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| 1 | The Structure of Ore-controlling Strain and Stress Fields in the Shangzhuang Gold Deposit in Shandong Province,China显示文摘Shangzhuang 改变岩石的类型金牌矿石存款位于中间的片断并且在 Jiaodong 金省的西北的部分由 Wang'ershan 差错地区控制了,中国。在 Shangzhuang 存款的变丑进化,紧张的结构和压力地和它的控制矿石的效果在这份报纸被讨论。变丑进化主要经历了四个阶段,这被揭示:早可锻的变丑,第二 NE 惹人注目水平简单砍,第三 NE 惹人注目的压缩砍和最后的 NW 惹人注目的压缩。矿化作用发生在在的第三个阶段期间最大的主要压力逐渐地从 NE 的 transited 到 NW。 3-D 压力地的数字模拟证明在最大的主要压力是NE惹人注目的条件上,在差错地区的破裂发展被赞成,当时当最大的主要压力是NW惹人注目的时,差错地区是相对 extensional 和它对形成矿石的液体的流入和炮兵阵地合适。压缩砍紧张地被类型结构在矿化作用期间描绘,积极的花结构,等等。Orebodies 等距离地主要位于 dilatational 空格,它在不可分的有压缩性的情形是分布式的。并且在差错态度变化的地方, dilatational 空格被开发或砍联合系统发展。在全面压缩砍应力地里,紧张地在多重规模忍受自我类似,包括 orebody,矿石存款和 orefield。结构的自我类似在各种各样的规模在一样的规模和破裂的类似的形状包括破裂的 subequidistant 分发。由于特殊地质的结构,然而, orebodies 主要在 Shangzhuang 存款位于挂的墙它与在 Jiaodong 金省的大多数存款不同。在存款的控制矿石的压力和紧张地的分析为寻求的沉积物提供一个重要基础。 | DENG Jun WANG Qingfei YANG Liqiang ZHOU Lei GONG Qingjie YUAN Wanming XU Hao GUO Chunying LIU Xiangwei | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 41 |
| 2 | Reconstruction of Ore-controlling Structures Resulting from Magmatic Intrusion into the Tongling Ore Cluster Area during the Yanshanian Epoch显示文摘摘要:Tongling 矿石簇区域经历了集中的压缩并且联系了在 Indosinian-Yanshanian 时代期间砍,它形成了一个箱子在 caprock 的控制矿石的褶层和差错系统。在 Yanshanian 时代的 magmatic 侵入导致了多相的液体的多级式的 unmixing,导致多层、宽范围、多种形式的式样描绘的矿化作用。在 Tongling 区域的 magmatic 侵入不仅供应了必要形成矿石的材料,而且重建控制矿石的结构根据下列五条阶层边界的趋势表面模拟:志留纪泥盆纪,泥盆纪含碳,含碳二叠,中间二叠上面二叠、二叠三叠纪。这模拟的结果证明那在那里存在在上面的部分和那些在的阶层之间的重要差别更低。而上面的趋势表面是 synform,更低的趋势表面是 antiform。另外,趋势迭加邻近的床边界出现(例如,志留纪泥盆纪边界在泥盆纪含碳的边界之上迭加) 证明更低的趋势表面总是上面穿透那。而且,不同迭加的趋势表面的穿透的部分的位置和取向是类似的并且根据地区性的 E-W-trending magmatic-metallogenic 带的分发显示出 E-W-trending 带的分发。基于阶层,结构的变丑机制,和地现象的机械性质的全面分析,看起来, stratal 趋势表面的特殊特征由于 magmatic 侵入源于 jacking 进一个 E-W-trending 地下室差错以前控制的 caprock。因此,主要控制矿石的结构,在地区性的水平压缩期间形成了,被形成矿石的岩浆的垂直 jacking 功能在 Yanshanian 时代期间重建,这被推出。在形成矿石的过程期间,岩浆的本地垂直 jacking,结合了地区性的水平压缩,在液体水管网络优化了广泛的环境并且加速了多相的液体的 unmixing 后面的 magmatic 炮兵阵地。Jacking 也加强了垂直、侧面的指导液体的结构,供应为多层的炮兵阵地和多相的液体的广阔运输的更合适的物理条件。 | DENG Jun WANG Qingfei YANG Liqiang GAO Bangfei HUANG Dinghua LIU Yah XU Hao JIANG Shaoqing | 2007 | Acta Geologica Sinica(English Edition)2007，81，2： | 13 |
| 3 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 4 | Tectonic Constraints on the Transformation of Paleozoic Framework of Uplift and Depression in the Ordos Area显示文摘During the Paleozoic, the Ordos area in the western North China Plate was located at the intersecting position of microplates and controlled by their interaction. The structural framework in the Ordos area, which underwent transformations in the Ordovician, the Carboniferous and the Permian respectively, was dominated by the alternation of uplift and depression. The transformations of structural framework are utilized as the clues to investigate the microplates’ interacting type and its response in the Ordos area. According to the regional structural evolution, the Ordos area is simplified into an isopachous, isotropic and elastic shell model, and under proposed various boundary conditions, three series of numerical simulations corresponding to the three structural transformations are carried out to determine the detailed tectonic constraints. Numerical simulations reveal that the structure of the uplift and depression, which is similar to the actual pattern, develops only under one special boundary condition in each of the three series, indicating that the structural framework responds to the unique tectonic background. The simulation results show that in the Early Paleozoic, the L-shaped paleouplift formed nearby the southwestern corner of the Ordos area because the intensity of the compressions in the southern and western boundaries resulting from the ocean-continent collisions was similar. In the Late Paleozoic, it evolved into continent-continent (or arc-continent) interaction in the southern and northern boundaries; in the preliminary stage of the interaction, since the interface between the North China Plate and the plates on the south and north was narrow, the relative acting force was little and the regional western boundary immobile, and the structural framework in the basin was characterized by the N-S trending slender-waist-shaped uplift; as the interface between the plates expanded gradually, the extrusive force in the southern and northern boundaries of the North China Plate increased, resulting in the paleogeographic divisions showing E-W trending, and, the western boundary of the basin was extruded westward due to the intense compression inducing the local NE trending of paleogeographic division in the central area. The simulation results further reflect that the symmetry of the uplift-depression pattern is restricted by that of the boundary conditions, suggesting that the Paleozoic structural transformations of the Ordos area under boundary constraints accord with the universal physical symmetrical principle. | WANG Qingfei DENG Jun HUANG Dinghua YANG Liqiang GAO Bangfei XU Hao JIANG Shaoqing | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 10 |
