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| 1 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 2 | An Ultra‑Durable Windmill‑Like Hybrid Nanogenerator for Steady and Efficient Harvesting of Low‑Speed Wind Energy显示文摘Wind energy is one of the most promising and renewable energy sources;however,owing to the limitations of device structures,collecting low-speed wind energy by triboelectric nanogenerators(TENGs)is still a huge challenge.To solve this problem,an ultra-durable and highly efficient windmill-like hybrid nanogenerator(W-HNG)is developed.Herein,the W-HNG composes coupled TENG and electromagnetic generator(EMG)and adopts a rotational contact-separation mode.This unique design efficiently avoids the wear of friction materials and ensures a prolonged service life.Moreover,the generator group is separated from the wind-driven part,which successfully prevents rotation resistance induced by the friction between rotor and stator in the conventional structures,and realizes low-speed wind energy harvesting.Additionally,the output characteristics of TENG can be complementary to the different performance advantages of EMG to achieve a satisfactory power production.The device is successfully driven when the wind speed is 1.8 m s−1,and the output power of TENG and EMG can achieve 0.95 and 3.7 mW,respectively.After power management,the W-HNG has been successfully applied as a power source for electronic devices.This work provides a simple,reliable,and durable device for improved performance toward large-scale low-speed breeze energy harvesting. | Ying Zhang Qixuan Zeng Yan Wu Jun Wu Songlei Yuan Dujuan Tan Chenguo Hu Xue Wang | 2020 | Nano-Micro Letters2020，12，12： | 6 |
| 3 | Biochar-based Solid Acids as Catalysts for Carbohydrate Hydrolysis: A Critical Review显示文摘Recently, increasing interest has been focused on the hydrolysis of carbohydrates to monosaccharides, among which, glucose and xylose as typical platform sugars can be used to produce chemicals and biofuels. As heterogeneous catalysts, solid acids have gained extensive attention for biomass biorefinery and could replace the conventional process owing to their excellent properties, including acceptable acidity and easy separation. In particular, biochar-based solid acids derived from biomass are promising for biomass conversion owing to the low-cost of feedstocks and the simple preparation procedure. Herein, we attempt to provide a critical overview of biochar-based solid acids for hydrolysis of carbohydrates into glucose and xylose. The preparation methods and properties of biochar-based catalysts as well as the influence of their properties on catalytic performance were discussed in detail. We also highlight the major challenges facing the use of biochar-based solid acids for carbohydrate hydrolysis. | XiaoHui Wang QiXuan Lin YuHuan Yan BangGui Cheng Tao Song JunLi Ren | 2018 | Paper And Biomaterials2018，3，2： | 2 |
| 4 | Fast co-pyrolysis of coal and biomass in a fluidized-bed reactor显示文摘 | WANG Jianfei YAN Qixuan ZHAO Jiantao | 2014 | Journal of Thermal Analysis and Calorimetry2014，118，3： | 1 |
| 5 | Single-atomic-site iron on N-doped carbon for chemoselective reduction of nitroarenes显示文摘A facile,gram-scale and sustainable approach has been established for the synthesis of single-atomic-site iron on N-doped carbon(Fe_(SA)@NC-20A)via the pyrolysis of aniline modified FeZn-ZIFs,in which the synthesis of zeolitic imidazolate frameworks(ZIFs)can be accomplished in water at room temperature,and no acid etching is required.The as-synthesized catalyst exhibits better performance on the chemoselective hydrogenation of nitroarenes with a broad substrate scope(turnover frequency(TOF)up to 1,727 h^(-1),23 examples)than most of previously reported works.Based on high-angle annular dark field scanning transmission microscopy(HAADF-STEM)images in combination with X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),electron spin resonance(ESR),and Mossbauer spectroscopy,Fe is dispersed as single atoms via forming FeNx(x=4-6).This work not only determines the active sites of FesA@NC-20A for hydrogenation(FeN4),but also proposes tentative pathways for both N-H activation of hydrazine and the reduction of nitroarene on FeN4 site,both of which are the key steps for the hydrogenation of nitroarenes.In addition,this catalyst shows excellent stability,and no significant activity degradation is observed when recycling for 10 times or restoring in air for 2 months. | Guoping Lu Kangkang Sun Yamei Lin Qixuan Du Jiawei Zhang Kui Wang Pengcheng Wang | 2022 | Nano Research2022，15，1： | 1 |
