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| 1 | 四价人乳头瘤病毒疫苗的效力和效果:10年真实世界研究的系统综述显示文摘预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索PubMed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病变的效力或效果的观察性研究的报道。十年来,真实世界环境中HPV疫苗效果越来越明显,尤其在疫苗接种率较高国家中那些在HPV暴露发生之前接种的女孩。据报道,疫苗可使HPV6、11、16、18感染最多减少约90%,生殖器疣减少约90%,低度宫颈细胞学异常减少约45%,经组织学证实的高度宫颈异常减少约85%。但HPV疫苗接种计划的公共卫生潜力尚未完全实现,HPV相关疾病仍具有较高的发病率和死亡率,因此仍需要提高HPV疫苗接种计划的人群覆盖率。 | Suzanne M.Garland Susanne K.Kjaer Nubia Muoz Stan L.Block Darron R.Brown Mark J.DiNubile Brianna R.Lindsay Barbara J.Kuter Gonzalo Perez Geraldine Dominiak-Felden Alfred J.Saah Rosybel Drury Rituparna Das Christine Velicer 王华庆 | 2018 | 中国病毒病杂志2018，8，4： | 9 |
| 2 | Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis显示文摘 | R.Lindsay J.Nieves C.Formica | | 0，，： | 1 |
| 3 | Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis显示文摘 | SoazigLe Lay EricHajduch Margaret R.Lindsay XavierLe Lièpvre ChristophThiele PascalFerré Robert G.Parton TeymurasKurzchalia KaiSimons IsabelleDugail | 2006 | Traffic2006，，5： | 1 |
| 4 | Australian sugarcane soldier fly’s salivary gland transcriptome in response to starvation and feeding on sugarcane crops显示文摘The soldier fly is an endemic pest of sugarcane in Australia.Small numbers of larvae can cause significant damage to roots and reduce the crop yields.Little is known about the composition and function of the soldier fly salivary gland,its secretions,and their roles in insect—plant interactions.In this study,we performed transcriptome analysis of the salivary glands of starved and sugarcane root-fed soldier fly larvae.A total of 31119 highly expressed assembled contigs were identified in the salivary glands and almost 50%of them showed high levels of similarity to known proteins in Nr databases.Of all the obtained contigs,only 9727 sequences contain an open reading frame of over 100 amino acids.Around 31%of contigs were predicted to encode secretory proteins,including some digestive and detoxifying enzymes and potential effectors.Some known salivary secreted peptides such as serine protease,cysteine proteinase inhibitors,antimicrobial peptides and venom proteins were among the top 100 highly expressed genes.Differential gene expression analysis revealed significant modulation of 850 transcripts in salivary glands upon exposure to plant roots or starvation stress.Here,we identified some venom proteins which were significantly upregulated in the salivary glands of soldier fly larvae exposed to sugarcane roots.In other insects and nematodes some of these proteins have been used to manipulate host plant defense systems and facilitate the invasion of the host plant.These findings provide a further insight into the identification of potential effector proteins involved in soldier fly-sugarcane interactions. | Kayvan Etebari Karel R.Lindsay Andrew L.Ward Michael J.Furlong | 2020 | Insect Science2020，27，4： | 0 |
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