| 5 | A novel heat-resistant Al–Si–Cu–Ni–Mg base material synergistically strengthened by Ni-rich intermetallics and nano-AlN_p microskeletons显示文摘In this work, nano-AlN particle(nano-AlN_p) microskeletons were introduced into an Al–Si–Cu–Ni–Mg alloy by Al–8 AlN master alloy in which the nano-AlN_p reinforcements connect with each other to form three-dimensional networks. It is found that these nano-AlN_p microskeletons mainly distribute in the binary Al–Si eutectic zones resulting in flaky eutectic Si phases being modified to particulates. Meanwhile,the microskeletons strengthen the matrix synergistically with semi-continuous Ni-rich intermetallics in three dimensions. The tensile mechanical properties, micro-hardness and thermal expansion properties of the alloy at different temperatures are significantly improved. Especially, the ultimate tensile strength(UTS) at 350℃ increases from 85MPa to 106MPa, rising by 24.7%, which is ascribed to nano-AlN_p microskeletons assisting intermetallics with undertaking mechanical loading, and to the modification of eutectic Si phases to reduce the stress concentration at elevated temperatures. | Kaiqi Hu Qingfei Xu Xia Ma Qianqian Sun Tong Gao Xiangfa Liu | 2019 | Journal of Materials Science & Technology2019，35，3： | 3 |
| 6 | Type III interferon-induced CBFβinhibits HBV replication by hijacking HBx显示文摘Hepatitis B virus(HBV)and its associated chronic infection remain serious health threats worldwide.However,there is still no impactful approach for clinical treatment of hepatitis B patients.Therefore,developing a better understanding of the interactions between HBV and its host is particularly important.HBV infection has been reported to induce type-III but not type-I or type-II interferon(IFN).In this study,we identified CBFβ,an HIV enhancer,as an HBV restriction factor that is specifically induced by type-III IFN in the early stages of HBV infection.Type-III IFN-induced IL-10 played an important role in the production of CBFβ.Interestingly,the interaction between CBFβ-and HBV-encoded regulatory protein X(HBx)enhanced the stability of CBFβ,but notably blocked HBx-mediated promotion of HBV replication.CBFβexpression was lower in HBV patients than in healthy persons,and the addition of serum from HBV patients inhibited CBFβexpression in HepG2 cells.On the contrary,HBV via HBsAg inhibited type-III IFN-induced CBFβexpression and decreased the anti-HBV activity of type-III IFN,suggesting that HBV inhibits antiviral interferon-stimulated gene(ISG)expression and induces IFN resistance.Collectively,our results demonstrate that type-III IFN-triggered and IL-10-induced CBFβare crucial factors for inhibiting HBV replication,and the HBx–CBFβ–HBsAg axis reveals a new molecular mechanism of interaction between HBV and its hosts. | Fengchao Xu Hongxiao Song Qingfei Xiao Na Li Hong Zhang Genhong Cheng Guangyun Tan | 2019 | Cellular & Molecular Immunology2019，16，4： | 3 |
| 7 | Lithosphere architecture characterized by crust±mantle decoupling controls the formation of orogenic gold deposits显示文摘This study,via combined analysis of geophysical and geochemical data,reveals a lithospheric architecture characterized by crust-mantle decoupling and vertical heat-flow conduits that control orogenic gold mineralization in the Ailaoshan gold belt on the southeastern margin of Tibet.The mantle seismic tomography indicates that the crust-mantle decoupled deformation,defined from previous seismic anisotropy analysis,was formed by upwelling and lateral flow of the asthenosphere,driven by deep sub duction of the Indian continent,Our magnetotelluric and seismic images show both a vertical conductor across the Moho and high Vp/Vs anomalies both in the uppermost mantle and lowest crust,suggesting that crust-mantle decoupling promotes ponding of mantle-derived basic melts at the base of the crust via a heat-flow conduit.Noble gas isotope and halogen ratios of gold-related ore minerals indicate a mantle source of ore fluid.A rapid decrease in Cl/F ratios of lamprophyres under conditions of 1.2 GPa and1050℃suggests that the ore fluid was derived from degassing of the basic melts.Similar lithospheric architecture is recognized in other orogenic gold provinces,implying analogous formational controls. | Zengqian Hou Qingfei Wang Haijiang Zhang Bo Xu Nian Yu Rui Wang David IGroves Yuanchuan Zheng Shoucheng Han Lei Gao Lin Yang | 2023 | National Science Review2023，10，3： | 2 |
