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| 1 | Role of monocytes and macrophages in experimental and human acute liver failure显示文摘Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the pathogenesis of ALF is activation of the immune system with mobilisation of cellular effectors and massive production of cytokines. As key components of the innate immune system, monocytes and macrophages are postulated to play a central role in the initiation, progression and resolution of ALF. ALF in humans follows a rapidly progressive clinical course that poses inherent difficulties in delineating the role of these pivotal immune cells. Therefore, a number of experimental models have been used to study the pathogenesis of ALF. Here we consider the evidence from experimental and human studies of ALF on the role of monocytes and macrophages in acute hepatic injury and the ensuing extrahepatic manifestations, including functional monocyte deactivation and multiple organ failure. | Lucia A Possamai Charalambos Gustav Antoniades Quentin M Anstee Alberto Quaglia Diego Vergani Mark Thursz Julia Wendon | 2010 | World Journal of Gastroenterology2010，16，15： | 12 |
| 2 | Helicobacter pylori:a foodborne pathogen?显示文摘Helicobacter pylori(H. pylori) is an organism that is widespread in the human population and is sometimes responsible for some of the most common chronic clinical disorders of the upper gastrointestinal tract in humans, such as chronic-active gastritis, duodenal and gastric ulcer disease, low-grade B-cell mucosa associated lymphoid tissue lymphoma of the stomach, and gastric adenocarcinoma, which is the third leading cause of cancer death worldwide. The routes of infection have not yet been firmly established, and different routes of transmission have been suggested, although the most commonly accepted hypothesis is that infection takes place through the faecal-oral route and that contaminated water and foods might play an important role in transmission of the microorganism to humans. Furthermore, several authors have considered H. pylori to be a foodborne pathogen because of some of its microbiological and epidemiological characteristics. H. pylori has been detected in drinking water, seawater, vegetables and foods of animal origin. H. pylori survives in complex foodstuffs such as milk, vegetables and ready-to-eat foods. This review article presents an overview of the present knowledge on the microbiological aspects in terms of phenotypic characteristics and growth requirements of H. pylori, focusing on the potential role that foodstuffs and water may play in the transmission of the pathogen to humans and the methods successfully used for the detection of this microorganism in foodstuffs and water. | Nicoletta C Quaglia Angela Dambrosio | 2018 | World Journal of Gastroenterology2018，24，31： | 10 |
| 3 | Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma显示文摘Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. | Ruchi Sharma Abid Suddle Alberto Quaglia Praveen Peddu John Karani Thomas Satyadas | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 7 |
| 4 | Review article: the investigation and management of gastric neuroendocrine tumours显示文摘 | R. Basuroy R. Srirajaskanthan A. Prachalias A. Quaglia J. K. Ramage | 2014 | Aliment Pharmacol Ther2014，，10： | 3 |
| 5 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 6 | High occurrence of Helicobacter pylori in raw goat, sheep and cow milk inferred by glm M gene: A risk of food-borne infection?显示文摘 | N.C. Quaglia A. Dambrosio G. Normanno A. Parisi R. Patrono G. Ranieri A. Rella G.V. Celano | 2008 | International Journal of Food Microbiology2008，，1： | 2 |
