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| 1 | Study on the creep permeability of mining-cracked N2 laterite as the key aquifuge for preserving water resources in Northwestern China显示文摘 | Wenping Li Qiqing Wang Shiliang Liu Yabing Pei | 2018 | International Journal of Coal Science & Technology2018，5，3： | 22 |
| 2 | A New Family of Sauropod Dinosaur from the Upper Cretaceous of Tianzhen, Shanxi Province, China显示文摘A new gigantic sauropod, Huabeisaurus allocates gen. et sp. nov., about 20 m in length and 5 m in height, was discovered in the Upper Cretaceous Huiquanpu Formation, Tianzhen County, Shanxi Province. It is notably different from Diplodocidae, Titanosauridae and Nemegtosauridae in the following aspects: the teeth are strong, peg-like with a length ratio of the tooth crown to tooth root at about 3 to 1; the cervical vertebrae are long with forked spines; the spines in dorsal vertebrae are relatively high, unbifiarcated; the caudal vertebrae are amphicoelous, with anterior neural spines and unbifurcated spines and chevrons; the femur is straight and long, narrow and flat and the tibia and fibula are long and flat. These characters show that the described genus should represent a new family, Huabeisauridae fam. nov. The discovery enriches the sauropod dinosaur record in China, and is quite significant to the study of the taxonomy, evolution, migration, extinction and palaeobiogeographic provincialism of | PANG Qiqing CHENG Zhengwu | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 10 |
| 3 | Controlling upconversion through interfacial energy transfer(IET):Fundamentals and applications显示文摘Photon upconversion has received substantial attention owing to its great promise in broad applications from bioimaging to other frontier fields like display,upconversion laser,information security and anticounterfeiting.A smart control and manipulation of the upconversion luminescence has always been a key topic,however,to date the most efficient mechanism for upconversion nanoparticles remains the energy transfer upconversion and recently reported energy migration mediated upconversion.Recently,we found that the interfacial energy transfer(IET)is also an efficient approach for enabling and tuning photon upconversion of lanthanide ions.Moreover,it can be used for the mechanistic understanding of the interionic interactions such as energy transfer and energy migration on the nanoscale.In this review,the recent advances of the research on the IET are summarized,the principles for designing IET process and typical examples are discussed together with its applications in both mechanistic research and frontier information security.The challenges and perspectives for future research are also commented. | Bo Zhou Qiqing Li Long Yan Qinynuan Zhang | 2020 | Journal of Rare Earths2020，38，5： | 8 |
| 4 | Effect of Huqian Wan on liver-Yin and kidney-Yin deficiency patterns in patients with knee osteoarthritis显示文摘OBJECTIVE: To observe the curative effect of Huqian Wan on liver and kidney-Yin deficiency knee osteoarthritis(KOA).METHODS: One hundred patients were randomly divided into a treatment(50 patients) and control group(50 patients). In the treatment group, patients orally took the Chinese medicine Huqian Wan. Control group patients orally took Votalin, 75 mg, once a day, for 8 weeks. The visual analog scale(VAS), Western Ontario and Mc Master University Osteoarthritis Index(WOMAC), and Medical Outcomes Study Short Form 36-Item Health Survey(SF36) were used to evaluate the curative effect before treatment and after 8 and 16 weeks of treatment.RESULTS: VAS and WOMAC scores significantly decreased and SF 36 scores significantly increased after treatment in both groups compared with before treatment(P < 0.05). There were significant differences in VAS, WOMAC, and SF 36 score changes between the two groups at week 16(P < 0.05).There was a significant increase in VAS and WOMAC scores in the control groups(P < 0.05) between weeks 8 and 16, but no significant difference was found in the treatment group(P > 0.05).CONCLUSION: Huqian Wan could effectively improve the clinical symptoms and quality of life in patients with KOA. It could also have a better and longer lasting curative effect without obvious adverse events compared with Votalin. | Chen Qiqing Jin Hongting He Bin Wang Liang Xiao Luwei Tong Peijian | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 8 |