| 8 | Hepatitis B virus X protein and its host partners显示文摘Hepatitis B virus(HBV)is a widespread human pathogen,especially in China,and is known to cause liver inflammation,cirrhosis,and hepatocellular carcinoma.A total of ten different genotypes of HBV(A–J)have been reported worldwide.HBV has partially double-stranded DNA,and the 3.2-kb viral genome is located in the nucleus of infected hepatocytes.All of the viral RNAs are transcribed from the covalently closed circular DNA(cccDNA),which acts as the transcription template.The seven main proteins of HBV include Core,pre-Core,Small S,Middle S,Large S,Polymerase,and the critical HBV-encoded regulatory protein hepatitis B virus X protein(HBx).HBx is a 154-amino acid(aa)protein that facilitates the efficient replication of HBV by stimulating HBV gene expression from the cccDNA template.However,the mechanism by which HBx interacts with host proteins and facilitates HBV replication is not precisely known. | Hongxiao Song Fengchao Xu Qingfei Xiao Guangyun Tan | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 9 | Linear instability analysis of planar non-Newtonian liquid sheets in two gas streams of unequal velocities显示文摘 | Yang Lijun Xu Bingrui Fu Qingfei | 2012 | Journal of Non-Newtonian Fluid Mechanics2012，，： | 1 |
| 10 | Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice显示文摘Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney injury.Previous studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is overlooked.To assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat diet.Genetic changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical calculi.Higher fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological structure.Transcriptome analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological observations.The expression of CXCL14 significantly increased in the bladder in the high-fat diet group.CXCL14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of calculi.In human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of CXCL14.Dietary fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,which provides new ideas for the reduction of morbidity of primary vesical calculi. | Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng Kang Xu Xiaojin Shi Liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 11 | Cooperation of Chinese and Western medicine treatment common youth smallpox 74 examples curative effect observation显示文摘 | XU HUI JU YING GU NA HU QINGFEI WANG WENYING | 2006 | Chinese skin and venereal diseases study magazine2006，20，4： | 1 |
| 12 | Can urban forests provide acoustic refuges for birds?Investigating the influence of vegetation structure and anthropogenic noise on bird sound diversity显示文摘As a crucial component of terrestrial ecosystems,urban forests play a pivotal role in protecting urban biodiversity by providing suitable habitats for acoustic spaces.Previous studies note that vegetation structure is a key factor influencing bird sounds in urban forests;hence,adjusting the frequency composition may be a strategy for birds to avoid anthropogenic noise to mask their songs.However,it is unknown whether the response mechanisms of bird vocalizations to vegetation structure remain consistent despite being impacted by anthropogenic noise.It was hypothesized that anthropogenic noise in urban forests occupies the low-frequency space of bird songs,leading to a possible reshaping of the acoustic niches of forests,and the vegetation structure of urban forests is the critical factor that shapes the acoustic space for bird vocalization.Passive acoustic monitoring in various urban forests was used to monitor natural and anthropogenic noises,and sounds were classified into three acoustic scenes(bird sounds,human sounds,and bird-human sounds)to determine interconnections between bird sounds,anthropogenic noise,and vegetation structure.Anthropogenic noise altered the acoustic niche of urban forests by intruding into the low-frequency space used by birds,and vegetation structures related to volume(trunk volume and branch volume)and density(number of branches and leaf area index)significantly impact the diversity of bird sounds.Our findings indicate that the response to low and high frequency signals to vegetation structure is distinct.By clarifying this relationship,our results contribute to understanding of how vegetation structure influences bird sounds in urban forests impacted by anthropogenic noise. | Zezhou Hao Chengyun Zhang Le Li Bing Sun Shuixing Luo Juyang Liao Qingfei Wang Ruichen Wu Xinhui Xu Christopher A.Lepczyk Nancai Pei | 2024 | Journal of Forestry Research2024，35，2： | 0 |
