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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Manipulating mRNA splicing by base editing in plants显示文摘Precursor-mRNAs(pre-mRNA) can be processed into one or more mature m RNA isoforms through constitutive or alternative splicing pathways. Constitutive splicing of pre-mRNA plays critical roles in gene expressional regulation, such as intronmediated enhancement(IME), whereas alternative splicing(AS) dramatically increases the protein diversity and gene functional regulation. However, the unavailability of mutants for individual spliced isoforms in plants has been a major limitation in studying the function of mRNA splicing. Here, we describe an efficient tool for manipulating the splicing of plant genes. Using a Cas9-directed base editor, we converted the 5′ splice sites in four Arabidopsis genes from the activated GT form to the inactive AT form. Silencing the AS of HAB 1.1(encoding a type 2 C phosphatase) validated its function in abscisic acid signaling, while perturbing the AS of RS31 A revealed its functional involvement in plant response to genotoxic treatment for the first time. Lastly,altering the constitutive splicing of Act2 via base editing facilitated the analysis of IME. This strategy provides an efficient tool for investigating the function and regulation of gene splicing in plants and other eukaryotes. | Chenxiao Xue Huawei Zhang Qiupeng Lin Rong Fan Caixia Gao | 2018 | Science China(Life Sciences)2018，61，11： | 18 |
| 3 | Three-dimensional Evolutionary Models of the Qiongxi Structures,Southwestern Sichuan Basin,China:Evidence from Seismic Interpretation and Geomorphology显示文摘褶层结束是在有压缩性的差错相关的褶层的学习的特色。如此的结束能由于戳差错上的排水量的损失或 / 并且形成一个侧面或倾斜的斜面。因此,高质量的地震数据将明白地帮助定义哪个机制应该为给定的差错相关的褶层的结束负责。在四川盆的 Qiongxi 和 Qiongxinan 结构,中国是拥有在他们之间的北结束和结构的僵绳的自然差错繁殖褶层的例子。合拢 / 指责几何学和沿着罢工排水量变化被工业 3-D 抑制地震体积。我们解释北结束和结构的僵绳附近的褶层的 plunge 由于排水量的损失罢工。与北结束联系的差错几何学变化从一在 Qiongxinan 结构的冠扁平斜面在排水量最大的地方,到简单地 Qiongxi 结构的北尖端附近的一个斜面,没有形成一个侧面或倾斜的斜面。在这研究,我们也使用排水模式,在沿着一个差错的排水量与推进为 Qiongxinan 的侧面的繁殖建议一个模型的持续时间成正比的 Qiongxinan 结构和假设的冠保存的胚胎的结构和 Qiongxi 结构。明确地,我们建议结构首先在易碎的单位以内作为一个孤立的差错斜面开始了。与弄短增加,差错变得以更弱的页岩单位与更低的分队连接创造 hybridized 差错繁殖褶层。我们的模型为 Qiongxinan 和 Qiongxi 结构的侧面的繁殖历史建议可能的解释,并且也提供一条其他的途径给在迟了的新生代在西南的四川盆证实以前的 Pingluoba 结构的活动。 | JIA Qiupeng JIA Dong LUO Liang CHEN Zhuxin LI Yiquan DENG Fei SUN Shengsi LI Haibin | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 17 |
| 4 | Magnetic fabrics in fault-related fold and its relation with finite strain: an example from Mingjiang thrust structures in Western Sichuan显示文摘磁性的危险性(AMS ) 的 anisotropy 是过去常测量微弱地使变形的沉积岩石的一种快、有效、敏感的技术,并且另外揭示差错相关的褶层的使变形的机制的一个可靠方法。在 Longmenshan 前面带,差错相关的褶层的一张典型剖面图被选择学习 AMS。224 个面向的标本的一个总数在在在 Xujiahe 形成开发的这结构的节的关键结构的位置分布式的 23 个不同采样地点被钻了上面三叠纪。磁性的织物的六种基本类型被认出并且通过这证实 AMS 们学习:1 ) 一件沉积织物;2 ) 一件起始的变丑织物;3 ) 一件铅笔结构织物;4 ) 一件弱劈开织物;5 ) 一件强壮的劈开织物;6 ) 一件拉长的线条织物。大多数磁性的织物被属于弄短的预先合拢的层平行(LPS ) 的纯砍结果的弱变丑的织物描绘,这被发现了。在差错拐弯褶层,几乎所有磁性的织物是弱变丑的起始的变丑织物,并且表示在前肢的变丑在背手足和没有有限紧张是比那强壮的,这在矿脉基卒下盘被显示出。当时在差错繁殖褶层,有限紧张在磁性的织物结果与运动学的模型的估计的后果近似一致的 trishear 地区被集中。磁性的织物显示的构造压力地是基本上沿着整个结构的节和表演的一样 NW 到 SE 压缩并且弄短它与 Longmenshan 褶层戳带的地区性的压缩压力地是一致的。 | Jia Dong Chen Zhuxin Luo Liang Hu Qianwei Jia Qiupeng | 2007 | Progress in Natural Science:Materials International2007，17，5： | 7 |
