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| 1 | Response of macrophages in rat skeletal muscle after eccentric exercise显示文摘PurposeMacrophages 被知道众多的受伤纸巾取决于为愈合重要他们响应不同刺激的功能的显型。这研究的目的是揭示涉及导致锻练的骨胳的肌肉损害的巨噬细胞 phenotypic 变化, regeneration.MethodsAdult 男性 Sprague-Dawley 老鼠经历了下坡的跑的一个会议(有超过 0.95 的最低的记录的相对的腐殖的酸流动(HAF ) 的 16ouling 性质。在另一方面, PVA-ZnO 加入改进了腐殖的酸拒绝直到 96.03 吗?4 th 等级,他们在部分理解上被估计并且进一步分类就象对没有困难?? | Qun Zuo Shu-Chen Wang Xin-Kai Yu Wei-Wei Chao | 2018 | Chinese Journal of Traumatology2018，21，2： | 6 |
| 2 | Variable stiffness design of redundantly actuated planar rotational parallel mechanisms显示文摘Redundantly actuated planar rotational parallel mechanisms(RAPRPMs) adapt to the requirements of robots under different working conditions by changing the antagonistic internal force to tune their stiffness.The geometrical parameters of the mechanism impact the performances of modulating stiffness.Analytical expressions relating stiffness and geometrical parameters of the mechanism were formulated to obtain the necessary conditions of variable stiffness.A novel method of variable stiffness design was presented to optimize the geometrical parameters of the mechanism.The stiffness variation with the internal force was maximized.The dynamic change of stiffness with the dynamic location of the mechanism was minimized,and the robustness of stiffness during the motion of the mechanism was ensured.This new approach to variable stiffness design can enable off-line planning of the internal force to avoid the difficulties of on-line control of the internal force. | Li Kangkang Jiang Hongzhou Cui Zuo Huang Qun | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 3 | Tuning the phase evolution pathway of LiNi_(0.5)Mn_(1.5)O_(4) synthesis from binary intermediates to ternary intermediates with thermal regulating agent显示文摘Transition metal cation ordering is essential for controlling the electrochemical performance of cubic spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO),which is conventionally adjusted by optimizing the high temperature sintering and annealing procedures.In this present work,multiple characterization techniques,including 6,7Li NMR,XRD and HRTEM,have been combined to trace the phase transformation and morphology evolution during synthesis.It has been illustrated that simultaneous formation of LiMn_(2)O_(4)(LMO)and LiNiO_(2)(LNO)binary oxides and their conversion into highly reactive LixNi^(3+)_(y)Mn_(3.5+)_(z)O ternary intermediate is a thermal dynamically difficult but crucial step in the synthesis of LNMO ternary oxide.A new strategy of modifying the intermediates formation pathway from binary mode to ternary mode using thermal regulating agent has been adopted.LNMO synthesized with thermal regulating agent exhibits supreme rate capability,long-cycling performance(even at elevated temperature)and excellent capacity efficiency.At a high rate of 100 C,the assembled battery delivers a discharge capacity of 99 mAh g^(-1).This study provides a way to control the formation pathway of complex oxides using thermal regulating agent. | Libin Wu Hua Huo Qun Wang Xucai Yin Shu Guo Jiajun Wang Chunyu Du Pengjian Zuo Geping Yin Yunzhi Gao | 2022 | Journal of Energy Chemistry2022，31，2： | 1 |
| 4 | 2D-IR Correlation Analysis of Deteriorative Process of Traditional Chinese Medicines ' Qing Kai Lingin ' Injection 显示文摘 | Zuo Lin Sun Suqin Zhou Qun | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，30，5： | 1 |
| 5 | Debittering ef- fect of Actinomucor elegans peptidases on soybean protein hydrolysates显示文摘 | Li Li Yang Zuo Yi Yang Xiao Qun | 2008 | J Ind Microbiol Biot2008，35，1： | 1 |
| 6 | Study on traditional Chinese medicine'Qing Kai Ling'injections from different manufactures by 2D IR correlation spectroscopy显示文摘 | ZHOW Qun SUN Suqin ZUO Lin | 2004 | Vibrational Spectroscopy2004，36，： | 1 |
| 7 | Analysis of Hospitalization Costs and Influencing Factors of AKI in Adult Patients显示文摘Objective:To investigate the economic burden of patients with acute kidney injury(AKI)by analyzing the distribution of hospitalization expenses and its influencing factors in the Affiliated Hospital of Hebei University.Methods:The hospitalization information of patients with AKI from January 2020 to January 2023 was collected and sorted through the hospital charging system and the factors affecting the total hospitalization cost were analyzed by multiple linear regression.Results:Univariate analysis showed that age,occupation,marriage,length of hospitalization,recovery of renal function,and stage of AKI had significant effects on hospitalization cost(P<0.05).The result of the multiple linear regression analysis model showed that age(t=4.11,P<0.0001),length of hospitalization(t=16.10,P<0.0001),recovery of renal function(t=3.26,P<0.0001),AKI stage(t=5.23,P=0.002)are factors affecting the economic burden of patients with AKI.Conclusion:AKI patients should be managed according