| 5 | Self-organizing feature map neural network classification of the ASTER data based on wavelet fusion显示文摘Most methods for classification of remote sensing data are based on the statistical parameter evaluation with the assumption that the samples obey the normal distribution. How-ever, more accurate classification results can be obtained with the neural network method through getting knowledge from environments and adjusting the parameter (or weight) step by step by a specific measurement. This paper focuses on the double-layer structured Kohonen self-organizing feature map (SOFM), for which all neurons within the two layers are linked one another and those of the competition layers are linked as well along the sides. Therefore, the self-adapting learning ability is improved due to the effective competition and suppression in this method. The SOFM has become a hot topic in the research area of remote sensing data classi-fication. The Advanced Spaceborne Thermal Emission and Reflectance Radiometer (ASTER) is a new satellite-borne remote sensing instrument with three 15-m resolution bands and three 30-m resolution bands at the near infrared. The ASTER data of Dagang district, Tianjin Munici-pality is used as the test data in this study. At first, the wavelet fusion is carried out to make the spatial resolutions of the ASTER data identical; then, the SOFM method is applied to classifying the land cover types. The classification results are compared with those of the maximum likeli-hood method (MLH). As a consequence, the classification accuracy of SOFM increases about by 7% in general and, in particular, it is almost as twice as that of the MLH method in the town. | HASI Bagan MA Jianwen LI Qiqing HAN Xiuzhen LIU Zhili | 2004 | Science China Earth Sciences2004，47，7： | 7 |
| 6 | Preparation and Characterization of Collagen-GAGs Bioactive Matrices for Tissue Engineering显示文摘Collagen materials were crosslinked by 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) in the presence of chondroitin sulfate (CS), one of glycosaminoglycans (GAGs). PVA and chitosan were also blended with collagen. The physical and chemical properties of the matrices were characterized by SEM, DSC, and ESCA. L929 cells were implanted on the matrices to show the cytotoxic and the biological characters of the materials. The results indicate that EDC is an effective and non-cytotoxic cross-link reagent, which can replace the common dialdehyde reagent. The attachment of CS can improve the stability of collagen and accelerate cell growth. The addition of PVA can prepare porous matrices with smaller bore size. There are reactions between the chitosan and collagen, and the composite has good biological character. The presence of chitosan can also increase the amount of incorporated CS. | Hongyi YANG and Qiqing ZHANG Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin 300192, China | 2001 | Journal of Materials Science & Technology2001，17，5： | 7 |
| 7 | Synthesis of magnetic polyphosphazene-Ag composite particles as surface enhanced Raman spectroscopy substrates for the detection of melamine显示文摘Magnetic polyphosphazene(MPZS) particles coated by Ag nanoparticles(MPZS-Ag) have been developed as surface enhanced Raman spectroscopy(SERS) substrates for sensitive detection of melamine in aqueous solutions and milk samples.5,5’-Dithiobis-(2-nitrobenzoic acid)(DTNB) was used as model analyte to test the SERS activity of the MPZS-Ag particles.The prepared MPZS-Ag particles possess both magnetic responsiveness and excellent SERS properties.SERS detection of different concentrations of melamine aqueous solutions and spiked milk samples were performed by the MPZS-Ag particles.The limit of detection(LOD) of the melamine in aqueous solutions was 10^-7 mol/L(0.0126 mg/L) and 0.6 mg/L in real milk samples using the MPZS-Ag particles as SERS substrates.The LOD of the melamine are much lower than the safety values of Food and Drug Administration and Codex Alimentarius Commission.These results indicate that the MPZS-Ag particles have promising application prospect for SERS analysis in food safety fields. | Ci Huang Feifei Lu Ke Xu Guanjun Ding Lijun You Jiabin Wang Qiqing Zhang | 2019 | Chinese Chemical Letters2019，30，12： | 6 |
| 8 | Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii显示文摘The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase(HDR) is the last step key enzyme of the methylerythritol phosphate(MEP) pathway,synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate,which is important for regulation of isoprenoid biosynthesis.Here the full-length cDNA of HDR,designated TwHDR(GenBank Accession No.KJ933412.1),was isolated from Tripterygium wilfordii for the first time.TwHDR has an open reading frame(ORF) of 1386 bp encoding461 amino acids.TwHDR exhibits high homology with HDRs of other plants,with an N-terminal conserved domain and three conserved cysteine residues.TwHDR cDNA was cloned into an expression vector and transformed into an Escherichia coli hdr mutant.Since loss-of-function E.coli hdr mutant is lethal,the result showed that transformation of TwHDR cDNA rescued the E.coli hdr mutant.This complementation assay suggests that the TwHDR cDNA encodes a functional HDR enzyme.The expression of TwHDR was induced by methyl-jasmonate(MJ) in T.wilfordii suspension cells.The expression of TwHDR reached the highest level after 1 h of MJ treatment.These results indicate that we have identified a functional TwHDR enzyme,which may play a pivotal role in the biosynthesis of diterpenoid triptolide in T.wilfordii. | Qiqing Cheng Yuru Tong Zihao Wang Ping Su Wei Gao Luqi Huang | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 5 |
