|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 2 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 3 | Molecular characterization, expression profiles of the porcine SDC2 and HSPG2 genes and their association with hematologic parameters显示文摘 | Weimin Wang Cong Tao Ping Zhou Xiang Zhou Qingde Zhang Bang Liu | 2013 | Molecular Biology Reports2013，，3： | 1 |
| 4 | Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes显示文摘 | Cong Tao Weimin Wang Ping Zhou Tian Xia Xiang Zhou Cuiping Zeng Qingde Zhang Bang Liu | 2013 | Journal of Applied Genetics2013，，1： | 1 |
| 5 | Association of two porcine reproductive and respiratory syndrome virus (PRRSV) receptor genes, CD163 and SN with immune traits显示文摘 | Fengli Wang Haifang Qiu Qingde Zhang Zhongzhen Peng Bang Liu | 2012 | Molecular Biology Reports2012，，4： | 1 |
| 6 | Astrocytic effect of low molecular weight heparin-superoxide dismutase conjugate in interleukin-6 overexpressing mice following local cerebral ischemia显示文摘BACKGROUND:Studies have shown that low molecular weight heparin-superoxide dismutase conjugate exhibits a remarkable neuroprotective effect. OBJECTIVE:To investigate the effect of low molecular weight heparin-superoxide dismutase conjugate on astrocytes in an interleukin-6(IL-6) overexpressing mice following local cerebral ischemia. DESIGN,TIME AND SETTING:Randomized,cytological,controlled,animal study was performed in the Department of Physiology and Neuroscience,Neurology and Biochemistry and Molecular Biology,Medical University of South Carolina from January 2005 to March 2005. MATERIALS:Nine IL-6 transgenic mice,irrespective of gender,were randomly divided into three groups:sham-operated,model,and treatment,with three mice in each group.With exception of the sham-operated group,right middle cerebral artery occlusion was induced in the mice. Expression of glial fibrillary acidic protein,an astrocyte marker,was determined by immunohistochemistry.Low molecular weight heparin-superoxide dismutase conjugate was purchased from Biochemistry and Biotechnique Institute,Shandong University. METHODS:Two minutes prior to ischemia induction,0.5 mL/kg saline or 20 000 U/kg low molecular weight heparin-superoxide dismutase conjugate were administrated via the femoral artery in the model group and treatment group,respectively.The sham-operated group underwent the same protocols,with the exception of occlusion and treatment. MAIN OUTCOME MEASURES:The number of glial fibrillary acidic protein-positive cells was quantified under light microscopy(x200). RESULTS:In the sham-operated group,there were a large number of astrocytes in the IL-6 transgenic mice.However,the cell bodies were small,and the branches were few and thin.The number of astrocytes in the model group was remarkably less than the sham-operated group. Compared to the model and sham-operated groups,the number of astrocytes significantly increased,and the cell body became larger,following treatment with low molecular weight heparin-superoxide dismutase conjugate.Astrocytes exhibited hypertrophy and hyperplasia,and the processes became longer and thicker. CONCLUSION:The low molecular weight heparin-superoxide dismutase conjugate may provide neuroprotection through astrocytic activation at the super-early stage of cerebral ischemia and reperfusion. | Yizhao Li Guixiang Cui Qingde Wang Hongxia Liu Xiaoxia Zhang Fengshan Wang Keqin Xie | 2009 | Neural Regeneration Research2009，4，2： | 1 |
| 7 | Optical properties of nanocrystalline ceria 显示文摘 | Liu Fangxin Wang Chengyun Su Qingde | 1997 | Applied Optics1997，36，13： | 1 |
| 8 | Acoustic multipole logging in transversely isotropic two-phase medium显示文摘 | Zhang Bixing Wang Kexie Dong Qingde | 1995 | J Acoust Soc Am1995，97，6： | 1 |
