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| 1 | Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release显示文摘Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration,which usually demands appropriate carriers like microspheres(MS)to control drugs releases.Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate.In this study,we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres,with smaller poly(lactic-co-glycolic acid)MS(~8-10 lm in diameter)embedded in a larger chitosan MS(~250-300 lm in diameter).The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or voltage.Two kinds of model drugs,bovine serum albumin and chlorhexidine acetate,were encapsulated in the microspheres.The fluorescence-labeled rhodamine-fluoresceine isothiocyanate(Rho-FITC)and ultraviolet(UV)spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres,as well as sustained,slow release in vitro.In addition,far-UV circular dichroism and matrixassisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS)results indicated original secondary structure and molecular weight of drugs after electrospraying.Generally speaking,our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded,which could be applied in sequential,multi-modality therapy. | Zhu Liu Weilong Ye Jingchuan Zheng Qindong Wang Guowu Ma Huiying Liu Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，4： | 5 |
| 2 | A Study on Influential User Identification in Online Social Networks显示文摘Influential user evaluation is great importance in many application areas of online social networks.In order to identify influential users in a more adequate and practical way, we propose a Dynamic regional interaction model(DRI) to evaluate user influence in online social networks. Influential users can be identified by the influence effect on different distance users based on dynamic regional interaction model. We have applied the influential user identification method to Sina Weibo and the experimental results show that compared with the existing methods the proposed method can identify the influence users in a more accuracy and efficiency way. | WANG Nan SUN Qindong ZHOU Yadong SHEN Si | 2016 | Chinese Journal of Electronics2016，25，3： | 4 |
| 3 | Solution-processed lead-free bulk 0D Cs3Cu2I5 single crystal for indirect gamma-ray spectroscopy application显示文摘Bulk scintillators that are with high density,low cost,and fine pulse-height energy spectral resolution,and are nonhygroscopic and user friendly,are desired for high-energy gamma-ray spectroscopy application.Recently,low-cost solution-processed perovskite nanoscintillators have been demonstrated with outstanding performances for indirect low-energy X-ray detection;however,the stability and thickness are not suitable for high-energy gamma-ray detection.Here,we report scintillation performances of a low-cost solution-processed bulk 0D Cs3Cu2I5 single crystal.The self-trapped exciton emission results in a large Stokes shift (109 nm) that is reabsorption free.A broad X-ray excited emission matches well with the sensitivity of a silicon photodiode.The unique Cs+ surrounded isolated [Cu2I5]3-cluster scintillator provides ultra-stability in air and strong radiation hardness under high-dose gammaray exposure from a 60Co source.This solution-processed Cs3Cu2I5 scintillator is expected with low-cost and has detection performances comparable to commercial alkali-halide scintillator products. | Qiang Xu Juan Wang Qindong Zhang Xiao Ouyang Maheng Ye Weiting Xie Xuewen Yan Deyuan Li Xiaoping Ouyang Xiaobing Tang Xiaodong Zhang | 2021 | Photonics Research2021，9，3： | 3 |
| 4 | A block particle coupled model and its application to landslides显示文摘To simulate the progressive failure of slope,a block particle coupled model is introduced.Particle oriented cell mapping(POCM)algorithm is used to enhance the search efficiency,and particlepoint,particle-edge,particle-face contact detecting method is adopted to establish contact pair between particles and blocks precisely.Strain softening Mohr Coulomb model with tensile cutoff is adopted for blocks,and brittle Mohr Coulomb model is used for particles.The particle-block replacement approach is used to describe the fracture and fragmentation process of continuum media.Once the cohesion or tensile strength of one block reaches zero,the block will be deleted,and particles are generated at the same place with all information inherited from the deleted block.Some numerical cases related to landslides demonstrate the precision and rationality of the coupled model. | Chun Feng Shihai Li Qindong Lin | 2020 | Theoretical & Applied Mechanics Letters2020，10，2： | 2 |