| 9 | Physicochemical properties,antimicrobial activity and oil release of fish gelatin films incorporated with cinnamon essential oil显示文摘Fish skin gelatin films incorporated with various concentrations of cinnamon essential oil(CEO)were prepared and characterized.The results showed that tensile strength(TS),elongation at break(EAB),and water content(WC)of the gelatin based film decreased with the increasing concentrations of CEO,but water vapor permeability(WVP)increased.Addition of CEO improved light barrier property of the film.The Scanning electron microscope(SEM)showed that the heterogeneous surface and porous formation appeared in gelatin-CEO films.Fourier transform infrared spectroscopy analyses(FTIR-ATR)spectra indicated the interactions existed between gelatin and CEO.The gelatin-CEO films exhibited good inhibitory effects against the tested microorganisms(Escherichia coli,Staphylococcus aureus,Aspergillus niger,Rhizopus oryzae,and Paecilomyces varioti)and their antifungal activity seemed to be more effective than the resistance to bacterial growth.In vitro release studies showed an initial burst effect of CEO release and that subsequently slowed down at 40℃,but the initial burst release was not obvious at 4℃.The obtained results suggested that incorporation of CEO as a natural antimicrobial agent into gelatin film has potential for developing as active food packaging. | Jiulin Wu Xinyu Sun Xiaoban Guo Shangying Ge Qiqing Zhang | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 10 | Interaction mechanism of the interface between a deep buried sand and a paleo-weathered rock mass using a high normal stress direct shear apparatus显示文摘In order to evaluate the feasibility of safe mining close to the contact zone under reduced security coal pillar conditions at a coal mine in eastern China, the interaction mechanism of the interface between deep buried sand and a paleo-weathered rock mass was investigated in the laboratory by direct shear testing. A DRS-1 high pressure soil shear testing machine and orthogonal design method were used in the direct shear tests. Variance and range methods were applied to analyze the sensitivity of each factor that has an influence on the mechanical characters of the interface. The test results show that the normal pressure is the main influencing factor for mechanical characteristics of the interface, while the lithological characters and roughness are minor factors; the shear stress against shear displacement curve for the interface shows an overall hyperbola relationship, no obvious peak stress and dilatancy was observed.When the normal pressure is 6 MPa, the shear strengths of interfaces with different roughness are basically the same, and when the normal pressure is more than 8 MPa, the larger the roughness of the interface, the larger will be the shear strength; the shear strength has a better linear relationship with the normal pressure, which can be described by a linear Mohr–Coulomb criterion. | Bai Hanying Li Wenping Ding Qingfeng Wang Qiqing Yang Dongdong | 2015 | International Journal of Mining Science and Technology2015，25，4： | 4 |
| 11 | Internal OH^(-)induced cascade quenching of upconversio n luminesce nee in NaYF4:Yb/Er nanocrystals显示文摘Internal hydroxyl impurity is known as one of the main detrimental factors affecting the upconversion(UC)efficiency of upconversion luminescence(UCL)nanomaterials.Different from surface'ligand-related emission quenching which can be effectively diminished by,e.g.,core'shell structure,internal hydroxyl is easy to be introduced in synthesis but difficult to be quantified and controlled.Therefore,it becomes an obstacle to fully understand the relevant UC mechanism and improve UC efficiency of nanomaterials.Here we report a progress in quantifying and large-range adjustment of the internal hydroxyl impurity in NaYF4 nanocrystals.By combining the spectroscopy study and model simulation,we have quantitatively unraveled the microscopic in teractions underlying UCL que nching between internal hydroxyl and the sensitizers and activators,respectively.Furthermore,the internal hydroxyl-involved UC dynamical process is interpreted with a vivid concept of'Survivor effect' i.e.;the shorter the migration path of an excited state,the larger the possibility of its surviving from hydroxyl-induced quenchi ng.Apart from the consist ent experimental results,this concept can be further evidenced by Monte Carlo simulation,which monitors the variation of energy migration step distribution before and after the hydroxyl introduction.The new quantitative insights shall promote the construction of highly efficient UC materials. | Yansong Feng Zhi Li Qiqing Li Jun Yuan Langping Tu Lixin Ning Hong Zhang | 2021 | Light(Science & Applications)2021，10，6： | 3 |
