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| 1 | Overlapping expression of microRNAs in human embryonic colon and colorectal cancer显示文摘MicroRNAs (miRNAs ) 为调整房间区别并且维持干细胞的 pluripotent 状态是必要的。尽管特定的 miRNAs 的 dysregulation 与癌症的某些类型被联系了,到日期,没有证据连接了 miRNA 表示在胚胎并且肿瘤纸巾。我们在人的胚胎的结肠组织,并且在 colorectal 癌症估计了成熟 miRNAs 的表示并且配对正常结肠组织。重叠 miRNA 表示在胚胎的结肠的 mucosa 和 colorectal 癌症之间被检测。我们发现了 miR-17-92 聚类,调整在两个盒子中的房间增长并且它的目标, E2F1,在人的冒号开发和结肠的 carcinogenesis 展出表示的一个类似的模式。在 situ,杂交在地窟祖先分隔空间证实了 miR-17-5p 的表示的高水平。我们断定 miRNA 小径在胚胎的开发和结肠的上皮的肿瘤的转变起一个主要作用。 | Mariano Monzo Alfons Navarro Eva Bandres Rosa Artells Isabel Moreno Bemat Gel Rafael Ibeas Jose Moreno Francisco Martinez Tania Diaz Antonio Martinez Olga Balague Jesus Garcia-Foncillas | 2008 | Cell Research2008，18，8： | 32 |
| 2 | Land cover changes and fragmentation in mountain neotropical ecosystems of Oaxaca, Mexico under community forest management显示文摘Changes in land cover have a direct impact on forest ecosystem goods and services. In this study, changes in land cover in Sierra de Juarez–Oaxaca ecosystems were estimated using a consistent processing of Landsat images and OBIA methodology. Additionally, landscape analyses using FRAGSTAT were conducted. In 2014, Sierra de Juarez–Oaxaca was covered by approximately 84% of forests, mainly pine-oak and cloud forests. After extensive deforestation until 2001, this trend was reversed and the forest cover surface area in 2014 was slightly higher than in 1979. The comparison of the landscape structure of the forested and agricultural lands suggests an increase in habitat heterogeneity. However, interspersion and juxtaposition indices, showing the patch shape by patch area and perimeter, were similar throughout the study period(1979–2014). Social and economic drivers can explain this situation: namely, community organization, forest enterprises, payment for ecosystem services programs, and changes of agricultural activity. Communities in the Sierra of Oaxaca have reforested degraded lands, created community forest enterprises, and preserved the forest under conservation schemes like those proposed by the Mexican payment for ecosystem services programs. However, their sustainable management faces internal challenges and has become highly dependent on political and institutional decisions beyond their control. | Rafael M~a Navarro Cerrillo Dennis J.Esteves Vieira Susana Ochoa-Gaona Bernardus H.J.de Jong M~a del Mar Delgado Serrano | 2019 | Journal of Forestry Research2019，30，1： | 4 |
| 3 | FACTORS ASSOCIATED TO INFECTION BY Toxoplasma gondii IN PREGNANT WOMEN ATTENDED IN BASIC HEALTH UNITS IN THE CITY OF ROL?NDIA, PARANá, BRAZIL显示文摘 | Dias Renata Cristina Ferreira Lopes-Mori Fabiana Maria Ruiz Mitsuka-Breganó Regina Dias Rafael André Ferreira Tokano Deise Vieira Reiche Edna Maria Vissoci Freire Roberta Lemos Navarro Italmar Teodorico | 2011 | Revista do Instituto de Medicina Tropical de S茫o Paulo2011，，4： | 1 |
| 4 | 'Changes in the Intellectual Structure of Strategic Management Research: A Bibliometric Study of the Strategic Management Journal: 1980- 2000显示文摘 | Antonio - Rafael Ramos - Rodriguez and Jose Ruiz -Navarro | 2004 | Strategic Management Journal2004，，25： | 1 |
| 5 | Modulation transfer of the human eye as a function of retinal eccentricity显示文摘 | Rafael Navarro Pablo Artal | 1993 | JOSA1993，10，2： | 1 |
| 6 | Lugar de la cirugía local en el adenocarcinoma de recto T 2 N 0 M 0显示文摘 | Xavier Serra Aracil Jordi Bombardó Juncá Laura Mora López Manuel Alcantara Moral Isidro Ayguavives Garnica Ana Darnell Marti Alex Casalots Casado Carles Pericay Pijaume Rafael Campo Fernández de Los Ríos Salvador Navarro Soto | 2008 | Cirugia Espanola2008，，2： | 1 |
| 7 | Off-axis aberrations of a wide-angle schematic eye model显示文摘 | Isabel Escudero-Sanz Rafael Navarro | 1999 | JOSA A1999，16，8： | 1 |
| 8 | Phase plates for wave-aberration compensation in the human eye显示文摘 | Esther Moreno-Barriuso | 2000 | Optics Letters2000，25，： | 1 |
| 9 | Laser ray-tracing versus Hartmann-Shack sensor for measuring optical aberrations in the human eye显示文摘 | Moreno-Barriuso Esther Navarro Rafael | 2000 | J Opt Soc Am A2000，17，6： | 1 |
| 10 | Gaussian wavelet transform: Two alternative fast implementations for images显示文摘 | Rafael Navarro Antonio Tabernero | 1991 | Multidimensional Systems and Signal Processing1991，，4： | 1 |
| 11 | Scatteromater using a bidirectional ring laser 显示文摘 | RAFAEL Q T NAVARRO M ACKERMAN M | 2004 | Optics Communications2004，241，1： | 1 |
| 12 | Gaussian wavelet transform: Two alternative fast implementations for images显示文摘 | Rafael Navarro Antonio Tabernero | 1991 | Multidimensional Systems and Signal Processing1991，，4： | 1 |
| 13 | Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors显示文摘 | R. Valero Catiana Cabrer Frederic Oppenheimer Esteve Trias Jacinto Sánchez-Ibá?ez Francisco M. De Cabo Aurora Navarro David Paredes Antonio Alcaraz Rafael Gutiérrez Martí Manyalich | | 0，，： | 1 |
