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| 1 | Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?显示文摘AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were analyzed.RESULTS Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren subtype.CONCLUSION The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC. | Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao | 2017 | World Journal of Gastroenterology2017，23，9： | 47 |
| 2 | A CuNi/C Nanosheet Array Based on a Metal–Organic Framework Derivate as a Supersensitive Non-Enzymatic Glucose Sensor显示文摘Bimetal catalysts are good alternatives for nonenzymatic glucose sensors owing to their low cost, high activity, good conductivity, and ease of fabrication. In the present study, a self-supported CuNi/C electrode prepared by electrodepositing Cu nanoparticles on a Ni-based metal–organic framework(MOF) derivate was used as a non-enzymatic glucose sensor. The porous construction and carbon scaffold inherited from the Ni-MOF guarantee good kinetics of the electrode process in electrochemical glucose detection. Furthermore, Cu nanoparticles disturb the array structure of MOF derived films and evidently enhance their electrochemical performances in glucose detection. Electrochemical measurements indicate that the CuNi/C electrode possesses a high sensitivity of17.12 mA mM^(-1) cm^(-2), a low detection limit of 66.67 nM,and a wider linearity range from 0.20 to 2.72 mM. Additionally, the electrode exhibits good reusability, reproducibility, and stability, thereby catering to the practical use of glucose sensors. Similar values of glucose concentrations in human blood serum samples are detected with our electrode and with the method involving glucose-6-phosphate dehydrogenase; the results further demonstrate the practical feasibility of our electrode. | Li Zhang Chen Ye Xu Li Yaru Ding Hongbo Liang Guangyu Zhao Yan Wang | 2018 | Nano-Micro Letters2018，10，2： | 4 |
| 3 | Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures显示文摘An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic seizures.Irisin reportedly attenuates the apoptosis and injury induced by oxidative stress.Therefore,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat model.The results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and seizures.Irisin treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA administration.Furthermore,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of irisin.The reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin administration.Our findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and UCP2.Moreover,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous irisin.The protective effects of irisin may be mediated through the BDNF-mediated UCP2 level.Our results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures. | Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang Hongliu Sun | 2022 | Neuroscience Bulletin2022，38，11： | 1 |
| 4 | Image encryption combining multiple generating sequences controlled fractional DCT with dependent scrambling and diffusion显示文摘 | Yaru Liang Guoping Liu Nanrun Zhou Jianhua Wu | 2015 | Journal of Modern Optics2015，，4： | 1 |
| 5 | Image encryption combining multiple generating sequences controlled fractional DCT with dependent scrambling and diffusion显示文摘 | Yaru Liang Guoping Liu Nanrun Zhou | 2015 | Joumal of Modem Optics2015，62，2： | 1 |
| 6 | Role of local coordination in bimetallic sites for oxygen reduction: A theoretical analysis显示文摘Understanding of the oxygen reduction reaction(ORR)mechanism for single atom catalysts is pivotal for the rational design of non-precious metal cathode materials and the commercialization of fuel cells.Herein,a series of non-precious metal electrocatalysts based on nitrogen-doped bimetallic(Fe and Co)carbide were modeled by density functional theory calculations to predict the corresponding reaction pathways.The study elucidated prior oxygen adsorption on the Fe atom in the dual site and the modifier role of Co atoms to tune the electronic structures of Fe.The reaction activity was highly correlated with the bimetallic center and the coordination environment of the adjacent nitrogen.Interestingly,the preadsorption of*OH resulted in the apparent change of metal atoms'electronic states with the d-band center shifting toward the Fermi level,thereby boosting reaction activity.The result should help promote the fundamental understanding of active sites in ORR catalysts and provide an effective approach to the design of highly efficient ORR catalysts on an atomic scale. | Yuqi Yang Hao Zhang Zhaofeng Liang Yaru Yin Bingbao Mei Fei Song Fanfei Sun Songqi Gu Zheng Jiang Yuen Wu Zhiyuan Zhu | 2020 | Journal of Energy Chemistry2020，29，5： | 1 |
