverage genome sequencing followed by graph-based cluster analysis. The results showed that 63.23%, 59.20%, and 61.57% of the respective genome of MR, DD, and DL were repetitive DNA sequence. The proportions of different repetitive sequences varied greatly among the three species. Fluorescence in situ hybridization(FISH) analysis of mitotic metaphase chromosomes with satellite repeats as the probes showed that the FISH signal patterns of DL were more similar to that of DD than to that of MR. Comparative analysis of the repeats also showed that DL shared more common repeat families with DD than with MR. Phylogenetic analysis of internal transcribed spacer region sequences further supported the evolutionary relationship among the three species. Repetitive sequences comparison showed that Tripsacum shared more repeat families with Zea than with Coix and Sorghum. Our study sheds new light on the genomics of Tripsacum and differential speciation in the Poaceae family. | Qilin Zhu Zexi Cai Qilin Tang Weiwei Jin | 2016 | The Crop Journal2016，4，4： | 0 |
| 12 | The effect of kiwi berry(Actinidia arguta)on preventing and alleviating loperamide-induced constipation显示文摘This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to mice that were constipated.The number of stools and the water content of stools both increased by 138.5%and 106.5%,respectively.The gastrointestinal transit rate increased by 45.3%,and the time it took for the first dark stool to form decreased by 57.5%.The levels of the excitability neurotransmitters were found to be higher in the group that had been given kiwi berries in comparison to the group that had been given loperamide.The opposite results were produced by vasoactive intestinal peptide(VIP)and aquaporin-3(AQP3).In addition,kiwi berry consumption may lessen epithelial cell apoptosis and promote colon health.All the results point to kiwi berries as an extremely promising food supplement for the prevention and relief of constipation in the future since they successfully prevent and alleviate constipation brought on by loperamide. | Jiyue Zhang Dongnan Li Qilin Tian Yumeng Ding Hanqian Jiang Guang Xin Shunchang Cheng Siyi Tang Chenyu Jin Jinlong Tian Bin Li | 2023 | Food Innovation and Advances2023，2，1： | 0 |
| 13 | Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution显示文摘Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex chromosomes.We sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and P.vera cv.Bagyolu,the male parent.Two chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were assembled.The ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 Mya.Three inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining region.These W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in pistachio.The W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or differentiation.Demographic history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in Iran.We identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought tolerance.These findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks. | Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del Val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming | 2023 | Plant Communications2023，4，3： | 0 |
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