| 9 | PTEN and TNF-α regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κB–dependent pathway显示文摘 | Sunghoon Kim Claire Domon-Dell Qingding Wang Dai H. Chung Antonio Di Cristofano Pier Paolo Pandolfi Jean-Noel Freund B.Mark Evers | 2002 | Gastroenterology2002，，4： | 1 |
| 10 | A method for near-infrared spectral calibration of complex plant samples with wavelet transform and elimination of uninformative variables显示文摘 | Xueguang Shao Fang Wang Da Chen Qingde Su | 2004 | Analytical and Bioanalytical Chemistry2004，，5： | 1 |
| 11 | Robust Fuzzy Variable Structure Control of PMLSM Servo System显示文摘 | Guo QingDing Wang Limei Luo Ruifu | 1997 | IEEE International Conference on Intelligent Proceedings Systems1997，，： | 1 |
| 12 | Pyrolysis-gas chromatography/mass spectrometry as a useful technique to evaluate the pyrolysis pathways of phenylalanine显示文摘 | Wang Sufang Liu Baizhan Su Qingde | 2004 | J Anual Appl Pyrolysis2004，71，： | 1 |
| 13 | Investigation of four porcine candidate genes (H-FABP, MYOD1, UCP3 and MASTR) for meat quality traits in Large White pigs显示文摘 | Xuelei Han Tengfei Jiang Huawei Yang Qingde Zhang Weimin Wang Bin Fan Bang Liu | 2012 | Molecular Biology Reports2012，，6： | 1 |
| 14 | Pyrolysis-gas chromatography/mass spectrometry as a useful technique to evaluate the pyrolysis pathways of phenylalanine显示文摘 | Wang Sufang Liu Baizhan Su Qingde | 2004 | J Annual Appl Pyrolysis2004，，71： | 1 |
| 15 | Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells显示文摘 | Zheng Guo Yuning Zhou B. Mark Evers Qingding Wang | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 16 | On the edge-graceful indices of the wheel graphs显示文摘 | Lee Sin-Min? Wang Ling Kang Qingde | | submitted to Discrete Mathematics0，，： | 1 |
| 17 | Inflammatory cytokine production in a mouse model of Aicardi-Goutieres syndrome and neuroinflammation显示文摘Most neurological diseases are associated with a tissue injury that is detected by the innate immune response(IIR),leading to an inflammatory component.The IIR is activated through conserved Pattern Recognition Receptors,including membrane bound Toll like receptors(TLRs),intracellular nucleotide-binding oligomerization domain like receptors and the receptors for advanced glycation end-products(Amor et al.,2010;Heppnerrt et al.,2015).These receptors detect highly conserved structural motifs of damaged or stressed tissues(danger-associated molecular patterns(DAMP)).Cytosolic receptors of nucleic acids,such as cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)and melanoma differentiation associated gene 5(MDA-5)can also trigger IIR activation leading to interferon(IFN)and IFN stimulated gene(ISG)expression through DNA/RNA sensing signaling pathways(Yang and Li,2020). | Clayton A.Wiley Qingde Wang | 2022 | Neural Regeneration Research2022，17，12： | 0 |
| 18 | Effects of low molecular weight heparin-superoxide dismutase conjugate on serum levels of nitric oxide,glutathione peroxidase,and myeloperoxidase in a gerbil model of cerebral ischemia/reperfusion injury显示文摘BACKGROUND:Several studies have demonstrated that low molecular weight heparin-superoxide dismutase (LMWH-SOD) conjugate may exhibit good neuroprotective effects on cerebral ischemia/reperfusion injury though anticoagulation,decreasing blood viscosity,having anti-inflammatory activity,and scavenging oxygen free radicals. OBJECTIVE: To investigate the intervention effects of LMWH-SOD conjugate on serum levels of nitric oxide (NO),glutathione peroxidase (GSH-Px),and myeloperoxidase (MPO) following cerebral ischemia/reperfusion injury. DESIGN,TIME AND SETTING: A randomized,controlled,and neurobiochemical experiment was performed at the Institute of Biochemical Pharmacy,School of Pharmaceutical Sciences,Shandong University between April and July 2004. MATERIALS: A total of 60 