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| 1 | Health risk assessment of heavy metals in soils and vegetables from wastewater irrigated area,Beijing-Tianjin city cluster,China显示文摘The possible health risks of heavy metals contamination to local population through food chain were evaluated in Beijing and Tianjin city cluster,China,where have a long history of sewage irrigation.The transfer factors(TF) for heavy metals from soil to vegetables for six elements including Cu,Zn,Pb,Cr,As and Cd were calculated and the pollution load indexes(PLI) were also assessed.Results indicate that only Cd exceeded the maximum acceptable limit in these sites.So far,the heavy metal concentrations in soils and vegetables were all below the permissible limits set by the Ministry of Environmental Protection of China and World Health Organization.The transfer factors of six heavy metals showed the trend as Cd > Zn > Cu > Pb > As > Cr,which were dependent on the vegetable species.The estimated dietary intakes of Cu,Zn,Pb,Cr,As and Cd were far below the tolerable limits and the target hazard quotient(THQ) values were less than 1,which suggested that the health risks of heavy metals exposure through consuming vegetables were generally assumed to be safe. | Yanchun Wang Min Qiao Yunxia Liu Yongguan Zhu | 2012 | Journal of Environmental Sciences2012，24，4： | 52 |
| 2 | Combined toxicity of copper and cadmium to six rice genotypes (Oryza sativa L.)显示文摘Accumulations of copper (Cu) and cadmium (Cd) in six rice cultivars (94D-22, 94D-54, 94D-64, Gui630, YY-1, and KY1360) were evaluated through exposure to heavy metal contamination (100 mg/kg Cu, 1.0 mg/kg Cd, and 100 mg/kg Cu + 1.0 mg/kg Cd) in a greenhouse. The dry weights of shoot and root, concentrations of Cu and Cd in plant tissues and the Cu, Cd, P, Fe concentrations in the root surface iron plaques were analyzed eight weeks later after treatment. The results indicated that the plant biomass was mainly determined by rice genotypes, not Cu and Cd content in soil. Separated treatment with Cu/Cd increased each metal level in shoot, root and iron plaques. Soil Cu enhanced Cd accumulation in tissues. In contrast, Cu concentrations in shoot and root was unaffected by soil Cd. Compared to single metal contamination, combined treatment increased Cd content by 110.6%, 77.0%, and 45.2% in shoot, and by 112.7%, 51.2% and 18.4% in root for Gui630, YY-1, and KY1360, respectively. The content level of Cu or Cd in root surface iron plaques was not affected by their soil content. Cu promoted Fe accumulation in iron plaques, while Cd has no effect on P and Fe accumulation in it. The translocation of Cu and Cd from iron plaques to root and shoot was also discussed. These results might be beneficial in selecting cultivars with low heavy metal accumulation and designing strategies for soil bioremediation. | HUANG Yizong, HU Ying, LIU Yunxia Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2009 | Journal of Environmental Sciences2009，21，5： | 33 |
| 3 | Fe/Fe2O3 nanoparticles anchored on Fe-N-doped carbon nanosheets as bifunctional oxygen electrocatalysts for rechargeable zinc-air batteries显示文摘有高催化的活动和稳定性玩的 Electrocatalysts 在有希望的可更新的精力技术的一个关键角色,例如燃料房间和金属空气电池。这里,我们报导 Fe/Fe 2 O 3 nanoparticles 在 Fe-N-doped 碳 nanosheets 上抛锚了(Fe/Fe 2 导出壳的做 N 的碳 nanodots 由一条简单热分解途径面对 FeCl 3 作为碳和氮采购的 O 3@Fe-N-C) 使用虾。Fe/Fe 2 O 3@Fe-N-C 在 1,000 的热分解温度获得了 ??????????? ″ ? 猼灵资 ? ??( ?? | Yipeng Zang Haimin Zhang Xian Zhang Rongrong Liu Shengwen Liu Guozhong Wang Yunxia Zhang Huijun Zhao | 2016 | Nano Research2016，9，7： | 10 |
| 4 | Characterization and fine mapping of an early senescence mutant (es-t) in Oryza sativa L.显示文摘An es-t (early senescence-temporary) mutant, produced by ethylene methylsulfonate treatment of strain Nipponbare, was identified in rice. The leaves of es-t appeared yellow at the seedling stage, and had decreased chlorophyll content. Rust spots were found during growth in es-t, especially at the leaf margin and tip. The plants showed a typical early-senescence phenotype at the milky stage. The leaf surface of es-t appeared smoother than wild-type leaves under a scanning electron microscope, because the leaves lack siliceous protuberances around the stoma. Chloroplasts grow abnormally and are filled with many starch grains in es-t. Paraffin section analysis showed that the development of the sclerenchyma cells and vascular bundles were also abnormal in es-t. Genetic analysis indicated that es-t was controlled by a recessive gene, which was finely mapped to a 42-kb interval on chromosome 5. These results will facilitate the positional cloning and functional studies of the gene. | YANG YaoLong RAO YuChun LIU HuiJuan FANG YunXia DONG GuoJun HUANG LiChao LENG YuJia GUO LonBiao ZHANG GuangHeng HU Jiang GAO ZhenYu QIAN Qian ZENG DaLi | 2011 | Chinese Science Bulletin2011，56，23： | 8 |