| 5 | Time-Domain Spectral Induced Polarization Based on Pseudo-random Sequence显示文摘 | Mei Li Wenbo Wei Weibin Luo Qindong Xu | 2013 | Pure and Applied Geophysics2013，，12： | 1 |
| 6 | The characteristics of frequency-time azimuth spectrum estimation by a vector hydrophone in shallow water显示文摘 | DA Lianglong HOU Wenshu SUN Qindong | 2018 | Chinese Journal of Acoustics2018，37，1： | 1 |
| 7 | Corrigendum to:Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release显示文摘 | Zhu Liu Weilong Ye Jingchuan Zheng Qindong Wang Guowu Ma Huiying Liu Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，4： | 1 |
| 8 | Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo显示文摘 | Yongbo Zhao Peng Luo Qindong Guo Sanzhong Li Lei Zhang Mingming Zhao Haoxiang Xu Yuefan Yang Waisang Poon Zhou Fei | 2012 | Experimental Neurology2012，，2： | 1 |
| 9 | Endopolygalacturonases in apple (Malus domestica) and its expression during fruit ripening显示文摘 | Qindong W Maria S D Minou H | 1993 | Plant Physiol1993，，102： | 1 |
| 10 | Active reverse fault-fold zones and earthquakes along northern Tianshan, Xinjiang, China显示文摘 | DENG Qindong FENG Xianyue ZHANG Peizhan | 1996 | Seismology and Geology1996，，： | 1 |
| 11 | Quantitative characterization of damage-aggravation effect caused by progressive damage显示文摘Aiming at the progressive damage phenomenon in geotechnical field,it attempts to study the effect of progressive damage on the macro-bearing capacity.Firstly,based on the theoretical analysis of a two-dimensional plane inside representative volume element,it is proposed that progressive damage will occur if the bearing capacity of microplanes is different.Besides,“damage-aggravation effect”is proposed according to the difference between the macro-bearing capacity of entire plane and the sum of bearing capacity of all microplanes when progressive damage occurs.Secondly,progressive damage ratio K_(t)is proposed to quantify“damage-aggravation effect”.Finally,based on the rod model,the correspondence between K_(t),and some influence factors is studied by theoretical analysis and numerical simulation.The results show that“damage-aggravation effect”does exist,and the macro-bearing capacity of entire plane is less than the sum of bearing capacity of all microplanes when progressive damage occurs.If the bearing capacity of rods in the rod model obeys uniform distribution,as the minimum of bearing capacity increases linearly,the macro-bearing capacity increases linearly,and K_(t)decreases inversely. | Qindong Lin Shihai Li Chun Feng Dong Zhou | 2021 | Acta Mechanica Sinica2021，37，2： | 0 |
| 12 | Co-digestion of food waste and hydrothermal liquid digestate:Promotion effect of self-generated hydrochars显示文摘Hydrothermal treatment(HTT)can efficiently valorize the digestate after anaerobic digestion.However,the disposal of the HTT liquid is challenging.This paper proposes a method to recover energy through the anaerobic co-digestion of food waste and HTT liquid fraction.The effect of HTT liquid recirculation on anaerobic co-digestion performance was investigated.This study focused on the self-generated hydrochars that remained in the HTT supernatant after centrifugation.The effect of the self-generated hydrochars on the methane(CH_(4))yield and microbial communities were discussed.After adding HTT liquids treated at 140 and 180C,the maximum CH4 production increased to 309.36 and 331.61 mL per g COD,respectively.The HTT liquid exhibited a pH buffering effect and kept a favorable pH for the anaerobic co-digestion.In addition,the self-generated hydrochars with higher carbon content and large oxygen-containing functional groups remained in HTT liquid.They increased the electron transferring rate of the anaerobic co-digestion.The increased relative abundance of Methanosarcina,Syntrophomonadaceae,and Synergistota was observed with adding HTT liquid.The results of the principal component analysis indicate that the electron transferring rate constant had positive correlationships with the relative abundance of Methanosarcina,Syntrophomonadaceae,and Synergistota.This study can provide a good reference for the disposal of the HTT liquid and a novel insight regarding the mechanism for the anaerobic co-digestion. | Mingshuai Shao Chao Zhang Xue Wang Ning Wang Qindong Chen Guangyu Cui Qiyong Xu | 2023 | Environmental Science and Ecotechnology2023，，3： | 0 |
