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54篇 您的检索式：作者名="Rabelo L"

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	题名	作者	年代	出处	被引量
1	Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.	Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa	2018	Hepatobiliary & Pancreatic Diseases International2018，17，4：	2
2	Multi-agent-based agile scheduling显示文摘	RABELO R J CAMARINHA-MATOS L M AFSARMANESH H	1999	Robotic and Autonomous System1999，27，12：	1
3	Infrastructure develop- ments for agile virtual enterprises 显示文摘	Camarinha-Matos L Afsarmanesh H Rabelo R	2003	International Journal of Computer Integrated Manufacturing2003，16，45：	1
4	Detection of fungi in beans by the laser biospeckle technique显示文摘	Braga R A Rabelo G F Granato L R	2005	Biosystems Engineering2005，91，4：	1
5	Disaster and prevention management for the NASA shuttle during lift off 显示文摘	Rabelo L Sepulveda J Compton J	2006	Disaster Prevention and Management2006，15，2：	1
6	The Wnt signaling pathway and rheumatoid arthritis显示文摘	Rabelo F D da Mota L M Lima R A	2010	Autoimmun Rev2010，9，4：	1
7	A methodology for realistic space launch risk estimation using information fusion based metri显示文摘	Sala Diakanda S N Sepulveda J A Rabelo L C	2010	Information Fusion2010，11，36：	1
8	Multi-agent-based agile scheduling 显示文摘	Camarinha-matos L M Afsarmanesh H	1999	Robotics and Autonomous System1999，27，1：	1
9	Simulation modeling of space missions using the high level arehiteeture显示文摘	RABELO L SALA-DIAKANDA S PASTRANA J	2013	Modelling and Simulation in Engineering2013，，：	1
10	Multi-agent-based agile scheduling显示文摘	R J Rabelo L M Camarinha-Matos H Afsarmanesh	1999	Robotics and Autonomous Systems1999，27，：	1
11	Assessment framework for the evaluation and prioritization of university inventions for licensing and commercialization显示文摘	AHMAD D RABELO R L C	2006	Engineering Management Journal2006，，12：	1
12	The technology adoption life cycle attractor:Understanding the dynamics of high-tech markets显示文摘	MEADE P T RABELO L	2004	Technological Forecasting and Social Change2004，71，：	1
13	Multi-Agent-based agile scheduling显示文摘	RABELO R J CAMARINHA-MATOS L M AFSARMANESH H	1999	Robotic and Autonomous System1999，27，12：	1
14	Multi-agent-based agile scheduling显示文摘	RABELO R J CAMARINHA MATOS L M AFSARMANESH H	1999	Robotics and Autonomous Systems1999，27，12：	1
15	Stability study of crude dextransucrase from Leuconostoc citreum NRRL B-742 显示文摘	RABELO M C FONTES C M L RODRIGUES S	2011	Indian Journal of Microbiology2011，51，2：	1
16	Estimating parameters of the three - parameter Weibull distribution using a neural network 显示文摘	ABBASI B RABELO L HOSSEINKOUCHACK M	2008	European Jour- nal of Industrial Engineering2008，2，4：	1
17	Effects of transition diets varying in dietary energy density on lactation performance and ruminal parameters of dairy cows 显示文摘	Rabelo E Rezende R L Bertics S J et ol	2003	J Dairy Sci2003，86，：	1
18	Multi-agent-based agile scheduling显示文摘	R J Rabelo L M Camarinha-Mstos H Afsarmanesh	1999	Robotics and Autonomous Systems1999，27，：	1
19	Multi-agent based agile scheduling显示文摘	Rabelo R J Camarinha-Matos L M Afsarmanesh H	1999	Robotics and Autonomous System1999，27，：	1
20	Effects of transition diets varying in dietary energy density on lactation performance and ruminal parameters of dairy cows显示文摘	RABELO E REZENDE R L BERTICS S J	2003	Journal of Dairy Science2003，86，3：	1

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