| 12 | Analysis of sensitivity and specificity:precise recognition of neutrophils during regeneration of contused skeletal muscle in rats显示文摘In this report,we applied the TissueFAXS 200 digital pathological analysis system to rapidly and accurately identify neutrophils during regeneration of contused skeletal muscle,and to provide information for follow-up studies on neutrophils to estimate wound age.Rat injury model was established,and skeletal muscle samples were obtained from the control group and contusion groups at 1,1.5,2,3,4,and 6 h,as well as at 1,3,5,and 15 d post-injury(n紏5 per group).The expression of nuclei and neutrophils was detected by hematoxylin and eosin(HE)staining and immunohistochemical(IHC)staining.A total of 20 injury site areas of 0.25mm^(2)(0.5mm0.5mm)were then randomly selected at all time points.A TissueFAXS 200 digital pathological analysis system was used to identify the positive and negative numbers.Knowledge of five professional medical workers were considered the gold standard to measure the false positive rate(FPR),false negative rate(FNR),sensitivity,specificity,and area under the curve(AUC)of receiver operating characteristic(ROC)curves.As a result,with a staining area of neutrophils from 8 μm^(2) to 15 μm^(2),the FPR was 4.28%–12.14%,the FNR was 12.42%–64.08%,the sensitivity was 35.92%–87.58%,the specificity was 87.86%–95.72%,the Youden index was 0.316–0.754,the accuracy was 82.80%–88.30%,and the AUC was 0.771–0.826.The AUC was largest when the cut-off value of the staining area was 12 mm^(2).Our results show that this software-based method is more accurate than the human eye in evaluating neutrophil infiltration.Based on the sensitivity and specificity,neutrophils can be accurately identified during regeneration of contused skeletal muscle.The TissueFAXS 200 digital pathological analysis system can also be used to optimize conditions for different cell types under various injury conditions to determine the optimal cut-off value of the staining area and provide optimal conditions for further study.Furthermore,it will provide evidence for forensic pathology cases. | Jiajia Niu Guoshuai An Zhen Gu Peng Li Qiqing Liu Rufeng Bai Junhong Sun Qiuxiang Du | 2022 | Forensic Sciences Research2022，7，2： | 2 |
| 13 | The regulatory network behind maize seed germination: Effects of temperature, water, phytohormones, and nutrients显示文摘Seed germination is the process by which an organism grows from a seed. It requires suitable conditions and environmental factors. Maize is one of the most important crops worldwide. Germination influences both final maize yield and quality. Seed germination is regulated by a complex gene network. It is also influenced by endogenous(phytohormones and nutrients) and exogenous(temperature and water)inputs, involving molecular networks only partly identified to date. This review describes current understanding of the influence of temperature, water, phytohormones, and nutrients in regulating maize seed germination, and indicates knowledge gaps that should be addressed. | Xiaofei Xue Shangyi Du Fuchao Jiao Menghan Xi Aiguo Wang Haicheng Xu Qiqing Jiao Xin Zhang Hao Jiang Jingtang Chen Ming Wang | 2021 | The Crop Journal2021，9，4： | 2 |
| 14 | Whole-exome sequencing reveals twovariants in thegene in two Chinese patients with left ventricular non-compaction cardiomyopathy显示文摘Importance:Pathogenic variants in theRBM20 gene are associated with aggressive dilated cardiomyopathy(DCM).Recently,RBM20 was found to be associated with left ventricular non-compaction cardiomyopathy(LVNC).Thus far,only five families with LVNC have been reported to carry variants inRBM20.It remains unknown whether the variants inRBM20 associated with DCM can also cause LVNC.Objective:To elucidate the causativeRBM20 variant in two unrelated patients with both LVNC and DCM,and to identify the clinical characteristics associated with variants inRBM20.Methods:Trio whole-exome sequencing(WES)was performed.Variants were filtered and classified in accordance with the guidelines of the American College of Medical Genetics and Genomics(ACMG).Results:We identified two distinctde novo variants inRBM20(one per patient)in these two patients with LVNC.Both variants have been reported in patients with DCM,without the LVNC phenotype.Patient 1 was an 11-year-old girl who had DCM,LVNC,and heart failure;the ratio of noncompacted-to-compacted myocardium was 2.7:1.Ade novo heterozygous variant c.1907G>A(p.Arg636His)in exon 9 was