| 5 | Micro-structure sensors based on ZnO microcrystals with contact-controlled ethanol sensing显示文摘ZnO microcrystals are synthesized through a facile solution method and characterized by field-emission scanning electron microscopy, transmission electron microscopy, selected area electron diffraction and X-ray diffraction. The ethanol sensing properties of these microcrystals are investigated by spin-coating them on a silicon substrate with Pt electrodes to fabricate a micro-structure sensor. The sensitivity is up to 8 when the sensor is exposed to 50 ppm ethanol, and the response time and recovery time are 10 s and 20 s, respectively. A contact-controlled model is established to explain the sensing properties of the microcrystals, which provides another approach to realize high-performance gas sensors. | LIU Li ZHANG Tong LI ShouChun WANG LianYuan TIAN YunXia | 2009 | Chinese Science Bulletin2009，54，23： | 7 |
| 6 | Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells显示文摘Iron is an essential trophic element that is required for cell viability and differentiation, especially in oligodendrocytes, which consume relatively high rates of energy to produce myelin. Multiple iron metabolism proteins are expressed in the brain including transferrin receptor and ferritin-H. However, it is still unknown whether they are developmentally regulated in oligodendrocyte lineage cells for myelination. Here, using an in vitro cultured differentiation model of oligodendrocytes, we found that both transferrin receptor and ferritin-H are significantly upregulated during oligodendrocyte maturation, implying the essential role of iron in the development of oligodendrocytes. Additional different doses of Fe3+ in the cultured medium did not affect oligodendrocyte precursor cell maturation or ferritin-H expression but decreased the expression of the transferrin receptor. These results indicate that upregulation of both transferrin receptor and ferritin-H contributes to maturation and myelination of oligodendrocyte precursor cells. | Yunxia Li Qiang Guan Yuhui Chen Hongjie Han Wuchao Liu Zhiyu Nie | 2013 | Neural Regeneration Research2013，8，1： | 7 |
| 7 | Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b显示文摘Objective: The aim of this study was to investigate the underlying mechanism whereby HBx modulates the targeting of NUSAP1 by miR-18b to enhance hepatocarcinogenesis.Methods: We employed an integrated approach of bioinformatics analysis and molecular experiments in hepatoma cells, HBV transgenic mice, and clinical liver cancer tissues to investigate the role of HBx-regulated miR-18b in the development of liver cancer.Results: In this study, we report that the HBx-mediated tumor suppressor miR-18b modulates hepatocarcinogenesis during the host-HBV interaction. The expression levels of miR-18b were lower in clinical HBV-positive liver cancer tissues and liver tissues of HBV-transgenic mice. Interestingly, HBx inhibited miR-18b expression by inducing the methylation of CpG islands in its promoter. Accordingly, we tested the hypothesis that HBx enhanced hepatocarcinogenesis by increasing the expression of target genes of miR-18b. Moreover, we identified nucleolar spindle-associated protein 1(NUSAP1) as one of the target genes of miR-18b.NUSAP1 was expressed at high levels in liver cancer tissues. Interestingly, HBx up-regulated NUSAP1 by suppressing miR-18b.Functionally, miR-18b significantly inhibited the proliferation of hepatoma cells by depressing NUSAP1 levels in vivo and in vitro.Conclusions: Thus, we conclude that the targeting of NUSAP1 mRNA by the tumor suppressor miR-18b is controlled by HBxmodulated promoter methylation during the host-virus interaction, leading to hepatocarcinogenesis. Our findings provide new insights into the mechanism by which HBx-mediated miRNAs modulate hepatocarcinogenesis. | Zhe Yang Jiong Li Guoxing Feng Yuan Wang Guang Yang Yunxia Liu Shuqin Zhang Jinyan Feng Xiaodong Zhang | 2019 | Cancer Biology & Medicine2019，16，2： | 6 |
