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| 1 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | The Lancet2012，，9819： | 1 |
| 2 | cGMP mediates thevascular and platelet actions of nitric oxide: Confirmation using aninhibitor of the soluble guanylyl cyclase显示文摘 | MORO M A RACHEL J RUSSEL L | 1996 | Proc Natl Acad Scl1996，93，： | 1 |
| 3 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | 2012 (9819)2012，，9819： | 1 |
| 4 | Hepatitis E vi- rus in blood components: a prevalence and transmis- sion study in southeast England显示文摘 | Hewitt Patricia E Ijaz Samreen Brailsford Su R Brett Rachel Dicks Steven Haywood Becky Kenne- dy Iain T R Kitchen Alan Patel Poorvi Poh John Russell Katherine Tettmar Kate I Tossell Joanne Ushiro-Lumb Ines Tedder Richard S | 2014 | Lancet2014，384，9956： | 1 |
| 5 | eGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase显示文摘 | Moro MA Rachel J Russell | 1996 | Proc Natl Acad Sci1996，93，： | 1 |
| 6 | Use of sirolimus in liver transplant recipients with renal insufficiency: A systematic review and meta‐analysis显示文摘 | Sumeet K. Asrani Michael D. Leise Colin P. West M. Hassan Murad Rachel A. Pedersen Patricia J. Erwin Jianmin Tian Russell H. Wiesner W. Ray Kim | 2010 | Hepatology2010，，4： | 1 |
| 7 | Hepatic pseudotumor associated with Strongyloides infection:A case report显示文摘BACKGROUND Strongyloides sterocoralis is a parasitic infection caused by a roundworm that is transmitted through soil contaminated with larvae.It can infrequently cause hepatic abscesses in immunocompromised patients and is rarely reported to form hepatic lesions in immunocompetent hosts.CASE SUMMARY We present a case study of a 45-year-old female who presented with right upper quadrant abdominal pain and constitutional symptoms for several weeks.Crosssectional imaging identified several malignant-appearing liver masses.Further investigation,including serological testing and histopathologic examination,revealed the presence of serum Strongyloides antibodies and hepatic granulomas with extensive necrosis.Following treatment with ivermectin for 2 wk,there was complete resolution of the liver lesions and associated symptoms.CONCLUSION This case highlights the importance of considering parasitic infections,such as Strongyloides,in the differential diagnosis of hepatic masses.Early recognition and appropriate treatment can lead to a favorable outcome and prevent unnecessary invasive procedures.Increased awareness among clinicians is crucial to ensure the timely diagnosis and management of such cases. | Jessica P Gialanella Tyler Steidl Kokkola Korpela Miral S Grandhi Russell C Langan H Richard Alexander Rachel M Hudacko Brett L Ecker | 2023 | World Journal of Hepatology2023，15，12： | 0 |
| 8 | Challenges of modern day transition care in inflammatory bowel disease: From inflammatory bowel disease to biosimilars显示文摘In this article we discuss the challenges of delivering a high quality Transition care. A good understanding of the adolescent needs with good communication between Transition care physicians and the patient is essential for good continuity of care. Despite availability of several guidelines, one model doesn't fit all and any transition service development should be determined by the local need and available healthcare facilities. | Ali Hakizimana Iftikhar Ahmed Rachel Russell Mark Wright Nadeem A Afzal | 2017 | World Journal of Gastroenterology2017，23，25： | 0 |
| 9 | Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice显示文摘Parallel to major changes in fatty acid and glucose metabolism,defect in branched-chain amino acid(BCAA)catabolism has also been recognized as a metabolic hallmark and potential therapeutic target for heart failure.However,BCAA catabolic enzymes are ubiquitously expressed in all cell types and a systemic BCAA catabolic defect is also manifested in metabolic disorder associated with obesity and diabetes.Therefore,it remains to be determined the cell-autonomous impact of BCAA catabolic defect in cardiomyocytes in intact hearts independent from its potential global effects.In this study,we developed two mouse models.One is cardiomyocyte and temporal-specific inactivation of the E1αsubunit(BCKDHA-cKO)of the branched-chainα-ketoacid dehydrogenase(BCKDH)complex,which blocks BCAA catabolism.Another model is cardiomyocyte specific inactivation of the BCKDH kinase(BCKDK-cKO),which promotes BCAA catabolism by constitutively activating BCKDH activity in adult cardiomyocytes.Functional and molecular characterizations showed E1αinactivation in cardiomyocytes was sufficient to induce loss of cardiac function,systolic chamber dilation and pathological transcriptome reprogramming.On the other hand,inactivation of BCKDK in intact heart does not have an impact on baseline cardiac function or cardiac dysfunction under pressure overload.Our results for the first time established the cardiomyocyte cell autonomous role of BCAA catabolism in cardiac physiology.These mouse lines will serve as valuable model systems to investigate the underlying mechanisms of BCAA catabolic defect induced heart failure and to provide potential insights for BCAA targeted therapy. | Jia-yu Yu Nancy Cao Christoph DRau Ro-Po Lee Jieping Yang Rachel JRoth Flach Lauren Petersen Cansheng Zhu Yea-Lyn Pak Russell AMiller Yunxia Liu Yibin Wang Zhaoping Li Haipeng Sun Chen Gao | 2023 | Acta Pharmacologica Sinica2023，44，7： | 0 |
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