| 6 | Current Status and Analysis of Machine Learning in Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma(HCC)is a common tumor.Although the diagnosis and treatment of HCC have made great progress,the overall prognosis remains poor.As the core component of artificial intelligence,machine learning(ML)has developed rapidly in the past decade.In particular,ML has become widely used in the medical field,and it has helped in the diagnosis and treatment of cancer.Different algorithms of ML have different roles in diagnosis,treatment,and prognosis.This article reviews recent research,explains the application of different ML models in HCC,and provides suggestions for follow-up research. | Sijia Feng Jianhua Wang Liheng Wang Qixuan Qiu Dongdong Chen Huo Su Xiaoli Li Yao Xiao Chiayen Lin | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 1 |
| 7 | Inverse design and realization of an optical cavity-based displacement transducer with arbitrary responses显示文摘Optical cavity has long been critical for a variety of applications ranging from precise measurement to spectral analysis.A number of theories and methods have been successful in describing the optical response of a stratified optical cavity,while the inverse problem,especially the inverse design of a displacement sensitive cavity,remains a significant challenge due to the cost of computation and comprehensive performance requirements.This paper reports a novel inverse design methodology combining the characteristic matrix method,mixed-discrete variables optimization algorithm,and Monte Carlo method-based tolerance analysis.The material characteristics are indexed to enable the mixed-discrete variables optimization,which yields considerable speed and efficiency improvements.This method allows arbitrary response adjustment with technical feasibility and gives a glimpse into the analytical characterization of the optical response.Two entirely different light-displacement responses,including an asymmetric sawtooth-like response and a highly symmetric response,are dug out and experimentally achieved,which fully confirms the validity of the method.The compact Fabry-Perot cavities have a good balance between performance and feasibility,making them promising candidates for displacement transducers.More importantly,the proposed inverse design paves the way for a universal design of optical cavities,or even nanophotonic devices. | Qianbo Lu Qingxiong Xiao Chengxiu Liu Yinan Wang Qixuan Zhu Manzhang Xu Xuewen Wang Xiaoxu Wang Wei Huang | 2023 | Opto-Electronic Advances2023，6，3： | 0 |
| 8 | In situ surface-confined fabrication of single atomic Fe-N_(4) on N-doped carbon nanoleaves for oxygen reduction reaction显示文摘Controllable fabrication of Fe-N-C based single-atom catalysts(SACs)for enhanced electrocatalytic performance is highly desirable but still challenging.Here,an in situ surface-confined strategy was demonstrated for the synthesis of single atomic Fe-N_(4))on N-doped carbon nanoleaves(L-FeNC).The in situ generated Zn3[Fe(CN)6]2 could not only serve as a protection layer against collapse of nanoleaves but also provide abundant Fe source for the formation of Fe-N moieties during pyrolysis,leading to high surface area and high graphitization degree of L-FeNC simultaneously.Benefiting from abundant Fe-N_(4))active sites,enhanced mass and charge transfer,the as-prepared L-FeNC manifested a half-wave potential of 0.89 V for oxygen reduction reaction(ORR)in 0.1 M KOH.A maximum power density of 140 m W cm^(-2)and stable discharge voltage even after