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| 1 | Advanced hydrogels for the repair of cartilage defects and regeneration显示文摘Cartilage defects are one of the most common symptoms of osteoarthritis(OA),a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society.Hydrogels,which are a class of biomaterials that are elastic,and display smooth surfaces while exhibiting high water content,are promising candidates for cartilage regeneration.In recent years,various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo,some of which are hopeful to enter clinical trials.In this review,recent research findings and developments of hydrogels for cartilage defects repair are summarized.We discuss the principle of cartilage regeneration,and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications.We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. | Wei Wei Yuanzhu Ma Xudong Yao Wenyan Zhou Xiaozhao Wang Chenglin Li Junxin Lin Qiulin He Sebastian Leptihn Hongwei Ouyang | 2021 | Bioactive Materials2021，6，4： | 8 |
| 2 | In -situ Tests and Stochastic Structural Model of Rock and Soil Aggregate in the Three Gorges Reservoir Area 显示文摘 | Xiao Li Qiulin Liao Jianming He | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，3： | 1 |
| 3 | Effect of combined magnetic field on the eliminating inclusions from liquid aluminum alloy 显示文摘 | He Yanjie Li Qiulin Liu Wei | | Materials Letters0，65，8： | 1 |
| 4 | Characteristics of Volcanic Reservoirs and Hydrocarbon Accumulation of Carboniferous System in Junggar Basin, China显示文摘The Carboniferous volcanic reservoirs in Junggar Basin contain rich hydrocarbon resources,implying a great exploration potential,so that they have become a key replacement target for“three-dimensional exploration”.The study on the Carboniferous volcanic reservoirs and their hydrocarbon accumulation elements is significant for clarifying the orientation for exploration.In this paper,based on 37 reserves reports and 3200 reservoir test data,the Carboniferous volcanic reservoirs in Junggar Basin were discussed from the prospective of lithology and lithofacies,physical properties,reservoir types,main controls on hydrocarbon accumulation,and hydrocarbon accumulation patterns.It is found that the Carboniferous in the basin is mostly in the multi-island ocean-volcanic island arc structural-sedimentary environment,so it is geologically eligible for forming in-situ volcanic reservoirs.The volcanic rocks are:(1)mostly distributed along deep and large faults,with the lithology and lithofacies controlled by volcanic architectures;(2)dominantly lava,followed by volcaniclastic lava and volcaniclastic rock;(3)distributed in the periphery of hydrocarbon-generating sag and within the source rocks horizontally,and concentrated in the weathering crust at the top longitudinally,possibly leading to reworked weathering crust reservoir;and(4)liable to form inner reservoirs.The volcanic reservoirs can be concluded into four hydrocarbon accumulation patterns,i.e.,self-generating&self-storing in paleo-uplift and vertical migration,self-generating&self-storing in paleo-uplift and lateral migration,young-generating&old-storing in fault zone and vertical migration,and young-generating&old-storing in paleo-uplift and lateral migration.Future exploration will focus on the effective source rock development and hydrocarbon supply zones and the selfgenerating&self-storing and young-generating&old-storing patterns.The exploration prospects are determined to be the Ludong-Wucaiwan-Baijiahai slope belt and the southern slope belt of the Shaqi uplift(self-generating&self-storing pattern)in eastern Junggar,and the fault and nasal arch zone at the northwestern margin and the nasal arch zone(deep and large structure)in the Luxi area(younggenerating&old-storing pattern)in western Junggar. | Xiaozhi Wu Qiulin Guo Wei Zhang Dengfa He Xuefeng Qi Di Li | 2021 | Journal of Earth Science2021，32，4： | 1 |
| 5 | Effect of combined magnetic field on the eliminating inclusions from liquid aluminum alloy显示文摘 | Yanjie He Qiulin Li Wei Liu | 2011 | Materials Letters2011，，8： | 1 |
