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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China显示文摘Objective To explore the effects of particulate matters less than 2.5 μm in aerodynamic diameter (PM 2.5) on heart repolarization/depolarization and heart rate variability (HRV). Methods We conducted a panel study for elderly subjects with heart disease in Beijing from 2007 to 2008. PM 2.5 was measured at a fixed station for 20 h continuously each day while electrocardiogram (ECG) indexes of 42 subjects were also recorded repeatedly. Meteorological data was obtained from the China Meteorological Data Sharing Service System. A mixed linear regression model was used to estimate the associations between PM 2.5 and the ECG indexes. The model was adjusted for age, body mass index, sex, day of the week andmeteorology. Results Significant adverse effects of PM 2.5 on ECG indexes reflecting HRV were observed statistically and the strongest effect of PM 2.5 on HRV was on lag 1 day in our study. However, there were no associations between PM 2.5 and ECG indexes reflecting heart repolarization/depolarization. Additionally, the effects of PM 2.5 on subjects with hypertension were larger than on the subjects without hypertension. Conclusion This study showed ambient PM 2.5 could affect cardiac autonomic function of the elderly people with heart disease, and subjects with hypertension appeared to be more susceptive to the autonomic dysfunction induced by PM 2.5. | XU Mei Mei JIA Yu Ping LI Guo Xing LIU Li Qun MO Yun Zheng JIN Xiao Bin PAN Xiao Chuan | 2013 | Biomedical and Environmental Sciences2013，26，8： | 6 |
| 3 | Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury显示文摘A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor are all peptides or proteins that may be rapidly deactivated at the focal injury site; their local effective concentration time following a single medication cannot meet the required time for spinal axons to regenerate and cross the glial scar. In this study, we produced polymer sustained-release microspheres based on the polylactic-co-glycolic acid copolymer; the microspheres at 300-μm diameter contained nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor. Six microspheres were longitudinally implanted into the sciatic nerve at the anastomosis site, serving as the experimental group; while the sciatic nerve in the control group was subjected to the end-to-end anastomosis using 10/0 suture thread. At 6 weeks after implantation, the lower limb activity, weight of triceps surae muscle, sciatic nerve conduction velocity and the maximum amplitude were obviously better in the experimental group than in the control group. Compared with the control group, more regenerating nerve fibers were observed and distributed in a dense and ordered manner with thicker myelin sheaths in the experimental group. More angiogenesis was also visible. Experimental findings indicate that polylactic-co-glycolic acid composite microspheres containing nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor can promote the restoration of sciatic nerve in rats after injury. | Qun Zhao Zhi-yue Li Ze-peng Zhang Zhou-yun Mo Shi-jie Chen Si-yu Xiang Qing-shan Zhang Min Xue | 2015 | Neural Regeneration Research2015，10，9： | 4 |
| 4 | Efficacy of irinotecan-based chemotherapy after exposure to an anti-PD-1 antibody in patients with advanced esophageal squamous cell carcinoma显示文摘Objective:Several anti-programmed cell death 1(anti-PD-1)antibodies have demonstrated potential efficacy in the treatment of advanced esophageal squamous cell cancer(ESCC).However,the response to subsequent chemotherapy after the failure of PD-1 blockade in ESCC patients has not been reported,and the optimal sequencing of immunotherapy and chemotherapy remains controversial.The aim of the present study was to evaluate responses to irinotecan-based subsequent chemotherapy in advanced ESCC patients who had progressed after treatment with camrelizumab(SHR-1210),a novel anti-PD-1 antibody.Methods:We retrospectively reviewed the medical records of patients with advanced ESCC treated with camrelizumab at a single institution.Consecutive