| 5 | Genome editing in plants with MAD7 nuclease显示文摘MAD7 is an engineered nuclease of the Class 2 type V-A CRISPR-Cas(Cas12 a/Cpf1)family with a low level of homology to canonical Cas12 a nucleases.It has been publicly released as a royalty-free nuclease for both academic and commercial use.Here,we demonstrate that the CRISPR-MAD7 system can be used for genome editing and recognizes T-rich PAM sequences(YTTN)in plants.Its editing efficiency in rice and wheat is comparable to that of the widely used CRISPR-Lb Cas12 a system.We develop two variants,MAD7-RR and MAD7-RVR that increase the target range of MAD7,as well as an M-AFID(a MAD7-APOBEC fusion-induced deletion)system that creates predictable deletions from 50-deaminated Cs to the MAD7-cleavage site.Moreover,we show that MAD7 can be used for multiplex gene editing and that it is effective in generating indels when combined with other CRISPR RNA orthologs.Using the CRISPR-MAD7 system,we have obtained regenerated mutant rice and wheat plants with up to 65.6%efficiency. | Qiupeng Lin Zixu Zhu Guanwen Liu Chao Sun Dexing Lin Chenxiao Xue Shengnan Li Dandan Zhang Caixia Gao Yanpeng Wang Jin-Long Qiu | 2021 | Journal of Genetics and Genomics2021，48，6： | 4 |
| 6 | Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis显示文摘 | Yunlei Cao Jianhua Xu Zhaofeng Zhang Xianliang Huang Aiping Zhang Jian Wang Qiupeng Zheng Lingyuan Fu Jing Du | 2013 | Gene2013，，2： | 1 |
| 7 | Quantized consensus over directed networks with switching topologies显示文摘 | Dequan Li Qiupeng Liu Xiaofan Wang Zhixiang Yin | 2013 | Systems & Control Letters2013，，： | 1 |
| 8 | Effect of the air pollution on atmospheric visibility in Beijing-Tianjin area显示文摘Simultaneous measurements of air pollutant concentrations and atmospheric visibility were made in Beijing and Tianjin areas in 1983-1985. The relationship between air pollution and visibility was studied. It was found that atmospheric particulates have the most high contribution to visibility decreasing. The percentages of contributions of sulfates and soot are 52-58% and 22-29% respectively. According to the results, we suggest that the emission of SO2 and particulates must be controlled in order to improve the atmospheric visibility. | Su Weihan, Zhang Qiupeng, Song Wenzhi, Luo Chao and Yuan Jiwen1 Research Center for Eco-Environmental Sciences,Academia Sinica,P.O.Box 934,beijing 100083,China2 Tianjin Environmental Monitoring Center,Tianjin,China. | 1990 | Journal of Environmental Sciences1990，2，1： | 0 |
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