| 7 | Transient Elastography Is a Useful Noninvasive Tool for the Evaluation of Fibrosis in Paediatric Chronic Liver Disease显示文摘 | Emer Fitzpatrick Alberto Quaglia Sunitha Vimalesvaran Maria Sole Basso Anil Dhawan | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 2 |
| 8 | Liver resection for the treatment of a congenital intrahepatic portosystemic venous shunt显示文摘Intrahepatic portosystemic shunts(IPSS) are rare congenital anomalies arising from disordered portal vein embryogenesis.It has been described in both children and adults and may be asymptomatic or be associated with a variety of neurophysiological and pulmonary complications.When recognized,early intervention to occlude the shunt will reverse the associated complications.Literature review reports of surgical and radiological occlusion of the shunt,but due to its rarity,a standard therapeutic protocol has not been established.A case of a 38-year-old woman with abdominal pain and low grade encephalopathy,diagnosed with an IPSS and treated by right hepatectomy was reported. | michail papamichail amir ali alberto quaglia john karani nigel heaton | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 2 |
| 9 | Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's disease显示文摘瞄准:在 Crohn 的疾病(CD ) 调查单核白血球的函数病人并且相关这与联系疾病的核苷酸绑定 oligomerization domain-2 (NOD2 ) 基因变体。方法:从 47 个连续地提交的 CD 病人和 9 健康供血者的单核白血球与 interleukin (IL ) 是有教养的 -4 和 granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) ,并且与脂肪的多糖(LPS ) 或 muramyldipeptide (MDP ) 刺激了, NOD2 的通常认为的 ligand。结果:我们发现从 CD 病人的单核白血球区分了在试管内到成熟树枝状的房间(DC ) ,由免疫显型和形态学决定了。NOD2 遗传型在所有题目被估计,并且我们观察到在 NOD2 的不成熟、刺激 LPS 的 DC 上的高 CD86 表示变异 CD 病人,作为与 wtNOD2 CD 病人和控制相比。由对比,导致到成熟, MDP 源于变异 NOD2 的题目的 DC 的 CD86 表示层次比得上正常题目的那些。在耐心房间的文化的 IL-12p70 的数量与 MDP 比在在 LPS 治疗,然而并非术后疗法以后的控制大。结论:我们的结果建议在 NOD2 基因与变化从病人获得的 DC 显示高 CD86 表示描绘的激活的显型,但是当与终端相比区别分阶段执行时,有减少的回答到 MDP。我们推测单核白血球的改变的区别可能导致在发炎和单核白血球的杀死的能力之间的不平衡,并且可能与 CD 的致病相关。 | Marilena Granzotto Elisa Fabbro Massimo Maschio Stefano Martelossi Sara Quaglia Alberto Tommasini Gianni Presani Alessandro Ventura | 2007 | World Journal of Gastroenterology2007，13，46： | 2 |
| 10 | Wireless therapeutic en- doscopic capsule: in vivo experiment显示文摘 | Valdastri P Quaglia C Susilo E | 2008 | Endoscopy2008，40，12： | 1 |
| 11 | Liver disease in pregnancy 显示文摘 | Joshi D James A Quaglia A | 2010 | Lancet2010，375，9714： | 1 |
| 12 | Advances in the surgical treatment of neuroblastoma: a review 显示文摘 | Murphy JM La Quaglia MP | 2014 | Eur J Pediatr Surg2014，24，6： | 1 |
| 13 | The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs 显示文摘 | Fabiana Quaglia Luisanna Ostacolo Antonino Mazzaglia | 2009 | Biomaterials2009，30，3： | 1 |
| 14 | Highly effectiv induction therapy for stage 4 neuroblastoma in children over 1 year of age 显示文摘 | La quaglia MP Bonilla MA | 1994 | J Clin Oncol1994，12，： | 1 |
| 15 | Influence of enzymatic hydrolysis on struc-ture and emulsifying properties of sardine(Sardina pilchardus)proteinhydrolysate显示文摘 | QUAGLIA G B ORBAN E | 1990 | Journal of Food Science1990，55，15： | 1 |
| 16 | Idiopthic membranous nephropathy:management strategies显示文摘 | Quaglia M Stratta P | | 0，，10： | 1 |
| 17 | Lower control arm rear bushing development an integrated approach显示文摘 | Stephem William Hope Gustavo Nunes Pinto Villela Conrado Alexandre de Paula Pinto Joao Luis Corradini Quaglia Dominique Cadiot Charles Pintos | 2003 | SAE2003，，： | 1 |
| 18 | Blood and graft eosinophils in acute cellular rejection of liver allografts显示文摘 | Nagral A Quaglia A Sabin CA | 2001 | Transplant Proc2001，33，4： | 1 |
| 19 | Enzymic solubilisation of proteins of shardine (Shardine pilchardus) by commercial proteases显示文摘 | Quaglia G B Orban E | 1987 | J Sci Food Agri1987，38，： | 1 |
| 20 | A tool for checking probabilis-tic properties of COWS services显示文摘 | CAPPELLO I QUAGLIA P | 2010 | Lecture Notes in Com-puter Science2010，6084，： | 1 |
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