| 6 | Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl(BSN-GelMA)hydrogel显示文摘Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice.Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface,graft necrosis and sclerosis.However,poor gap integration is a serious concern,which eventually leads to deterioration of joint function.To deal with such complications,this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl(GelMA)hydrogel(BSN-GelMA).A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty,as early as six weeks.Moreover,the International Cartilage Repair Society score,histology score,glycosaminoglycan content,subchondral bone volume,and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated group.This improved outcome was due to bio-interactive materials,which acted as tissue fillers to bridge the gap,prevent cartilage degeneration,and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA hydrogel.This study provides a powerful and applicable approach to improve gap integration after autologous mosaicplasty.It is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration. | Hongwei Wu Yuna Shang Wei Sun Xinyi Ouyang Wenyan Zhou Jieji Lu Shuhui Yang Wei Wei Xudong Yao g Xiaozhao Wang Xianzhu Zhang Yishan Chen Qiulin He Zhimou Yang Hongwei Ouyang | 2023 | Bioactive Materials2023，，1： | 1 |
| 7 | In-situ tests and a stochastic structural model of rock and soil aggregate in the Three Gorges Res- ervoir Area, China 显示文摘 | Li Xiao Liao Qiulin He Jianming | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，41，： | 1 |
| 8 | In--situ Tests and Stochastic Structural Model of Rock and Soil Aggregate in the Three Gorges ReservoirArea 显示文摘 | Xiao Li Qiulin Liao Jianming He | 2004 | International Journal of RockMechanics and Mining Sciences2004，41，3： | 1 |
| 9 | In-Situ Tests and a Stochastic Structural Model of Rock and Soil Aggre- gate in the Three Gorges Reservoir Area, China显示文摘 | Li Xiao Liao Qiulin He Jianming | 2004 | International Journal of Rock Mechanics Mining Sciences2004，41，3： | 1 |
| 10 | In-situ Tests and Stochastic Structural Model of Rock and Soil Aggregate in the Three Gorges Reservoir Area显示文摘 | Li Xiao Liao Qiulin He Jianming | | 0，，03： | 1 |
| 11 | Effect of combined magnetic field on the eliminating inclusions from liquid aluminum alloy显示文摘 | Yanjie He Qiulin Li Wei Liu | 2011 | Materials Letters2011，，8： | 1 |
| 12 | In-situ Tests and Stochastic Structural Model of Rock and Soil Aggre- gate in the Three Gorges Reservoir Area显示文摘 | Xiao li Qiulin Lian Jianming He | 2004 | Interna- tional Journal of Rock Mechanics and Mining Sciences2004，41，3： | 1 |
| 13 | The prewarning value of Alexandrium tamarense PSP in an area with frequent outburst of red tide显示文摘The PSP toxicity of Alexandrium tamarense (Lebour) Balech on the blue mussel (Mytilus edulis) from the western waters of Xiamen in China was studied by following the standard method of PSP mouse bioassay developed by the Association of Official Analytical Chemists (AOAC). The results showed that the mice survived when the density of A. tamarense cells was lower than 1×105 cells per cubic decimetre and died when the density was higher than 1×106 cells per cubic decimetre. The past record of red tide events in the western waters of Xiamen showed a general trend of starting from the bloom of non-toxic planktonic diatoms in local waters and resulting in a harmful algal bloom due to the fade of planktonic diatoms which failed in the survival competition in the unfavorable and deteriorated eco-environment. On the basis of experimental results and natural environment of Xiamen waters and by making reference to the critical criteria of shellfish toxins in various states, a prewarning value 1×105 cells per cubic decimetre of A. tamarense PSP toxicity was proposed for the areas in South China where red tides frequently occur. | JI Weidong ZHOU Qiulin HUO Wenmian CHEN Weifen LIN Hui HE Qing CHEN Baohong LIANG Junrong GAO Yahui HUANG Deqiang LI Yang | 2007 | Acta Oceanologica Sinica2007，26，1： | 0 |
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