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| 1 | APstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene — a risk factor for coronary artery disease显示文摘 | Shui Qing Ye MD PhD David Usher Donna Virgil Li Qin Zhang Scott E. Yochim Rana Gupta | 1999 | Journal of Biomedical Science1999，，1： | 1 |
| 2 | Upper thoracic postsynaptic dorsal column neurons conduct cardiac mechanoreceptive information,but not cardiac chemical nociception in rats显示文摘 | Goodman MD Qin C Thompson AM | 2010 | Brain Res2010，1366，： | 1 |
| 3 | Comparison of activity characteristics of the cuneate nucleusand thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in rats显示文摘 | Qin C Goodman MD Little JM | 2010 | Brain Res2010，1346，： | 1 |
| 4 | A novel transfection methodfor eukaryotic cells using polyethylenimine coated albumin mi- crobubbles显示文摘 | Dang SP Wang RX Qin MD | 2011 | Plasmid2011，66，1： | 1 |
| 5 | Articular Cartilage Increases Transition Zone Regeneration in Bone-tendon Junction Healing显示文摘 | Margaret Wan Nar Wong FRCS Ling Qin PhD Kwong Man Lee PhD Kwok Sui Leung MD | 2009 | Clinical Orthopaedics and Related Research2009，，4： | 1 |
| 6 | Upper thoracic postsynaptic dorsal column neurons conduct cardiac mechano- receptive information, hut not cardiac chemical nocieeption in rats显示文摘 | Goodman MD Qin C Thompson AM | 2010 | Brain Res2010，1346，： | 1 |
| 7 | Comparison of activity characteristics of the cuneate nucleusand thoracic spinal neu- rons receiving noxious cardiac and/or somatic inputs in rats 显示文摘 | Qin C Goodman MD Little JM | 2010 | BrainRes2010，1346，： | 1 |
| 8 | Adipose inflammation and mac-rophage infiltration after binge ethanol and bum injury 显示文摘 | Qin Y Hamilton JL Bird MD | 2014 | AlcoholClin Exp Res2014，38，1： | 1 |
| 9 | Non-escaping frost tolerant QTL linked genetic loci at reproductive stage in six wheat DH populations显示文摘Reproductive stage frost poses a major constraint for wheat production in countries such as Australia.However,little progress has been made in identifying key genes to overcome the constraint.In the present study,a severe frost event hit two large-scale field trials consisting of six doubled haploid(DH)wheat populations at reproductive stage(young microspore stage)in Western Australia,leading to the identification of 30 robust frost QTL on 17 chromosomes.The major 18 QTL with the phenotype variation over 9.5%were located on 13 chromosomes including 2 A,2 B,2 D,3 A,4 A,4 B,4 D,5 A,5 D,6 D,7 A,7 B and7 D.Most frost QTL were closely linked to the QTL of anthesis,maturity,Zadok stages as well as linked to anthesis related genes.Out of those,six QTL were repetitively detected on the homologous regions on 2 B,4 B,4 D,5 A,5 D,7 A in more than two populations.Results showed that the frost damage is associated with alleles of Vrn-A1 a,Vrn-D1 a,Rht-B1 b,Rht-D1 b,and the high copy number of Ppd-B1.However,anthesis QTL and anthesis related genes of Vrn-B1 a and Ta FT3-1 B on chromosomes 5 B and 1 B did not lead to frost damage,indicating that these early-flowering phenotype related genes are compatible with frost tolerance and thus can be utilised in breeding.Our results also indicate that wild-type alleles Rht-B1 a and Rht-D1 a can be used when breeding for frost-tolerant varieties without delaying flowering time. | Jingjuan Zhang MD Shahidul Islam Yun Zhao Masood Anwar Zaid Alhabbar Maoyun She Rongchang Yang Angela Juhasz Guixiang Tang Jiansheng Chen Hang Liu Yanjie Jiang Shengnan Zhai Xin Hu Junkang Rong Yingquan Zhang Yebo Qin Qier Liu Zitong Yu Yujuan Zhang Sadegh Balotf Mirza Dowla Sonia Afrin Nandita Roy Md Resad Mallik Md Atik Us Saieed Shanjida Rahman Nigarin Sultana Sarah Al-Sheikh Ahmed Chris Florides Kefei Chen Darshan Sharma Nathan Height Ben Biddulph Meiqin Lu Jorge EMayer Wujun Ma | 2022 | The Crop Journal2022，10，1： | 0 |
| 10 | Green Lignosulphonate as co-surfactant for wettability alteration显示文摘Surfactant flooding is one of the common tertiary method to recover remaining oil in the reservoir, byreducing the interfacial tension (IFT) between two immiscible fluids nevertheless, current surfactantforms emulsion and difficult to achieve ultra-low IFT between the water and oil without addition of cosurfactant. In this research, two types of anionic lignosulphonate-based surfactants, Sodium Lignosulphonate (SLS) and Calcium Lignosulphonate (CLS) are chosen as co-surfactant. The main surfactantused in this project is the common anionic surfactant, Sodium Dodecyl Sulfate (SDS) at a fixed concentration of 4 mmol/l. Each type of co-surfactant with different concentrations (0.5%, 1.0%, 1.5% and2.0 wt %) was mixed with 4 mmol/L of SDS at each test tube to create the surfactant solution. The result ofthe experiment showed that at 0.5 wt % for SLS and CLS surfactant solution, the contact angle of oil tosurface lowered down with a reduction of 6° and 7° respectively. This indicate that the system will bemore water-wet which the oil droplet will be less adhesive to the rock surface. In conclusion, by using theoptimum concentration of 0.5 wt % lignosulphonate as co-surfactant is able to alter the wettability ofrocks and it is recommended to test the biological-based co-surfactant at increasing temperature as analternative to enhance the surfactant flooding performance which improves the oil recovery. | Zhe Qin Lim Nabilla Afzan Abdul Aziz Ahmad Kamal Idris Nur Asyraf Md Akhir | 2020 | Petroleum Research2020，5，2： | 0 |
| 11 | Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity显示文摘Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations. | Yuri Svirkin Jaeweon Lee Richard Marx Seongkyu Yoon Nelson Landrau Md Abul Kaisar Bin Qin Jin H.Park Khondoker Alam Darby Kozak Yan Wang Xiaoming Xu Jiwen Zheng Benjamin Rivnay | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 0 |
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