operation for 50,000 s have been demonstrated when the L-FeNC was used as air cathode for Zn-air battery.This work not only provided a unique surfaceconfined strategy for the synthesis of two-dimensional nanocarbons,but also demonstrated the significant benefit from rational design and engineering of Fe-N-C SACs,thus offering great opportunities for fabrication of efficient energy conversion and storage devices. | Xiaojing Jiang Jianian Chen Fenglei Lyu Chen Cheng Qixuan Zhong Xuchun Wang Ayaz Mahsud Liang Zhang Qiao Zhang | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 9 | Triethylamine-catalyzed Isomerization of Glucose to Fructose under Low Temperature Conditions in Aqueous Phase显示文摘Isomerization of glucose derived from lignocellulosic biomass is an important step in biorefinery.Fructose isomerized from glucose,is used as a highly attractive sweetener in the food and beverages industries.However,the prevalence of side reactions at high glucose concentrations is a serious issue,leading to a significant reduction in the fructose yield,especially in the aqueous phase.In this study,an efficient method for the conversion of highly concentrated glucose into fructose under low temperature conditions using triethylamine as the catalyst was developed.It was demonstrated that high fructose yield could be maintained at high glucose concentration.At 60℃,fructose yield of 38.7%and fructose selectivity of 80.6%were achieved in 1 mol/L(approximately 17 wt%)glucose.When glucose concentration was increased to 2 mol/L(approximately 31 wt%),the fructose yield and selectivity were maintained at 34.7%and 77.4%,respectively.13C nuclear magnetic resonance(NMR)spectrometer was used to examine the glucose isomerization reaction.Compared to the NaOH catalytic system,triethylamine acted as a buffer to provide a stable alkaline environment for the catalytic system,further maintaining a high level of catalytic efficiency for the isomerization of glucose to fructose. | Xiao Zhang Banggui Cheng Qixuan Lin Xiaohui Wang Rui Li Junli Ren | 2020 | Paper And Biomaterials2020，5，4： | 0 |
| 10 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 11 | Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy显示文摘Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment. | Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin | 2023 | Cancer Biology & Medicine2023，20，4： | 0 |
| 12 | Dealuminated Hβ zeolite for selective conversion of fructose to furfural and formic acid显示文摘The fructose-to-furfural transformation is facing major challenges in the selectivity and high efficiency. Herein, we have developed a simple and effective approach for the selective conversion of fructose to furfural using Hβ zeolite modified by organic acids for dealuminization to regulate its textural and acidic properties. It was found that citric acid-dealuminized Hβ zeolite possessed high specific surface areas, wide channels and high Brønsted acid amount, which facilitated the selective conversion of fructose to furfural with a maximum yield of 76.2% at433 K for 1 h in the γ-butyrolactone(GBL)-H_(2)O system, as well as the concomitant formation of 83.0% formic acid. The^(13)C-isotope labelling experiments and the mechanism revealed that the selective cleavage of C1–C2 or C5–C6 bond on fructose was firstly occurred to form pentose or C5 intermediate by weak Brønsted acid, which was then dehydrated to furfural by strong Brønsted acid. Also this dealuminized Hβ catalyst showed the great recycling performance and was active for the conversion of glucose and mannose. | Rui Li Qixuan Lin Junli Ren Xiaobao Yang Yingxiong Wang Lingzhao Kong | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 13 | Anti-Overturning Fully Symmetrical Triboelectric Nanogenerator Based on an Elliptic Cylindrical Structure for All-Weather Blue Energy Harvesting显示文摘Triboelectric nanogenerators(TENGs) have shown promising potential for large-scale blue energy harvesting. However, the lack of reasonable designs has largely hindered TENG from harvesting energy from both rough and tranquil seas. Herein, a