to age stratification to effectively control the progression of the disease and improve the quality of the medical services provided.This will reduce the economic burden of patients. | Yan-Li Gou Hong-Fang Zhang Yang Huang Chun-ling Sun Chunliu Li Qun Zuo Xi-Jie Zheng | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 8 | The dislocation structure of slip bands in deformed high entropy alloy nanopillars显示文摘Remarkable diversity is observed in dislocation interactions that are responsible for intermittent and sudden crystal slips.While large crystal slips can be easily observed on the surface of deformed crystals,unraveling the underlying dislocation interaction mechanisms,however,has been a longstanding challenge in the study of single-crystal plasticity.A recent study demonstrated that the sluggish dislocation dynamics in the high entropy alloy(HEA)of Al_(0.1)CoCrFeNi enables the observation of slip bands for a direct link to dislocation avalanches in a nanopillar.Here,we further examined the dislocation structure of slip bands in the HEA nanopillars oriented for single slip.Experimental evidence was provided on the dislocation organization in a slip band based on groups of primary dislocations,secondary dislocations,and dislocation pileups.The results were compared with the previously proposed slip band models.The unique aspects of the HEA that enable such observations were also investigated through an examination of the dislocation microstructure and its response to applied forces in the HEA nanopillars. | Qun Yang Yang Hu Jian-Min Zuo | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 9 | Expression and purification of Ctomp2aa167-aa434 and preparation of its mAb显示文摘Chlamydia trachomatis outer membrane protein 2 (Ctomp2) is a major immunogen in chlamydial infections and a highly genus-conserved structural protein of all Chlamydia species . To purify the protein and to prepare monoclonal antibodies (mAbs) against it, the recombinant protein was induced by IPTG, which was confirmed by SDS-PAGE and purified by means of a Ni2+ -charged resin column. The denatured protein was refolded in the GSH-GSSH buffer gradually and identified by Western blotting. Then the BALB/c mice were immunized with the recombinant protein to prepare the mAb against Ctomp2. The obtained mAbs were characterized. Genital specimens were tested with indirect ELISA mostly made of the mAb and cell culture in 84 patients with genital symptoms. The results showed that high-level expression of the recombinant protein was achieved, which existed as inclusion body and amounted to 38 % of total bacterium protein. A mAb against Ctomp2 was obtained. It belongs to IgG 2b. The titers were as high as 1:40 000. The Western blotting showed that the mAb only reacted with the recombinant protein. It had no crossing reactions against E. coli, N. gonorhoea, M. hominis, U. urealyticum and M. penetrans . It had high specifity. In comparison with gold standard test-cell culture, the sensitivities, specificities, positive predictive values and negative predictive values of indirect ELISA were 95.24%, 100%, 100% and 98.44%, respectively. The above-mentioned research work contributed not only to the further study of the structure and function of this protein , but also to the establishment of the method for its clinical application, for it had not been reported before. | JIAN HONG ZUO LI ZHI TAN CHAO QUN CHEN NING ZHENG DONG XIA BAI CHANG GENG RUAN | 2006 | Journal of Microbiology and Immunology2006，4，1： | 0 |
| 10 | A Novel Maximum Resolved Shear Stress Gradient Criterion and Its Application for Crack Deflection Behavior in Polycrystalline Silicon Materials显示文摘In this paper,a development of new resolved shear stress gradient criteria is performed for the study of crack propagation behavior in polycrystalline materials with an emphasis on the effect of slip plane and slip direction.The prediction of crack deflection behavior by the maximum resolved shear stress gradient criterion shows good agreement with the experimental results.Comparison study for the prediction of crack propagation behavior in poly crystalline materials by other criteria demonstrates that the maximum resolved shear stress gradient criterion is superior to other fracture criteria.This suggests that the new criterion could be further applied for predicting the crack deflection behavior in other polycrystalline materials. | Yangbo Zhang Qida Liu Qun Li Yangdong Ni Yuanjie Yu Jean-Nicolas Jaubert Eric Lajoie-Mazenc Emmanuel Boyere Metais Thomas Hong Zuo | 2022 | Acta Mechanica Solida Sinica2022，35，3： | 0 |