| 7 | Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice显示文摘Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney injury.Previous studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is overlooked.To assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat diet.Genetic changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical calculi.Higher fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological structure.Transcriptome analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological observations.The expression of CXCL14 significantly increased in the bladder in the high-fat diet group.CXCL14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of calculi.In human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of CXCL14.Dietary fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,which provides new ideas for the reduction of morbidity of primary vesical calculi. | Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng Kang Xu Xiaojin Shi Liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 8 | A novel thermophilic xylanase from Achaetomium sp. Xz-8 with high catalytic efficiency and application potentials in the brewing and other industries显示文摘 | Liang Zhao Kun Meng Pengjun Shi Yingguo Bai Huiying Luo Huoqing Huang Yaru Wang Peilong Yang Bin Yao | 2013 | Process Biochemistry2013，，12： | 1 |
| 9 | Image encryption combining multiple generating sequences controlled fractional DCT with dependent scrambling and diffusion显示文摘 | Liang Yaru Liu Guoping Zhou Nanrun | 2015 | Journal of Modern Optics2015，62，4： | 1 |
| 10 | Image encryption based on compressed sensing and variable parameter chaotic map显示文摘 | LIANG Yaru WU Jianhua | 2015 | Journal of Photoelectron Laser2015，26，3： | 1 |
| 11 | Influence of dynamic unbalance of wheelsets on the dynamic performance of high-speed cars显示文摘With further increasing in running speed of newer high-speed EMUs(electric multiple units),higher demand for wheelset dynamic balance is required.In order to study the influence of the dynamic unbalance of wheelset on the stability,ride quality,and curving performance for a high-speed car,a detailed dynamic model of a high-speed EMU car is established using the software SIMPACK.The analysis results indicate that the dynamic unbalance of the wheelset significantly influences the dynamic performance of the high-speed car.The increase in dynamic unbalance of the wheelset will decrease the hunting critical speed,worsen the vertical ride quality,and increase the wheelset lateral force,derailment coefficient,and wheel unloading ratio.Therefore,in order to improve the stability,ride quality,and running safety of high-speed car,the values of dynamic unbalance of wheelset should be strictly controlled in manufacturing,and periodically monitored in operation. | Yong WANG Hongjun KANG Xiaowen SONG Yaru LIANG | 2011 | Journal of Modern Transportation2011，19，3： | 1 |
| 12 | Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells显示文摘 | Yuping Luo Volkan Coskun Aibing Liang Juehua Yu Liming Cheng Weihong Ge Zhanping Shi Kunshan Zhang Chun Li Yaru Cui Haijun Lin Dandan Luo Junbang Wang Connie Lin Zachary Dai Hongwen Zhu Jun Zhang Jie Liu Hailiang Liu Jean deVellis Steve Horvath Yi Eve Sun | 2015 | Cell2015，，5： | 1 |
| 13 | Two-in-one shell configuration for bimetal selenides toward fast sodium storage within broadened voltage windows显示文摘The shell structure design has been recognized as a highly efficient strategy to buffer the severe volume expansion and consecutive pulverization of conversion-type anodes.Nevertheless,construction of a functional shell with a stabilized structure that meets the demands of both high electronic conductivity and feasible pathways for Na^(+)ions has been a challenge so far.Herein,we design a two-in-one shell configuration for bimetal selenides to achieve fast sodium storage within broadened voltage windows.The hybridized shell,which benefits from the combination of titanium dioxide quantum dots and amorphous carbon,can not only effectively buffer the strain and maintain structural integrity but also allow facile and reversible transport of electrons and Na^(+)uptake for electrode materials during sodiation/desodiation processes,resulting in increased reaction kinetics and diffusion of sodium ions,conferring many benefits to the functionality of conversion-type electrode materials.As a representative material,Ni-CoSe_(2) with such structural engineering shows a reversible capacity of 515 mAh g^(−1)at 0.1 A g^(−1)and a stable capacity of 416 mAh g^(−1)even at 6.4 A g^(−1);more than 80%of the capacity at 0.1 A g^(−1)could be preserved,so that this strategy holds great promise for designing fast-charging conversion-type anodes in the future. | Zichao Yan Lingfei Zhao Yaru Liang Lei Zhang Hanwen Liu Zhiqiang Zhu Yunxiao Wang Shu-Lei Chou | 2022 | Carbon Energy2022，4，4： | 1 |