fully symmetrical triboelectric nanogenerator based on an elliptical cylindrical structure(EC-TENG) is proposed for all-weather blue energy harvesting. The novel elliptical cylindrical shell provides a unique selfstability, high sensitivity to wave triggering, and most importantly, an anti-overturning capability for the EC-TENG. Moreover, benefiting from its internal symmetrical design, the EC-TENG can produce energy normally, even if it was overturned under a rude oscillation in the rough seas, which distinguishes this work from previous reported TENGs. The working mechanism and output performance are systematically studied. The as-fabricated EC-TENG is capable of lighting 400 light-emitting diodes and driving small electronics. More than that, an automatic monitoring system powered by the EC-TENG can also monitor the water level in real-time and provide an alarm if necessary. This work presents an innovative and reliable approach toward all-weather wave energy harvesting in actual marine environments. | Dujuan Tan Qixuan Zeng Xue Wang Songlei Yuan Yanlin Luo Xiaofang Zhang Liming Tan Chenguo Hu Guanlin Liu | 2022 | Nano-Micro Letters2022，14，7： | 0 |
| 14 | Focus on perovskite emitters in blue light-emitting diodes显示文摘Blue perovskite light-emitting diodes(PeLEDs)are essential in pixels of perovskite displays,while their progress lags far behind their red and green counterparts.Here,we focus on recent advances of blue PeLEDs and systematically review the noteworthy strategies,which are categorized into compositional engineering,dimensional control,and size confinement,on optimizing microstructures,energy landscapes,and charge behaviors of wide-bandgap perovskite emitters(bandgap>2.5 eV).Moreover,the stability of perovskite blue emitters and related devices is discussed.In the end,we propose a technical roadmap for the fabrication of state-of-the-art blue PeLEDs to chase and achieve comparable performance with the other two primary-color devices. | Xiaoyu Yang Li Ma Maotao Yu Hao-Hsin Chen Yongqiang Ji An Hu Qixuan Zhong Xiaohan Jia Yanju Wang Yuzhuo Zhang Rui Zhu Xinqiang Wang Changjun Lu | 2023 | Light(Science & Applications)2023，12，8： | 0 |
| 15 | Biodegradable Materials as Nanocarriers for Drugs and Nutrients显示文摘Several important drugs and nutritional supplements are limited by their lack of bioavailability.Nanomaterials display unique beneficial properties that might help improve the bioavailability of drugs and nutritional supplements.Unfortunately,nanomaterials produced from synthetic polymers and metals may have similar difficulties with bioavailability and toxicity.Naturally occurring biopolymers are biodegradable and non-toxic and are adaptable to the synthesis of nanoparticles.Drugs and other substances can be encapsulated or embedded in such particles with an increase in bioavailability.The search for biodegradable nanomaterials is an active research field.This review summarizes the research on nanocrystalline cellulose,starch,lignin,and other biological and environment-friendly nanocomposites which are commonly used as nanocarriers for drugs and nutrients.Further,prospects for the use of biodegradable nanomaterials in targeted therapy,including environmentally responsive therapy,are discussed. | Xingran Kou Qixuan Zhao Wenwen Xu Zuobing Xiao Yunwei Niu Kai Wang | 2021 | Journal of Renewable Materials2021，9，7： | 0 |
| 16 | Synergistic combination of Pd nanosheets and porous Bi(OH)_(3) boosts activity and durability for ethanol oxidation reaction显示文摘Highly active and durable Pd-based electrocatalysts for ethanol oxidation reaction(EOR)play a crucial role in the commercialization of direct ethanol fuel cells(DEFCs).However,the poisonous intermediates(especially adsorbed CO species(COad))formed during the EOR process can easily adsorb and block the active sites on Pd electrodes,which in turn limits the catalytic efficiency.Hence,we present a series of Pd-based composites with a strong coupling interface consisting of Pd nanosheets and amorphous Bi(OH)_(3)species.The incorporation of Bi(OH)3 can induce an