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| 1 | Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements显示文摘Primary liver cancers carry significant morbidity and mortality.Hepatocellular carcinoma(HCC)develops within the hepatic parenchyma and is the most common malignancy originating from the liver.Although 80%of HCCs develop within background cirrhosis,20%may arise in a non-cirrhotic milieu and are referred to non-cirrhotic-HCC(NCHCC).NCHCC is often diagnosed late due to lack of surveillance.In addition,the rising prevalence of non-alcoholic fatty liver disease and diabetes mellitus have increased the risk of developing HCC on noncirrhotic patients.Viral infections such as chronic Hepatitis B and less often chronic hepatitis C with advance fibrosis are associated with NCHCC.NCHCC individuals may have Hepatitis B core antibodies and occult HBV infection,signifying the role of Hepatitis B infection in NCHCC.Given the effectiveness of current antiviral therapies,surgical techniques and locoregional treatment options,nowadays such patients have more options and potential for cure.However,these lesions need early identification with diagnostic models and multiple surveillance strategies to improve overall outcomes.Better understanding of the NCHCC risk factors,tumorigenesis,diagnostic tools and treatment options are critical to improving prognosis and overall outcomes on these patients.In this review,we aim to discuss NCHCC epidemiology,risk factors,and pathogenesis,and elaborate on NCHCC diagnosis and treatment strategies. | Abhilash Perisetti Hemant Goyal Rachana Yendala Ragesh B Thandassery Emmanouil Giorgakis | 2021 | World Journal of Gastroenterology2021，27，24： | 6 |
| 2 | Endoscopic ultrasound guided drainage of pancreatic fluid collections: Assessment of the procedure, technical details and review of the literature显示文摘Endoscopic ultrasound(EUS) guided drainage of pancreatic fluid collections(PFC) has become increasingly popular and become first line management option in many centers. Use of therapeutic echoendoscopes has greatly increased the applicability of EUS guided transmural drainage. Drainage is indicated in symptomatic PFCs, PFC related infection, bleed, luminal obstruction, fistulization and biliary obstruction. EUS guided transmural drainage of PFCs is preferred in patients with non bulging lesions, portal hypertension, bleeding tendency and in those whom conventional drainage has failed. In the present decade significant progress has been made in minimally invasive endoscopic techniques. There are newer stent designs, access devices and techniques for more efficient drainage of PFCs. In this review, we discuss the EUS guided drainage of PFCs in acute pancreatitis. | Rajesh Puri Ragesh Babu Thandassery Abdulrahman A Alfadda Saad Al Kaabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 5 |
| 3 | Sarcopenia in hepatocellular carcinoma:Current knowledge and future directions显示文摘Liver cancer is the second most occurring cancer worldwide and is one of the leading causes of cancer-related deaths.Hepatocellular carcinoma(HCC)is the most common(80%-90%)type among malignant liver cancers.Sarcopenia occurs very early in HCC and can predict and provide an opportunity to improve muscle health before engaging in the treatment options such as loco-regional,systemic,and transplant management.Multiple prognostic stating systems have been developed in HCC,such as Barcelona Clinic Liver Cancer,Child-Pugh score and Albumin-Bilirubin grade.However,the evaluation of patients’performance status is a major limitation of these scoring systems.In this review,we aim to summarize the current knowledge and recent advances about the role of sarcopenia in cirrhosis in general,while focusing specifically on HCC.Additionally,the role of sarcopenia in predicting clinical outcomes and prognostication in HCC patients undergoing loco-regional therapies,liver resection,liver transplantation and systematic therapy has been discussed.A literature review was performed using databases PubMed/MEDLINE,EMBASE,Cochrane,Web of Science,and CINAHL on April 1,2021,to identify published reports on sarcopenia in HCC.Sarcopenia can independently predict HCC-related mortality especially in patients undergoing treatments such as loco-regional,surgical liver transplantation and systemic therapies.Basic research is focused on evaluating a balance of anabolic and catabolic pathways responsible for muscle health.Early