Mongolian gerbils of either gender were included in this study. Total cerebral ischemia/reperfusion injury was induced in 50 gerbils by occluding bilateral common carotid arteries. The remaining 10 gerbils received a sham-operation (sham-operated group). Kits of SOD,NO,and MPO were sourced from Nanjing Jiancheng Bioengineering Institute,China. LMWH,SOD,and LMWH-SOD conjugates were provided by Institute of Biochemistry and Biotechnique,Shandong University,China. METHODS: Fifty successful gerbil models of total cerebral ischemia/reperfusion injury were evenly randomized to five groups: physiological saline,LMWH-SOD,SOD,LMWH + SOD,and LMWH. At 2 minutes prior to ischemia,0.5 mL/65 g physiological saline,20 000 U/kg LMWH-SOD conjugate,20 000 U/kg SOD,a mixture of SOD (20 000 U/kg) and LMWH (LMWH dose calculated according to weight ratio,LMWH: SOD=23.6:51),and LMWH (dose as in the LMWH + SOD group) were administered through the femoral artery in each above-mentioned group,respectively. MAIN OUTCOME MEASURES: Serum levels of NO,MPO,and GSH-Px. RESULTS: Compared with 10 sham-operated gerbils,the cerebral ischemia/reperfusion injury gerbils exhibited decreased serum levels of GSH-Px and increased serum levels of NO and MPO (P<0.01). The serum level of GSH-Px was significantly upregulated in all groups,in particular in the LMWH-SOD group (P<0.01),compared with the physiological saline group (P<0.05-0.01). Following medical treatment,serum levels of NO and MPO were significantly downregulated in all groups,in particular in the LMWH-SOD group (P<0.01). Serum levels of GSH-Px,NO,and MPO in the LMWH-SOD group were close to those in the sham-operated group (P > 0.05). CONCLUSION: In cerebral ischemia/reperfusion injury,LMWH-SOD conjugate exhibits stronger neuroprotective effects on free radical scavenging,inflammation inhibition,and cytotoxicity inhibition than simple or combined application of LMWH and SOD by downregulating NO and MPO levels and upregulating the GSH-Px level. | Qingde Wang Guixiang Cui Hongxia Liu Yizhao Li Fengshan Wang | 2008 | Neural Regeneration Research2008，3，11： | 0 |
| 19 | Efficacy of oral nicotinic acid and choline in the treatment and preventionoffattyliverindairycow显示文摘Efficacy of oral nicotinic acid and choline in the treatment and preventionoffattyliverindairycowEfficacyoforalnicotinicacida... | Tian Wenru Zheng Changle Li Shoujun Zhou Jnanping Yang Hongjiang(Northeast Agricultural University,Harbin 150030,P.R.China)Wang Tao(Dairy Farm of Harbin City)Hu Qingde,Bai Yinmin,Ma Chengchang(Dairy Farm of Songhuajiang)Yang Dianjun (Dairy Farm of Sandao, | 1994 | Journal of Northeast Agricultural University(English Edition)1994，1，1： | 0 |
| 20 | RNA editing enzyme ADAR1 is required for early T cell development显示文摘The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation,embryonic development,and regulation of immune responses.Here,we present evidence in a T-cell-specific gene knockout mouse model that ADAR1 is required for early T cell development.Loss of ADAR1 led to cell death of the progenitors at the double negative stage and prevented T cell maturation in the thymus.Furthermore,ADAR1 deletion in pre-T cells preferentially affected TCRb-expressing cells causing TCRb positive cell depletion.Interruption of IFN signaling occurred in the premature T cells,indicating a role of IFN signaling in the survival of TCRb-expressing cells regulated by ADAR1.This study demonstrated an essential role for the RNA editing enzyme ADAR1 as a potential regulator for T-cell fate determination during clonal selection,which,in turn,contributes to immunologic homeostasis. | Richard Xufeng Daibang Nie Qiong Yang Wang Wang Tao Cheng Qingde Wang | 2020 | Blood Science2020，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员