| 8 | Preferential loss of gut-homing a4β7 CD4+T cells and their circulating functional subsets in acute HIV-1 infection显示文摘 | Xiaofan Lu Zhen Li Qunhui Li Yanmei Jiao Yunxia Ji Hongwei Zhang Zhuoming Liu Wei Li Hao Wu | 2016 | Cellular & Molecular Immunology2016，13，6： | 6 |
| 9 | Sensitive electrochemical DNA sensor for the detection of HIV based on a polyaniline/graphene nanocomposite显示文摘A nanocomposite of polyaniline/graphene(PAN/GN)was prepared using reverse-phase polymerization.The nanocomposite material was dropcast onto a glassy carbon electrode(GCE).Then,a single-stranded DNA(ssDNA)probe for HIV-1 gene detection was immobilized on the modified electrode,and the negative charged phosphate backbone of the HIV-1 was bound to the modified electrode surface via p-p*stacking interactions.The hybridization between the ssDNA probe and the target HIV-1 formed doublestranded DNA(dsDNA),and the electron transfer resistance of the electrode was measured using impedimetric studies with a[Fe(CN)6]^(3-/4-)redox couple.Under the optimized experimental conditions,the change of the impedance value was linearly related to the logarithm of the concentration of HIV genes in the range from 5.0×10^(-16)M to 1.0×10^(-10)M(R=0.9930),and the HIV sensor exhibited a lower detection limit of 1.0×10^(-16)M(S/N=3).The results show that this biosensor presented wonderful selectivity,sensitivity and specificity for HIV-1 gene detection.Thus,this biosensor provides a new method for the detection of HIV gene fragments. | Qiaojuan Gong Haixia Han Haiying Yang Meiling Zhang Xiaoling Sun Yunxia Liang Zhaorong Liu Wenchan Zhang Jinli Qiao | 2019 | Journal of Materiomics2019，5，2： | 5 |
| 10 | Arsenic uptake, accumulation and phytofiltration by duckweed (Spirodela polyrhiza L.)显示文摘This study investigates arsenic (As) accumulation and tolerance of duckweed Spirodela polyrhiza L. and its potential for As phytofiltration. S. polyrhiza was able to survive in high concentration of As(V) solution. The EC 50 values (± SE) based on the external As(V) were (181.66 ± 20.12) μmol/L. It accumulated (999 ± 95) mg As/kg dw when exposed in 320 μmol/L As(V) solution for one week, and was able to take up appropriately 400 mg As/kg dw in tissues without a significant biomass loss. The EC 50 values (the effective concentration of As(V) in the nutrient solution that caused a 50% inhibition on biomass production) was (866 ± 68) mg/kg dw for the tissues, indicating that S. polyrhiza had a high capability of As accumulation and tolerance. The uptake kinetic parameters V max was (55.33 ± 2.24) nmol/(g dw·min) and K m was (0.144 ± 0.011) mmol/L. Within 72 hr, S. polyrhiza decreased As concentration in the solution from 190 to 113 ng/mL with a removal rate of 41%. The study suggested that this floating aquatic plant has some potential for As phytofiltration in contaminated water bodies or paddy soils. | Xin Zhang Ying Hu Yunxia Liu Baodong Chen | 2011 | Journal of Environmental Sciences2011，23，4： | 5 |
| 11 | Microvascular pathological features and changes in related injury factors in a rat acute blood stasis model显示文摘OBJECTIVE: To examine the microvascular pathological characteristics and changes in related injury factors in a rat model of acute blood stasis.METHODS: A total of 75 Sprague-Dawley rats were divided randomly and equally into a control group and four experimental groups assessed at different times after the induction of stasis(0, 1, 3 or 6 h after stasis)(n = 15). The acute blood stasis model was established through rat tail-vein injection of high-molecular-weight dextran. After Electrocardiograph(ECG) detection at predetermined times(0,1, 3 and 6 h after induction of stasis), the rats were sacrificed and blood and cardiac samples were harvested for analysis. Hematoxylin-eosin(HE) staining and transmission electron microscopy were used for histopathological detection; an enzyme linked immunosorbent assay(ELISA) was used to detect thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) concentrations; a real-time polymerase chain reaction(PCR) reaction system was used to detect intercellular adhesion molecule1(ICAM-1) and vascular cell adhesion molecule1(VCAM-1) m RNA expression; western blotting was used to detect vascular endothelial cadherin(VE-cadherin) protein expression.RESULTS: The ST segment in the ECG showed gradual elevation after induction of stasis and continued elevation at a high level