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| 1 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 2 | L-amino acid oxidase from Naja atra venom activates and binds to human platelets显示文摘L 氨基的酸 oxidase (LAAO ) , NA-LAAO,从 Naja atra 的毒液被净化。它有从另外的蛇毒液的 LAAO 的 N 终端顺序表演伟人类似。NA-LAAO dose-dependently 导致了洗的人的血小板的聚集。然而,它没在充满血小板的血浆在血小板上举办活动。NA-LAAO 的低集中极大地支持了氢过氧化物的效果,而氢每氧化物本身穿上小激活效果板让。NA-LAAO 包括 Src kinase,怒气酷氨酸 kinase,和 phospholipase C 2 导致了很多血小板蛋白质的酷氨酸 phosphorylation。不同于 convulxin, Fc 受体链和 T 淋巴细胞改编者蛋白质不是在 NA-LAAO-activated 血小板的 phosphorylated,建议与 glycoprotein VI 小径不同的激活机制。过氧化氢酶禁止了 NA-LAAO 导致的血小板聚集和血小板蛋白质 phosphorylation。NA-LAAO 跳了到固定血小板以及到西方的污点的血小板 lysates。而且, NA-LAAO-Sepharose 4B 列上的血小板蛋白质的亲密关系层析孤立一些血小板膜蛋白质,建议到血小板膜的 NA-LAAO 的那绑定可能起在它血小板上的行动的一个作用。 | Rui Li Shaowen Zhu Jianbo Wu Wanyu Wang Qiumin Lu Kenneth J. Clemetson | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 2 |
| 3 | Double Plasma Molecular Adsorption System with Sequential Low-dose Plasma Exchange in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure:A Prospective Study显示文摘Background and Aims:To investigate the safety and efficacy of double plasma molecular adsorption system(DPMAS)with sequential low-dose plasma exchange(LPE)in treating early hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).Methods:Clinical data of patients with HBVACLF were prospectively collected,including patients in a DPMAS with sequential LPE(DPMAS+LPE)group and those in a standard medical treatment(SMT)group.The primary endpoint was death or liver transplantation(LT)at 12 weeks of follow-up.Propensity-score matching was performed to control the effects of confounding factors on prognosis between the two groups.Results:After 2 weeks,total bilirubin,alanine aminotransferase,blood urea nitrogen levels,and Chinese Group on the Study of Severe Hepatitis B score,were significantly lower in the DPMAS+LPE group than those in the SMT group(p<0.05).After 4 weeks,laboratory parameters of the two groups were similar.The cumulative survival rate of the DPMAS+LPE group was significantly higher than that of the SMT group at 4 weeks(97.9%vs.85.4%,p=0.027),but not at 12 weeks(85.4%vs.83.3%,p=0.687).Cytokine levels were significantly lower in 12-week survival group than in the death-or-LT group(p<0.05).Functional enrichment analysis showed that downregulated cytokines were mainly involved in positive regulation of proliferation and activation of lymphocytes and monocytes,regulation of immune effect response,regulation of endotoxin response,and glial cell proliferation.Conclusion:DPMAS+LPE significantly improved the 4-week cumulative survival rate,and ameliorated the inflammatory response in patients.DPMAS+LPE may be a promising modality for patients with early HBV-ACLF. | Lu Wang Wenxiong Xu Shu Zhu Guoli Lin Jing Lai Yufeng Zhang Ying Liu Lihua Zheng Qiumin Luo Zhiliang Gao Chan Xie Liang Peng | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 1 |
| 4 | Lithium improves memory by decreasing A-beta production and tau phosphorylation in rats chronically exposed to aluminum显示文摘Objective: To investigate the effects of lithium on cognitive function and metabolism of Amyloid-beta Protein Precursor (APP) and tau phosphorylation in rats chronically exposed to aluminum. Methods: Twenty-four chronically aluminum-exposed rats were randomly divided into 2 groups: a lithium-treatment group and a non-treatment group (n=12 per group). Lithium chloride was administered to the lithium-treatment group via gastric gavage daily for 6 weeks (200 mg/kg·d LiCl), while the non-treatment group was administered the same volume of sodium chloride by the same means. An additional control group (n=12) received no intervention. Memory function was evaluated by the Morris water maze test. Aβ was measured by immunohistochemical staining, while total APP, phosphorylated-tau protein, CDK5 and PP2A were determined by Western Blotting. Results: (1) Compared to the non-treatment group, the lithium-treatment group had a significantly shorter mean escape latency and a lower proportion of random navigation pattern in the spatial probe test (P<0.05). After the platform was taken away, the rats in the lithium-treatment group crossed the platform quadrant significantly more and stayed longer in the platform quadrant than those in the non-treatment group (P<0.05). (2) The number of Aβ positive neurons in the hippocampus and cortex was significantly less in the lithium-treatment group than in the non-treatment group (P<0.05), but the content of APP was not different between groups (P=0.730). (3) Phosphorylation of tau protein decreased significantly in the lithium-treatment group than that in the non-treatment group (P<0.05). The content of CDK5 in the lithium-treatment group was significantly less than that in the non-treatment group in the cortex and hippocampus, while there was no difference in the content of PP2A between the 2 groups. The expression of CDK5 was significantly correlated with phosphorylated tau (r=0.871, P=0.024) in the lithium-treatment group. Conclusion: Lithium may improve memory function in rats chronically exposed to aluminum by decreasing both the production of Aβ and tau phosphorylation, with the latter results from inhibiting expression of CDK5. | Cao Hongmei Qu Qiumin Lu Wenhui Kang Li Yang Xiaobo | 2009 | Journal of Medical Colleges of PLA(China)2009，24，6： | 0 |
| 5 | SWVM:a light-weighted virtualization platform based on Sunway CPU architecture显示文摘Dear editor,The national-dominated Sunway CPU architecture[1-3]is now becoming mature in supporting professional application areas from large-scale numeric computing in supercomputer to maintaining online services in the network. | Jianguo YAO Qiumin LU Xingyan WANG Chao WANG Hanyang MA Haibing GUAN | 2022 | Science China(Information Sciences)2022，65，6： | 0 |
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