identified in this patient.Patient 2 was a 13-year-old boy who had clinical phenotypes identical to those of Patient 1;the ratio of noncompacted-to-compacted myocardium was 3.2:1 in this patient.WES revealed ade novo heterozygous variant c.1909A>G(p.Ser637Gly)in exon 9.Both variants were previously characterized as pathogenic,and our study classified them as pathogenic variants based on the ACMG guidelines.Interpretation:We found that two patients with LVNC had variants inRBM20.Our results extended the clinical spectrum of the twoRBM20 variants and illustrated that the same variant inRBM20 can cause DCM,with or without the LVNC phenotype. | Qiqing Sun Jun Guo Chanjuan Hao Ruolan Guo Xuyun Hu Yuanying Chen Weili Yang Wei Li Yingjun Feng | 2020 | Pediatric Investigation2020，4，1： | 2 |
| 15 | Influence of tanshinone on N-methyl-D-aspartate receptor 1 protein expression in a rat model of spinal cord ischemia/reperfusion injury显示文摘BACKGROUND: Tanshinone has been previously shown to be involved in the prevention and treatment of cerebral ischemia/reperfusion injury. In addition, excitatory amino acid-mediated neu- rotoxicity may induce neuronal damage following spinal cord ischemia/reperfusion injury. OBJECTIVE: To explore the interventional effect of tanshinone on N-methyl-D-aspartate receptor 1 (NMDAR1) protein expression in a rat model of spinal cord ischemia/reperfusion injury. DESIGN, TIME AND SETTING: A randomized molecular biology experiment was conducted at the Traumatology & Orthopedics Laboratory of Fujian Hospital of Traditional Chinese Medicine (Key Laboratory of State Administration of Traditional Chinese Medicine) between September 2007 and May 2008. MATERIALS: A total of 88 Sprague Dawley rats were randomly divided into a sham operation (n = 8), model (n = 40), and tanshinone (n = 40) groups. Thirty minutes after ischemia, rats in the model and tanshinone groups were observed at hour 0.5, 1, 4, 8, and 12 following perfusion, with eight rats for each time point. METHODS: Abdominal aorta occlusion was performed along the right renal arterial root using a Scoville-Lewis clamp to induce spinal cord ischemia. Blood flow was recovered 30 minutes following occlusion to establish models of spinal cord ischemia/reperfusion injury. Abdominal aorta occlusion was not performed in the sham operation group. An intraperitoneal injection of tanshinone ⅡA sul- fonic sodium solution (0.2 L/g) was administered to rats in the tanshinone group, preoperatively. In addition, rats in the sham operation and model groups were treated with an intraperitoneal injection of the same concentration of saline, preoperatively. MAIN OUTCOME MEASURES: NMDAR1 protein expression in the anterior horn of the spinal cord, accumulative absorbance, average absorbance, and area of positive cells were detected in the three groups through immunohistochemistry. RESULTS: All 88 rats were included in the final analysis. (1) NMDAR1 protein expression increased following 30-minute ischemia/1-hour reperfusion injury to the spinal cord, and reached a peak 4 hours after reperfusion. (2) Accumulative absorbance and average absorbance of NMDAR1, as well as area of positive cells in the model group, were significantly greater than the sham operation group at each time point (P < 0.05). However, values in the tanshinone group were significantly less than the model group (P < 0.05). CONCLUSION: NMDAR1 protein expression was rapidly increased following spinal cord ische- mia/reperfusion injury and reached a peak 4 hours following reperfusion. In addition, tanshinone downregulated NMDAR1 protein expression in the anterior horn of the spinal cord. | Li Zhang Xiang Lin Yong Fu Guangrui Nie Qiqing Zeng | 2009 | Neural Regeneration Research2009，4，1： | 2 |
| 16 | Studies on preparation of oligoglucosamine by oxidative degradation under microwave irradition显示文摘 | Shao Jian Yang Yumin Zhong Qiqing | 2003 | Polymer Degradation and Stability2003，82，： | 1 |
| 17 | Preparation and characterization of collagen-chitosan composites 显示文摘 | Qiqing Zhang Ling-rong Liu Lei Ren etal | 1997 | Journal of Applied Polymer Sciences1997，，64： | 1 |
| 18 | Evaluation of porous collagen membrane in guided tissue regeneration 显示文摘 | Qiqing Zhang Kangde Yao Lingrong Liu etal | 1999 | Artificial Cell Blood Substitutes and Immobilization Biotechnology1999，27，3： | 1 |
| 19 | In vitro antioxidant effects and cytotoxicity of polysaccharides extracted from Laminaria japonica显示文摘 | Zhenfei Peng Min Liu Zhexiang Fang Qiqing Zhang | 2012 | International Journal of Biological Macromolecules2012，，5： | 1 |
| 20 | The modification of scaffold material in building artificial dermis显示文摘 | Zhang lihai Ma dongrui Zhang qiqing | 2002 | Artificial Cell Blood Substitutes and Immobilization Biotechnology2002，30，4： | 1 |
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