patients who received subsequent irinotecan-based chemotherapy were selected for data collection and analysis.Results:Overall,a total of 28 patients were included.All patients had received at least two lines of systemic treatment prior to irinotecan salvage.The most common regimen that was administered after PD-1 blockade was irinotecan in combination with 5-fluorouracil(5-Fu)(or its derivatives),which was given to 19 patients.The objective response rate(ORR)and disease control rate(DCR)were 17.9%(5/28)and 64.3%(18/28),respectively,with 5(17.9%)patients achieving a partial response and 13(46.4%)having stable disease.The median progressionfree survival(PFS)was 3.18[95%confidence interval(95%CI),2.48-3.88]months and the median overall survival(OS)was 6.23(95%CI,4.71-7.75)months.No new safety issues,either immune-related or otherwise,were observed.Conclusions:Our results suggested that the response to irinotecan-based chemotherapy after PD-1 blockade in advanced ESCC patients appeared similar to that previously observed in patients who had not received PD-1 antibodies,and further study in larger cohorts or randomized trials is warranted to verify our observation. | Bo Zhang Xi Wang Qun Li Hongnan Mo Xingyuan Wang Yan Song Jianping Xu Tao Qu Jing Huang | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 5 | Multiwavelet Frames from Refinable Function Vectors显示文摘 | Bin Han Qun Mo | 2003 | Advances in Computational Mathematics (-)2003，，2： | 1 |
| 6 | Muhiwavelet frames from refinable function vectors显示文摘 | Hn Bin Mo Qun | 2003 | Adv Comput Math2003，，18： | 1 |
| 7 | A study on effect of sonochemistry in a reverberation field显示文摘In this paper,an ultrasound with frequency of 815 kHz was used to re-search the sonochemical yield in a small-size reverberation field by the methodof fluorescent spectrum analysis.There are two characteristics on the effect ofsonochemistry in the reverberation field:First,the cavitation threshold wasabout 0.3W/cm^2(it was 0.7W/cm^2 in travelling field);Second,when thesound intensity was larger than the threshold,the sonochemical yield increasedas the intensity increased and increased rapidly after the intensity was at1.69-2.13W/cm^2,so that there was a upturned point in the curve of the result(which would tend to saturation in the travelling field).The theoretical analysisshows that the reason of the threshold decrease is that the sound energy densitybecomes high in the reverberation field,and the upturned point results from thedisturbance of the radiation pressure on the liquid surface.Therefore,by exper-iment and theory this paper shows that a reverberation field has to be built forthe higher | WANG Shuangwei(Dep. of Physics. Northeast Normal University, Changchun 130024)FENG Ruo , MO Xiping and SHI Qun (Institute of Acoustics, Department of Chemistry, Nanjing University. Nanjing 210008) | 1993 | Chinese Journal of Acoustics1993，12，2： | 1 |
| 8 | Multiwavelet Frames from Refinable Function Vectors显示文摘 | Bin Han Qun Mo | 2003 | Advances in Computational Mathematics2003，，2： | 1 |
| 9 | A remark on the restricted isometry property in orthogonal matching pursuit显示文摘 | Mo Qun Shen Yi | 2012 | IEEE Transactions on Information Theory2012，58，6： | 1 |
| 10 | Multiwavelet Frames from Refinable Function Vectors显示文摘 | Bin Han Qun Mo | 2003 | Advances in Computational Mathematics (-)2003，，2： | 1 |
| 11 | Complex wavelets and framelets from pseudo splines显示文摘 | SHEN Yi LI Song MO Qun | 2010 | J Fourier Anal Appl2010，16，6： | 1 |
| 12 | Reversible Data Hiding in Encrypted Image Based on Block Classification Permutation显示文摘Recently,reversible data hiding in encrypted image(RDHEI)has attracted extensive attention,which can be used in secure cloud computing and privacy protection effectively.In this paper,a novel RDHEI scheme based on block classification and permutation is proposed.Content owner first divides original image into non-overlapping blocks and then set a threshold to classify these blocks into smooth and non-smooth blocks respectively.After block classification,content owner utilizes a specific encryption method,including stream cipher encryption and block permutation to protect