at 3 and 6 h. The HE staining showed changes in myocardial cell necrosis and tissue dissociation after the induction of stasis, along with inflammatory infiltration. Results of transmission electron microscopy showed immediate changes in blood stasis and lumen occlusion in the microvasculature, along with endothelial cell swelling. After the induction of stasis, TXB2 concentrations gradually increased while 6-Keto-PGF1αconcentrations were immediately significantly reduced. The TXB2/6-Keto-PGF1αratio was maintained at a high level. ICAM-1 m RNA expression showed an unstable elevation while VCAM-1 m RNA expression was significantly reduced after the induction of stasis. Compared with the control group, VE-cadherin protein expression increased at 0 and 3 h after the induction of stasis, while no change occurred at 1 and 6 h.CONCLUSION: The pathological manifestations of acute blood stasis are microvascular blood retention, lumen stenosis and even occlusion. The condition is also called 'blood coagulation and weep' in Traditional Chinese Medicine. The blood stasis model resulted in the injury and necrosis of endothelial cells and cardiomyocytes, along with the presence of an imbalance of vasomotor factor levels, platelet activation, and increases in the expression of adhesion molecules and endothelial barrier dysfunction,which corresponds to 'blood failed to nourish' in Traditional Chinese Medicine. | Zhang Junxiu Feng Yu Li Shaodan, Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 5 |
| 12 | Design and experimental study of seed precise delivery mechanism for high-speed maize planter显示文摘Aiming at improving the seed spacing uniformity of maize planter at high forward speed,a seed precise delivery mechanism driven by electric motor has been developed and evaluated in laboratory.The mechanism was designed to deliver single seed from seed meter to furrow.Seed’s movement from the seed release point in a seed meter to the seed delivery cavity in the belt was analyzed,the mathematical model of seed movement in the seed precise delivery mechanism was established based on seed delivery time analysis.A mechanical prototype was designed and associated control system was developed.The performance contrast experiment was conducted between a traditional seed tube and newly developed seed precise delivery mechanism,and test results indicated that the qualities of feed index of the seed precise delivery mechanism were higher than those of the traditional seed tube delivery mechanism,and the coefficients of variation of the seed precise delivery mechanism were lower than those of the traditional seed tube delivery mechanism when the forward speed of planter was set at 10 km/h,12 km/h and 14 km/h,respectively.It indicated the seed precise delivery mechanism significantly improved seed spacing uniformity of maize planter compared with the traditional seed tube delivery mechanism. | Quanwei Liu Tao Cui Dongxing Zhang Li Yang Yunxia Wang Xiantao He Mantao Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 13 | Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion显示文摘Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the urine.Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment. | Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal Alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2020 | Bone Research2020，8，2： | 4 |
| 14 | Growth and metal uptake of energy sugarcane (Saccharum spp.) in different metal mine tailings with soil amendments显示文摘A pot experiment was conducted to investigate the feasibility of growing energy sugarcane(Saccharum spp.) in three different metal mine tailings(Cu, Sn and Pb/Zn tailings) amended with uncontaminated soil at different mixing ratios. The results indicated that sugarcane was highly tolerant to tailing environments. Amendments of 20% soil to Sn tailings and 30% soil to Cu tailings could increase the biomass of cane-stem for use as the raw material for bioethanol production. Heavy metals were mostly retained in roots, which indicated that sugarcane was useful for the stabilization of the tailings. Bagasse and juice, as the most valuable parts to produce bioethanol, only accounted for 0.6%– 3% and 0.6%–7% of the total metal content. Our study supported the potential use of sugarcane for tailing phytostabilization and bioenergy production. | Xin Zhang Yongguan Zhu Yuebin Zhang Yunxia Liu Shaochun Liu Jiawen Guo Rudan Li Songlin Wu Baodong Chen | 2014 | Journal of Environmental Sciences2014，26，5： | 4 |