electron-rich state adjacent to the Pd sites and effectively separate the Pd ensemble,leading to excellent CO tolerance.The optimal Pd-Bi(OH)_(3)NSs catalyst manifests a mass activity of 2.2 A·mgPd^(-1),which is 5.7 and 2.0 times higher than that of Pd NSs and commercial Pd/C catalyst,respectively.Further CO-stripping experiments and CO-DRIFTS tests confirm the excellent CO tolerance on Pd-Bi(OH)3 NSs electrode,leading to the enhanced EOR durability. | Mingyu Chu Jialu Huang Jin Gong Yi Qu Guoling Chen Hu Yang Xuchun Wang Qixuan Zhong Chengwei Deng Muhan Cao Jinxing Chen Xiaolei Yuan Qiao Zhang | 2022 | Nano Research2022，15，5： | 0 |
| 17 | N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways显示文摘Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases.However,there is a lack of effective drugs to treat neuroinflammation.N-acetyldopamine dimer(NADD)is a natural compound from the traditional Chinese medicine Isaria cicada.In our previous study,we found that NADD can attenuate DSS-induced ulcerative colitis by suppressing the NF-κB and MAPK pathways.Does NADD inhibit neuroinflammation,and what is the target of NADD?To answer this question,lipopolysaccharide(LPS)-stimulated BV-2 microglia was used as a cell model to investigate the effect of NADD on neuroinflammation.Nitric oxide(NO)detection,reactive oxygen species(ROS)detection and enzyme-linked immunosorbent assay(ELISA)results show that NADD attenuates inflammatory signals and proinflammatory cytokines in LPS-stimulated BV-2 microglia,including NO,ROS,tumor necrosis factor(TNF)-α,interleukin(IL)-1βand interleukin-6(IL-6).Western blot analysis show that NADD inhibits the protein levels of Toll-like receptor 4(TLR4),nuclear factor kappa-B(NF-κB),NOD-like receptor thermal protein domain associated protein 3(NLRP3),ASC and cysteinyl aspartate specific proteinase(Caspase)-1,indicating that NADD may inhibit neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 signaling pathways.In addition,surface plasmon resonance assays and molecular docking demonstrate that NADD binds with TLR4 directly.Our study reveals a new role of NADD in inhibiting the TLR4/NF-κB and NLRP3/Caspase-1 pathways,and shows that TLR4-MD2 is the direct target of NADD,which may provide a potential therapeutic candidate for the treatment of neuroinflammation. | Lijun Huang Leiqiang Gong Xueyan Huo Lirong Lei Qi Zhang Yunjie Hu Qixuan Kuang Yu Gui Yifei Dai Yucheng Gu Yun Deng Dong Wang Dale Guo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 18 | Triple-Columned and Multiple-Layered 3D Polymers:Design,Synthesis,Aggregation-Induced Emission(AIE),and Computational Study显示文摘Conjugated polymers and oligomers have great potentials in various fields,especially in materials and biological sciences because of their intriguing electronic and optoelectronic properties.In recent years,the through-space conjugation system has emerged as a new assembled pattern of multidimensional polymers.Here,a novel series of structurally condensed multicolumn/multilayer 3D polymers and oligomers have been designed and synthesized through one-pot Suzuki polycondensation(SPC).The intramolecularly stacked arrangement of polymers can be supported by either X-ray structural analysis or computational analysis.In all cases,polymers were obtained with modest to good yields,as determined by GPC and 1 H-NMR.MALDI-TOF analysis has proven the speculation of the step-growth process of this polymerization.The computational study of ab initio and DFT calculations based on trimer and pentamer models gives details of the structures and the electronic transition.Experimental results of optical and AIE research confirmed by calculation indicates that the present work would facilitate the research and applications in materials. | Guanzhao Wu Yangxue Liu Zhen Yang Liulei Ma Yao Tang Xianliang Zhao Hossein Rouh Qixuan Zheng Peng Zhou Jia-Yin Wang Farhan Siddique Sai Zhang Shengzhou Jin Daniel Unruh Adelia JAAquino Hans Lischka Kristin M.Hutchins Guigen Li | 2021 | Research2021，，1： | 0 |
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