| 14 | Room temperature spontaneous surface condensation of boronic acids observed by scanning tunneling microscopy显示文摘Herein,we discovered that the surface-confined condensation of boronic acid can happen spontaneously at room temperature,by comparing the kinetics of condensation of boronic acids with and without the negative sample bias,we found that the negative sample bias indeed accelerates the self-condensation reaction of boronic acid.Combining with in-situ STM images and ultraviolet photoemission spectrum(UPS)analysis,a reversible adsorption mechanism model was proposed and reasonably explains the reversible electric-field-induced phase transformation. | Qiu Liang Guangyuan Feng Hongzhen Ni Yaru Song Xinyu Zhang Shengbin Lei Wenping Hu | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 15 | Construction of AIEgen functionalized nanomicelles and their stability study through‘seesaw-like'fluorescence changes显示文摘As nanocarriers,nanomicelles play vital roles in the toolbox of drug delivery.The stability of nanomicelles affects the nanomedicines'bioactivity.Therefore,it is important to understand the stability of nanomicelles for further improvements.Here,we report a strategy to construct new nanomicelles(NM)by introducing aggregation-induced emission(AIE)functional group tetraphenylethylene(TPE)in the component polymer vitamin E(D-α-tocopheryl polyethylene glycol 1000 succinate)(TPGS).The stability of doxorubicin(DOX)loaded nanomicelles DOX@NM in different conditions was studied by fluorescence analysis.The fluorescence changes of DOX@NM are‘seesaw-like'when they transform between assembled and disassembled forms.In the assembled form,TPE gives emission from AIE effect,while in the disassembled form,the fluorescence of DOX is observed due to the disappearance of ACQ effect. | Xiaotong Wang Shizhu Chen Yaru Jia Kaihan Zhang Lili Ma Luwei Li Xingjie Liang Jinchao Zhang | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 16 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
| 17 | New image encryption combining fractional DCT via polynomial interpolation with dependent scrambling and diffusion显示文摘Based on the fractional discrete cosine transform(DCT) via polynomial interpolation(PI-Fr DCT) and the dependent scrambling and diffusion(DSD), an image encryption algorithm is proposed. Under certain conditions, the introduction of PI-Fr DCT reduces computational complexity compared with fractional DCT(Fr DCT). By using a sigmoid function, the encrypted results are limited within a range from 0 to 255. The real-valued output of PI-Fr DCT is beneficial to the storage, display and transmission of the cipher-text. During the stage of confusion and diffusion, the values of all PI-Fr DCT coefficients change simultaneously as their locations are replaced. DSD enhances the scrambling and diffusion level of encrypted images and provides nonlinearity to the encryption system. Simulation results demonstrate that the proposed encryption algorithm is feasible, effective and secure. | Liang Yaru Wu Jianhua | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，5： | 0 |
| 18 | Lithium-Ion Charged Polymer Channels Flattening Lithium Metal Anode显示文摘The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth.Resolving this issue will be key to achieving high-performance lithium metal batteries(LMBs).Herein,we construct a lithium nitrate(LiNO_(3))-implanted electroactiveβphase polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP)crystalline polymorph layer(PHL).The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels.These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes,decreasing the growth of lithium dendrites.The stretched molecular channels can also accelerate the transport of Li ions.The combined effects enable a high Coulombic efficiency of 97.0%for 250 cycles in lithium(Li)||copper(Cu)cell and a stable symmetric plating/stripping behavior over 2000 h at 3 mA cm^(-2)with ultrahigh Li utilization of 50%.Furthermore,the full cell coupled with PHL-Cu@Li anode and Li Fe PO_(4) cathode exhibits long-term cycle stability with high-capacity retention of 95.9%after 900 cycles.Impressively,the full cell paired with LiNi_(0.87)Co_(0.1)Mn_(0.03)O_(2)maintains a discharge capacity of 170.0 mAh g^(-1)with a capacity retention of 84.3%after 100 cycles even under harsh condition of ultralow N/P ratio of 0.83.This facile strategy will widen the potential application of LiNO_(3)in ester-based electrolyte for practical high-voltage LMBs. | Haofan Duan Yu You Gang Wang Xiangze Ou Jin Wen Qiao Huang Pengbo Lyu Yaru Liang Qingyu Li Jianyu Huang Yun‑Xiao Wang Hua‑Kun Liu Shi Xue Dou Wei‑Hong Lai | 2024 | Nano-Micro Letters2024，16，4： | 0 |
| 19 | The Yin and Yang of the protein corona on the delivery journey of nanoparticles显示文摘Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner.However,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in vivo.These challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological systems.Importantly,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the surface.The protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate results.Thus,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery efficiency.In this review,we first summarize the fundamental impact of the protein corona on the delivery journey of nanoparticles.Next,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in vivo.Finally,we highlight what we need to do as a next step towards better understanding and exploitation of the protein corona.We hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles. | Yi-Feng Wang Yaxin Zhou JiaBei Sun Xiaotong Wang Yaru Jia Kun Ge Yan Yan Kenneth A.Dawson Shutao Guo Jinchao Zhang Xing-Jie Liang | 2023 | Nano Research2023，16，1： | 0 |
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