image content securely.For the encrypted image,data hider embeds additional secret information in the most significant bits(MSB)of the encrypted pixels in smooth blocks and the final marked image can be obtained.At the receiver side,secret data will be extracted correctly with data-hiding key.When receiver only has encryption key,after stream cipher decryption,block scrambling decryption and MSB error prediction with threshold,decrypted image will be achieved.When data hiding key and encryption key are both obtained,receiver can find the smooth and non-smooth blocks correctly and MSB in smooth blocks will be predicted correctly,hence,receiver can recover marked image losslessly.Experimental results demonstrate that our scheme can achieve better rate-distortion performance than some of state-of-the-art schemes. | Qun Mo Heng Yao Fang Cao Zheng Chang Chuan Qin | 2019 | Computers, Materials & Continua2019，，4： | 1 |
| 13 | L^2-CONVERGENCE OF VECTOR CASCADE ALGORITHM显示文摘In this paper, the L2-comvergence of vector cascade algorithm (a very important concept in the wavelet the- ory ) is characterized in terms of the behavior of the given filter matrix H( ) and its associated transition opera- tor TH. More precisely, it is shown that the cascade algorithm defined by H( ) converges in L2 (Rd) if and on- ly if H ( ) satisfies Fundamental Condition (Condition F, a restriction on its values on the vertices of [ 0, ]d , and satisfies cither Conditon E(1 is a simple eigenvalue and the others have modulees less than one) or Condition E. Also,we describe a class of functions which can be chosen as initial functions. | Long Ruilin (1) Mo Qun (1) (2) | 1999 | Analysis in Theory and Applications1999，15，4： | 0 |
| 14 | Criterion of Semi-Markov Dependent Risk Model显示文摘A rigorous definition of semi-Markov dependent risk model is given.This model is a generalization of the Markov dependent risk model.A criterion and necessary conditions of semiMarkov dependent risk model are obtained.The results clarify relations between elements among semi-Markov dependent risk model more clear and are applicable for Markov dependent risk model. | Xiao Yun MO Xiang Qun YANG | 2014 | Acta Mathematica Sinica,English Series2014，30，7： | 0 |
| 15 | LncRNA-POIR knockdown promotes hepatocellular carcinoma sensitivity to sorafenib through upregulating miR-182-5p and inhibiting autophagy显示文摘Although sorafenib has been found to prolong the survival time of patients with hepatocellular carcinoma(HCC),sorafenib resistance remains an important challenge.Increasing studies have demonstrated that long noncoding RNAs(lncRNAs)contribute to drug resistance in a wide number of cancers.Human periodontal ligament stem cell(PDLSC)osteogenesis impairment-related lncRNA(POIR)is a recently defined lncRNA for which little is known regarding its function.Our study aimed to reveal the role of POIR in the development of HCC cell sorafenib resistance.The level of POIR expression in patients and tumor cells was examined by Reverse transcription-quantitative polymerase chain reaction(RT-qPCR)assay.CCK-8,EdU,and flow cytometry assay were adopted to examine cell viability,proliferation,and apoptosis,respectively.The autophagy-associated protein expressions were determined by western blotting and autophagic flux analysis.The results of this study exhibited increased POIR in HCC tissues and cells and may be correlated with sorafenib resistance.Knockdown of POIR elevated sorafenib sensitivity by suppressing autophagy in HCC cells.Mechanically,POIR knockdown upregulated miR-182-5p,implying that miR-182-5p mediates POIR regulation.MiR-182-5p overexpression significantly enhanced chemosensitivity to sorafenib,whereas miR-182-5p inhibition had the opposite effect.The sensitization of POIR siRNA to sorafenib was abolished by co-transfection with miR-182-5p inhibitor.Our findings provide a potential target for further clinical treatment of sorafenib-resistant HCC patients. | JIAN XU HAILONG GE CHEN CHAO FENG MO YU WANG DENGKUI ZHANG XIAOXIAO ZHENG LI ZHENG XUEMEI LU WEI CHEN QUN XU WEIXIN YU | 2022 | BIOCELL2022，46，6： | 0 |
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