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| 1 | Diabetes-and nondiabetes-Related Lower Extremity Amputation Incidence Before and After the Introduction of Better Organized Diabetes Foot Care:Continuous longitudinal monitoring using a standard method显示文摘 | Ronan J N igel C V illiam F | 2008 | Diabetes Care2008，31，5： | 1 |
| 2 | Understanding participation in e-learning in organi- zations : A largescale empirical study of employees 显示文摘 | Thomas N Garavan Ronan Carbery Grace O' Malley David O' Donnell | 2010 | Interna- tional Journal of Training and Development2010，14，3： | 1 |
| 3 | A global human walking model with real-time kinematic personification显示文摘 | Ronan Boulic N Thalmann D Thalmann | 1990 | Visual Computer1990，，6： | 1 |
| 4 | A new chemically defined medium for wine lactic acid bacteria显示文摘 | Nicolas T Ronan N Romain C | 2009 | Food Research International2009，42，3： | 1 |
| 5 | Homework Assignments in Cognitive and Behavioral Therapy: A Meta-analysis 显示文摘 | KAZANTZIS N DEANE F P RONAN K R | 2000 | Clinical Psychology: Science and Practice2000，7，2： | 1 |
| 6 | Acidic fibroblast growth factor accelerates dermal wound healing in diabetic mice 显示文摘 | MELLIN T N CASHEN D E RONAN J J | 1995 | J Invest Dermatol1995，104，5： | 1 |
| 7 | A new chemically defined medium for wine lactic acid bacteria 显示文摘 | Nicolas T Ronan N Romain C | 2009 | Food Research International2009，42，3： | 1 |
| 8 | Diabetes - and Nondiabetes- Related Lower Extremity Amputation Incidence Before and After the Intro - duction of Bet-ter Organized Diabetes Foot Care: Continuous longitu - dinal monitoring using a standard method显示文摘 | Ronan J N igel C V illiam F | 2008 | Dia- betes Care2008，31，5： | 1 |
| 9 | A new chemically defined medium for wine lactic acid bacteria显示文摘 | NICOLAS T RONAN N ROMAIN C | 2009 | Food Research International2009，42，3： | 1 |
| 10 | Acupuncture and schizophrenia: choices for collecting evidence: limitations and significance显示文摘 | Ronan P Robinson N Harbinson D MacInnes D | 2010 | Eur J Orient Med2010，6，5： | 1 |
| 11 | Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure显示文摘 | GOONEWARDENA S N GEMIGNANI A RONAN A | | 0，，05： | 1 |
| 12 | Acidic fibroblast growth factor accelerates dermal wound healing in diabetic mice显示文摘 | MEIIJN T N CASHEN D E RONAN J J | 1995 | J Invest Dermatol1995，104，5： | 1 |
| 13 | Diabetes-and nondiabetes-re- lated lower extremity amputation incidence before and after the Intro-duction of better organized diabetes foot care: continuous longitu-dinal monitoring using a standard method显示文摘 | Ronan J N igel C V illiam F | 2008 | Diabetes Care2008，31，5： | 1 |
| 14 | High yield reproducible rat model recapitulating human Barrett's carcinogenesis显示文摘AIM To efficiently replicate the biology and pathogenesis of human esophageal adenocarcinoma(EAC) using the modified Levrat model of end-to-side esophagojejunostomy. METHODS End-to-side esophagojejunostomy was performed on rats to induce gastroduodenoesophageal reflux to develop EAC. Animals were randomly selected and serially euthanized at 10(n = 6),17(n = 8),24(n = 9),31(n = 6),38(n = 6),and 40(n = 6) wk postoperatively. The esophagi were harvested for downstream histopathology and gene expression. Histological evaluation wascompleted to determine respective rates of carcinogenic development. Quantitative reverse transcriptionpolymerase chain reaction was performed to determine gene expression levels of MUC2,CK19,and CK20,and results were compared to determine significant differences throughout disease progression stages.RESULTS The overall study mortality was 15%. Causes of mortality included anastomotic leak,gastrointestinal hemorrhage,stomach ulcer perforation,respiratory infection secondary to aspiration,and obstruction due to tumor or late anastomotic stricture. 10 wk following surgery,100% of animals presented with esophagitis. Barrett's esophagus(BE) was first observed at 10 wk,and was present in 100% of animals by 17 wk. Dysplasia was confirmed in 87.5% of animals at 17 wk,and increased to 100% by 31 wk. EAC was first observed in 44.4% of animals at 24 wk and increased to 100% by 40 wk. In addition,two animals at 38-40 wk post-surgery had confirmed macro-metastases in the lung/liver and small intestine,respectively. MUC2 gene expression was progressively down-regulated from BE to dysplasia to EAC. Both CK19 and CK20 gene expression significantly increased in a stepwise manner from esophagitis to EAC. CONCLUSION Esophagojejunostomy was successfully replicated in rats with low mortality and a high tumor burden,which may facilitate broader adoption to study EAC development,progression,and therapeutics. | Daisuke Matsui Ashten N Omstead Juliann E Kosovec Yoshihiro Komatsu Emily J Lloyd Hailey Raphael Ronan J Kelly Ali H Zaidi Blair A Jobe | 2017 | World Journal of Gastroenterology2017，23，33： | 0 |
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