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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients显示文摘 | Wang-Johanning F Radvanyi L Rycaj K | 2008 | Cancer Res2008，68，14： | 1 |
| 3 | Advances in the treatment of metastatic melanoma: Adoptive T-cell therapy 显示文摘 | Bernatchez C Radvanyi LG Hwu P | 2012 | Semin Oncol2012，39，2： | 1 |
| 4 | Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder显示文摘 | Patard J J Brasseur F Gil-Diez S Radvanyi F Marchand M | 1995 | Int J Cancer1995，64，1： | 1 |
| 5 | Differences in steroid 5alpha-reductase iso-enzymes ex- pression between normal and pathological human pros- tate tissue显示文摘 | Iehle C Radvanyi F Gil Diez de Medina S | 1999 | J Steroid Biochem Mol Biol1999，68，56： | 1 |
| 6 | The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer 显示文摘 | Radvanyi L Singh-Sandhu D Galliehan S | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 7 | The IL-2 cytokine family in cancer immuno- therapy显示文摘 | Sim GC Radvanyi L | 2014 | Cytokine Growth Factor Rev2014，25，4： | 1 |
| 8 | The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate显示文摘 | Van-Rhi jn BW Lurkin 1 Radvanyi F | 2001 | Cancer Res2001，61，4： | 1 |
| 9 | The IL-2 cytokine family in cancer im- munotherapy 显示文摘 | SIM G C RADVANYI L | 2014 | Cytokine Growth Factor Rev2014，25，4： | 1 |
| 10 | Discovery and immunologic validation of new antigens for therapeutic cancer vaccines 显示文摘 | Radvanyi L | 2004 | International Archives of Allergy and Immunology2004，133，： | 1 |
| 11 | Neovascularization is associated with a switch to the export of bFGF inthe multistep deve lopment of fibrosarcoma显示文摘 | Kandel J Bossy-Wetzel E Radvanyi F | 1991 | Cell1991，66，： | 1 |
| 12 | A study of behaviour profiles among intellectually disabled people in residential care in Hungary显示文摘 | Csorha J Radvanyi K Regenyi E | 2011 | Res Dev Disabil2011，32，5： | 1 |
| 13 | Computational auditory scene analysis in cellular wave computing framework显示文摘 | FODROCZI Z RADVANYI A | 2006 | International Journal of Circuit Theory and Applications2006，34，4： | 1 |
| 14 | Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-alpha显示文摘 | Wang C Al-Omar HM Radvanyi L | 1999 | Exp Hematol1999，27，7： | 1 |
| 15 | Harnessing the power of the immune system to target cancer 显示文摘 | Lizée G Overwijk WW Radvanyi L | 2013 | Annu Rev Med2013，64，： | 1 |
| 16 | Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients显示文摘 | Radvanyi LG Bernatchez C Zhang M | | 0，，： | 1 |
| 17 | Under- standing and addressing barriers to implementation of envi- ronmental and policy interventions to support physical ac- tivity and healthy eating in rural communities显示文摘 | Barnidge E K Radvanyi C Duggan K | 2013 | J Rural Health2013，29，1： | 1 |
| 18 | Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue显示文摘 | Iehle C Radvanyi F Gil Diez dM | 1999 | J Steroid Biochem Mol Biol1999，68，56： | 1 |
| 19 | Tumor-Infiltrating Lymphocyte Therapy for Melanoma: Rationale and Issues for Further Clinical Development显示文摘 | Geok Choo Sim Jessica Chacon Cara Haymaker Krit Ritthipichai Manish Singh Patrick Hwu Laszlo Radvanyi | 2014 | BioDrugs2014，，： | 1 |
| 20 | Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma 显示文摘 | Kandel J Bossy-Wetzel E Radvanyi F | 1991 | Cell1991，66，6： | 1 |
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