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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Adsorption of uranium(Ⅵ) onto amidoxime-functionalized ultrahigh molecular weight polyethylene fibers from aqueous solution显示文摘Amidoxime-functionalized ultra-high molecular weight polyethylene fibers(UHMWPEF-AO) were used to absorb uranium U(VI) from aqueous solutions.In this paper,we study effects of pH,initial U(VI) concentration,contact time,and temperature on U(VI) adsorption by UHMWPEF-AO.The adsorption process agrees well with pseudo-second-order and Langmuir model.UHMWPEFAO exhibits excellent adsorptive performance for U(VI)with a maximum adsorption capacity of 176.12 mg/g at pH4 and 298 K.The structures of UHMWPEF-AO and U(VI)-loaded UHMWPEF-AO are characterized by FT-IR and nano-CT.U(VI)-loaded UHMWPEF-AO is sintered after adsorption process to recycle absorbed U(VI).Powders collected after sintering process are examined by scanning electron microscopy and X-ray diffraction.These results indicate that UHMWPEF-AO is a promising candidate to remove U(VI) from uranium aqueous solutions. | Chun-Yu Xie Shi-Pei Jing Yu Wang Xiao Lin Hong-Liang Bao Cheng-Zhi Guan Chan Jin Jian-Qiang Wang | 2017 | Nuclear Science and Techniques2017，28，7： | 3 |
| 3 | Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions显示文摘 | Sang Hoon Ahn Henry L. Y. Chan Pei-Jer Chen Jun Cheng Mahesh K. Goenka Jinlin Hou Seng Gee Lim Masao Omata Teerha Piratvisuth Qing Xie Hyung Joon Yim Man-Fung Yuen | 2010 | Hepatology International2010，，1： | 3 |
| 4 | Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism显示文摘 | Yuping Chen Steve S. Choi Gregory A. Michelotti Isaac S. Chan Marzena Swiderska-Syn Gamze F. Karaca Guanhua Xie Cynthia A. Moylan Francesca Garibaldi Richard Premont Hagir B. Suliman Claude A. Piantadosi Anna Mae Diehl | 2012 | Gastroenterology2012，，5： | 2 |
| 5 | Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells显示文摘Background and Aims:The safety and efficacy of mesenchymal stem cells(MSCs)in the treatment of acute-onchronic liver failure(ACLF)have been validated.However,the impact of the pathological ACLF microenvironment on MSCs is less well understood.This study was designed to explore the changes in the functional properties of MSCs exposed to ACLF serum.Methods:MSCs were cultured in the presence of 10%,30%and 50%serum concentrations from ACLF patients and healthy volunteers.Then,the cell morphology,phenotype,apoptosis and proliferation of MSCs were evaluated,including the immunosuppressive effects.Subsequently,mRNA sequencing analysis was used to identify the molecules and pathways involved in MSC functional changes in the context of ACLF.Results:In the presence of ACLF serum,MSC morphology significantly changed but phenotype did not.Besides,MSC proliferation activity was weakened,while the apoptosis rate was lightly increased.Most importantly,the immunosuppressive function of MSCs was enhanced in a lowconcentration serum environment but transformed into a proinflammatory response in a high-concentration serum environment.RNA sequencing indicated that 10%serum concentration from ACLF patients mediated the PI3K-Akt pathway to enhance the anti-inflammatory effect of MSCs,while the 50%serum concentration from ACLF patients promoted the conversion of MSCs into a proinflammatory function by affecting the cell cycle.Conclusions:The 50%ACLF serum concentration is more similar to the environment in the human body,which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of transplantation.Combining treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect. | Yongyuan Zheng Shu Zhu Xingrong Zheng Wenxiong Xu Xuejun Li Jianguo Li Zhiliang Gao Chan Xie Liang Peng | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 6 | Establishment of Hamster-and Human-PRNP Transgenic Mice显示文摘Objective To create transgenic