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| 1 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 2 | Supercapacitor electrodes obtained by directly bonding 2D MoS2 on reduced graphene oxide显示文摘 | Firmiano E G D S Rabelo A C Leite E R | 2014 | Adv Energy Mater2014，4，13： | 1 |
| 3 | Bromelain partitioning in two-phase aqueous systems containing PEO- PPO-PEO block copolymers 显示文摘 | Rabelo A P B Tambourgi E B Pessoa Jr A | 2004 | Journal of Chromatography B2004，807，： | 1 |
| 4 | Baroreflex sensitivity and oxidative stress in adriamycin-induced heart failure显示文摘 | Rabelo E De Angelis K Bock P | 2001 | Hypertension2001，38，32： | 1 |
| 5 | Effects of transition diets varying in dietary energy density on lactation performance and ruminal parameters of dairy cows 显示文摘 | Rabelo E Rezende R L Bertics S J et ol | 2003 | J Dairy Sci2003，86，： | 1 |
| 6 | Effects of transition diets varying in dietary energy density on lactation performance and ruminal parameters of dairy cows显示文摘 | RABELO E REZENDE R L BERTICS S J | 2003 | Journal of Dairy Science2003，86，3： | 1 |
| 7 | Reguration of the uncoupling protein gene expression显示文摘 | Salva J E R Rabelo | 1997 | Eur J Endocrinol1997，136，： | 1 |
| 8 | Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis显示文摘 | Thayane Rodrigues Leite Clemente Aline Noronha dos Santos José Narciso Sturaro érica Martins Ferreira Gotardo Caroline Candida de Oliveira Simone Coghetto Acedo Cintia Rabelo e Paiva Caria José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2012 | Scandinavian Journal of Gastroenterology (-)2012，，8： | 1 |
| 9 | Effects of two kinds of aerobic training on body fat content and serum lipid profile in cadets显示文摘 | De Souza e Silva M J de Souza Rabelo A Vale RG | 2009 | Biomed Human Kinet2009，，1： | 1 |
| 10 | Comparison of different direct diag- nostic methods to identify Babesia bovis and Babesia bi- gemina in animals vaccinated with live attenuated para- sites显示文摘 | COSTA-JUNIOR L M RABELO E M L MARTINS FILHO O A | 2006 | Vet Parasitol2006，139，： | 1 |
| 11 | Synthesis of magnese ferrite nanoparticles in macroporous styrenedivinylbenzene copolymer显示文摘 | Rabelo D Lima E C D Tavares Filho N | 2004 | J of Magnetism and Magnetic Mater2004，，： | 1 |
| 12 | Bar oreflex sensitivity and oxidat-ive stress in adriamycin-induced heart failure 显示文摘 | Rabelo E De Angelis K Boek P | 2001 | Hypertension2001，38，2： | 1 |
| 13 | Baroreflex sensitivity and oxidative stress in adriamycin-indueed heart failure显示文摘 | RABELO E D E ANGELIS K BOCK P | 2001 | Hypertension2001，38，： | 1 |
| 14 | Baroreflex sensitivity and oxidative stress in adriamycin-induced heart failure 显示文摘 | Rabelo E De Angelis K Bock P | 2001 | Hypertension2001，38，32： | 1 |
| 15 | Effects of transition diets varying in dietary energy density on lactation performance and ruminal parameters of dairy cows显示文摘 | Rabelo E Rezende R L Bertics S J | 2003 | J Dairy Sci2003，86，： | 1 |
| 16 | Characterization of a Caenorhabditis elegans glc seven-like phosphatase (gsp) orthologue from Haemonchus contortus (Nematoda) 显示文摘 | Campbell B E Rabelo E M Hofmann A | 2010 | Mol Cell Probes2010，24，： | 1 |
| 17 | Graphene oxide as a highly selective substrate to synthesize a layered MoS2 hybrid elec- trocatalyst显示文摘 | Firmiano E G Cordeiro M A Rabelo A C | 2012 | Chem Commun2012，48，62： | 1 |
| 18 | Baroreflex sensitivity and oxidative stress in adriamycin-induced heart failure显示文摘 | RABELO E D E ANGELIS K BOCK P | 2001 | Hypertension2001，38，： | 1 |
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