| 11 | Morphologic evolution of bifurcated reaches in a macrotidal estuary with mountain streams显示文摘A macrotidal estuary with mountain streams(MEMS)is characterized by rapidly rising and falling flood peaks and large tidal ranges and is a typical estuary type with strong flow dynamics that is found worldwide.Understanding the morphodynamic evolution of MEMSs has great significance for river management.The roles of the mountain stream river flood process and macrotides on the morphology evolution still needs further quantitative study.Taking the Oujiang Estuary as an example,the evolution mechanisms of bifurcated reaches of a MEMS are studied by analyzing the hydrologic and topographic data and using a two-dimensional numerical model for flow-sediment transport.The results show that(1)under the combined actions of runoff and macrotides,sediment transport is active and morphological evolution is intensive,the main branch and subbranch historically switch frequently,and erosion generally occurs in wet years,while deposition occurs in dry years.(2)The river flood process of mountain streams causes rapid erosion,which rises and falls rapidly with a kurtosis index(K)of approximately 2.9.There is a logarithmic relation between the sediment transport load and K.The volume of sediment transport will be 40%larger than the river flood process with K=1.2 as for the Yangtze River.(3)Macrotides with large tidal ranges could enhance the discharge asymmetry(ψ).When the ψ is greater than 1,the side branches are dominated by flood tides.Although the current study is site specific,the results are expected to provide a valuable reference for sustainable management in similar estuaries. | Jing Liu Yongjun Lu Liqin Zuo Huaixiang Liu Qun Xu Qingzhi Hou | 2022 | International Journal of Sediment Research2022，37，6： | 0 |
| 12 | The Application of Theoretical Models in the Studies of Physical Activity Behaviors of the Elderly in China显示文摘By using the method of literature review, this paper introduces the popular theoretical models which have shown to better explain physical activity behaviors at a certain degree, summarizes the dominating theoretical models in the studies of physical activity behaviors of the elderly in China. In addition, shortcomings and future prospects are pointed out at the end. | Yuquan Chen Yuqi Wang Fanxuan Meng Zifei Du Qun Zuo | 2019 | Journal of Advances in Medicine Science2019，2，2： | 0 |
| 13 | Intracortical screw insertion plus limited open reduction in treating type 31A3 irreducible intertrochanteric fractures in the elderly显示文摘BACKGROUND In most elderly patients with intertrochanteric fractures,satisfactory fracture reduction can be achieved by closed reduction using a traction table.However,intertrochanteric fractures cannot achieve satisfactory reduction in a few patients,which is called irreducible intertrochanteric fractures.Especially for type 31A3 irreducible intertrochanteric fractures,limited open reduction of the broken end with different intraoperative reduction methods is required to achieve satisfactory reduction and fixation.AIM To discuss clinical efficacy of intracortical screw insertion plus limited open reduction in type 31A3 irreducible intertrochanteric fractures in the elderly.METHODS A retrospective analysis was performed on 23 elderly patients with type 31A3 irreducible intertrochanteric fractures(12 males and 11 females,aged 65-89-yearsold)who received treatment at the orthopedics department.After type 31A3 irreducible intertrochanteric fractures were confirmed by intraoperative C-arm,all of these cases received intracortical screw insertion plus limited open reduction in the broken end with intramedullary screw internal fixation.The basic information of surgery,reduction effects,and functional recovery scores of the hip joint were assessed.RESULTS All patients were followed up for 13.8 mo on average.The operation time was 53.8±13.6 min(40-95 min).The intraoperative blood loss was 218.5±28.6 mL(170-320 mL).The average number of intraoperative X-rays was 22.8±4.6(18-33).The average time to fracture union was 4.8±0.7 mo.The reduction effect was assessed using Kim’s fracture reduction evaluation.Twenty cases achieved grade I fracture reduction and three cases grade II fracture reduction.All of them achieved excellent or good fracture reduction.Upon the last follow-up,the functional recovery scores score was 83.6±9.8,which was not significantly different from the functional recovery scores score(84.8±10.7)before the fracture(t=0.397,P=0.694).CONCLUSION With careful preoperative preparation,intracortical screw insertion plus limited open reduction contributed to high-quality fracture reduction and fixation.Good clinical outcomes were achieved without increasing operation time and intraoperative blood loss. | Xiao-Wen Huang Gu-Qi Hong Qiang Zuo Qun Chen | 2021 | World Journal of Clinical Cases2021，9，32： | 0 |