| 13 | A metallogenic model for the supergiant gold system in Jiaodong province:Constraints from crustal velocity structure显示文摘We investigate the role of crustal architectures playing in controlling the genesis and nature of supergiant Jiaodong orogenic gold system via seismic imaging.We deployed an NWW-SEE-trending broadband seismic linear array traversing the province to construct a shear wave velocity(V_S)transect based on ambient noise tomography.Our crustal V_S transect reveals a prominent low velocity zone(LVZ)at 12–20 km depths across the whole province and high V_S anomalies at 8–12 km depths underneath the western part that hosts most of the ore tonnage.We interpret the former as a hydrothermal alteration zone related to mineralization and the latter as a crustal component containing large amounts of mafic rocks(e.g.,amphibolites).In addition,a listric fault system and a strike-slip fault system are imaged in the western and eastern parts of the province,respectively.Combining features of crustal velocities with regional geological observations that ores are tempo-spatially associated with mafic dikes,we propose a model of gold metallogenic processes.In this model,ponding and degassing of the mafic magmas led to the formation of a hydrothermal alteration LVZ in the middle crust prior to mineralization.Later,auriferous fluid was released from this intra-crustal hydrothermal alteration zone as it was heated by upwelling asthenosphere.The ore fluid ascending along the listric fault system possibly leached extra gold from the upper-crustal amphibolites.Then,the gold-rich fluid migrated up along different fault systems,leading to the disseminated-veinlet mineralization with great gold endowment in the western listric fault system and the quartz-vein type mineralization with relatively small ore tonnage in the eastern strike-slip fault system. | Jue HOU Tao XU Yinshuang AI Guiping YU Yingjie YANG Bo XU Qingfei WANG | 2023 | Science China Earth Sciences2023，66，12： | 0 |
| 14 | Community structure of aerobic anoxygenic phototrophic bacteria in algae-and macrophyte-dominated areas in Taihu Lake,China显示文摘Aerobic anoxygenic phototrophic bacteria(AAPB)repre sent a major group of bacterioplankton assemblages in many water systems and some are assumed to be closely associated with phytoplankton.However,studies on relationships between AAPB and cyanobacterial blooms are in scarcity.The dynamics of the abundance and diversity of AAPB was compared based on pufM gene in Meiliang Bay(featured by cyanobacterial blooms)and East Bay(featured by macrophyte)of Taihu Lake,a shallow subtropical lake in the East China plain.AAPB abundance was not significantly different between the two sites,and they were positively correlated with dissolved organic carbon(DOC)concentration.The ratios of AAPB to total bacteria varied from 3.4%to 11.5%and peaked in winter in both site s.No significant differences of AAPB community compositions were detected between the two sites,but there was a separation between warm seasons(June,August,and October)and cold seasons(December,February,and April).Rhizobiales and Limnohabitans-like pufM sequences were significantly contributors for the difference between two seasons,and specially enriched in cold seasons.Chlorophyll a(Ch1 a)and DOC were the most significant variables influencing the AAPB community structure.Furthermore,Porphyrobacter and Rhodospirillales-like pufM sequences were positively correlated with Ch1 a,indicating potential influence of cyanobacterial blooms on these AAPB taxa.These results suggested that diverse AAPB ecotypes coexisted in Taihu Lake,and their ecological role in carbon cycling in the lake may not be ignored. | Limei SHI Yuanfeng CAI Xiaoli SHI Min ZHANG Qingfei ZENG Fanxiang KONG Ping XU | 2022 | Journal of Oceanology and Limnology2022，40，5： | 0 |
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