| 13 | Sparse asymptotic minimum variance based bearing estimation algorithm for a single vector hydrophone显示文摘For underwater target detection using a single vector hydrophone,sparse asymptotic minimum variance(SAMV)method is used to estimate the target bearing.The SAMV discretizes the entire scanning space and the target bearing is located at the position of the discrete direction.The SAMV algorithm utilizes the sparsity of the spatial signal to improve the estimation performance of the target bearing.Background noise level(BNL)of the bearing estimation of SAMV algorithm is lower than those of the conventional beam forming(CBF)method and minimum variance distortionless response(MVDR)method for different signal noise ratios(SNRs).When the SNR is higher than 0 d B,the direction-finding error of this algorithm is less than 2°.Moreover,the SAMV algorithm has a better dimensional orientation resolution capability.The experimental results show that the SAMV algorithm gives a bearing and time recording map with a lower BNL,which effectively verifies the effectiveness of SAMV algorithm in terms of underwater target detection. | WANG Chao DA Lianglong HAN Mei SUN Qindong WANG Wenlong | 2022 | Chinese Journal of Acoustics2022，41，1： | 0 |
| 14 | Approach to extracting hot topics based on network traffic content显示文摘This article presents the formal definition and description of popular topics on the Internet,analyzes the relationship between popular words and topics,and finally introduces a method that uses statistics and correlation of the popular words in traffic content and network flow characteristics as input for extracting popular topics on the Internet.Based on this,this article adapts a clustering algorithm to extract popular topics and gives formalized results.The test results show that this method has an accuracy of 16.7%in extracting popular topics on the Internet.Compared with web mining and topic detection and tracking(TDT),it can provide a more suitable data source for effective recovery of Internet public opinions. | Yadong ZHOU Xiaohong GUAN Qindong SUN Wei LI Jing TAO | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，1： | 0 |
| 15 | NFHP-RN:AMethod of Few-Shot Network Attack Detection Based on the Network Flow Holographic Picture-ResNet显示文摘Due to the rapid evolution of Advanced Persistent Threats(APTs)attacks,the emergence of new and rare attack samples,and even those never seen before,make it challenging for traditional rule-based detection methods to extract universal rules for effective detection.With the progress in techniques such as transfer learning and meta-learning,few-shot network attack detection has progressed.However,challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning,difficulties in capturing rich information from original flow in the case of insufficient samples,and the challenge of high-level abstract representation.To address these challenges,a few-shot network attack detection based on NFHP(Network Flow Holographic Picture)-RN(ResNet)is proposed.Specifically,leveraging inherent properties of images such as translation invariance,rotation invariance,scale invariance,and illumination invariance,network attack traffic features and contextual relationships are intuitively represented in NFHP.In addition,an improved RN network model is employed for high-level abstract feature extraction,ensuring that the extracted high-level abstract features maintain the detailed characteristics of the original traffic behavior,regardless of changes in background traffic.Finally,a meta-learning model based on the self-attention mechanism is constructed,achieving the detection of novel APT few-shot network attacks through the empirical generalization of high-level abstract feature representations of known-class network attack behaviors.Experimental results demonstrate that the proposed method can learn high-level abstract features of network attacks across different traffic detail granularities.Comparedwith state-of-the-artmethods,it achieves favorable accuracy,precision,recall,and F1 scores for the identification of unknown-class network attacks through cross-validation onmultiple datasets. | Tao Yi Xingshu Chen Mingdong Yang Qindong Li Yi Zhu | 2024 | Computer Modeling in Engineering & Sciences2024，140，7： | 0 |
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