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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Surgical repair of ruptured Achilles tendon in sportsmen and sedentary patients: a longitudinal ultrasound assessment显示文摘 | Maffulli N Dymond NP Regine R | 1990 | Int J Sports Med1990，11，： | 1 |
| 3 | Recovery of polyphenols from the by-products of plant food processing and application as valuable food ingredients显示文摘 | DIETMAR R K JUDITH K REGINE V | 2014 | Food Research International2014，，： | 1 |
| 4 | Direct decompressive surreal resection in the treatment of spinal cord compression causeb by metastatic cancer:a randomised trial 显示文摘 | Patchell R Tibbs P Regine W | 2005 | Lancet2005，366，20： | 1 |
| 5 | A bovine oviduct epithelial cell suspension culture sys- tem suitable for studying tions: morphological and 显示文摘 | REGINE R SUSANNE E U SABINE K | 2006 | Reproduction2006，132，： | 1 |
| 6 | RTOG 9704 a phase m study of adjuvant pre and post chemoradiation (CRT)5-Fu vs gemcitabine(G) for resected pancreatic ade- nocawSnoma显示文摘 | Regine WF Winter KW Abrams R et aI | 2006 | J Clin Oneol2006，24，185： | 1 |
| 7 | The effect of quercetin on the mRNA expression of different antioxidant enzymes in hepatoma cells显示文摘 | Elke R?hrdanz Achim Bittner Quynh-Hoa Tran-Thi Regine Kahl | 2003 | Archives of Toxicology2003，，9： | 1 |
| 8 | A dose-ranging study of peglated interferon alfa-2b and ribavirin in chronic hepatitis C 显示文摘 | Paul G Regine R P Glauder R | 2000 | J Hepatol2000，32，3： | 1 |
| 9 | accelerated hyperfractionated radiotherapy: An analy sis ftom Radiation Therapy Oncology Group 91 04 显示文摘 | Regine WF Scott C Murray R et aL Neurocognitive outcome in brain metastases patients treated with Accelerated fractiona tion vs | 2001 | Int J Radiat Oncol Biol Phys2001，51，3： | 1 |
| 10 | Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK显示文摘 | Neufert Clemens Becker Christoph Türeci ?zlem Waldner Maximilian J Backert Ingo FIoh Katharina Atreya lmke Leppkes Moritz Jefremow Andre Vieth Michael Schneider-Stock Regine Klinger Patricia Greten Florian R Threadgill David W Sahin Ugur Ne | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
| 11 | Randomized trial of direct decompressive surgical resection in the treatment of spinal cord compression caused by metastasis显示文摘 | Patchell R Tibbs PA Regine WF et a1 | 2003 | Proe AM Soe Clin ontl2003，22，1： | 1 |
| 12 | Role of contrast enhanced ultrasound in acute scrotal diseases显示文摘 | Lobianco R Regine R Siero MD | 2011 | Eur Radiol2011，21，4： | 1 |
| 13 | Computed tomography scan in the early detection of silicosis显示文摘 | Regin R Ostiguy G Fillion R | 1991 | J Am Rev Respir Dis1991，144，： | 1 |
| 14 | An optimalcoarse-grained arc consistency algorithm显示文摘 | BESSIERE C REGIN J C YAP R H C | 2005 | Artificial Intelli-gence2005，165，2： | 1 |
| 15 | Postoperative radiotherapy in the treatment of single metastases to the brain:a randomized trial显示文摘 | PATCHELL R A TIBBS P A REGINE W F | | 0，，： | 1 |
| 16 | Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial显示文摘 | Patchell R Tibbs PA Regine WF | 2005 | Lancet2005，366，9486： | 1 |
| 17 | Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial显示文摘 | PATCHELL R A TIBBS P A REGINE W F | 1998 | JAMA1998，280，17： | 1 |
| 18 | Postoperative radiotherapy in the treatment of single me- tastases to the brain: a randomized trial 显示文摘 | PATCHELL R A TIBBS P A REGINE W F | 1998 | JAMA1998，280，17： | 1 |
| 19 | Distinct melanogenic response of human melanocytes in mono-culture, in co-culture, in co-culture with keratinocytes and in reconstructed epidermis, to UVA exposure 显示文摘 | Reginer M Schmidt R | 2001 | Pigment Cell Res2001，14，5： | 1 |
| 20 | Metabolism of ferulic acid by Paecilomyces variotii and pestalotia palmarurn 显示文摘 | Mohammed R Francoise S M Regine S | 2011 | Applied and Environmental Microbiology2011，55，9： | 1 |
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