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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Topology of the ternary phase system poly (p-phenylene terephthalamide)- sulfuric acid-water 显示文摘 | ROMMEL H FORSTER G | 1994 | Macromolecules1994，27，16： | 1 |
| 3 | Early diagnosis inpost-traumatic complex regional pain syndrome显示文摘 | Schurmann M Gradl G Rommel O | 2007 | Or-thopedics2007，30，6： | 1 |
| 4 | Large offset approximation to seismic reflection traveltimes显示文摘 | Causse E ttaugen G Rommel B | 2000 | Geophysical Prospecting2000，48，4： | 1 |
| 5 | Improved strategies for Radial Basis Function methods for global optimization显示文摘 | ROMMEL G Regis CHRISTINE A Shoemaker | 2007 | Journal of Global Optimization2007，37，： | 1 |
| 6 | Plug nozzle flow field analysis显示文摘 | ROMMEL T HAGEMANN G | 1997 | Journal of propulsion and power1997，13，5： | 1 |
| 7 | Larger-offset approximation to seismic reflection traveltimes 显示文摘 | Causse E Haugen G U Rommel B E | 2000 | Geophysical Prospecting2000，48，2： | 1 |
| 8 | Autosomal dominant isolated velopharyngeal insufficiency显示文摘 | Vantrappen G Rommel N Wellens W | 2002 | Clin Genet2002，1，： | 1 |
| 9 | Large --offset approximation to seismic reflection travel- times显示文摘 | CAUSSE E HAUGEN G U ROMMEL B E | 2000 | Geophys2000，48，8： | 1 |
| 10 | Improved Strategies for Radial Basis Function Methods for Global Optimization显示文摘 | ROMMEL G | 2007 | Journal of Global Optimization2007，37，： | 1 |
| 11 | Plug nozzle flowfield analysis显示文摘 | Rommel T Hagemann G Schley C A | 1997 | Journal of Propulsion and Power1997，13，5： | 1 |
| 12 | Activated Ras dis places 14-3-3 protein from the amino terminus of c-Raf-1 显示文摘 | Rommel C Radziwill G Lovric J | 1996 | Oncogene1996，12，3： | 1 |
| 13 | Prevalence of antibodies to hepatitis C virus (HCV) in haemophiliacs显示文摘 | W. Schramm M. Roggendorf F. Rommel R. Kammerer H. Pohlmann R. Ra?hofer L. Gürtler F. Deinhardt | 1989 | Blut1989，，4： | 1 |
| 14 | Muscle pain in myophosphorylase deficiency (McArdle's disease):The role of gender,genotype,and pain-related coping显示文摘 | Rommel O Kley RA Dekomien G | 2006 | Pain2006，20，： | 1 |
| 15 | Large offset approximation to seismic reflection traveltimes 显示文摘 | Causse E Haugen G Rommel B | 2000 | ~physical Prospecting2000，48，： | 1 |
| 16 | Large-offset approximation to seismic reflection traveltime显示文摘 | Causse E Haugen G U Rommel B E | 2000 | Geophysical Prospecting2000，48，4： | 1 |
| 17 | The Migra- tion Behavior of Tramsuranium Elements in Gorle- ben Aquifer Systems: Colloid Generation and Reten- tion Process 显示文摘 | Kim J I Buckau G Rommel H | 1989 | Mat Res Soc Symp Proc1989，，127： | 1 |
| 18 | Experimental observation of FIB induced lateral damage on silicon samples显示文摘 | SPOLDI G BEUER S ROMMEL M | 2009 | Microelectronic Engineering2009，86，： | 1 |
| 19 | The migration behavior of transuranium elements in Gorleben aquifer system: colloid generation and retention processes显示文摘 | Kim UI Buckau G Rommel H | 1989 | Mat Res Soc Syrup Proc1989，127，： | 1 |
| 20 | Plug nozzle flow field analysis显示文摘 | ROMMEL T HAGEMANN G | 1997 | Journal of propulsion and power1997，13，5： | 1 |
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