mice expressing hamster‐ and human‐PRNP as a model for understanding the physiological function and pathology of prion protein (PrP),as well as the mechanism of cross‐species transmission of transmissible spongiform encephalopathies (TSEs).Methods Hamster and human‐PRNP transgenic mice were established by conventional methods.The copy number of integrated PRNP in various mouse lines was mapped by real‐time PCR.PRNP mRNA and protein levels were determined by semi‐quantitative RT‐PCR,real‐time RT‐PCR,and western blot analysis.Histological analyses of transgenic mice were performed by hematoxylin and eosin (H & E) staining and immunohistochemical (IHC) methods.Results Integrated PRNP copy number in various mouse lines was 53 (Tg‐haPrP1),18 (Tg‐huPrP1),3 (Tg‐huPrP2),and 16 (Tg‐huPrP5),respectively.Exogenous PrPs were expressed at both the transcriptional and translational level.Histological assays did not detect any abnormalities in brain or other organs.Conclusion We have established one hamster‐PRNP transgenic mouse line and three human‐PRNP transgenic mouse lines.These four transgenic mouse lines provide ideal models for additional research. | GONG Han Shi TIAN Chan ZHANG Bao Yun WANG Zhao Yun XIE Wu Ling JING Yuan Yuan GAO Chen JIANG Hui Ying SHI Qi LIU Yong DONG Xiao Ping | 2011 | Biomedical and Environmental Sciences2011，24，6： | 2 |
| 7 | Imbalance of interleukin‐17‐producing CD 4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus‐related acute‐on‐chronic liver failure显示文摘 | Geng‐Lin Zhang Dong‐Ying Xie Bing‐Liang Lin Chan Xie Yi‐Nong Ye Liang Peng Shao‐Quan Zhang Yu‐Feng Zhang Qing Lai Jian‐Yun Zhu Ying Zhang Yang‐Su Huang Zhao‐Xia Hu Zhi‐Liang Gao | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 8 | Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson’s disease in Chinese: An independent pathogenic role显示文摘 | Chaodong Wang Huili Ma Xiuli Feng Shu Xie Piu Chan | 2010 | Brain Research2010，，： | 2 |
| 9 | Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation显示文摘 | Chuan-Ming Xie Wood Yee Chan Sidney Yu Jun Zhao Christopher H.K. Cheng | 2011 | Free Radical Biology and Medicine2011，，7： | 2 |
| 10 | CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients显示文摘 | Chen Leilei Chan Tim Hon Man Yuan Yun-Fei Hu Liang Huang Jun Ma Stephanie Wang Jian Dong Sui-Sui Tang Kwan Ho Xie Dan Li Yan Guan Xin-Yuan | 2010 | Journal of Clinical Investigation2010，，4： | 2 |
| 11 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 12 | Quality control of herbal medicines显示文摘 | LIANG Yi-zeng XIE Pei-shan CHAN K | 2004 | Journal of Chromatography B2004，812，12： | 1 |
| 13 | A Multiple-Model Prediction Approach for Sea Clutter Modeling显示文摘 | Xie N Leung H Chan H | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，6： | 1 |
| 14 | Quality control of herbal medi- cines显示文摘 | Liang YZ Xie PS Chan K | 2004 | J Chromatogr B2004，812，： | 1 |
| 15 | UV laser micromachining of piezoelectric ceramic using a pulsed Nd:YAG laser显示文摘 | D.W. Zeng K. Li K.C. Yung H.L.W. Chan C.L. Choy C.S. Xie | 2004 | Applied Physics A2004，，3： | 1 |
| 16 | RNA silencing genes control de novo DNA methylation显示文摘 | Chan SW Zilberman D Xie Z | 2004 | Science2004，303，5662： | 1 |
| 17 | Distributed and dynamic mobility management in mobile internet: current approaches and issues显示文摘 | Chan H A Yokota H Xie J | 2011 | Journal of Communications2011，6，1： | 1 |
| 18 | Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage显示文摘 | Lo PH Xie D Chan KC | 2007 | Cancer Lett2007，257，2： | 1 |
| 19 | Reduced expression of RASSF1Ain esophageal and nasopharyngeal carcinomas significantlycorrelates with tumor stage显示文摘 | Lo PH Xie D Chan KC | 2007 | Cancer Lett2007，257，2： | 1 |
| 20 | Perspective of chemical fingerprint- ing of Chinese herbs显示文摘 | Liang YZ Xie PS Chan K | 2010 | Planta Med2010，76，17： | 1 |
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