| 15 | Oblique wave scattering by a semi-infinite elastic plate with finite draft floating on a step topography显示文摘On the basis of a potential theory and Euler-Bernoulli beam theory,an analytical solution for oblique wave scattering by a semi-infinite elastic plate with finite draft floating on a step topography is developed using matched eigenfunction expansions.Different from previous studies,the effects of a wave incident angle,a plate draft,three different plate edge conditions(free,simply supported and built-in) and a sea-bottom topography are all taken into account.Moreover,the plate edge conditions are directly incorporated into linear algebraic equations for determining unknown expansion coefficients in velocity potentials,which leads to a simple and efficient solving procedure.Numerical results show that the convergence of the present solution is good,and an energy conservation relation is well satisfied.Also,the present predictions are in good agreement with known results for special cases.The effects of the wave incident angle,the plate draft,the plate edge conditions and the sea-bottom topography on various hydrodynamic quantities are analyzed.Some useful results are presented for engineering designs. | GUO Yunxia LIU Yong MENG Xun | 2016 | Acta Oceanologica Sinica2016，35，7： | 4 |
| 16 | Preparation and tribological properties of Sol-Gel TiO_2-ZrO_2 composite thin films显示文摘High oriented TiO2-ZrO2 composite thin films on Si (100) and glass sheet were suc-cessfully prepared by sol-gel process followed by dip-coating the ethanol solution of zirconiumoxychloride and titanium tetrachloride. The sol-gel process, microstructure, morphology and tri-bological properties of TiO2 -ZrO2 films were investigated using TGA, DSC, XPS, XRD, AFM anddynamic-static tribometer. The results show that the TiO2-ZrO2films are dense, homogeneous andat a complete tetragonal phase with an excellent antiwear and friction reduction performance. Un-der 0.5N applied load, the friction coefficient is 0.14-0.20 and the antiwear life is more than 5000sliding cycles for both TiO2-ZrO2/ AISI 52100 steel and TiO2-ZrO2/ Si3N4. SEM observation sug-gests that wear mechanism of TiO2 -ZrO2 composite film under low load was fatigue wear, andunder high load was adhesive wear. The TiO2 -ZrO2 films show potential applications as coatingsfor antiwear and friction reduction under the harsh condition. | CHEN Yunxia ZHOU Jinfang LIU Weimin State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical, Physics, Chinese Academy of Sciences, Lanzhou 730000, China | 2001 | Science China Mathematics2001，44，S1： | 3 |
| 17 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 18 | Pingwei capsules improve gastrointestinal motility in rats with functional dyspepsia显示文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC. | Liang Qiankun Mao Lanfang Du Xiaojuan Li Yunxia Yan Yuan Liang Jingjing Liu Junhong Wang Longde Li Hongfang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 19 | Liquid metal as energy transportation medium or coolant under harsh environment with temperature below zero centigrade显示文摘 | Yunxia GA0 Lei WANG Haiyan LI Jing LIU | 2014 | Frontiers in Energy2014，8，1： | 3 |
| 20 | MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice显示文摘Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, multi-tillering dwarf1(mtd1), a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtd1 mutant exhibited pleiotropic phenotypes, including dwarfism, more tillers, brittle culms and delayed heading date.By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOC_Os09g02650(BC12) in mtd1 mutant had a single nucleotide substitution(G to A), which generated a premature translation stop. Over-expressing MTD1/BC12 coding sequence rescued all the phenotypes of mtd1 mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtd1 mutant.Quantitative reverse transcription-PCR analysis showed that MTD1/BC12 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remarkably, a-amylase activity analysis and gibberellic acid(GA)treatment showed that the dwarf phenotype of mtd1 mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice. | Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang Zhenyuan Shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao | 2016 | Science Bulletin2016，61，23： | 3 |
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