clinical studies have shown promising results in methods to improve sarcopenia in HCC which can potentially increase prognosis in these patients.As sarcopenia occurs very early in HCC,it can predict and provide an opportunity to improve muscle health before engaging in the treatment options such as loco-regional,systemic,and transplant management.Further,sarcopenia measurement can obviate the confounding caused by the abdominal ascites in these patients.The use of sarcopenia can add to the existing scoring systems to better prognosticate the HCC. | Abhilash Perisetti Hemant Goyal Rachana Yendala Saurabh Chandan Benjamin Tharian Ragesh BabuThandassery | 2022 | World Journal of Gastroenterology2022，28，4： | 3 |
| 4 | Endoscopic ultrasound guided liver biopsy: Recent evidence显示文摘Liver biopsy(LB)is an essential tool in diagnosing,evaluating and managing various diseases of the liver.As such,histopathological results are critical as they establish or aid in diagnosis,provide information on prognosis,and guide the appropriate selection of medical therapy for patients.Indications for LB include evaluation of persistent elevation of liver chemistries of unclear etiology,diagnosis of chronic liver diseases such as Wilson's disease,autoimmune hepatitis,small duct primary sclerosing cholangitis,work up of fever of unknown origin,amyloidosis and more.Traditionally,methods of acquiring liver tissue have included percutaneous LB(PCLB),transjugular LB(TJLB)or biopsy taken surgically via laparotomy or laparoscopy.However,traditional methods of LB may be inferior to newer methods.Additionally,PCLB and TJLB carry higher risks of adverse events and complications.More recently,endoscopic ultrasound guided LB(EUS-LB)has evolved as an alternative method of tissue sampling that has proven to be safe and effective,with limited adverse events.Compared to PC and TJ routes,EUS-LB may also have a greater diagnostic yield of tissue,be superior for a targeted approach of focal lesions,provide higher quality images and allow for greater patient comfort.These advantages have contributed to the increased use of EUS-LB as a technique for obtaining liver tissue.Herein,we provide a review of the recent evidence of EUS-LB for liver disease. | Kemmian D Johnson Passisd Laoveeravat Eric U Yee Abhilash Perisetti Ragesh Babu Thandassery Benjamin Tharian | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，3： | 2 |
| 5 | Mechanical properties and morphology of PP/ABS blendscompatibilized with PP-g- 2-HEMA显示文摘 | Alpesh C Ragesh B B Surekha D | 2003 | Journal of Applied Polymer Science2003，88，7： | 1 |
| 6 | Diagnostic yield of EUS-guided FNA and cytology in suspected tubercular intra-abdominal lymphadenopathy显示文摘 | Rajesh Puri Rakhee Mangla Mohamad Eloubeidi Peter Vilmann Ragesh Thandassery Randhir Sud | 2012 | Gastrointestinal Endoscopy2012，，5： | 1 |
| 7 | Ion-enhanced chemical etching of HfO2 for integration in metal-oxide-semiconductor field effect transistors显示文摘 | Sha Lir Ragesh Puthenkovilakam Lin Yousheng Chang Jane P | | 0，，： | 1 |
| 8 | An accurate determination of barrier heights at the HfO2/Si interfaces显示文摘 | Ragesh Puthenkovilakam Jane P Chang | 2004 | J Appl Phys2004，96，5： | 1 |
| 9 | Endoscopic ultrasound in the diagnosis and management ofcarcinoma pancreas显示文摘Endoscopic ultrasound(EUS) has become an important component in the diagnosis and treatment of carcinoma pancreas. With the advent of advanced imaging techniques and tissue acquisition methods the role of EUS is becoming increasingly important. Small pancreatic tumors can be reliably diagnosed with EUS. EUS guided fine needle aspiration establishes diagnosis in some cases. EUS plays an important role in staging of carcinoma pancreas and in some important therapeutic methods that include celiac plexus neurolysis, EUS guided biliary drainage and drug delivery. In this review we attempt to review the role of EUS in diagnosis and management of carcinoma pancreas. | Rajesh Puri Manish Manrai Ragesh Babu Thandassery Abdulrahman A Alfadda | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 1 |
| 10 | Chang,Electrical characteristics of postdeposition annealed HfO2 on silicon 显示文摘 | Ragesh Puthenkovilakam Monica Sawkar Jane P | 2005 | Appl Phys Lett2005，86，20： | 1 |
| 11 | A review on 'self-cleaning and multifunctional materials' 显示文摘 | RAGESH P GANESH V A NAIR S V | 2014 | Journal of Materials Chemistry A2014，2，14： | 1 |
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