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您的检索式：作者名="Qinwen Tai"
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| 1 | MiRNA-206 inhibits hepatocellular carcinoma cell proliferation and migration but promotes apoptosis by modulating cMET expression显示文摘A close relationship between cancer progression and microRNAs(miRNAs)regulation has been demonstrated.Abnormal microRNA-206(miR-206)expression has been shown to be related to the development of malignancies.However,the role of miR-206 in hepatocellular carcinoma(HCC)remains unclear.Here,we evaluated the function of miR-206 in HCC.Results showed that miR-206 expression was decreased in 27 human HCC tissues compared with that of adjacent normal tissues.Conversely,cMET was up-regulated in human HCC cancer tissues,and cMET levels were shown to be negatively correlated with miR-206 expression.Abnormally increased miR-206 expression in three HCC cell lines(SMMC-7721,HepG2,and Huh7)attenuated cell viability,migration,and invasion.Increased apoptosis was also observed in these miR-206 expressing cells.Furthermore,we identified that miR-206 targets the 3′-UTR of the cMET gene for silencing,and restoration of cMET expression reversed the inhibitory effect of miR-206 on HCC.Tumor cells expressing miR-206 also showed delayed growth in the in vivo experiments compared with the controls.Altogether,our findings provide new insights into the molecular mechanisms of HCC oncogenesis. | Yuanxi Wang Qinwen Tai Jinhui Zhang Junsheng Kang Feng Gao Feng Zhong Liquan Cai Fa Fang Yi Gao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 7 |
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