| 14 | Sunflower-Like SrCo_(2)S_(4)@f-MWCNTs Hybrid Wrapped by Engineering N-Reduced Graphene Oxide for High Performance Dye-Sensitized Solar Cells显示文摘A novel sunflower-like nanocomposite of SrCo_(2)S_(4)nanoflakes and functionalized multiwall carbon nanotubes(f-MWCNTs)entanglement enveloped in nitrogen-reduced graphene oxide(N-RGO)is prepared by a cheap process.The unique entanglement structure of the material exhibits higher specific surface area,better electrical conductivity and other properties.This helps to reduce the transfer resistance in the photoelectric process of the battery and improve the electrochemical activity,thus increasing the photoelectric conversion efficiency of the battery.The new ternary cobalt-based sulfide material can replace platinum as the counter electrode(CE)material loaded on dye-sensitized solar cells(DSSCs).DSSCs with SrCo_(2)S_(4)@f-MWCNTs@N-RGO(SCS@f-M@N-R)as CE material show excellent photoelectric conversion efficiency(PCE,8.06%),even surpassing than that of Pt CE material(7.51%).The low cost,excellent electrocatalytic performance and simple preparation method of SCS@f-M@N-R nanomaterial provide feasibility for replacing platinum material as the CE material of DSSCs,which is of great significance and persuasion. | Weiming Zhang Muhammad Wasim Khan Xueqin Zuo Qun Yang Huaibao Tang Shaowei Jin Guang Li | 2020 | Journal of Renewable Materials2020，8，4： | 0 |
| 15 | Effect of Huoxue Huayu Detoxification on GSK-3β and β-catenin levels in OSF patients and its mechanism显示文摘Objective:To explore the effects of Huoxue Huayu detoxification method on the levels of GSK-3βandβ-catenin in OSF patients and its mechanism.Methods:A total of 120 patients with oral submucosal fibrosis(OSF)treated in our hospital from May 2018 to December 2019 were selected and divided into routine treatment group and Huoxue Huayu detoxification group of 60 cases according to the lottery method.The routine treatment group was treated with triamcinolone acetonide injection,and the Huoxue Huayu detoxification group was treated with Huoxue Huayu detoxification.The lesion area,mouth opening degree,SFRP1 level in gingival crevicular fluid and saliva,TCM symptom score,TGF-β1,IL-6,GSK-3β,β-catenin expression and clinical effect were observed in the two groups.Results:After treatment,the lesion area of oral mucosa in the Huoxue Huayu detoxification group was smaller than that in the routine treatment group(P<0.05),and the mouth opening degree in the Huoxue Huayu detoxification group was larger than that in the routine treatment group(P<0.05);After treatment,the level of SFRP1 in gingival crevicular fluid and saliva and clinical effect in the Huoxue Huayu detoxification group were higher than those in the routine treatment group(P<0.05);the TCM syndrome score,TGF-β1,IL-6,GSK-3β,β-catenin expression in the Huoxue Huayu detoxification group were lower than those in the routine treatment group(P<0.05).Conclusion:By acting on Wnt/β-catenin signaling pathway,Huoxue Huayu detoxification method can regulate the expression of TGF-β1,IL-6,GSK-3β,β-catenin,improve the clinical symptoms of patients with oral submucous fibrosis,alleviate the body inflammation,alleviate the pain,with remarkable effect. | Qiao-Juan Zuo Jin Tan Jie Yu Shi-Juan Chen Qun Li Xuan Zhu | 2021 | Journal of Hainan Medical University2021，27，5： | 0 |
| 16 | Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule显示文摘Human metallothionein(MT)is a small-size yet efficient metal-binding protein,playing an essential role in metal homeostasis and heavy metal detoxification.MT contains two domains,each forming a polynuclear metal cluster with an exquisite hexatomic ring structure.The apoprotein is intrinsically disordered,which may strongly influence the clusters and the metal-thiolate(M-S)bonds,leading to a highly dynamic structure.However,these features are challenging to identify due to the transient nature of these species.The individual signal from dynamic conformations with different states of the cluster and M-S bond will be averaged and blurred in classic ensemble measurement.To circumvent these problems,we combined a single-molecule approach and multiscale molecular simulations to investigate the rupture mechanism and chemical stability of the metal cluster by a single MT molecule,focusing on the Zn4S11 cluster in theαdomain upon unfolding.Unusual multiple unfolding pathways and intermediates are observed for both domains,corresponding to different combinations of M-S bond rupture.None of the pathways is clearly preferred suggesting that unfolding proceeds from the distribution of protein conformational substates with similar M-S bond strengths.Simulations indicate that the metal cluster may rearrange,forming and breaking metal-thiolate bonds even when MT is folded independently of large protein backbone reconfiguration.Thus,a highly dynamic polynuclear metal cluster with multiple conformational states is revealed in MT,responsible for the binding promiscuity and diverse cellular functions of this metal-carrier protein. | Guodong Yuan Felipe Curtolo Yibing Deng Tao Wu Fang Tian Qun Ma Yutong Liu Jinglin Zuo Guilherme Menegon Arantes Peng Zheng | 2021 | Research2021，，1： | 0 |
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