| 14 | Rock mass structural recognition from drill monitoring technology in underground mining using discontinuity index and machine learning techniques显示文摘A procedure to recognize individual discontinuities in rock mass from measurement while drilling(MWD)technology is developed,using the binary pattern of structural rock characteristics obtained from in-hole images for calibration.Data from two underground operations with different drilling technology and different rock mass characteristics are considered,which generalizes the application of the methodology to different sites and ensures the full operational integration of MWD data analysis.Two approaches are followed for site-specific structural model building:a discontinuity index(DI)built from variations in MWD parameters,and a machine learning(ML)classifier as function of the drilling parameters and their variability.The prediction ability of the models is quantitatively assessed as the rate of recognition of discontinuities observed in borehole logs.Differences between the parameters involved in the models for each site,and differences in their weights,highlight the site-dependence of the resulting models.The ML approach offers better performance than the classical DI,with recognition rates in the range 89%to 96%.However,the simpler DI still yields fairly accurate results,with recognition rates 70%to 90%.These results validate the adaptive MWD-based methodology as an engineering solution to predict rock structural condition in underground mining operations. | Alberto Fernández JoséA.Sanchidrián Pablo Segarra Santiago Gómez Enming Li Rafael Navarro | 2023 | International Journal of Mining Science and Technology2023，33，5： | 0 |
| 15 | Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis显示文摘AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.RESULTS:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was more frequent in the TE than in the TN patients(57% vs 40%,P = 0.01). With respect to severe haematological disorders,neutropaenia was more likely to affect the patients treated with BOC(33% vs 20%,P ≤ 0.0001),and thrombocytopaenia and anaemia,the F4 patients(P = 0.000,P = 0.025,respectively). CONCLUSION:In a real clinical practice setting with a high proportion of patients with advanced fibrosis,effectiveness of first-generation PIs was high except for NR patients,with similar SVR rates being achieved by BOC and TVR. | Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
| 16 | Image analysis of Moroccan carob seeds(Ceratonia siliqua L.)revealed substantial intraspecific variations depending on climate and geographic origin显示文摘Background:The carob tree(Ceratonia siliqua L.)is one of the most iconic tree species of the Mediterranean region,with valuable economic,ecological and cultural value.Carob has been exploited around the Mediterranean region since antiquity and has been regarded as an important component of natural habitats and traditional agroecosystems.Several studies have focused on its morphological,biochemical,and genetic diversity.However,less is known about the intraspecific variation of seed traits.In this regard,and as an overall objective,we intend to evaluate the amplitude and the expression of intraspecific variations of carob seed traits at different ecological scales ranging from individual trees to different geographical landscapes.In addition,we investigated how the climate along the study area affects the extent of carob seed variability.Using image analysis techniques,we measured seven traits related to the size and the shape of 1740 seeds collected from 18 populations of spontaneous C.siliqua distributed along a latitudinal transect in Morocco under different bioclimatic conditions.Results:The morphometric analysis of carob seed showed the effectiveness of adopted approach to highlight the amount and the amplitude of intraspecific variation according to geographic and climatic factors.Seed trait analysis revealed high intraspecific variability,explained by differences between and among carob populations and geographic zones.Seed area,perimeter,length,and width showed the largest variability between geographic zones.However,circularity,aspect ratio,and seed roundness showed higher variability at the tree level.Finally,our results show that seed traits vary depending on altitude and climate condition.Conclusions:Revealing the amount and the structure of intraspecific traits variability of carob seed provides interesting insights to understand the mechanisms underlying trees adaptation to various environmental and ecological conditions.Therefore,intraspecific variation of seed traits should be integrated into trait‑based functional ecology to assess plant species responses to environmental changes. | Jalal Kassout Younes Hmimsa Salama El Fatehi Abdeltif El Ouahrani Khalil Kadaoui Soufian Chakkour David Ariza‑Mateos Guillermo Palacios‑Rodríguez Rafael Navarro‑Cerrillo Mohammed Ater | 2022 | Ecological Processes2022，11，1： | 0 |
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